{"id":"https://openalex.org/W2734330164","doi":"https://doi.org/10.1504/ijdmb.2017.10006247","title":"Validation of the merged co-variation signal in interacting protein pairs by mirror-dendrogram","display_name":"Validation of the merged co-variation signal in interacting protein pairs by mirror-dendrogram","publication_year":2017,"publication_date":"2017-01-01","ids":{"openalex":"https://openalex.org/W2734330164","doi":"https://doi.org/10.1504/ijdmb.2017.10006247","mag":"2734330164"},"language":"en","primary_location":{"id":"doi:10.1504/ijdmb.2017.10006247","is_oa":false,"landing_page_url":"https://doi.org/10.1504/ijdmb.2017.10006247","pdf_url":null,"source":{"id":"https://openalex.org/S35771696","display_name":"International Journal of Data Mining and Bioinformatics","issn_l":"1748-5673","issn":["1748-5673","1748-5681"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310317825","host_organization_name":"Inderscience Publishers","host_organization_lineage":["https://openalex.org/P4310317825"],"host_organization_lineage_names":["Inderscience Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Data Mining and Bioinformatics","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031995365","display_name":"Yezhong Tang","orcid":"https://orcid.org/0000-0002-6302-9308"},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210152908","display_name":"Chengdu Institute of Biology","ror":"https://ror.org/04w5etv87","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210152908"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yezhong Tang","raw_affiliation_strings":["Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210152908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100454881","display_name":"Yajun Wang","orcid":"https://orcid.org/0000-0002-0165-0561"},"institutions":[{"id":"https://openalex.org/I24185976","display_name":"Sichuan University","ror":"https://ror.org/011ashp19","country_code":"CN","type":"education","lineage":["https://openalex.org/I24185976"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yajun Wang","raw_affiliation_strings":["College of Life Science, Sichuan University, Chengdu 610064, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Life Science, Sichuan University, Chengdu 610064, China","institution_ids":["https://openalex.org/I24185976"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101777772","display_name":"Xingjian He","orcid":"https://orcid.org/0000-0001-5396-6253"},"institutions":[{"id":"https://openalex.org/I3129593085","display_name":"Chengdu Sport University","ror":"https://ror.org/05580ht21","country_code":"CN","type":"education","lineage":["https://openalex.org/I3129593085"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xingjian He","raw_affiliation_strings":["Foreign Language Department, Chengdu Sport University, Chengdu 610041, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Foreign Language Department, Chengdu Sport University, Chengdu 610041, China","institution_ids":["https://openalex.org/I3129593085"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108049924","display_name":"Xiaowei Song","orcid":"https://orcid.org/0000-0001-6146-3381"},"institutions":[{"id":"https://openalex.org/I130750295","display_name":"Xinyang Normal University","ror":"https://ror.org/0190x2a66","country_code":"CN","type":"education","lineage":["https://openalex.org/I130750295"]},{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210152908","display_name":"Chengdu Institute of Biology","ror":"https://ror.org/04w5etv87","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210152908"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaowei Song","raw_affiliation_strings":["College of Life Sciences and Institute for Conservation and Utilization of Agro-bioresources in Dabie Mountains, Xinyang Normal University, Xinyang 464000, China; Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China","College of Life Sciences and Institute for Conservation and Utilization of Agro-bioresources in Dabie Mountains, Xinyang Normal University, Xinyang 464000, China","Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Life Sciences and Institute for Conservation and Utilization of Agro-bioresources in Dabie Mountains, Xinyang Normal University, Xinyang 464000, China; Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China","institution_ids":["https://openalex.org/I130750295"]},{"raw_affiliation_string":"College of Life Sciences and Institute for Conservation and Utilization of Agro-bioresources in Dabie Mountains, Xinyang Normal University, Xinyang 464000, China","institution_ids":["https://openalex.org/I130750295"]},{"raw_affiliation_string":"Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210152908"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.05647212,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":"3","first_page":"238","last_page":"238"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dendrogram","display_name":"Dendrogram","score":0.8961952924728394},{"id":"https://openalex.org/keywords/proteome","display_name":"Proteome","score":0.5503576993942261},{"id":"https://openalex.org/keywords/tree","display_name":"Tree (set theory)","score":0.5190290212631226},{"id":"https://openalex.org/keywords/variation","display_name":"Variation (astronomy)","score":0.47883370518684387},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4525623917579651},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4379178583621979},{"id":"https://openalex.org/keywords/evolutionary-biology","display_name":"Evolutionary biology","score":0.41977617144584656},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.40257126092910767},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3320220708847046},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.2726777493953705},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.21792292594909668},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.18788620829582214},{"id":"https://openalex.org/keywords/combinatorics","display_name":"Combinatorics","score":0.12261292338371277},{"id":"https://openalex.org/keywords/genetic-diversity","display_name":"Genetic diversity","score":0.09337946772575378},{"id":"https://openalex.org/keywords/astrophysics","display_name":"Astrophysics","score":0.08549940586090088}],"concepts":[{"id":"https://openalex.org/C172312944","wikidata":"https://www.wikidata.org/wiki/Q1957903","display_name":"Dendrogram","level":4,"score":0.8961952924728394},{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.5503576993942261},{"id":"https://openalex.org/C113174947","wikidata":"https://www.wikidata.org/wiki/Q2859736","display_name":"Tree (set theory)","level":2,"score":0.5190290212631226},{"id":"https://openalex.org/C2778334786","wikidata":"https://www.wikidata.org/wiki/Q1586270","display_name":"Variation (astronomy)","level":2,"score":0.47883370518684387},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4525623917579651},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4379178583621979},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.41977617144584656},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.40257126092910767},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3320220708847046},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2726777493953705},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.21792292594909668},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.18788620829582214},{"id":"https://openalex.org/C114614502","wikidata":"https://www.wikidata.org/wiki/Q76592","display_name":"Combinatorics","level":1,"score":0.12261292338371277},{"id":"https://openalex.org/C81977670","wikidata":"https://www.wikidata.org/wiki/Q585259","display_name":"Genetic diversity","level":3,"score":0.09337946772575378},{"id":"https://openalex.org/C44870925","wikidata":"https://www.wikidata.org/wiki/Q37547","display_name":"Astrophysics","level":1,"score":0.08549940586090088},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1504/ijdmb.2017.10006247","is_oa":false,"landing_page_url":"https://doi.org/10.1504/ijdmb.2017.10006247","pdf_url":null,"source":{"id":"https://openalex.org/S35771696","display_name":"International Journal of Data Mining and Bioinformatics","issn_l":"1748-5673","issn":["1748-5673","1748-5681"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310317825","host_organization_name":"Inderscience Publishers","host_organization_lineage":["https://openalex.org/P4310317825"],"host_organization_lineage_names":["Inderscience Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Data Mining and Bioinformatics","raw_type":"journal-article"},{"id":"pmh:oai:210.75.237.14:351003/29032","is_oa":false,"landing_page_url":"http://210.75.237.14/handle/351003/29032","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/15","display_name":"Life in Land","score":0.5899999737739563}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2386430105","https://openalex.org/W3003858429","https://openalex.org/W2356521405","https://openalex.org/W2030091455","https://openalex.org/W2084729635","https://openalex.org/W2229498988","https://openalex.org/W2123606904","https://openalex.org/W2048336162","https://openalex.org/W2038534795","https://openalex.org/W2353814608"],"abstract_inverted_index":{"In":[0],"the":[1,61,83,102,115,140,152],"post-genomic":[2],"era,":[3],"in":[4,43,75,82],"silico":[5],"methods":[6],"have":[7,97],"proven":[8],"increasingly":[9],"useful":[10],"for":[11,28],"constructing":[12],"interactomes,":[13],"especially":[14],"protein-protein":[15],"interaction":[16],"networks.":[17],"Here":[18],"we":[19],"describe":[20],"a":[21,35,64,110,122],"structural":[22,39,132],"co-variation":[23,124,154],"based":[24],"method":[25],"(i.e.":[26,48,68],"mirror-dendrogram)":[27,74],"prediction":[29],"of":[30,45,63,66,71,79,90,104,142],"binary":[31],"interacting":[32,118,144],"proteins":[33,145],"at":[34],"proteome-wide":[36],"scale.":[37],"The":[38,107],"variation":[40],"was":[41,94],"measured":[42],"terms":[44],"physicochemical":[46],"traits":[47],"Kyte-Doolittle":[49],"hydrophobicity,":[50],"molecular":[51,54],"weight":[52],"and":[53,73,131],"Van":[55],"der":[56],"Waals":[57],"volume).":[58],"We":[59,134],"explored":[60],"performance":[62,103],"series":[65],"mirror-algorithms":[67],"mirror-tree,":[69],"tree":[70],"life-mirror-tree":[72],"1117":[76],"orthologous":[77,92],"groups":[78],"21":[80],"species":[81],"Enterobacteriaceae":[84],"family.":[85],"Interestingly,":[86],"sequence":[87],"divergence":[88],"degree":[89],"each":[91],"group":[93],"found":[95],"to":[96,113],"an":[98],"important":[99],"effect":[100],"on":[101],"these":[105],"algorithms.":[106],"mirror-dendrogram":[108,137],"is":[109],"robust":[111],"way":[112],"validate":[114],"hypothesis":[116],"that":[117,136],"protein":[119],"pairs":[120],"possess":[121],"mixed":[123],"signal,":[125],"which":[126],"originates":[127],"from":[128,146],"background":[129],"co-evolution":[130],"co-adaptation.":[133],"consider":[135],"will":[138],"promote":[139],"distinguishment":[141],"physically":[143],"functionally":[147],"related":[148],"ones":[149],"by":[150],"characterising":[151],"merged":[153],"signal.":[155]},"counts_by_year":[],"updated_date":"2026-07-25T15:57:00.446498","created_date":"2025-10-10T00:00:00"}