{"id":"https://openalex.org/W4414890193","doi":"https://doi.org/10.1504/ijdmb.2025.148968","title":"Identification of key abnormally expressed gene modules and pathways in keloid via weighted gene co-expression network analysis","display_name":"Identification of key abnormally expressed gene modules and pathways in keloid via weighted gene co-expression network analysis","publication_year":2025,"publication_date":"2025-01-01","ids":{"openalex":"https://openalex.org/W4414890193","doi":"https://doi.org/10.1504/ijdmb.2025.148968"},"language":"en","primary_location":{"id":"doi:10.1504/ijdmb.2025.148968","is_oa":false,"landing_page_url":"https://doi.org/10.1504/ijdmb.2025.148968","pdf_url":null,"source":{"id":"https://openalex.org/S35771696","display_name":"International Journal of Data Mining and Bioinformatics","issn_l":"1748-5673","issn":["1748-5673","1748-5681"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310317825","host_organization_name":"Inderscience Publishers","host_organization_lineage":["https://openalex.org/P4310317825"],"host_organization_lineage_names":["Inderscience Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Data Mining and Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064177622","display_name":"Jun Chai","orcid":"https://orcid.org/0000-0003-0240-6621"},"institutions":[{"id":"https://openalex.org/I4210116071","display_name":"Suzhou Municipal Hospital","ror":"https://ror.org/02cdyrc89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116071"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jun Chai","raw_affiliation_strings":["Department of Plastic and Reconstructive Surgery, Suzhou Municipal Hospital, Suzhou, China; Affiliated to: Suzhou Hospital of Nanjing Medical University, Gusu School of Nanjing Medical University, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Plastic and Reconstructive Surgery, Suzhou Municipal Hospital, Suzhou, China; Affiliated to: Suzhou Hospital of Nanjing Medical University, Gusu School of Nanjing Medical University, China","institution_ids":["https://openalex.org/I4210116071"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100456227","display_name":"Yan Zhang","orcid":"https://orcid.org/0000-0002-2947-1629"},"institutions":[{"id":"https://openalex.org/I4210116071","display_name":"Suzhou Municipal Hospital","ror":"https://ror.org/02cdyrc89","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210116071"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yan Zhang","raw_affiliation_strings":["Department of General Surgery, Suzhou Municipal Hospital, Suzhou, China; Affiliated to: Suzhou Hospital of Nanjing Medical University, Gusu School of Nanjing Medical University, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, Suzhou Municipal Hospital, Suzhou, China; Affiliated to: Suzhou Hospital of Nanjing Medical University, Gusu School of Nanjing Medical University, China","institution_ids":["https://openalex.org/I4210116071"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210116071"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.43862508,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"29","issue":"4","first_page":"451","last_page":"472"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11172","display_name":"Dermatologic Treatments and Research","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11172","display_name":"Dermatologic Treatments and Research","score":0.9987000226974487,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11144","display_name":"melanin and skin pigmentation","score":0.9850000143051147,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/keloid","display_name":"Keloid","score":0.9239000082015991},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.7311999797821045},{"id":"https://openalex.org/keywords/kegg","display_name":"KEGG","score":0.7172999978065491},{"id":"https://openalex.org/keywords/immune-system","display_name":"Immune system","score":0.4828999936580658},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"Gene expression profiling","score":0.4456999897956848},{"id":"https://openalex.org/keywords/identification","display_name":"Identification (biology)","score":0.43220001459121704},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.4309999942779541}],"concepts":[{"id":"https://openalex.org/C2777538232","wikidata":"https://www.wikidata.org/wiki/Q1131260","display_name":"Keloid","level":2,"score":0.9239000082015991},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.7311999797821045},{"id":"https://openalex.org/C152724338","wikidata":"https://www.wikidata.org/wiki/Q909442","display_name":"KEGG","level":5,"score":0.7172999978065491},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5898000001907349},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5853000283241272},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.4828999936580658},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.4456999897956848},{"id":"https://openalex.org/C116834253","wikidata":"https://www.wikidata.org/wiki/Q2039217","display_name":"Identification (biology)","level":2,"score":0.43220001459121704},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4309999942779541},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3889999985694885},{"id":"https://openalex.org/C2778022302","wikidata":"https://www.wikidata.org/wiki/Q18207329","display_name":"Gene co-expression network","level":5,"score":0.374099999666214},{"id":"https://openalex.org/C153400128","wikidata":"https://www.wikidata.org/wiki/Q3150731","display_name":"Infiltration (HVAC)","level":2,"score":0.3400999903678894},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.30320000648498535},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.2930999994277954},{"id":"https://openalex.org/C9927688","wikidata":"https://www.wikidata.org/wiki/Q4915012","display_name":"Biological pathway","level":4,"score":0.2806999981403351},{"id":"https://openalex.org/C26517878","wikidata":"https://www.wikidata.org/wiki/Q228039","display_name":"Key (lock)","level":2,"score":0.2612999975681305},{"id":"https://openalex.org/C2991772755","wikidata":"https://www.wikidata.org/wiki/Q751748","display_name":"Gene interaction","level":3,"score":0.2606000006198883},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2529999911785126}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1504/ijdmb.2025.148968","is_oa":false,"landing_page_url":"https://doi.org/10.1504/ijdmb.2025.148968","pdf_url":null,"source":{"id":"https://openalex.org/S35771696","display_name":"International Journal of Data Mining and Bioinformatics","issn_l":"1748-5673","issn":["1748-5673","1748-5681"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310317825","host_organization_name":"Inderscience Publishers","host_organization_lineage":["https://openalex.org/P4310317825"],"host_organization_lineage_names":["Inderscience Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Data Mining and Bioinformatics","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":[],"abstract_inverted_index":{"Keloid":[0],"is":[1,8],"a":[2],"common":[3],"human":[4],"skin":[5],"disease":[6],"that":[7,139],"related":[9],"to":[10,34,71],"the":[11,20,36,58,73,87,101,108,130],"environment,":[12],"heredity,":[13],"tension,":[14],"lifestyles,":[15],"and":[16,41,53,61,65,75,91,94,113,118,125],"other":[17],"factors.":[18],"However,":[19],"complicated":[21],"molecular":[22],"mechanisms":[23],"of":[24,51,89,104],"keloid":[25,146],"formation":[26],"are":[27],"still":[28],"unknown.":[29],"Thus,":[30],"this":[31],"study":[32],"aimed":[33],"identify":[35,72],"key":[37,76],"abnormally":[38],"expressed":[39],"genes":[40,103,112],"functionally":[42],"enriched":[43],"pathways":[44],"in":[45,68],"keloid.":[46,80],"The":[47],"gene":[48],"expression":[49],"profiles":[50],"GSE173900":[52],"GSE92566":[54],"were":[55,127,142],"downloaded":[56],"from":[57],"GEO":[59],"database":[60],"analysed":[62],"by":[63],"'limma'":[64],"'WGCNA'":[66],"package":[67],"R":[69],"4.1.1":[70],"DEGs":[74],"modules":[77],"associated":[78],"with":[79,145],"Then,":[81],"enrichment":[82],"analysis":[83,117,137],"was":[84,98],"performed":[85,114],"on":[86],"basis":[88],"GO":[90],"KEGG":[92],"pathway,":[93],"protein-protein":[95],"interaction":[96],"network":[97],"constructed":[99],"using":[100],"overlapped":[102],"DEGs.":[105],"We":[106],"confirmed":[107],"top":[109,131],"5":[110],"hub":[111,133],"immune":[115],"infiltration":[116,136],"survival":[119],"curve.":[120],"CCR5,":[121],"CYBB,":[122],"MNDA,":[123],"PLEK,":[124],"PTPRC":[126],"identified":[128],"as":[129],"five":[132],"genes.":[134],"Immune":[135],"showed":[138],"M1":[140],"macrophages":[141],"significantly":[143],"correlated":[144],"formation.":[147]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}