{"id":"https://openalex.org/W2805034662","doi":"https://doi.org/10.1504/ijdmb.2018.10013376","title":"Gene-gene interaction analysis for quantitative trait using cluster-based multifactor dimensionality reduction method","display_name":"Gene-gene interaction analysis for quantitative trait using cluster-based multifactor dimensionality reduction method","publication_year":2018,"publication_date":"2018-01-01","ids":{"openalex":"https://openalex.org/W2805034662","doi":"https://doi.org/10.1504/ijdmb.2018.10013376","mag":"2805034662"},"language":"en","primary_location":{"id":"doi:10.1504/ijdmb.2018.10013376","is_oa":true,"landing_page_url":"http://doi.org/10.1504/ijdmb.2018.10013376","pdf_url":"https://doi.org/10.1504/ijdmb.2018.10013376","source":{"id":"https://openalex.org/S35771696","display_name":"International Journal of Data Mining and Bioinformatics","issn_l":"1748-5673","issn":["1748-5673","1748-5681"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310317825","host_organization_name":"Inderscience Publishers","host_organization_lineage":["https://openalex.org/P4310317825"],"host_organization_lineage_names":["Inderscience Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Data Mining and Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://doi.org/10.1504/ijdmb.2018.10013376","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101790537","display_name":"You-Jung Lee","orcid":null},"institutions":[{"id":"https://openalex.org/I1317225278","display_name":"Statistics Korea","ror":"https://ror.org/004g7jm05","country_code":"KR","type":"government","lineage":["https://openalex.org/I1317225278","https://openalex.org/I2801339556","https://openalex.org/I4210126005"]},{"id":"https://openalex.org/I197347611","display_name":"Korea University","ror":"https://ror.org/047dqcg40","country_code":"KR","type":"education","lineage":["https://openalex.org/I197347611"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Youjung Lee","raw_affiliation_strings":["Department of Statistics, Korea University, Seoul, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Statistics, Korea University, Seoul, South Korea","institution_ids":["https://openalex.org/I1317225278","https://openalex.org/I197347611"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100447427","display_name":"Mira Park","orcid":"https://orcid.org/0000-0003-3827-9089"},"institutions":[{"id":"https://openalex.org/I1317225278","display_name":"Statistics Korea","ror":"https://ror.org/004g7jm05","country_code":"KR","type":"government","lineage":["https://openalex.org/I1317225278","https://openalex.org/I2801339556","https://openalex.org/I4210126005"]},{"id":"https://openalex.org/I197347611","display_name":"Korea University","ror":"https://ror.org/047dqcg40","country_code":"KR","type":"education","lineage":["https://openalex.org/I197347611"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Mira Park","raw_affiliation_strings":["Department of Statistics, Korea University, Seoul, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Statistics, Korea University, Seoul, South Korea","institution_ids":["https://openalex.org/I1317225278","https://openalex.org/I197347611"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100643662","display_name":"Taesung Park","orcid":"https://orcid.org/0000-0002-8294-590X"},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Taesung Park","raw_affiliation_strings":["Department of Statistics, Seoul National University, Seoul, South Korea#TAB#"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Statistics, Seoul National University, Seoul, South Korea#TAB#","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100643035","display_name":"Hyein Kim","orcid":"https://orcid.org/0000-0001-8611-5703"},"institutions":[{"id":"https://openalex.org/I21028721","display_name":"Eulji University","ror":"https://ror.org/005bty106","country_code":"KR","type":"education","lineage":["https://openalex.org/I21028721"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Hyein Kim","raw_affiliation_strings":["Department of Preventive Medicine, Eulji University, Daejon, South Korea"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Preventive Medicine, Eulji University, Daejon, South Korea","institution_ids":["https://openalex.org/I21028721"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.3296,"has_fulltext":false,"cited_by_count":5,"citation_normalized_percentile":{"value":0.55365866,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"20","issue":"1","first_page":"1","last_page":"1"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9801999926567078,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9801999926567078,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11468","display_name":"Genetic Mapping and Diversity in Plants and Animals","score":0.9747999906539917,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.9740999937057495,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/multifactor-dimensionality-reduction","display_name":"Multifactor dimensionality reduction","score":0.853360652923584},{"id":"https://openalex.org/keywords/genome-wide-association-study","display_name":"Genome-wide association study","score":0.7209142446517944},{"id":"https://openalex.org/keywords/quantitative-trait-locus","display_name":"Quantitative trait locus","score":0.7054302096366882},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5978624224662781},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5425783395767212},{"id":"https://openalex.org/keywords/genetic-association","display_name":"Genetic association","score":0.5145032405853271},{"id":"https://openalex.org/keywords/gene-interaction","display_name":"Gene interaction","score":0.49306532740592957},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.4701072573661804},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.4417816698551178},{"id":"https://openalex.org/keywords/genotype","display_name":"Genotype","score":0.23578926920890808},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphism","display_name":"Single-nucleotide polymorphism","score":0.2248268723487854}],"concepts":[{"id":"https://openalex.org/C25249476","wikidata":"https://www.wikidata.org/wiki/Q6934678","display_name":"Multifactor dimensionality reduction","level":5,"score":0.853360652923584},{"id":"https://openalex.org/C106208931","wikidata":"https://www.wikidata.org/wiki/Q1098876","display_name":"Genome-wide association study","level":5,"score":0.7209142446517944},{"id":"https://openalex.org/C81941488","wikidata":"https://www.wikidata.org/wiki/Q853421","display_name":"Quantitative trait locus","level":3,"score":0.7054302096366882},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5978624224662781},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5425783395767212},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.5145032405853271},{"id":"https://openalex.org/C2991772755","wikidata":"https://www.wikidata.org/wiki/Q751748","display_name":"Gene interaction","level":3,"score":0.49306532740592957},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.4701072573661804},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4417816698551178},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.23578926920890808},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.2248268723487854}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1504/ijdmb.2018.10013376","is_oa":true,"landing_page_url":"http://doi.org/10.1504/ijdmb.2018.10013376","pdf_url":"https://doi.org/10.1504/ijdmb.2018.10013376","source":{"id":"https://openalex.org/S35771696","display_name":"International Journal of Data Mining and Bioinformatics","issn_l":"1748-5673","issn":["1748-5673","1748-5681"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310317825","host_organization_name":"Inderscience Publishers","host_organization_lineage":["https://openalex.org/P4310317825"],"host_organization_lineage_names":["Inderscience Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Data Mining and Bioinformatics","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1504/ijdmb.2018.10013376","is_oa":true,"landing_page_url":"http://doi.org/10.1504/ijdmb.2018.10013376","pdf_url":"https://doi.org/10.1504/ijdmb.2018.10013376","source":{"id":"https://openalex.org/S35771696","display_name":"International Journal of Data Mining and Bioinformatics","issn_l":"1748-5673","issn":["1748-5673","1748-5681"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310317825","host_organization_name":"Inderscience Publishers","host_organization_lineage":["https://openalex.org/P4310317825"],"host_organization_lineage_names":["Inderscience Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Data Mining and Bioinformatics","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2092969276","https://openalex.org/W1971424770","https://openalex.org/W2111842731","https://openalex.org/W2066467839","https://openalex.org/W2594299395","https://openalex.org/W2765794416","https://openalex.org/W2170506381","https://openalex.org/W2039666944","https://openalex.org/W1531630856","https://openalex.org/W2794350630"],"abstract_inverted_index":{"With":[0],"recent":[1],"advances":[2],"in":[3,38,42,60],"high-throughput":[4],"genotyping":[5],"techniques,":[6],"many":[7,30,61],"genome-wide":[8],"association":[9],"studies":[10,63],"have":[11,73,138],"been":[12,74],"conducted":[13],"to":[14,67,76,143],"understand":[15],"the":[16,91],"relationship":[17],"between":[18],"genes":[19],"and":[20,56],"complex":[21,43,46],"diseases.":[22,44],"Though":[23],"single":[24,53],"SNP":[25],"analysis":[26],"is":[27,107],"common":[28],"for":[29,80,89,115,148],"genetic":[31,40,62,92],"studies,":[32,125],"this":[33,100],"approach":[34,142],"has":[35],"a":[36,52,108,144],"limitation":[37],"explaining":[39],"changes":[41],"Most":[45],"diseases":[47],"cannot":[48],"be":[49,65],"explained":[50],"by":[51,123],"gene":[54],"mutation,":[55],"lack":[57],"of":[58,111],"success":[59],"could":[64],"attributed":[66],"gene-gene":[68,78],"interactions.":[69],"Although":[70],"various":[71],"methods":[72,85],"developed":[75],"identify":[77],"interactions":[79,93,132],"binary":[81],"traits,":[82],"few":[83],"statistical":[84],"are":[86],"currently":[87],"available":[88],"determining":[90],"associated":[94,133],"with":[95,134],"quantitative":[96,116,135],"traits.":[97,117,136],"To":[98],"address":[99],"problem,":[101],"we":[102],"propose":[103],"CL-MDR":[104,129],"method.":[105],"It":[106],"modified":[109],"version":[110],"multifactor":[112],"dimensionality":[113],"reduction":[114],"The":[118],"proposed":[119],"method":[120],"was":[121],"examined":[122],"simulation":[124],"which":[126],"showed":[127],"that":[128],"successfully":[130],"identified":[131],"We":[137],"also":[139],"applied":[140],"our":[141],"Korean":[145],"GWAS":[146],"data":[147],"illustration.":[149]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2019,"cited_by_count":1}],"updated_date":"2026-07-22T07:51:19.307946","created_date":"2025-10-10T00:00:00"}