{"id":"https://openalex.org/W2318938587","doi":"https://doi.org/10.1504/ijcbdd.2016.074984","title":"Next generation sequencing reveals disparate population frequencies among cytochrome P450 genes: clinical pharmacogenomics of the CYP2 family","display_name":"Next generation sequencing reveals disparate population frequencies among cytochrome P450 genes: clinical pharmacogenomics of the CYP2 family","publication_year":2016,"publication_date":"2016-01-01","ids":{"openalex":"https://openalex.org/W2318938587","doi":"https://doi.org/10.1504/ijcbdd.2016.074984","mag":"2318938587"},"language":"en","primary_location":{"id":"doi:10.1504/ijcbdd.2016.074984","is_oa":false,"landing_page_url":"https://doi.org/10.1504/ijcbdd.2016.074984","pdf_url":null,"source":{"id":"https://openalex.org/S200215862","display_name":"International Journal of Computational Biology and Drug Design","issn_l":"1756-0756","issn":["1756-0756","1756-0764"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310317825","host_organization_name":"Inderscience Publishers","host_organization_lineage":["https://openalex.org/P4310317825"],"host_organization_lineage_names":["Inderscience Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Computational Biology and Drug Design","raw_type":"journal-article"},"type":"article","indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5052264424","display_name":"William T. Budd","orcid":null},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"William T. Budd","raw_affiliation_strings":["American International Biotechnology, 601 Biotech Drive, Richmond, VA 23235, USA"],"affiliations":[{"raw_affiliation_string":"American International Biotechnology, 601 Biotech Drive, Richmond, VA 23235, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111658375","display_name":"Greg Meyers","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Greg Meyers","raw_affiliation_strings":["American International Biotechnology, 601 Biotech Drive, Richmond, VA 23235, USA"],"affiliations":[{"raw_affiliation_string":"American International Biotechnology, 601 Biotech Drive, Richmond, VA 23235, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009591380","display_name":"Jeri R. Dilts","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jeri R. Dilts","raw_affiliation_strings":["American International Biotechnology, 601 Biotech Drive, Richmond, VA 23235, USA"],"affiliations":[{"raw_affiliation_string":"American International Biotechnology, 601 Biotech Drive, Richmond, VA 23235, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111981146","display_name":"Katherine O'","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Katherine O'","raw_affiliation_strings":["American International Biotechnology, 601 Biotech Drive, Richmond, VA 23235, USA"],"affiliations":[{"raw_affiliation_string":"American International Biotechnology, 601 Biotech Drive, Richmond, VA 23235, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039341054","display_name":"Neil Hanlon","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N.A. Hanlon","raw_affiliation_strings":["American International Biotechnology, 601 Biotech Drive, Richmond, VA 23235, USA"],"affiliations":[{"raw_affiliation_string":"American International Biotechnology, 601 Biotech Drive, Richmond, VA 23235, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112071896","display_name":"John R. Woody","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John R. Woody","raw_affiliation_strings":["American International Biotechnology, 601 Biotech Drive, Richmond, VA 23235, USA"],"affiliations":[{"raw_affiliation_string":"American International Biotechnology, 601 Biotech Drive, Richmond, VA 23235, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111726165","display_name":"David G. Bostwick","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David G. Bostwick","raw_affiliation_strings":["American International Biotechnology, 601 Biotech Drive, Richmond, VA 23235, USA"],"affiliations":[{"raw_affiliation_string":"American International Biotechnology, 601 Biotech Drive, Richmond, VA 23235, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110336278","display_name":"John R. Drury","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John R. Drury","raw_affiliation_strings":["American International Biotechnology, 601 Biotech Drive, Richmond, VA 23235, USA"],"affiliations":[{"raw_affiliation_string":"American International Biotechnology, 601 Biotech Drive, Richmond, VA 23235, USA","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102733210","display_name":"Thomas Reynolds","orcid":"https://orcid.org/0009-0000-1966-8877"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Thomas Reynolds","raw_affiliation_strings":["American International Biotechnology, 601 Biotech Drive, Richmond, VA 23235, USA"],"affiliations":[{"raw_affiliation_string":"American International Biotechnology, 601 Biotech Drive, Richmond, VA 23235, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5052264424"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.7866,"has_fulltext":false,"cited_by_count":8,"citation_normalized_percentile":{"value":0.76788563,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"9","issue":"1/2","first_page":"54","last_page":"54"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9815000295639038,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9625999927520752,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pharmacogenomics","display_name":"Pharmacogenomics","score":0.9302856922149658},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.6887446641921997},{"id":"https://openalex.org/keywords/single-nucleotide-polymorphism","display_name":"Single-nucleotide polymorphism","score":0.658894956111908},{"id":"https://openalex.org/keywords/pharmacogenetics","display_name":"Pharmacogenetics","score":0.5781093239784241},{"id":"https://openalex.org/keywords/genotype","display_name":"Genotype","score":0.5719996094703674},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5709168910980225},{"id":"https://openalex.org/keywords/genetic-variation","display_name":"Genetic variation","score":0.5331612825393677},{"id":"https://openalex.org/keywords/ethnic-group","display_name":"Ethnic group","score":0.5141575336456299},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.49833226203918457},{"id":"https://openalex.org/keywords/cyp2c9","display_name":"CYP2C9","score":0.49335208535194397},{"id":"https://openalex.org/keywords/allele-frequency","display_name":"Allele frequency","score":0.41255927085876465},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3613027334213257},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3528515696525574}],"concepts":[{"id":"https://openalex.org/C170734499","wikidata":"https://www.wikidata.org/wiki/Q1152227","display_name":"Pharmacogenomics","level":2,"score":0.9302856922149658},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6887446641921997},{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.658894956111908},{"id":"https://openalex.org/C55775858","wikidata":"https://www.wikidata.org/wiki/Q1152227","display_name":"Pharmacogenetics","level":4,"score":0.5781093239784241},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.5719996094703674},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5709168910980225},{"id":"https://openalex.org/C68873052","wikidata":"https://www.wikidata.org/wiki/Q349856","display_name":"Genetic variation","level":3,"score":0.5331612825393677},{"id":"https://openalex.org/C137403100","wikidata":"https://www.wikidata.org/wiki/Q41710","display_name":"Ethnic group","level":2,"score":0.5141575336456299},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.49833226203918457},{"id":"https://openalex.org/C3946865","wikidata":"https://www.wikidata.org/wiki/Q5014962","display_name":"CYP2C9","level":4,"score":0.49335208535194397},{"id":"https://openalex.org/C37463918","wikidata":"https://www.wikidata.org/wiki/Q387981","display_name":"Allele frequency","level":4,"score":0.41255927085876465},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3613027334213257},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3528515696525574},{"id":"https://openalex.org/C19165224","wikidata":"https://www.wikidata.org/wiki/Q23404","display_name":"Anthropology","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1504/ijcbdd.2016.074984","is_oa":false,"landing_page_url":"https://doi.org/10.1504/ijcbdd.2016.074984","pdf_url":null,"source":{"id":"https://openalex.org/S200215862","display_name":"International Journal of Computational Biology and Drug Design","issn_l":"1756-0756","issn":["1756-0756","1756-0764"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310317825","host_organization_name":"Inderscience Publishers","host_organization_lineage":["https://openalex.org/P4310317825"],"host_organization_lineage_names":["Inderscience Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Computational Biology and Drug Design","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5400000214576721,"display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2318262866","https://openalex.org/W2036094388","https://openalex.org/W2327821609","https://openalex.org/W4361242895","https://openalex.org/W2462959210","https://openalex.org/W2019271482","https://openalex.org/W4223968696","https://openalex.org/W1546831097","https://openalex.org/W2144337598","https://openalex.org/W2323964980"],"abstract_inverted_index":{"85%":[0],"of":[1,30,59,72,81,97,114,126,131,143],"medications":[2],"prescribed":[3],"are":[4],"metabolised":[5],"by":[6],"a":[7,57,69,94,115],"CYP450":[8],"superfamily":[9],"member.":[10],"This":[11],"family":[12],"contains":[13],"SNPs":[14],"linked":[15],"to":[16,23,43,56,61],"medication":[17,45,62],"response.":[18],"30,000":[19],"participants":[20],"were":[21,53],"evaluated":[22],"determine":[24],"potential":[25],"differences":[26],"in":[27,49],"ethnic":[28,77,105],"distributions":[29],"nucleotide":[31],"polymorphisms.":[32],"Next":[33],"generation":[34],"sequencing":[35],"with":[36],"the":[37,83,112,121,141],"Ion":[38],"Torrent":[39],"PGM":[40],"was":[41],"used":[42],"genotype":[44,86],"response":[46,133],"genes.":[47],"Variations":[48],"these":[50],"key":[51],"enzymes":[52],"common":[54],"leading":[55],"variety":[58],"responses":[60],"therapy.":[63],"Our":[64,118],"study":[65],"showed":[66,93],"there":[67],"exists":[68],"large":[70],"range":[71],"genetic":[73],"variation":[74],"within/between":[75],"various":[76],"groups.":[78,106],"With":[79],"exception":[80],"CYP2C9,":[82],"wild":[84],"type":[85],"is":[87],"not":[88],"most":[89],"common.":[90],"Each":[91],"gene":[92],"unique":[95],"pattern":[96],"distribution":[98],"that":[99],"significantly":[100],"differed":[101],"within":[102],"and":[103,124,139],"across":[104],"These":[107],"findings":[108],"call":[109],"into":[110],"question":[111],"concept":[113],"'normal'":[116],"patient.":[117],"results":[119],"highlight":[120],"need":[122],"for":[123],"applicability":[125],"pharmacogenomic":[127],"testing.":[128],"Genetic":[129],"determination":[130],"patient":[132],"groups":[134],"can":[135],"help":[136],"tailor":[137],"therapies":[138],"increase":[140],"likelihood":[142],"success.":[144]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1}],"updated_date":"2025-11-06T03:46:38.306776","created_date":"2025-10-10T00:00:00"}
