{"id":"https://openalex.org/W792367607","doi":"https://doi.org/10.1515/bams-2012-0024","title":"Structural Analysis of the Lactoferrin Iron Binding Pockets","display_name":"Structural Analysis of the Lactoferrin Iron Binding Pockets","publication_year":2012,"publication_date":"2012-12-01","ids":{"openalex":"https://openalex.org/W792367607","doi":"https://doi.org/10.1515/bams-2012-0024","mag":"792367607"},"language":"en","primary_location":{"id":"doi:10.1515/bams-2012-0024","is_oa":false,"landing_page_url":"https://doi.org/10.1515/bams-2012-0024","pdf_url":null,"source":{"id":"https://openalex.org/S2764861201","display_name":"Bio-Algorithms and Med-Systems","issn_l":"1895-9091","issn":["1895-9091","1896-530X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310313990","host_organization_name":"De Gruyter","host_organization_lineage":["https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bams","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042186084","display_name":"Damian Marchewka","orcid":null},"institutions":[{"id":"https://openalex.org/I126596746","display_name":"Jagiellonian University","ror":"https://ror.org/03bqmcz70","country_code":"PL","type":"education","lineage":["https://openalex.org/I126596746"]}],"countries":["PL"],"is_corresponding":true,"raw_author_name":"Damian Marchewka","raw_affiliation_strings":["Department of Bioinformatics and Telemedicine, Jagiellonian University \u2013 Medical College, Lazarza 16, 31-530 Krakow, PL","Faculty of Physics, Astronomy and Applied Computer Science \u2013 Jagiellonian University, Reymonta 4, 30-059 Krakow, PL"],"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics and Telemedicine, Jagiellonian University \u2013 Medical College, Lazarza 16, 31-530 Krakow, PL","institution_ids":["https://openalex.org/I126596746"]},{"raw_affiliation_string":"Faculty of Physics, Astronomy and Applied Computer Science \u2013 Jagiellonian University, Reymonta 4, 30-059 Krakow, PL","institution_ids":["https://openalex.org/I126596746"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087239926","display_name":"Irena Roterman","orcid":"https://orcid.org/0000-0003-3652-9099"},"institutions":[{"id":"https://openalex.org/I126596746","display_name":"Jagiellonian University","ror":"https://ror.org/03bqmcz70","country_code":"PL","type":"education","lineage":["https://openalex.org/I126596746"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Irena Roterman","raw_affiliation_strings":["Department of Bioinformatics and Telemedicine, Jagiellonian University \u2013 Medical College, Lazarza 16, 31-530 Krakow, PL"],"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics and Telemedicine, Jagiellonian University \u2013 Medical College, Lazarza 16, 31-530 Krakow, PL","institution_ids":["https://openalex.org/I126596746"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056813435","display_name":"Magdalena Strus","orcid":"https://orcid.org/0000-0002-7437-5230"},"institutions":[{"id":"https://openalex.org/I126596746","display_name":"Jagiellonian University","ror":"https://ror.org/03bqmcz70","country_code":"PL","type":"education","lineage":["https://openalex.org/I126596746"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Magdalena Strus","raw_affiliation_strings":["Chair of Microbiology, Jagiellonian University \u2013 Medical College, Czysta 18, 31-121 Krakow, PL"],"affiliations":[{"raw_affiliation_string":"Chair of Microbiology, Jagiellonian University \u2013 Medical College, Czysta 18, 31-121 Krakow, PL","institution_ids":["https://openalex.org/I126596746"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078143662","display_name":"Klaudyna \u015apiewak","orcid":null},"institutions":[{"id":"https://openalex.org/I126596746","display_name":"Jagiellonian University","ror":"https://ror.org/03bqmcz70","country_code":"PL","type":"education","lineage":["https://openalex.org/I126596746"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Klaudyna \u015apiewak","raw_affiliation_strings":["Chair of Microbiology, Jagiellonian University \u2013 Medical College, Czysta 18, 31-121 Krakow, PL"],"affiliations":[{"raw_affiliation_string":"Chair of Microbiology, Jagiellonian University \u2013 Medical College, Czysta 18, 31-121 Krakow, PL","institution_ids":["https://openalex.org/I126596746"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5032136091","display_name":"Grzegorz Majka","orcid":"https://orcid.org/0000-0001-8617-9395"},"institutions":[{"id":"https://openalex.org/I126596746","display_name":"Jagiellonian University","ror":"https://ror.org/03bqmcz70","country_code":"PL","type":"education","lineage":["https://openalex.org/I126596746"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Grzegorz Majka","raw_affiliation_strings":["Chair of Microbiology, Jagiellonian University \u2013 Medical College, Czysta 18, 31-121 Krakow, PL"],"affiliations":[{"raw_affiliation_string":"Chair of Microbiology, Jagiellonian University \u2013 Medical College, Czysta 18, 31-121 Krakow, PL","institution_ids":["https://openalex.org/I126596746"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5042186084"],"corresponding_institution_ids":["https://openalex.org/I126596746"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.0347725,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"8","issue":"4","first_page":"351","last_page":"359"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11294","display_name":"Infant Nutrition and Health","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11294","display_name":"Infant Nutrition and Health","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.9918000102043152,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10602","display_name":"Glycosylation and Glycoproteins Research","score":0.991599977016449,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lactoferrin","display_name":"Lactoferrin","score":0.9822231531143188},{"id":"https://openalex.org/keywords/transferrin","display_name":"Transferrin","score":0.8286470174789429},{"id":"https://openalex.org/keywords/protein-tertiary-structure","display_name":"Protein tertiary structure","score":0.674216628074646},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.5219082832336426},{"id":"https://openalex.org/keywords/ligand","display_name":"Ligand (biochemistry)","score":0.4409445822238922},{"id":"https://openalex.org/keywords/iron-binding-proteins","display_name":"Iron-binding proteins","score":0.43532803654670715},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.3699570596218109},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.3294062614440918},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.27494144439697266},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.21684333682060242}],"concepts":[{"id":"https://openalex.org/C2779170986","wikidata":"https://www.wikidata.org/wiki/Q410246","display_name":"Lactoferrin","level":2,"score":0.9822231531143188},{"id":"https://openalex.org/C22814914","wikidata":"https://www.wikidata.org/wiki/Q410473","display_name":"Transferrin","level":2,"score":0.8286470174789429},{"id":"https://openalex.org/C75599170","wikidata":"https://www.wikidata.org/wiki/Q898483","display_name":"Protein tertiary structure","level":2,"score":0.674216628074646},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5219082832336426},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.4409445822238922},{"id":"https://openalex.org/C2779369046","wikidata":"https://www.wikidata.org/wiki/Q6072234","display_name":"Iron-binding proteins","level":3,"score":0.43532803654670715},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3699570596218109},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3294062614440918},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.27494144439697266},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.21684333682060242}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1515/bams-2012-0024","is_oa":false,"landing_page_url":"https://doi.org/10.1515/bams-2012-0024","pdf_url":null,"source":{"id":"https://openalex.org/S2764861201","display_name":"Bio-Algorithms and Med-Systems","issn_l":"1895-9091","issn":["1895-9091","1896-530X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310313990","host_organization_name":"De Gruyter","host_organization_lineage":["https://openalex.org/P4310313990"],"host_organization_lineage_names":["De Gruyter"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"bams","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320337160","display_name":"Academic Computer Centre Cyfronet, AGH University of Science and Technology","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":3,"referenced_works":["https://openalex.org/W184834241","https://openalex.org/W1982162383","https://openalex.org/W2066165525"],"related_works":["https://openalex.org/W2410301455","https://openalex.org/W2076108540","https://openalex.org/W2956909865","https://openalex.org/W37145320","https://openalex.org/W2093027170","https://openalex.org/W1975983011","https://openalex.org/W1953496394","https://openalex.org/W1973037096","https://openalex.org/W2182820329","https://openalex.org/W1999550122"],"abstract_inverted_index":{"ABSTRACT":[0],"Lactoferrin":[1],"(Lf)":[2],"-":[3],"member":[4],"of":[5,9,19,24,39,46,58,66,90,113],"the":[6,17,29,33,44,55,67,93,106,114,121,127,135],"transferrin":[7],"family":[8],"proteins":[10],"responsible":[11],"for":[12],"many":[13],"different":[14],"functions":[15,94],"in":[16,22,28,54,76,80,139,147],"body":[18,30],"mammals":[20],"participates":[21],"regulation":[23],"free":[25],"iron":[26],"level":[27],"fluids":[31],"making":[32],"protein":[34,117],"bacteriostatic.":[35],"The":[36,111,130],"main":[37],"goal":[38],"studies":[40],"was":[41,72,118],"to":[42,50,61,101],"test":[43],"suitability":[45],"molecular":[47],"dynamic":[48,124],"simulation":[49,125,136],"study":[51],"structural":[52,143],"changes":[53,133,144],"tertiary":[56,131],"structure":[57,132],"lactoferrin.":[59,97],"According":[60],"ConSurf":[62],"Server":[63],"analysis":[64],"one":[65],"most":[68],"conservative":[69],"amino":[70],"acids":[71],"found":[73],"not":[74],"only":[75],"iron-":[77],"but":[78],"also":[79],"carbohydrates-":[81],"binding":[82,109],"pockets":[83,104],"which":[84],"may":[85],"suggest":[86],"a":[87],"significant":[88],"impact":[89],"carbohydrates":[91],"on":[92],"performed":[95],"by":[96],"Pocket-Finder":[98],"program":[99],"applied":[100],"find":[102],"iron-binding":[103,149],"revealed":[105],"potential":[107],"Fe":[108],"area.":[110],"stability":[112],"ligand":[115],"deprived":[116],"verified":[119],"performing":[120],"50":[122],"ns":[123],"using":[126],"Gromacs":[128],"program.":[129],"during":[134],"were":[137,145],"observed":[138,146],"N-lob":[140],"solely.":[141],"No":[142],"C-lob":[148],"pocket.":[150]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
