{"id":"https://openalex.org/W2011383566","doi":"https://doi.org/10.1515/bams-2013-0009","title":"Structural role of exons in hemoglobin","display_name":"Structural role of exons in hemoglobin","publication_year":2013,"publication_date":"2013-05-31","ids":{"openalex":"https://openalex.org/W2011383566","doi":"https://doi.org/10.1515/bams-2013-0009","mag":"2011383566"},"language":"en","primary_location":{"id":"doi:10.1515/bams-2013-0009","is_oa":false,"landing_page_url":"https://doi.org/10.1515/bams-2013-0009","pdf_url":null,"source":{"id":"https://openalex.org/S2764861201","display_name":"Bio-Algorithms and Med-Systems","issn_l":"1895-9091","issn":["1895-9091","1896-530X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310313990","host_organization_name":"De Gruyter","host_organization_lineage":["https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bams","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://ruj.uj.edu.pl/xmlui/handle/item/102478","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5054698572","display_name":"Monika Piwowar","orcid":"https://orcid.org/0000-0003-4645-8730"},"institutions":[{"id":"https://openalex.org/I126596746","display_name":"Jagiellonian University","ror":"https://ror.org/03bqmcz70","country_code":"PL","type":"education","lineage":["https://openalex.org/I126596746"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Monika Piwowar","raw_affiliation_strings":["Department of Bioinformatics and Telemedicine, Jagiellonian University Medical College, Lazarza 16, 31-530 Krakow, Poland","Department of bioinformatics and Telemedicine, Jagiellonian University - Medical College, Lazarza 16, 31-530 Krakow, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics and Telemedicine, Jagiellonian University Medical College, Lazarza 16, 31-530 Krakow, Poland","institution_ids":["https://openalex.org/I126596746"]},{"raw_affiliation_string":"Department of bioinformatics and Telemedicine, Jagiellonian University - Medical College, Lazarza 16, 31-530 Krakow, Poland","institution_ids":["https://openalex.org/I126596746"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068559370","display_name":"Mateusz Banach","orcid":"https://orcid.org/0000-0003-1806-9877"},"institutions":[{"id":"https://openalex.org/I126596746","display_name":"Jagiellonian University","ror":"https://ror.org/03bqmcz70","country_code":"PL","type":"education","lineage":["https://openalex.org/I126596746"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Mateusz Banach","raw_affiliation_strings":["Department of bioinformatics and Telemedicine, Jagiellonian University - Medical College, Lazarza 16, 31-530 Krakow, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of bioinformatics and Telemedicine, Jagiellonian University - Medical College, Lazarza 16, 31-530 Krakow, Poland","institution_ids":["https://openalex.org/I126596746"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027144155","display_name":"Leszek Konieczny","orcid":null},"institutions":[{"id":"https://openalex.org/I126596746","display_name":"Jagiellonian University","ror":"https://ror.org/03bqmcz70","country_code":"PL","type":"education","lineage":["https://openalex.org/I126596746"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Leszek Konieczny","raw_affiliation_strings":["Chair of Medical Biochemistry, Jagiellonian University Medical College, Kopernika 7, 31-034 Krakow, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chair of Medical Biochemistry, Jagiellonian University Medical College, Kopernika 7, 31-034 Krakow, Poland","institution_ids":["https://openalex.org/I126596746"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033642937","display_name":"Jacques Chomilier","orcid":"https://orcid.org/0000-0002-4250-0762"},"institutions":[{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I39804081","display_name":"Sorbonne Universit\u00e9","ror":"https://ror.org/02en5vm52","country_code":"FR","type":"education","lineage":["https://openalex.org/I39804081"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Jacques Chomilier","raw_affiliation_strings":["IMPMC, Universit\u00e9 Pierre et Marie Curie, CNRS, 4 Place Jussieu, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"IMPMC, Universit\u00e9 Pierre et Marie Curie, CNRS, 4 Place Jussieu, Paris, France","institution_ids":["https://openalex.org/I39804081","https://openalex.org/I1294671590"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5087239926","display_name":"Irena Roterman","orcid":"https://orcid.org/0000-0003-3652-9099"},"institutions":[{"id":"https://openalex.org/I126596746","display_name":"Jagiellonian University","ror":"https://ror.org/03bqmcz70","country_code":"PL","type":"education","lineage":["https://openalex.org/I126596746"]}],"countries":["PL"],"is_corresponding":true,"raw_author_name":"Irena Roterman","raw_affiliation_strings":["Department of Bioinformatics and Telemedicine, Jagiellonian University Medical College, Lazarza 16, 31-530 Krakow, Poland","Department of bioinformatics and Telemedicine, Jagiellonian University - Medical College, Lazarza 16, 31-530 Krakow, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics and Telemedicine, Jagiellonian University Medical College, Lazarza 16, 31-530 Krakow, Poland","institution_ids":["https://openalex.org/I126596746"]},{"raw_affiliation_string":"Department of bioinformatics and Telemedicine, Jagiellonian University - Medical College, Lazarza 16, 31-530 Krakow, Poland","institution_ids":["https://openalex.org/I126596746"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5087239926"],"corresponding_institution_ids":["https://openalex.org/I126596746"],"apc_list":null,"apc_paid":null,"fwci":0.2992,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.61404913,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"9","issue":"2","first_page":"81","last_page":"90"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9973000288009644,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12094","display_name":"Hemoglobin structure and function","score":0.9965000152587891,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/exon","display_name":"Exon","score":0.950697660446167},{"id":"https://openalex.org/keywords/tandem-exon-duplication","display_name":"Tandem exon duplication","score":0.7335221171379089},{"id":"https://openalex.org/keywords/exon-shuffling","display_name":"Exon shuffling","score":0.6661301851272583},{"id":"https://openalex.org/keywords/genbank","display_name":"GenBank","score":0.5656589269638062},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.5100443959236145},{"id":"https://openalex.org/keywords/protein-tertiary-structure","display_name":"Protein tertiary structure","score":0.4586792588233948},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.439540833234787},{"id":"https://openalex.org/keywords/protein-structure","display_name":"Protein structure","score":0.4298911690711975},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4277365803718567},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.34892478585243225},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.33681851625442505},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.25682181119918823}],"concepts":[{"id":"https://openalex.org/C36823959","wikidata":"https://www.wikidata.org/wiki/Q373027","display_name":"Exon","level":3,"score":0.950697660446167},{"id":"https://openalex.org/C156446351","wikidata":"https://www.wikidata.org/wiki/Q7682435","display_name":"Tandem exon duplication","level":4,"score":0.7335221171379089},{"id":"https://openalex.org/C190017056","wikidata":"https://www.wikidata.org/wiki/Q5420611","display_name":"Exon shuffling","level":5,"score":0.6661301851272583},{"id":"https://openalex.org/C79029880","wikidata":"https://www.wikidata.org/wiki/Q901755","display_name":"GenBank","level":3,"score":0.5656589269638062},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5100443959236145},{"id":"https://openalex.org/C75599170","wikidata":"https://www.wikidata.org/wiki/Q898483","display_name":"Protein tertiary structure","level":2,"score":0.4586792588233948},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.439540833234787},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.4298911690711975},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4277365803718567},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.34892478585243225},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33681851625442505},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.25682181119918823}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.1515/bams-2013-0009","is_oa":false,"landing_page_url":"https://doi.org/10.1515/bams-2013-0009","pdf_url":null,"source":{"id":"https://openalex.org/S2764861201","display_name":"Bio-Algorithms and Med-Systems","issn_l":"1895-9091","issn":["1895-9091","1896-530X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310313990","host_organization_name":"De Gruyter","host_organization_lineage":["https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bams","raw_type":"journal-article"},{"id":"pmh:oai:ruj.uj.edu.pl:item/102478","is_oa":true,"landing_page_url":"https://ruj.uj.edu.pl/xmlui/handle/item/102478","pdf_url":null,"source":{"id":"https://openalex.org/S4306400316","display_name":"Homo Politicus (Academy of Humanities and Economics in Lodz)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"artyku\u0142 w czasopi\u015bmie"},{"id":"pmh:oai:ruj.uj.edu.pl:item/113867","is_oa":true,"landing_page_url":"https://ruj.uj.edu.pl/xmlui/handle/item/113867","pdf_url":null,"source":{"id":"https://openalex.org/S4306401249","display_name":"Jagiellonian University Repository (Jagiellonian University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I126596746","host_organization_name":"Jagiellonian University","host_organization_lineage":["https://openalex.org/I126596746"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:ruj.uj.edu.pl:item/131422","is_oa":true,"landing_page_url":"https://ruj.uj.edu.pl/xmlui/handle/item/131422","pdf_url":null,"source":{"id":"https://openalex.org/S4306401249","display_name":"Jagiellonian University Repository (Jagiellonian University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I126596746","host_organization_name":"Jagiellonian University","host_organization_lineage":["https://openalex.org/I126596746"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:HAL:hal-01002041v1","is_oa":false,"landing_page_url":"https://hal.science/hal-01002041","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL (Le Centre pour la Communication Scientifique Directe)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1294671590","host_organization_name":"Centre National de la Recherche Scientifique","host_organization_lineage":["https://openalex.org/I1294671590"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"BAMS, 2013, pp.81-90","raw_type":"Journal articles"}],"best_oa_location":{"id":"pmh:oai:ruj.uj.edu.pl:item/102478","is_oa":true,"landing_page_url":"https://ruj.uj.edu.pl/xmlui/handle/item/102478","pdf_url":null,"source":{"id":"https://openalex.org/S4306400316","display_name":"Homo Politicus (Academy of Humanities and Economics in Lodz)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"artyku\u0142 w czasopi\u015bmie"},"sustainable_development_goals":[{"score":0.41999998688697815,"id":"https://metadata.un.org/sdg/12","display_name":"Responsible consumption and production"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W113763381","https://openalex.org/W157808733","https://openalex.org/W277359049","https://openalex.org/W1530353793","https://openalex.org/W1965555277","https://openalex.org/W1967450389","https://openalex.org/W1971135687","https://openalex.org/W1972117902","https://openalex.org/W1975304761","https://openalex.org/W1981404559","https://openalex.org/W1984547849","https://openalex.org/W1994520578","https://openalex.org/W1995169238","https://openalex.org/W1997130795","https://openalex.org/W2001014276","https://openalex.org/W2004641057","https://openalex.org/W2004954843","https://openalex.org/W2007084076","https://openalex.org/W2009804911","https://openalex.org/W2010228913","https://openalex.org/W2016785081","https://openalex.org/W2025422660","https://openalex.org/W2026593599","https://openalex.org/W2034477756","https://openalex.org/W2044223477","https://openalex.org/W2044770225","https://openalex.org/W2044881953","https://openalex.org/W2052814505","https://openalex.org/W2055140399","https://openalex.org/W2055684086","https://openalex.org/W2057565092","https://openalex.org/W2058261916","https://openalex.org/W2058628818","https://openalex.org/W2060131806","https://openalex.org/W2073028977","https://openalex.org/W2074238193","https://openalex.org/W2079268119","https://openalex.org/W2079589162","https://openalex.org/W2086808970","https://openalex.org/W2089091329","https://openalex.org/W2099835330","https://openalex.org/W2102138191","https://openalex.org/W2114441129","https://openalex.org/W2118278961","https://openalex.org/W2135683634","https://openalex.org/W2149946713","https://openalex.org/W2156954132","https://openalex.org/W2166813898","https://openalex.org/W2170535845"],"related_works":["https://openalex.org/W1539107620","https://openalex.org/W2093401651","https://openalex.org/W1813070175","https://openalex.org/W2006004944","https://openalex.org/W1610209323","https://openalex.org/W2031872306","https://openalex.org/W2025633862","https://openalex.org/W1926883706","https://openalex.org/W1984349060","https://openalex.org/W2132922440"],"abstract_inverted_index":{"Abstract":[0],"The":[1,48,158],"role":[2,74,106,207],"of":[3,12,62,75,87,91,95,114,128,140,154,160,169,208],"exons":[4,76,118],"can":[5,81],"be":[6,82],"studied":[7],"on":[8,125],"many":[9],"levels,":[10],"one":[11,46,187,211],"which":[13,189,222],"pertains":[14],"to":[15,31,68,84,152,217],"protein":[16,64,171,183,215],"structure.":[17],"It":[18,178],"is":[19,66,216],"a":[20,63,191,219],"well-known":[21],"fact":[22],"that":[23,181,204],"secondary":[24],"structural":[25,156,192,229],"motifs":[26],"do":[27],"not":[28],"directly":[29],"correspond":[30],"exons:":[32],"helices,":[33],"\u03b2-sheets":[34],"and":[35,53],"loops":[36],"have":[37,122],"all":[38],"been":[39,123],"identified":[40,124],"as":[41],"encoded":[42],"by":[43,108],"more":[44],"than":[45],"exon.":[47],"relation":[49],"between":[50],"exon":[51,148,162,188,212],"fragments":[52,98],"their":[54],"involvement":[55],"in":[56,77,101,119,164,194,213,224],"shaping":[57,165],"the":[58,73,85,88,92,105,112,115,126,133,137,166,170,197,205],"three-dimensional":[59],"(3D)":[60],"structure":[61,86],"body":[65],"subject":[67],"ongoing":[69],"studies.":[70],"In":[71,111],"particular,":[72],"stabilizing":[78],"tertiary":[79,228],"structures":[80],"related":[83],"hydrophobic":[89,102,167,199,220],"core":[90,168,200,221],"protein.":[93],"Participation":[94],"specific":[96],"polypeptide":[97],"(single":[99],"exons)":[100],"stabilization":[103],"reveals":[104],"played":[107],"each":[109,147,161,182,214],"fragment.":[110],"course":[113],"presented":[116],"research,":[117],"selected":[120],"proteins":[121],"basis":[127],"GenBank":[129],"files,":[130],"imported":[131],"from":[132],"nucleotide":[134],"database":[135],"at":[136,185,209],"National":[138],"Center":[139],"Biotechnology":[141],"Information.":[142],"Amino":[143],"acid":[144],"sequences":[145],"representing":[146],"were":[149],"subsequently":[150],"traced":[151],"parts":[153],"3D":[155],"forms.":[157],"participation":[159],"fragment":[163,193],"was":[172,179],"measured":[173],"using":[174],"divergence":[175],"entropy":[176],"calculations.":[177],"found":[180],"contains":[184],"least":[186,210],"encodes":[190],"accordance":[195],"with":[196],"theoretical":[198],"model.":[201],"This":[202],"implies":[203],"likely":[206],"generate":[218],"is,":[223],"turn,":[225],"responsible":[226],"for":[227],"stabilization.":[230]},"counts_by_year":[{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-06-16T09:24:06.705377","created_date":"2025-10-10T00:00:00"}