{"id":"https://openalex.org/W2076512092","doi":"https://doi.org/10.1504/ijbra.2008.018344","title":"Modelling of the mitochondrial apoptosis network","display_name":"Modelling of the mitochondrial apoptosis network","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W2076512092","doi":"https://doi.org/10.1504/ijbra.2008.018344","mag":"2076512092","pmid":"https://pubmed.ncbi.nlm.nih.gov/18490261"},"language":"en","primary_location":{"id":"doi:10.1504/ijbra.2008.018344","is_oa":false,"landing_page_url":"https://doi.org/10.1504/ijbra.2008.018344","pdf_url":null,"source":{"id":"https://openalex.org/S207086575","display_name":"International Journal of Bioinformatics Research and Applications","issn_l":"1744-5485","issn":["1744-5485","1744-5493"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310317825","host_organization_name":"Inderscience Publishers","host_organization_lineage":["https://openalex.org/P4310317825"],"host_organization_lineage_names":["Inderscience Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Bioinformatics Research and Applications","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022770208","display_name":"Jun Cui","orcid":"https://orcid.org/0000-0002-8000-3708"},"institutions":[{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]},{"id":"https://openalex.org/I161716053","display_name":"China Pharmaceutical University","ror":"https://ror.org/01sfm2718","country_code":"CN","type":"education","lineage":["https://openalex.org/I161716053"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"J. Cui","raw_affiliation_strings":["State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, People's Republic of China. junc@bcm.tmc.edu","State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, People#TAB#"],"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing, People's Republic of China. junc@bcm.tmc.edu","institution_ids":["https://openalex.org/I161716053","https://openalex.org/I881766915"]},{"raw_affiliation_string":"State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, People#TAB#","institution_ids":["https://openalex.org/I881766915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038255821","display_name":"C. Chen","orcid":"https://orcid.org/0009-0005-2081-7549"},"institutions":[{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"C. Chen","raw_affiliation_strings":["State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, People's Republic of China","s Republic of China.#TAB#"],"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, People's Republic of China","institution_ids":["https://openalex.org/I881766915"]},{"raw_affiliation_string":"s Republic of China.#TAB#","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100646206","display_name":"Huiming Lu","orcid":"https://orcid.org/0000-0002-2743-7419"},"institutions":[{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"H. Lu","raw_affiliation_strings":["State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, People's Republic of China","State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, People#TAB#"],"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, People's Republic of China","institution_ids":["https://openalex.org/I881766915"]},{"raw_affiliation_string":"State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, People#TAB#","institution_ids":["https://openalex.org/I881766915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5018224315","display_name":"Pingping Shen","orcid":"https://orcid.org/0000-0002-1072-784X"},"institutions":[{"id":"https://openalex.org/I881766915","display_name":"Nanjing University","ror":"https://ror.org/01rxvg760","country_code":"CN","type":"education","lineage":["https://openalex.org/I881766915"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"P. Shen","raw_affiliation_strings":["State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, People's Republic of China","s Republic of China.#TAB#"],"affiliations":[{"raw_affiliation_string":"State Key Laboratory of Pharmaceutical Biotechnology, Nanjing University, Nanjing 210093, People's Republic of China","institution_ids":["https://openalex.org/I881766915"]},{"raw_affiliation_string":"s Republic of China.#TAB#","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5022770208"],"corresponding_institution_ids":["https://openalex.org/I161716053","https://openalex.org/I881766915"],"apc_list":null,"apc_paid":null,"fwci":0.404,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.63168501,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":94},"biblio":{"volume":"4","issue":"2","first_page":"172","last_page":"172"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.9958000183105469,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10301","display_name":"Mitochondrial Function and Pathology","score":0.9958000183105469,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10294","display_name":"Cell death mechanisms and regulation","score":0.9937999844551086,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12763","display_name":"ATP Synthase and ATPases Research","score":0.9908000230789185,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/apoptosis","display_name":"Apoptosis","score":0.8680288791656494},{"id":"https://openalex.org/keywords/cytochrome-c","display_name":"Cytochrome c","score":0.8200600147247314},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.5912510752677917},{"id":"https://openalex.org/keywords/bcl-2-family","display_name":"Bcl-2 family","score":0.5447145700454712},{"id":"https://openalex.org/keywords/mitochondrion","display_name":"Mitochondrion","score":0.5319163203239441},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.47448065876960754},{"id":"https://openalex.org/keywords/intrinsic-apoptosis","display_name":"Intrinsic apoptosis","score":0.4328606426715851},{"id":"https://openalex.org/keywords/inhibitor-of-apoptosis-domain","display_name":"Inhibitor of apoptosis domain","score":0.42619284987449646},{"id":"https://openalex.org/keywords/caspase","display_name":"Caspase","score":0.41004231572151184},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.38377076387405396},{"id":"https://openalex.org/keywords/programmed-cell-death","display_name":"Programmed cell death","score":0.216461181640625},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.20004180073738098}],"concepts":[{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.8680288791656494},{"id":"https://openalex.org/C29311851","wikidata":"https://www.wikidata.org/wiki/Q408223","display_name":"Cytochrome c","level":3,"score":0.8200600147247314},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5912510752677917},{"id":"https://openalex.org/C149150037","wikidata":"https://www.wikidata.org/wiki/Q554446","display_name":"Bcl-2 family","level":4,"score":0.5447145700454712},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.5319163203239441},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47448065876960754},{"id":"https://openalex.org/C163421366","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Intrinsic apoptosis","level":5,"score":0.4328606426715851},{"id":"https://openalex.org/C170301204","wikidata":"https://www.wikidata.org/wiki/Q24788681","display_name":"Inhibitor of apoptosis domain","level":5,"score":0.42619284987449646},{"id":"https://openalex.org/C98424977","wikidata":"https://www.wikidata.org/wiki/Q25805","display_name":"Caspase","level":4,"score":0.41004231572151184},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.38377076387405396},{"id":"https://openalex.org/C31573885","wikidata":"https://www.wikidata.org/wiki/Q304484","display_name":"Programmed cell death","level":3,"score":0.216461181640625},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20004180073738098}],"mesh":[{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008928","descriptor_name":"Mitochondria","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019253","descriptor_name":"Proto-Oncogene Proteins c-bcl-2","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019253","descriptor_name":"Proto-Oncogene Proteins c-bcl-2","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019253","descriptor_name":"Proto-Oncogene Proteins c-bcl-2","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020169","descriptor_name":"Caspases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020169","descriptor_name":"Caspases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020169","descriptor_name":"Caspases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1504/ijbra.2008.018344","is_oa":false,"landing_page_url":"https://doi.org/10.1504/ijbra.2008.018344","pdf_url":null,"source":{"id":"https://openalex.org/S207086575","display_name":"International Journal of Bioinformatics Research and Applications","issn_l":"1744-5485","issn":["1744-5485","1744-5493"],"is_oa":false,"is_in_doaj":false,"is_core":true,"host_organization":"https://openalex.org/P4310317825","host_organization_name":"Inderscience Publishers","host_organization_lineage":["https://openalex.org/P4310317825"],"host_organization_lineage_names":["Inderscience Publishers"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Bioinformatics Research and Applications","raw_type":"journal-article"},{"id":"pmid:18490261","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18490261","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of bioinformatics research and applications","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320322769","display_name":"Natural Science Foundation of Jiangsu Province","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W4355260","https://openalex.org/W1607777232","https://openalex.org/W1679452661","https://openalex.org/W1745634660","https://openalex.org/W1925794468","https://openalex.org/W1972636570","https://openalex.org/W1974341306","https://openalex.org/W1994469526","https://openalex.org/W1999625286","https://openalex.org/W2017102177","https://openalex.org/W2051258629","https://openalex.org/W2069777912","https://openalex.org/W2074911197","https://openalex.org/W2077319000","https://openalex.org/W2077341939","https://openalex.org/W2079195402","https://openalex.org/W2087450028","https://openalex.org/W2101950400","https://openalex.org/W2104713798","https://openalex.org/W2105073777","https://openalex.org/W2110252008","https://openalex.org/W2125593117","https://openalex.org/W2126882473","https://openalex.org/W2130866079","https://openalex.org/W2143952085","https://openalex.org/W2152449875","https://openalex.org/W2153442184","https://openalex.org/W2162036597","https://openalex.org/W2168639189","https://openalex.org/W2364987884","https://openalex.org/W2461284614"],"related_works":["https://openalex.org/W2058000280","https://openalex.org/W1971518346","https://openalex.org/W2136043745","https://openalex.org/W2050266038","https://openalex.org/W3144058814","https://openalex.org/W2349346132","https://openalex.org/W2067882654","https://openalex.org/W34494205","https://openalex.org/W2057585964","https://openalex.org/W1568506601"],"abstract_inverted_index":{"In":[0],"this":[1],"paper,":[2],"we":[3,19,39],"performed":[4],"an":[5],"experimental":[6,87],"observation-based":[7],"computer":[8],"simulation":[9],"of":[10,14,23,43,51,57,62,79,98],"the":[11,41,48,54,60,67,77,94],"regulatory":[12,55,96],"network":[13,56,68],"mitochondrial":[15,99],"apoptosis.":[16,58,100],"By":[17],"modelling":[18],"obtained":[20],"dynamical":[21],"understandings":[22],"various":[24],"apoptosis-related":[25],"proteins,":[26],"including":[27],"cytochrome":[28],"c":[29],"(cyt":[30],"c)":[31],"release":[32],"and":[33,47,75],"caspase":[34,73],"activation.":[35],"Through":[36],"parameter":[37],"analysis,":[38],"examined":[40],"role":[42],"Bcl-2":[44],"family":[45],"proteins":[46],"natural":[49],"inhibitors":[50],"apoptosis":[52,80],"in":[53,66],"Furthermore,":[59],"effects":[61],"several":[63],"amplified":[64],"loops":[65],"were":[69],"found":[70],"to":[71],"enhance":[72],"activation":[74],"make":[76],"decision":[78],"switch":[81],"like.":[82],"Consistent":[83],"with":[84],"most":[85],"available":[86],"evidences,":[88],"our":[89],"results":[90],"yield":[91],"insights":[92],"into":[93],"complex":[95],"mechanism":[97]},"counts_by_year":[{"year":2017,"cited_by_count":1}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}