{"id":"https://openalex.org/W2520043871","doi":"https://doi.org/10.1515/cmam-2015-0019","title":"Numerical Methods for Genetic Regulatory Network Identification Based on a Variational Approach","display_name":"Numerical Methods for Genetic Regulatory Network Identification Based on a Variational Approach","publication_year":2015,"publication_date":"2015-08-20","ids":{"openalex":"https://openalex.org/W2520043871","doi":"https://doi.org/10.1515/cmam-2015-0019","mag":"2520043871"},"language":"en","primary_location":{"id":"doi:10.1515/cmam-2015-0019","is_oa":true,"landing_page_url":"https://doi.org/10.1515/cmam-2015-0019","pdf_url":"http://www.degruyter.com/downloadpdf/j/cmam.2016.16.issue-1/cmam-2015-0019/cmam-2015-0019.xml","source":{"id":"https://openalex.org/S2765013998","display_name":"Computational Methods in Applied Mathematics","issn_l":"1609-4840","issn":["1609-4840","1609-9389"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310313990","host_organization_name":"De Gruyter","host_organization_lineage":["https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational Methods in Applied Mathematics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.degruyter.com/downloadpdf/j/cmam.2016.16.issue-1/cmam-2015-0019/cmam-2015-0019.xml","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5011365911","display_name":"Xiaobing Feng","orcid":"https://orcid.org/0000-0002-9191-9092"},"institutions":[{"id":"https://openalex.org/I75027704","display_name":"University of Tennessee at Knoxville","ror":"https://ror.org/020f3ap87","country_code":"US","type":"education","lineage":["https://openalex.org/I75027704"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Xiaobing Feng","raw_affiliation_strings":["Department of Mathematics, The University of Tennessee, Knoxville, TN 37996, USA"],"affiliations":[{"raw_affiliation_string":"Department of Mathematics, The University of Tennessee, Knoxville, TN 37996, USA","institution_ids":["https://openalex.org/I75027704"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047555816","display_name":"Miun Yoon","orcid":null},"institutions":[{"id":"https://openalex.org/I75027704","display_name":"University of Tennessee at Knoxville","ror":"https://ror.org/020f3ap87","country_code":"US","type":"education","lineage":["https://openalex.org/I75027704"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Miun Yoon","raw_affiliation_strings":["Department of Mathematics, The University of Tennessee, Knoxville, TN 37996, USA"],"affiliations":[{"raw_affiliation_string":"Department of Mathematics, The University of Tennessee, Knoxville, TN 37996, USA","institution_ids":["https://openalex.org/I75027704"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5011365911"],"corresponding_institution_ids":["https://openalex.org/I75027704"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.16464523,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":"1","first_page":"77","last_page":"103"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.9930999875068665,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.6590481996536255},{"id":"https://openalex.org/keywords/genetic-algorithm","display_name":"Genetic algorithm","score":0.6383382678031921},{"id":"https://openalex.org/keywords/subnetwork","display_name":"Subnetwork","score":0.6318784952163696},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.5674774050712585},{"id":"https://openalex.org/keywords/mathematical-optimization","display_name":"Mathematical optimization","score":0.5614756941795349},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.36275291442871094}],"concepts":[{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.6590481996536255},{"id":"https://openalex.org/C8880873","wikidata":"https://www.wikidata.org/wiki/Q187787","display_name":"Genetic algorithm","level":2,"score":0.6383382678031921},{"id":"https://openalex.org/C2780186347","wikidata":"https://www.wikidata.org/wiki/Q11414","display_name":"Subnetwork","level":2,"score":0.6318784952163696},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.5674774050712585},{"id":"https://openalex.org/C126255220","wikidata":"https://www.wikidata.org/wiki/Q141495","display_name":"Mathematical optimization","level":1,"score":0.5614756941795349},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.36275291442871094},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0},{"id":"https://openalex.org/C38652104","wikidata":"https://www.wikidata.org/wiki/Q3510521","display_name":"Computer security","level":1,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1515/cmam-2015-0019","is_oa":true,"landing_page_url":"https://doi.org/10.1515/cmam-2015-0019","pdf_url":"http://www.degruyter.com/downloadpdf/j/cmam.2016.16.issue-1/cmam-2015-0019/cmam-2015-0019.xml","source":{"id":"https://openalex.org/S2765013998","display_name":"Computational Methods in Applied Mathematics","issn_l":"1609-4840","issn":["1609-4840","1609-9389"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310313990","host_organization_name":"De Gruyter","host_organization_lineage":["https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational Methods in Applied Mathematics","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1515/cmam-2015-0019","is_oa":true,"landing_page_url":"https://doi.org/10.1515/cmam-2015-0019","pdf_url":"http://www.degruyter.com/downloadpdf/j/cmam.2016.16.issue-1/cmam-2015-0019/cmam-2015-0019.xml","source":{"id":"https://openalex.org/S2765013998","display_name":"Computational Methods in Applied Mathematics","issn_l":"1609-4840","issn":["1609-4840","1609-9389"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310313990","host_organization_name":"De Gruyter","host_organization_lineage":["https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Computational Methods in Applied Mathematics","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.6200000047683716,"display_name":"Affordable and clean energy","id":"https://metadata.un.org/sdg/7"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2520043871.pdf","grobid_xml":"https://content.openalex.org/works/W2520043871.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2060724872","https://openalex.org/W2082094785","https://openalex.org/W2202198356","https://openalex.org/W3087203342","https://openalex.org/W2377184161","https://openalex.org/W228984114","https://openalex.org/W2090026684","https://openalex.org/W4226360758","https://openalex.org/W2151093953","https://openalex.org/W2382431814"],"abstract_inverted_index":{"Abstract":[0],"This":[1],"paper":[2],"studies":[3],"differential":[4,108],"equation-based":[5],"mathematical":[6,116],"models":[7,135,178],"and":[8,24,30,75,140,144,152,161,168,179],"their":[9,148],"numerical":[10,31,142],"solutions":[11,37,149],"for":[12,33,38,146],"genetic":[13,41,57,123,186],"regulatory":[14,42,124,187],"network":[15,58,63,73,159,188],"identification.":[16],"The":[17,89],"primary":[18],"objectives":[19],"are":[20,150,171],"to":[21,99],"design,":[22],"analyze,":[23],"test":[25],"a":[26,79,96,180],"general":[27],"variational":[28,50,82,90,138,177],"framework":[29,139],"methods":[32,143,190],"seeking":[34],"its":[35],"approximate":[36],"reverse":[39],"engineering":[40],"networks":[43,125],"from":[44],"microarray":[45,69],"datasets.":[46],"In":[47],"the":[48,56,62,68,72,102,106,119,137],"proposed":[49,151,176],"framework,":[51],"no":[52],"structure":[53],"assumption":[54],"on":[55,173],"is":[59,64,76,191],"presumed,":[60],"instead,":[61],"solely":[65],"determined":[66],"by":[67],"profile":[70],"of":[71,105,118,122,164],"components":[74],"identified":[77],"through":[78],"well":[80],"chosen":[81],"principle":[83,91],"which":[84,126],"minimizes":[85],"an":[86,114],"energy":[87],"functional.":[88],"serves":[92],"not":[93],"only":[94],"as":[95],"selection":[97],"criterion":[98],"pick":[100],"up":[101],"right":[103],"solution":[104],"underlying":[107],"equation":[109],"model":[110],"but":[111],"also":[112,192],"provides":[113],"effective":[115],"characterization":[117],"small-world":[120],"property":[121],"has":[127],"been":[128],"observed":[129],"in":[130],"lab":[131],"experiments.":[132],"Five":[133],"specific":[134],"within":[136],"efficient":[141],"algorithms":[145],"computing":[147],"analyzed.":[153],"Model":[154],"validations":[155],"using":[156],"both":[157],"synthetic":[158],"datasets":[160,163],"subnetwork":[162],"Saccharomyces":[165],"cerevisiae":[166],"(yeast)":[167],"E.":[169],"coli":[170],"performed":[172],"all":[174],"five":[175],"performance":[181],"comparison":[182],"versus":[183],"some":[184],"existing":[185],"identification":[189],"provided.":[193]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}