{"id":"https://openalex.org/W2539657498","doi":"https://doi.org/10.1504/ijcbdd.2016.10000938","title":"The impact of plasma protein binding on toxic plasma drug concentration","display_name":"The impact of plasma protein binding on toxic plasma drug concentration","publication_year":2016,"publication_date":"2016-01-01","ids":{"openalex":"https://openalex.org/W2539657498","doi":"https://doi.org/10.1504/ijcbdd.2016.10000938","mag":"2539657498"},"language":"en","primary_location":{"id":"doi:10.1504/ijcbdd.2016.10000938","is_oa":false,"landing_page_url":"https://doi.org/10.1504/ijcbdd.2016.10000938","pdf_url":null,"source":{"id":"https://openalex.org/S200215862","display_name":"International Journal of Computational Biology and Drug Design","issn_l":"1756-0756","issn":["1756-0756","1756-0764"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310317825","host_organization_name":"Inderscience Publishers","host_organization_lineage":["https://openalex.org/P4310317825"],"host_organization_lineage_names":["Inderscience Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Computational Biology and Drug Design","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5025908810","display_name":"Andreas Svennebring","orcid":null},"institutions":[{"id":"https://openalex.org/I123387679","display_name":"Uppsala University","ror":"https://ror.org/048a87296","country_code":"SE","type":"education","lineage":["https://openalex.org/I123387679"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"Andreas Svennebring","raw_affiliation_strings":["Department of Pharmaceutical Biosciences, Division of Pharmaceutical Bioinformatics, Biomedical Centre, Box 591, Uppsala University, SE 751 24, Uppsala, Sweden"],"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Biosciences, Division of Pharmaceutical Bioinformatics, Biomedical Centre, Box 591, Uppsala University, SE 751 24, Uppsala, Sweden","institution_ids":["https://openalex.org/I123387679"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5025908810"],"corresponding_institution_ids":["https://openalex.org/I123387679"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.14630627,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"9","issue":"4","first_page":"345","last_page":"345"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11908","display_name":"Protein Interaction Studies and Fluorescence Analysis","score":0.9936000108718872,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10570","display_name":"Drug Transport and Resistance Mechanisms","score":0.9894000291824341,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lipophilicity","display_name":"Lipophilicity","score":0.8982300758361816},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.6792470216751099},{"id":"https://openalex.org/keywords/toxicity","display_name":"Toxicity","score":0.6780234575271606},{"id":"https://openalex.org/keywords/plasma-protein-binding","display_name":"Plasma protein binding","score":0.6154251098632812},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.602220356464386},{"id":"https://openalex.org/keywords/blood-proteins","display_name":"Blood proteins","score":0.5885450839996338},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.5408236980438232},{"id":"https://openalex.org/keywords/plasma-concentration","display_name":"Plasma concentration","score":0.510475754737854},{"id":"https://openalex.org/keywords/pharmacokinetics","display_name":"Pharmacokinetics","score":0.44726860523223877},{"id":"https://openalex.org/keywords/partition-coefficient","display_name":"Partition coefficient","score":0.4394304156303406},{"id":"https://openalex.org/keywords/therapeutic-index","display_name":"Therapeutic index","score":0.4158652722835541},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.26522669196128845},{"id":"https://openalex.org/keywords/chromatography","display_name":"Chromatography","score":0.22208398580551147},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.12379404902458191}],"concepts":[{"id":"https://openalex.org/C201399114","wikidata":"https://www.wikidata.org/wiki/Q898401","display_name":"Lipophilicity","level":2,"score":0.8982300758361816},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.6792470216751099},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.6780234575271606},{"id":"https://openalex.org/C51639874","wikidata":"https://www.wikidata.org/wiki/Q167149","display_name":"Plasma protein binding","level":2,"score":0.6154251098632812},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.602220356464386},{"id":"https://openalex.org/C146543888","wikidata":"https://www.wikidata.org/wiki/Q425056","display_name":"Blood proteins","level":2,"score":0.5885450839996338},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5408236980438232},{"id":"https://openalex.org/C3020079912","wikidata":"https://www.wikidata.org/wiki/Q3918988","display_name":"Plasma concentration","level":2,"score":0.510475754737854},{"id":"https://openalex.org/C112705442","wikidata":"https://www.wikidata.org/wiki/Q323936","display_name":"Pharmacokinetics","level":2,"score":0.44726860523223877},{"id":"https://openalex.org/C192552737","wikidata":"https://www.wikidata.org/wiki/Q898797","display_name":"Partition coefficient","level":2,"score":0.4394304156303406},{"id":"https://openalex.org/C19831878","wikidata":"https://www.wikidata.org/wiki/Q659446","display_name":"Therapeutic index","level":3,"score":0.4158652722835541},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.26522669196128845},{"id":"https://openalex.org/C43617362","wikidata":"https://www.wikidata.org/wiki/Q170050","display_name":"Chromatography","level":1,"score":0.22208398580551147},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.12379404902458191},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1504/ijcbdd.2016.10000938","is_oa":false,"landing_page_url":"https://doi.org/10.1504/ijcbdd.2016.10000938","pdf_url":null,"source":{"id":"https://openalex.org/S200215862","display_name":"International Journal of Computational Biology and Drug Design","issn_l":"1756-0756","issn":["1756-0756","1756-0764"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310317825","host_organization_name":"Inderscience Publishers","host_organization_lineage":["https://openalex.org/P4310317825"],"host_organization_lineage_names":["Inderscience Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Computational Biology and Drug Design","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.7400000095367432,"id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2070970132","https://openalex.org/W2077174232","https://openalex.org/W3202259820","https://openalex.org/W2315123365","https://openalex.org/W1990424107","https://openalex.org/W1965125714","https://openalex.org/W4317743663","https://openalex.org/W2052507080","https://openalex.org/W1988037532","https://openalex.org/W2073638061"],"abstract_inverted_index":{"Drugs":[0],"with":[1,59,105],"high":[2,22,52,69,106],"plasma":[3,23,34,53,71,107,111],"protein":[4,24,54,72,108,112],"binding":[5,55,73,113],"are":[6,15],"relatively":[7],"protected":[8],"from":[9],"first-pass":[10],"hepatic":[11],"metabolism.":[12],"However,":[13],"there":[14],"concerns":[16],"about":[17],"potential":[18],"problems":[19],"caused":[20],"by":[21,44,78],"binding,":[25],"one":[26],"of":[27,33,42,61,89,103,123],"which":[28,92],"is":[29,56,85],"toxicity.":[30],"Statistical":[31],"analyses":[32],"concentration":[35],"thresholds":[36],"for":[37],"toxic":[38],"and":[39,95],"comatose-lethal":[40],"effects":[41],"drugs":[43,62,104],"multiple":[45],"linear":[46],"regression":[47],"(MLR)":[48],"models":[49],"indicate":[50],"that":[51],"slightly":[57],"associated":[58],"toxicity":[60,102],"in":[63,67],"general,":[64],"but":[65],"not":[66],"the":[68,79,99,120],"(≥90%)":[70],"range.":[74],"Lipophilicity":[75],"as":[76],"determined":[77],"octanol/water":[80],"partition":[81],"coefficient":[82],"(Log":[83],"P)":[84],"a":[86],"major":[87],"driver":[88],"acute":[90,101],"toxicity,":[91],"can":[93],"largely":[94],"perhaps":[96],"entirely":[97],"explain":[98],"higher":[100],"binding.":[109],"Neither":[110],"nor":[114],"lipophilicity":[115],"have":[116],"any":[117],"relation":[118],"to":[119],"therapeutic":[121],"window":[122],"drugs.":[124]},"counts_by_year":[],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}