{"id":"https://openalex.org/W2542470497","doi":"https://doi.org/10.1504/ijcbdd.2016.10000929","title":"Functional annotation of putative conserved proteins from Borrelia burgdorferi to find potential drug targets","display_name":"Functional annotation of putative conserved proteins from Borrelia burgdorferi to find potential drug targets","publication_year":2016,"publication_date":"2016-01-01","ids":{"openalex":"https://openalex.org/W2542470497","doi":"https://doi.org/10.1504/ijcbdd.2016.10000929","mag":"2542470497"},"language":"en","primary_location":{"id":"doi:10.1504/ijcbdd.2016.10000929","is_oa":false,"landing_page_url":"https://doi.org/10.1504/ijcbdd.2016.10000929","pdf_url":null,"source":{"id":"https://openalex.org/S200215862","display_name":"International Journal of Computational Biology and Drug Design","issn_l":"1756-0756","issn":["1756-0756","1756-0764"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310317825","host_organization_name":"Inderscience Publishers","host_organization_lineage":["https://openalex.org/P4310317825"],"host_organization_lineage_names":["Inderscience Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Computational Biology and Drug Design","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100643883","display_name":"Md. Imtaiyaz Hassan","orcid":"https://orcid.org/0000-0002-3663-4940"},"institutions":[{"id":"https://openalex.org/I59475050","display_name":"Jamia Millia Islamia","ror":"https://ror.org/00pnhhv55","country_code":"IN","type":"education","lineage":["https://openalex.org/I59475050"]}],"countries":["IN"],"is_corresponding":true,"raw_author_name":"Md. Imtaiyaz Hassan","raw_affiliation_strings":["Center for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi, 110025, India"],"affiliations":[{"raw_affiliation_string":"Center for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi, 110025, India","institution_ids":["https://openalex.org/I59475050"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077513922","display_name":"Faizan Ahmad","orcid":"https://orcid.org/0000-0001-7021-7502"},"institutions":[{"id":"https://openalex.org/I59475050","display_name":"Jamia Millia Islamia","ror":"https://ror.org/00pnhhv55","country_code":"IN","type":"education","lineage":["https://openalex.org/I59475050"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Faizan Ahmad","raw_affiliation_strings":["Center for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi, 110025, India"],"affiliations":[{"raw_affiliation_string":"Center for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi, 110025, India","institution_ids":["https://openalex.org/I59475050"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033328922","display_name":"Abulaish Ansari","orcid":"https://orcid.org/0000-0001-8784-3390"},"institutions":[{"id":"https://openalex.org/I118590987","display_name":"Northern Border University","ror":"https://ror.org/03j9tzj20","country_code":"SA","type":"education","lineage":["https://openalex.org/I118590987"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Abulaish Ansari","raw_affiliation_strings":["Dept. of Biochemistry, College of Applied Medical Sciences, Northern Border University, Arar, 91431, Kingdom of Saudi Arabia"],"affiliations":[{"raw_affiliation_string":"Dept. of Biochemistry, College of Applied Medical Sciences, Northern Border University, Arar, 91431, Kingdom of Saudi Arabia","institution_ids":["https://openalex.org/I118590987"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066278286","display_name":"Asimul Islam","orcid":"https://orcid.org/0000-0001-9060-7970"},"institutions":[{"id":"https://openalex.org/I59475050","display_name":"Jamia Millia Islamia","ror":"https://ror.org/00pnhhv55","country_code":"IN","type":"education","lineage":["https://openalex.org/I59475050"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Asimul Islam","raw_affiliation_strings":["Center for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi, 110025, India"],"affiliations":[{"raw_affiliation_string":"Center for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi, 110025, India","institution_ids":["https://openalex.org/I59475050"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081771404","display_name":"Mahmood Rasool","orcid":"https://orcid.org/0000-0003-2997-5891"},"institutions":[{"id":"https://openalex.org/I185163786","display_name":"King Abdulaziz University","ror":"https://ror.org/02ma4wv74","country_code":"SA","type":"education","lineage":["https://openalex.org/I185163786"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Mahmood Rasool","raw_affiliation_strings":["Center of Excellence in Genomic Medicine Research, King Abdulaziz University, P.O. Box 80216, Jeddah, Kingdom of Saudi Arabia"],"affiliations":[{"raw_affiliation_string":"Center of Excellence in Genomic Medicine Research, King Abdulaziz University, P.O. Box 80216, Jeddah, Kingdom of Saudi Arabia","institution_ids":["https://openalex.org/I185163786"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026436933","display_name":"Farah Anjum","orcid":"https://orcid.org/0000-0002-8597-6015"},"institutions":[{"id":"https://openalex.org/I179331831","display_name":"Taif University","ror":"https://ror.org/014g1a453","country_code":"SA","type":"education","lineage":["https://openalex.org/I179331831"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Farah Anjum","raw_affiliation_strings":["Female College of Applied Medical Science, Taif University, Al-Taif, 21944, Kingdom of Saudi Arabia"],"affiliations":[{"raw_affiliation_string":"Female College of Applied Medical Science, Taif University, Al-Taif, 21944, Kingdom of Saudi Arabia","institution_ids":["https://openalex.org/I179331831"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030909615","display_name":"Mohammad Sarwar Jamal","orcid":"https://orcid.org/0000-0001-7044-887X"},"institutions":[{"id":"https://openalex.org/I185163786","display_name":"King Abdulaziz University","ror":"https://ror.org/02ma4wv74","country_code":"SA","type":"education","lineage":["https://openalex.org/I185163786"]}],"countries":["SA"],"is_corresponding":false,"raw_author_name":"Mohammad Sarwar Jamal","raw_affiliation_strings":["King Fahd Medical Research Center, King Abdulaziz University, P.O. Box 21589, Jeddah, Kingdom of Saudi Arabia"],"affiliations":[{"raw_affiliation_string":"King Fahd Medical Research Center, King Abdulaziz University, P.O. Box 21589, Jeddah, Kingdom of Saudi Arabia","institution_ids":["https://openalex.org/I185163786"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061818382","display_name":"Shama Khan","orcid":"https://orcid.org/0000-0002-0874-5029"},"institutions":[{"id":"https://openalex.org/I59475050","display_name":"Jamia Millia Islamia","ror":"https://ror.org/00pnhhv55","country_code":"IN","type":"education","lineage":["https://openalex.org/I59475050"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Shama Khan","raw_affiliation_strings":["Center for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi, 110025, India"],"affiliations":[{"raw_affiliation_string":"Center for Interdisciplinary Research in Basic Sciences, Jamia Millia Islamia, Jamia Nagar, New Delhi, 110025, India","institution_ids":["https://openalex.org/I59475050"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5100643883"],"corresponding_institution_ids":["https://openalex.org/I59475050"],"apc_list":null,"apc_paid":null,"fwci":0.1667,"has_fulltext":false,"cited_by_count":3,"citation_normalized_percentile":{"value":0.64056472,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":96},"biblio":{"volume":"9","issue":"4","first_page":"295","last_page":"295"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9871000051498413,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9871000051498413,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.9807000160217285,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9796000123023987,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/borrelia-burgdorferi","display_name":"Borrelia burgdorferi","score":0.925155758857727},{"id":"https://openalex.org/keywords/proteome","display_name":"Proteome","score":0.7602684497833252},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.669346034526825},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6438525319099426},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.5268211364746094},{"id":"https://openalex.org/keywords/virulence","display_name":"Virulence","score":0.4928031265735626},{"id":"https://openalex.org/keywords/function","display_name":"Function (biology)","score":0.4642190933227539},{"id":"https://openalex.org/keywords/annotation","display_name":"Annotation","score":0.431579053401947},{"id":"https://openalex.org/keywords/drug-target","display_name":"Drug target","score":0.41279134154319763},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.39599424600601196},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.20986664295196533}],"concepts":[{"id":"https://openalex.org/C2779159148","wikidata":"https://www.wikidata.org/wiki/Q2723634","display_name":"Borrelia burgdorferi","level":3,"score":0.925155758857727},{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.7602684497833252},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.669346034526825},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6438525319099426},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.5268211364746094},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.4928031265735626},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.4642190933227539},{"id":"https://openalex.org/C2776321320","wikidata":"https://www.wikidata.org/wiki/Q857525","display_name":"Annotation","level":2,"score":0.431579053401947},{"id":"https://openalex.org/C2989108626","wikidata":"https://www.wikidata.org/wiki/Q904407","display_name":"Drug target","level":2,"score":0.41279134154319763},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.39599424600601196},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.20986664295196533},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.0},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1504/ijcbdd.2016.10000929","is_oa":false,"landing_page_url":"https://doi.org/10.1504/ijcbdd.2016.10000929","pdf_url":null,"source":{"id":"https://openalex.org/S200215862","display_name":"International Journal of Computational Biology and Drug Design","issn_l":"1756-0756","issn":["1756-0756","1756-0764"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310317825","host_organization_name":"Inderscience Publishers","host_organization_lineage":["https://openalex.org/P4310317825"],"host_organization_lineage_names":["Inderscience Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Computational Biology and Drug Design","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.41999998688697815,"display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2114009169","https://openalex.org/W1979172052","https://openalex.org/W4205148382","https://openalex.org/W2194295138","https://openalex.org/W1506242385","https://openalex.org/W2049387417","https://openalex.org/W1972335439","https://openalex.org/W2148070420","https://openalex.org/W2053780827","https://openalex.org/W2010088550"],"abstract_inverted_index":{"The":[0],"spirochete":[1],"Borrelia":[2],"burgdorferi":[3,99],"is":[4],"causative":[5],"agent":[6],"of":[7,20,33,42,53,78,91,104],"Lyme":[8],"disease.":[9],"We":[10,59],"have":[11,37,60,69,82],"used":[12],"various":[13],"bioinformatics":[14],"tools":[15],"for":[16],"predicting":[17],"the":[18,30,76],"function":[19],"unknown":[21],"proteins":[22,45,49,52],"present":[23],"in":[24,95,112],"B.":[25,34,98],"burgdorferi's":[26],"genome.":[27],"While":[28],"analysing":[29],"proteome":[31],"data":[32],"burgdorferi,":[35],"we":[36,81],"found":[38],"819":[39],"proteins.":[40],"Out":[41],"these,":[43],"241":[44],"are":[46],"conserved":[47],"hypothetical":[48],"(HPs),":[50],"i.e.,":[51],"unspecified":[54],"structures":[55],"and":[56,65,89,110],"biochemical":[57],"functions.":[58],"successfully":[61],"annotated":[62],"120":[63],"HPs,":[64],"their":[66],"corresponding":[67],"functions":[68],"been":[70],"predicted":[71,79],"using":[72],"different":[73],"tools.":[74],"On":[75],"basis":[77],"functions,":[80],"divided":[83],"them":[84],"into":[85],"functional":[86,106],"classes.":[87],"Annotation":[88],"identification":[90],"functionally":[92],"important":[93],"regions":[94],"HPs":[96],"from":[97],"will":[100],"enhance":[101],"our":[102],"understanding":[103],"new":[105],"proteins,":[107],"virulence":[108],"mechanism":[109],"adaptability":[111],"host":[113],"system.":[114]},"counts_by_year":[{"year":2020,"cited_by_count":2},{"year":2017,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}