{"id":"https://openalex.org/W2889239034","doi":"https://doi.org/10.1504/ijcbdd.2018.10015807","title":"Designing of suitable linkers for the chimeric proteins to achieve the desired flexibility and extended conformation","display_name":"Designing of suitable linkers for the chimeric proteins to achieve the desired flexibility and extended conformation","publication_year":2018,"publication_date":"2018-01-01","ids":{"openalex":"https://openalex.org/W2889239034","doi":"https://doi.org/10.1504/ijcbdd.2018.10015807","mag":"2889239034"},"language":"en","primary_location":{"id":"doi:10.1504/ijcbdd.2018.10015807","is_oa":false,"landing_page_url":"https://doi.org/10.1504/ijcbdd.2018.10015807","pdf_url":null,"source":{"id":"https://openalex.org/S200215862","display_name":"International Journal of Computational Biology and Drug Design","issn_l":"1756-0756","issn":["1756-0756","1756-0764"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310317825","host_organization_name":"Inderscience Publishers","host_organization_lineage":["https://openalex.org/P4310317825"],"host_organization_lineage_names":["Inderscience Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Computational Biology and Drug Design","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5056114564","display_name":"Manoj Patidar","orcid":"https://orcid.org/0000-0001-8283-2190"},"institutions":[{"id":"https://openalex.org/I165831266","display_name":"Nirma University","ror":"https://ror.org/05qkq7x38","country_code":"IN","type":"education","lineage":["https://openalex.org/I165831266"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Manoj Patidar","raw_affiliation_strings":["Institute of Science, Nirma University, Ahmedabad 382481, India"],"affiliations":[{"raw_affiliation_string":"Institute of Science, Nirma University, Ahmedabad 382481, India","institution_ids":["https://openalex.org/I165831266"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101964184","display_name":"Naveen Yadav","orcid":"https://orcid.org/0000-0002-6931-6762"},"institutions":[{"id":"https://openalex.org/I165831266","display_name":"Nirma University","ror":"https://ror.org/05qkq7x38","country_code":"IN","type":"education","lineage":["https://openalex.org/I165831266"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Naveen Yadav","raw_affiliation_strings":["Institute of Science, Nirma University, Ahmedabad 382481, India"],"affiliations":[{"raw_affiliation_string":"Institute of Science, Nirma University, Ahmedabad 382481, India","institution_ids":["https://openalex.org/I165831266"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010388411","display_name":"Sarat K. Dalai","orcid":"https://orcid.org/0000-0003-1466-4265"},"institutions":[{"id":"https://openalex.org/I165831266","display_name":"Nirma University","ror":"https://ror.org/05qkq7x38","country_code":"IN","type":"education","lineage":["https://openalex.org/I165831266"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Sarat K. Dalai","raw_affiliation_strings":["Institute of Science, Nirma University, Ahmedabad 382481, India"],"affiliations":[{"raw_affiliation_string":"Institute of Science, Nirma University, Ahmedabad 382481, India","institution_ids":["https://openalex.org/I165831266"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5056114564"],"corresponding_institution_ids":["https://openalex.org/I165831266"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.13593954,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"11","issue":"3","first_page":"236","last_page":"236"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11016","display_name":"Monoclonal and Polyclonal Antibodies Research","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11663","display_name":"Viral Infectious Diseases and Gene Expression in Insects","score":0.9950000047683716,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9894000291824341,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/linker","display_name":"Linker","score":0.7404541373252869},{"id":"https://openalex.org/keywords/fusion-protein","display_name":"Fusion protein","score":0.6690086126327515},{"id":"https://openalex.org/keywords/steric-effects","display_name":"Steric effects","score":0.5945202112197876},{"id":"https://openalex.org/keywords/flexibility","display_name":"Flexibility (engineering)","score":0.590865433216095},{"id":"https://openalex.org/keywords/protein-engineering","display_name":"Protein engineering","score":0.5750520825386047},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.5373877882957458},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.48737937211990356},{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.43590646982192993},{"id":"https://openalex.org/keywords/combinatorial-chemistry","display_name":"Combinatorial chemistry","score":0.38100993633270264},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.3335426449775696},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.321367472410202},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.2612151801586151},{"id":"https://openalex.org/keywords/stereochemistry","display_name":"Stereochemistry","score":0.22525763511657715},{"id":"https://openalex.org/keywords/recombinant-dna","display_name":"Recombinant DNA","score":0.2078004777431488},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.2034997045993805},{"id":"https://openalex.org/keywords/enzyme","display_name":"Enzyme","score":0.09828406572341919},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.09816974401473999},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.078453928232193}],"concepts":[{"id":"https://openalex.org/C2780557392","wikidata":"https://www.wikidata.org/wiki/Q523796","display_name":"Linker","level":2,"score":0.7404541373252869},{"id":"https://openalex.org/C123894998","wikidata":"https://www.wikidata.org/wiki/Q425158","display_name":"Fusion protein","level":4,"score":0.6690086126327515},{"id":"https://openalex.org/C201194858","wikidata":"https://www.wikidata.org/wiki/Q898238","display_name":"Steric effects","level":2,"score":0.5945202112197876},{"id":"https://openalex.org/C2780598303","wikidata":"https://www.wikidata.org/wiki/Q65921492","display_name":"Flexibility (engineering)","level":2,"score":0.590865433216095},{"id":"https://openalex.org/C147816474","wikidata":"https://www.wikidata.org/wiki/Q169525","display_name":"Protein engineering","level":3,"score":0.5750520825386047},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5373877882957458},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.48737937211990356},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.43590646982192993},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.38100993633270264},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.3335426449775696},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.321367472410202},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2612151801586151},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.22525763511657715},{"id":"https://openalex.org/C40767141","wikidata":"https://www.wikidata.org/wiki/Q285697","display_name":"Recombinant DNA","level":3,"score":0.2078004777431488},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2034997045993805},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.09828406572341919},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09816974401473999},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.078453928232193},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1504/ijcbdd.2018.10015807","is_oa":false,"landing_page_url":"https://doi.org/10.1504/ijcbdd.2018.10015807","pdf_url":null,"source":{"id":"https://openalex.org/S200215862","display_name":"International Journal of Computational Biology and Drug Design","issn_l":"1756-0756","issn":["1756-0756","1756-0764"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310317825","host_organization_name":"Inderscience Publishers","host_organization_lineage":["https://openalex.org/P4310317825"],"host_organization_lineage_names":["Inderscience Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Computational Biology and Drug Design","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Industry, innovation and infrastructure","score":0.6299999952316284,"id":"https://metadata.un.org/sdg/9"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4294723901","https://openalex.org/W4310690213","https://openalex.org/W1965238818","https://openalex.org/W2090391251","https://openalex.org/W1558163028","https://openalex.org/W2071122984","https://openalex.org/W3015752896","https://openalex.org/W2608314674","https://openalex.org/W3112946098","https://openalex.org/W3115868579"],"abstract_inverted_index":{"The":[0,22,49],"designing":[1],"and":[2,19,36,63,86,110,114,123,126,156],"production":[3],"of":[4,13,25,44,94,107,139,144,152,158],"therapeutic":[5],"chimeric":[6,26,69,145,159],"proteins":[7,27,35,70],"is":[8,46],"the":[9,42,68,120,130,137,140,150],"central":[10],"focus":[11],"area":[12],"many":[14],"industrial":[15],"R":[16],"&":[17],"D":[18],"research":[20],"institutes.":[21],"efficient":[23],"productions":[24],"not":[28],"only":[29],"require":[30],"suitable":[31],"domains":[32],"or":[33],"partner":[34],"intact":[37],"receptor":[38],"binding":[39],"sites,":[40],"but":[41],"selection":[43],"linkers":[45,50,106,153],"equally":[47],"important.":[48],"are":[51],"essential":[52],"to":[53,66,118,128],"provide":[54,119],"space":[55],"between":[56],"two":[57],"domains,":[58],"prevent":[59],"from":[60],"steric":[61],"hindrance":[62],"most":[64],"importantly":[65],"make":[67],"flexible.":[71],"In":[72],"this":[73],"in":[74,142],"silico":[75],"study,":[76],"we":[77,91,134],"have":[78,135],"systematically":[79],"designed":[80,105],"various":[81,102,108],"linkers,":[82],"tested":[83,115,149],"their":[84,88,116],"feasibility":[85],"evaluated":[87,136],"essentiality.":[89],"Here,":[90],"fused":[92],"cytokine":[93],"interest":[95],"(i.e.,":[96],"IL-2)":[97],"with":[98],"IgG1":[99],"Fc":[100],"via":[101],"linkers.":[103],"We":[104,147],"lengths":[109],"amino":[111],"acid":[112],"composition":[113],"ability":[117],"extended":[121],"conformation":[122],"desired":[124],"flexibility":[125],"also":[127],"minimise":[129],"conformational":[131],"changes.":[132],"Additionally,":[133],"role":[138],"linker":[141],"dimerisation":[143],"proteins.":[146,160],"next":[148],"influence":[151],"on":[154],"stability":[155],"functionality":[157]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}