{"id":"https://openalex.org/W4413055506","doi":"https://doi.org/10.1371/journal.pcbi.1013345","title":"A neural network model enables worm tracking in challenging conditions and increases signal-to-noise ratio in phenotypic screens","display_name":"A neural network model enables worm tracking in challenging conditions and increases signal-to-noise ratio in phenotypic screens","publication_year":2025,"publication_date":"2025-08-08","ids":{"openalex":"https://openalex.org/W4413055506","doi":"https://doi.org/10.1371/journal.pcbi.1013345","pmid":"https://pubmed.ncbi.nlm.nih.gov/40779582"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1013345","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1013345","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1013345&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1013345&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5115615029","display_name":"Weheliye H. Weheliye","orcid":null},"institutions":[{"id":"https://openalex.org/I4210109636","display_name":"NIHR Imperial Biomedical Research Centre","ror":"https://ror.org/01kmhx639","country_code":"GB","type":"facility","lineage":["https://openalex.org/I34931013","https://openalex.org/I4210109636"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]},{"id":"https://openalex.org/I4210161592","display_name":"MRC London Institute of Medical Sciences","ror":"https://ror.org/05p1n6x86","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210161592","https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Weheliye H. Weheliye","raw_affiliation_strings":["Institute of Clinical Sciences, Imperial College London, London, United Kingdom","MRC Laboratory of Medical Sciences, London, United Kingdom"],"affiliations":[{"raw_affiliation_string":"Institute of Clinical Sciences, Imperial College London, London, United Kingdom","institution_ids":["https://openalex.org/I4210109636","https://openalex.org/I47508984"]},{"raw_affiliation_string":"MRC Laboratory of Medical Sciences, London, United Kingdom","institution_ids":["https://openalex.org/I4210161592"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060163473","display_name":"Javier Rodr\u00edguez","orcid":"https://orcid.org/0000-0002-9926-1969"},"institutions":[{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]},{"id":"https://openalex.org/I4210161592","display_name":"MRC London Institute of Medical Sciences","ror":"https://ror.org/05p1n6x86","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210161592","https://openalex.org/I47508984"]},{"id":"https://openalex.org/I4210109636","display_name":"NIHR Imperial Biomedical Research Centre","ror":"https://ror.org/01kmhx639","country_code":"GB","type":"facility","lineage":["https://openalex.org/I34931013","https://openalex.org/I4210109636"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Javier Rodriguez","raw_affiliation_strings":["Institute of Clinical Sciences, Imperial College London, London, United Kingdom","MRC Laboratory of Medical Sciences, London, United Kingdom"],"affiliations":[{"raw_affiliation_string":"Institute of Clinical Sciences, Imperial College London, London, United Kingdom","institution_ids":["https://openalex.org/I4210109636","https://openalex.org/I47508984"]},{"raw_affiliation_string":"MRC Laboratory of Medical Sciences, London, United Kingdom","institution_ids":["https://openalex.org/I4210161592"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066983851","display_name":"Luigi Feriani","orcid":"https://orcid.org/0000-0001-6349-7833"},"institutions":[{"id":"https://openalex.org/I4210161592","display_name":"MRC London Institute of Medical Sciences","ror":"https://ror.org/05p1n6x86","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210161592","https://openalex.org/I47508984"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]},{"id":"https://openalex.org/I4210109636","display_name":"NIHR Imperial Biomedical Research Centre","ror":"https://ror.org/01kmhx639","country_code":"GB","type":"facility","lineage":["https://openalex.org/I34931013","https://openalex.org/I4210109636"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Luigi Feriani","raw_affiliation_strings":["Institute of Clinical Sciences, Imperial College London, London, United Kingdom","MRC Laboratory of Medical Sciences, London, United Kingdom"],"affiliations":[{"raw_affiliation_string":"Institute of Clinical Sciences, Imperial College London, London, United Kingdom","institution_ids":["https://openalex.org/I4210109636","https://openalex.org/I47508984"]},{"raw_affiliation_string":"MRC Laboratory of Medical Sciences, London, United Kingdom","institution_ids":["https://openalex.org/I4210161592"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048899487","display_name":"Avelino Javer","orcid":"https://orcid.org/0000-0003-4100-6807"},"institutions":[{"id":"https://openalex.org/I4210161592","display_name":"MRC London Institute of Medical Sciences","ror":"https://ror.org/05p1n6x86","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210161592","https://openalex.org/I47508984"]},{"id":"https://openalex.org/I4210109636","display_name":"NIHR Imperial Biomedical Research Centre","ror":"https://ror.org/01kmhx639","country_code":"GB","type":"facility","lineage":["https://openalex.org/I34931013","https://openalex.org/I4210109636"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Avelino Javer","raw_affiliation_strings":["Institute of Clinical Sciences, Imperial College London, London, United Kingdom","MRC Laboratory of Medical Sciences, London, United Kingdom"],"affiliations":[{"raw_affiliation_string":"Institute of Clinical Sciences, Imperial College London, London, United Kingdom","institution_ids":["https://openalex.org/I4210109636","https://openalex.org/I47508984"]},{"raw_affiliation_string":"MRC Laboratory of Medical Sciences, London, United Kingdom","institution_ids":["https://openalex.org/I4210161592"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034638851","display_name":"Virginie Uhlmann","orcid":"https://orcid.org/0000-0002-2859-9241"},"institutions":[{"id":"https://openalex.org/I1303153112","display_name":"European Bioinformatics Institute","ror":"https://ror.org/02catss52","country_code":"GB","type":"facility","lineage":["https://openalex.org/I1303153112","https://openalex.org/I4210138560"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Virginie Uhlmann","raw_affiliation_strings":["European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Cambridge, United Kingdom"],"affiliations":[{"raw_affiliation_string":"European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Cambridge, United Kingdom","institution_ids":["https://openalex.org/I1303153112"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053777031","display_name":"Andr\u00e9 EX Brown","orcid":"https://orcid.org/0000-0002-1324-8764"},"institutions":[{"id":"https://openalex.org/I4210109636","display_name":"NIHR Imperial Biomedical Research Centre","ror":"https://ror.org/01kmhx639","country_code":"GB","type":"facility","lineage":["https://openalex.org/I34931013","https://openalex.org/I4210109636"]},{"id":"https://openalex.org/I4210161592","display_name":"MRC London Institute of Medical Sciences","ror":"https://ror.org/05p1n6x86","country_code":"GB","type":"facility","lineage":["https://openalex.org/I4210161592","https://openalex.org/I47508984"]},{"id":"https://openalex.org/I47508984","display_name":"Imperial College London","ror":"https://ror.org/041kmwe10","country_code":"GB","type":"education","lineage":["https://openalex.org/I47508984"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Andr\u00e9 E. X. Brown","raw_affiliation_strings":["Institute of Clinical Sciences, Imperial College London, London, United Kingdom","MRC Laboratory of Medical Sciences, London, United Kingdom"],"affiliations":[{"raw_affiliation_string":"Institute of Clinical Sciences, Imperial College London, London, United Kingdom","institution_ids":["https://openalex.org/I4210109636","https://openalex.org/I47508984"]},{"raw_affiliation_string":"MRC Laboratory of Medical Sciences, London, United Kingdom","institution_ids":["https://openalex.org/I4210161592"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5034638851","https://openalex.org/A5048899487","https://openalex.org/A5053777031","https://openalex.org/A5060163473","https://openalex.org/A5066983851","https://openalex.org/A5115615029"],"corresponding_institution_ids":["https://openalex.org/I1303153112","https://openalex.org/I4210109636","https://openalex.org/I4210161592","https://openalex.org/I47508984"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.0042,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.76534447,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":95},"biblio":{"volume":"21","issue":"8","first_page":"e1013345","last_page":"e1013345"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10676","display_name":"Genetics, Aging, and Longevity in Model Organisms","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/1302","display_name":"Aging"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11214","display_name":"Human-Animal Interaction Studies","score":0.9746999740600586,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.9699000120162964,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.6515061855316162},{"id":"https://openalex.org/keywords/crawling","display_name":"Crawling","score":0.6282047033309937},{"id":"https://openalex.org/keywords/tracking","display_name":"Tracking (education)","score":0.6281009316444397},{"id":"https://openalex.org/keywords/bittorrent-tracker","display_name":"BitTorrent tracker","score":0.6061811447143555},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.5415045022964478},{"id":"https://openalex.org/keywords/noise","display_name":"Noise (video)","score":0.49403315782546997},{"id":"https://openalex.org/keywords/signal","display_name":"SIGNAL (programming language)","score":0.4409826397895813},{"id":"https://openalex.org/keywords/computer-vision","display_name":"Computer vision","score":0.39887624979019165},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.36643654108047485},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.31220370531082153},{"id":"https://openalex.org/keywords/eye-tracking","display_name":"Eye tracking","score":0.2115687131881714},{"id":"https://openalex.org/keywords/image","display_name":"Image (mathematics)","score":0.16934794187545776},{"id":"https://openalex.org/keywords/anatomy","display_name":"Anatomy","score":0.1402517557144165}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.6515061855316162},{"id":"https://openalex.org/C100368936","wikidata":"https://www.wikidata.org/wiki/Q1411725","display_name":"Crawling","level":2,"score":0.6282047033309937},{"id":"https://openalex.org/C2775936607","wikidata":"https://www.wikidata.org/wiki/Q466845","display_name":"Tracking (education)","level":2,"score":0.6281009316444397},{"id":"https://openalex.org/C57501372","wikidata":"https://www.wikidata.org/wiki/Q2021268","display_name":"BitTorrent tracker","level":3,"score":0.6061811447143555},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.5415045022964478},{"id":"https://openalex.org/C99498987","wikidata":"https://www.wikidata.org/wiki/Q2210247","display_name":"Noise (video)","level":3,"score":0.49403315782546997},{"id":"https://openalex.org/C2779843651","wikidata":"https://www.wikidata.org/wiki/Q7390335","display_name":"SIGNAL (programming language)","level":2,"score":0.4409826397895813},{"id":"https://openalex.org/C31972630","wikidata":"https://www.wikidata.org/wiki/Q844240","display_name":"Computer vision","level":1,"score":0.39887624979019165},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.36643654108047485},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.31220370531082153},{"id":"https://openalex.org/C56461940","wikidata":"https://www.wikidata.org/wiki/Q970687","display_name":"Eye tracking","level":2,"score":0.2115687131881714},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.16934794187545776},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.1402517557144165},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.0},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C19417346","wikidata":"https://www.wikidata.org/wiki/Q7922","display_name":"Pedagogy","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000077321","descriptor_name":"Deep Learning","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008124","descriptor_name":"Locomotion","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008124","descriptor_name":"Locomotion","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008124","descriptor_name":"Locomotion","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016571","descriptor_name":"Neural Networks, Computer","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D017173","descriptor_name":"Caenorhabditis elegans","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059629","descriptor_name":"Signal-To-Noise Ratio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059629","descriptor_name":"Signal-To-Noise Ratio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059629","descriptor_name":"Signal-To-Noise Ratio","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1371/journal.pcbi.1013345","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1013345","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1013345&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:40779582","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40779582","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:c5159425f3ad4e43bc25f5e0c49fadd3","is_oa":true,"landing_page_url":"https://doaj.org/article/c5159425f3ad4e43bc25f5e0c49fadd3","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 21, Iss 8, p e1013345 (2025)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12360645","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12360645","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1013345","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1013345","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1013345&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Life below water","score":0.8299999833106995,"id":"https://metadata.un.org/sdg/14"}],"awards":[{"id":"https://openalex.org/G4677675672","display_name":null,"funder_award_id":"MC-A658-5TY30","funder_id":"https://openalex.org/F4320334626","funder_display_name":"Medical Research Council"}],"funders":[{"id":"https://openalex.org/F4320334626","display_name":"Medical Research Council","ror":"https://ror.org/03x94j517"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4413055506.pdf","grobid_xml":"https://content.openalex.org/works/W4413055506.grobid-xml"},"referenced_works_count":35,"referenced_works":["https://openalex.org/W1968335909","https://openalex.org/W1978993067","https://openalex.org/W2035694260","https://openalex.org/W2036085310","https://openalex.org/W2037478113","https://openalex.org/W2091284527","https://openalex.org/W2113242953","https://openalex.org/W2132599819","https://openalex.org/W2141533058","https://openalex.org/W2142254043","https://openalex.org/W2151969485","https://openalex.org/W2155899201","https://openalex.org/W2164857604","https://openalex.org/W2211008697","https://openalex.org/W2300300693","https://openalex.org/W2559085405","https://openalex.org/W2780868483","https://openalex.org/W2884436577","https://openalex.org/W2887114371","https://openalex.org/W2941352015","https://openalex.org/W2952476923","https://openalex.org/W2952956973","https://openalex.org/W3000267050","https://openalex.org/W3005113692","https://openalex.org/W3157861089","https://openalex.org/W3165031266","https://openalex.org/W4220806894","https://openalex.org/W4223962547","https://openalex.org/W4306411710","https://openalex.org/W4383533473","https://openalex.org/W4384652490","https://openalex.org/W4385491061","https://openalex.org/W4392367562","https://openalex.org/W4401171114","https://openalex.org/W4406153597"],"related_works":["https://openalex.org/W4393220254","https://openalex.org/W4321258516","https://openalex.org/W2914048681","https://openalex.org/W2806679586","https://openalex.org/W1984282557","https://openalex.org/W3216131935","https://openalex.org/W3183897436","https://openalex.org/W2803420671","https://openalex.org/W4226079751","https://openalex.org/W2091177731"],"abstract_inverted_index":{"High-resolution":[0],"posture":[1],"tracking":[2,37,58],"of":[3,66,77,127,164],"C.":[4],"elegans":[5],"has":[6],"applications":[7],"in":[8,33,57,136],"genetics,":[9],"neuroscience,":[10],"and":[11,38,83,98,131,156,176],"drug":[12],"screening.":[13],"While":[14],"classic":[15],"methods":[16],"can":[17],"reliably":[18],"track":[19],"isolated":[20],"worms":[21,28,73,115],"on":[22],"uniform":[23],"backgrounds,":[24],"they":[25],"fail":[26],"when":[27],"overlap,":[29],"coil,":[30],"or":[31,116],"move":[32],"complex":[34,170],"environments.":[35],"Model-based":[36],"deep":[39],"learning":[40],"approaches":[41],"have":[42],"addressed":[43],"these":[44],"issues":[45],"to":[46,109,146,168],"an":[47],"extent,":[48],"but":[49],"there":[50],"is":[51],"still":[52],"significant":[53],"room":[54],"for":[55,71,86,140],"improvement":[56],"crawling":[59],"worms.":[60],"Here":[61],"we":[62],"train":[63],"a":[64,75],"version":[65],"the":[67,125,133,162],"DeepTangle":[68],"algorithm":[69],"developed":[70],"swimming":[72],"using":[74],"combination":[76],"data":[78,85,141],"derived":[79],"from":[80],"Tierpsy":[81],"tracker":[82],"hand-annotated":[84],"more":[87,100,169,177],"difficult":[88],"cases.":[89],"DeepTangleCrawl":[90],"(DTC)":[91],"outperforms":[92],"existing":[93],"methods,":[94],"reducing":[95],"failure":[96],"rates":[97],"producing":[99],"continuous,":[101],"gap-free":[102],"worm":[103,154,166],"trajectories":[104],"that":[105,122,142,172],"are":[106],"less":[107],"likely":[108],"be":[110,147],"interrupted":[111],"by":[112],"collisions":[113],"between":[114],"self-intersecting":[117],"postures":[118],"(coils).":[119],"We":[120],"show":[121],"DTC":[123,160],"enables":[124],"analysis":[126],"previously":[128],"inaccessible":[129],"behaviours":[130,171],"increases":[132],"signal-to-noise":[134],"ratio":[135],"phenotypic":[137],"screens,":[138],"even":[139],"was":[143],"specifically":[144],"collected":[145],"compatible":[148],"with":[149],"legacy":[150],"trackers":[151],"including":[152,180],"low":[153],"density":[155],"thin":[157],"bacterial":[158,182],"lawns.":[159,183],"broadens":[161],"applicability":[163],"high-throughput":[165],"imaging":[167],"involve":[173],"worm-worm":[174],"interactions":[175],"naturalistic":[178],"environments":[179],"thicker":[181]},"counts_by_year":[{"year":2025,"cited_by_count":1}],"updated_date":"2026-03-20T23:20:44.827607","created_date":"2025-10-10T00:00:00"}
