{"id":"https://openalex.org/W4409494310","doi":"https://doi.org/10.1371/journal.pcbi.1012390","title":"Contributions of mechanical loading and hormonal changes to eccentric hypertrophy during volume overload: A Bayesian analysis using logic-based network models","display_name":"Contributions of mechanical loading and hormonal changes to eccentric hypertrophy during volume overload: A Bayesian analysis using logic-based network models","publication_year":2025,"publication_date":"2025-04-16","ids":{"openalex":"https://openalex.org/W4409494310","doi":"https://doi.org/10.1371/journal.pcbi.1012390","pmid":"https://pubmed.ncbi.nlm.nih.gov/40238825"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1012390","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1012390","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.pcbi.1012390","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026564504","display_name":"Johane Bracamonte","orcid":"https://orcid.org/0000-0002-2359-4361"},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Johane H. Bracamonte","raw_affiliation_strings":["Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, Alabama, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, Alabama, United States of America","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081800790","display_name":"Lionel Watkins","orcid":null},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lionel Watkins","raw_affiliation_strings":["Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia, United States of America","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044683782","display_name":"Betty Pat","orcid":"https://orcid.org/0000-0003-1280-1457"},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4210115616","display_name":"Birmingham VA Medical Center","ror":"https://ror.org/0242qs713","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210115616","https://openalex.org/I4210131075"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Betty Pat","raw_affiliation_strings":["Birmingham Veterans Affairs Health Care System, Birmingham, Alabama, United States of America","Division of Cardiovascular Disease, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America"],"affiliations":[{"raw_affiliation_string":"Birmingham Veterans Affairs Health Care System, Birmingham, Alabama, United States of America","institution_ids":["https://openalex.org/I4210115616"]},{"raw_affiliation_string":"Division of Cardiovascular Disease, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053149684","display_name":"Louis J. Dell\u2019Italia","orcid":"https://orcid.org/0000-0001-6654-0665"},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]},{"id":"https://openalex.org/I4210115616","display_name":"Birmingham VA Medical Center","ror":"https://ror.org/0242qs713","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210115616","https://openalex.org/I4210131075"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Louis J. Dell\u2019Italia","raw_affiliation_strings":["Birmingham Veterans Affairs Health Care System, Birmingham, Alabama, United States of America","Division of Cardiovascular Disease, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America"],"affiliations":[{"raw_affiliation_string":"Birmingham Veterans Affairs Health Care System, Birmingham, Alabama, United States of America","institution_ids":["https://openalex.org/I4210115616"]},{"raw_affiliation_string":"Division of Cardiovascular Disease, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America","institution_ids":["https://openalex.org/I32389192"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078974781","display_name":"Jeffrey J. Saucerman","orcid":"https://orcid.org/0000-0001-9464-8374"},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey J. Saucerman","raw_affiliation_strings":["Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia, United States of America","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101832571","display_name":"Jeffrey W. Holmes","orcid":"https://orcid.org/0000-0001-9125-7220"},"institutions":[{"id":"https://openalex.org/I32389192","display_name":"University of Alabama at Birmingham","ror":"https://ror.org/008s83205","country_code":"US","type":"education","lineage":["https://openalex.org/I32389192"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey W. Holmes","raw_affiliation_strings":["Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, Alabama, United States of America","Division of Cardiothoracic Surgery, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America","Division of Cardiovascular Disease, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, Alabama, United States of America","institution_ids":["https://openalex.org/I32389192"]},{"raw_affiliation_string":"Division of Cardiothoracic Surgery, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America","institution_ids":["https://openalex.org/I32389192"]},{"raw_affiliation_string":"Division of Cardiovascular Disease, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America","institution_ids":["https://openalex.org/I32389192"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5026564504"],"corresponding_institution_ids":["https://openalex.org/I32389192"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":2.5559,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.88780455,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":98},"biblio":{"volume":"21","issue":"4","first_page":"e1012390","last_page":"e1012390"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10172","display_name":"Cardiac Valve Diseases and Treatments","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10172","display_name":"Cardiac Valve Diseases and Treatments","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/volume-overload","display_name":"Volume overload","score":0.7847079038619995},{"id":"https://openalex.org/keywords/pressure-overload","display_name":"Pressure overload","score":0.751592755317688},{"id":"https://openalex.org/keywords/muscle-hypertrophy","display_name":"Muscle hypertrophy","score":0.7145521640777588},{"id":"https://openalex.org/keywords/ventricle","display_name":"Ventricle","score":0.706505537033081},{"id":"https://openalex.org/keywords/heart-failure","display_name":"Heart failure","score":0.5726637244224548},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.555495023727417},{"id":"https://openalex.org/keywords/cardiology","display_name":"Cardiology","score":0.5433550477027893},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.4985191822052002},{"id":"https://openalex.org/keywords/mitral-regurgitation","display_name":"Mitral regurgitation","score":0.4975908100605011},{"id":"https://openalex.org/keywords/eccentric","display_name":"Eccentric","score":0.480672687292099},{"id":"https://openalex.org/keywords/ventricular-remodeling","display_name":"Ventricular remodeling","score":0.46581199765205383},{"id":"https://openalex.org/keywords/cardiac-hypertrophy","display_name":"Cardiac hypertrophy","score":0.1695454716682434},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.09383097290992737}],"concepts":[{"id":"https://openalex.org/C24595384","wikidata":"https://www.wikidata.org/wiki/Q17143767","display_name":"Volume overload","level":3,"score":0.7847079038619995},{"id":"https://openalex.org/C2778271984","wikidata":"https://www.wikidata.org/wiki/Q17126794","display_name":"Pressure overload","level":4,"score":0.751592755317688},{"id":"https://openalex.org/C167414201","wikidata":"https://www.wikidata.org/wiki/Q1955391","display_name":"Muscle hypertrophy","level":2,"score":0.7145521640777588},{"id":"https://openalex.org/C2778921608","wikidata":"https://www.wikidata.org/wiki/Q2002035","display_name":"Ventricle","level":2,"score":0.706505537033081},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.5726637244224548},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.555495023727417},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.5433550477027893},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4985191822052002},{"id":"https://openalex.org/C2993373945","wikidata":"https://www.wikidata.org/wiki/Q268292","display_name":"Mitral regurgitation","level":2,"score":0.4975908100605011},{"id":"https://openalex.org/C100784341","wikidata":"https://www.wikidata.org/wiki/Q1340491","display_name":"Eccentric","level":2,"score":0.480672687292099},{"id":"https://openalex.org/C2779537366","wikidata":"https://www.wikidata.org/wiki/Q7920323","display_name":"Ventricular remodeling","level":3,"score":0.46581199765205383},{"id":"https://openalex.org/C3018791406","wikidata":"https://www.wikidata.org/wiki/Q945225","display_name":"Cardiac hypertrophy","level":3,"score":0.1695454716682434},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.09383097290992737},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001499","descriptor_name":"Bayes Theorem","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008944","descriptor_name":"Mitral Valve Insufficiency","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D008944","descriptor_name":"Mitral Valve Insufficiency","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D008944","descriptor_name":"Mitral Valve Insufficiency","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017379","descriptor_name":"Hypertrophy, Left Ventricular","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D017379","descriptor_name":"Hypertrophy, Left Ventricular","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D017379","descriptor_name":"Hypertrophy, Left Ventricular","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020257","descriptor_name":"Ventricular Remodeling","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020257","descriptor_name":"Ventricular Remodeling","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020257","descriptor_name":"Ventricular Remodeling","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1371/journal.pcbi.1012390","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1012390","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:40238825","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/40238825","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:44a4a078922648728e3a86c022b0ad67","is_oa":true,"landing_page_url":"https://doaj.org/article/44a4a078922648728e3a86c022b0ad67","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 21, Iss 4, p e1012390 (2025)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:12040246","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12040246","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1012390","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1012390","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.7900000214576721,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G1028382710","display_name":null,"funder_award_id":"P01HL051952","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G1591783325","display_name":null,"funder_award_id":"P50HL077100","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G3459158829","display_name":null,"funder_award_id":"John B. Barnwell Award","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G5701809602","display_name":null,"funder_award_id":"R01HL159945","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6207196654","display_name":null,"funder_award_id":"R01HL162925","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7513033196","display_name":null,"funder_award_id":"23POST1026645","funder_id":"https://openalex.org/F4320306230","funder_display_name":"American Heart Association"},{"id":"https://openalex.org/G8415161535","display_name":null,"funder_award_id":"1CX000993-01","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"}],"funders":[{"id":"https://openalex.org/F4320306127","display_name":"U.S. Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":142,"referenced_works":["https://openalex.org/W30956446","https://openalex.org/W47120531","https://openalex.org/W141401380","https://openalex.org/W201221548","https://openalex.org/W1640321628","https://openalex.org/W1785034234","https://openalex.org/W1797139864","https://openalex.org/W1840127740","https://openalex.org/W1863660946","https://openalex.org/W1915114808","https://openalex.org/W1916800720","https://openalex.org/W1938218641","https://openalex.org/W1965314086","https://openalex.org/W1965937201","https://openalex.org/W1966958836","https://openalex.org/W1967117834","https://openalex.org/W1968599987","https://openalex.org/W1970121068","https://openalex.org/W1972309881","https://openalex.org/W1973560858","https://openalex.org/W1976129244","https://openalex.org/W1977057915","https://openalex.org/W1979486981","https://openalex.org/W1982972799","https://openalex.org/W1983692570","https://openalex.org/W1985233782","https://openalex.org/W1986311077","https://openalex.org/W1991533858","https://openalex.org/W1994259586","https://openalex.org/W1997495045","https://openalex.org/W1998137758","https://openalex.org/W1998458312","https://openalex.org/W1998912200","https://openalex.org/W1999660801","https://openalex.org/W2003541384","https://openalex.org/W2004152780","https://openalex.org/W2004624746","https://openalex.org/W2005214015","https://openalex.org/W2008085837","https://openalex.org/W2015896598","https://openalex.org/W2019473043","https://openalex.org/W2020159458","https://openalex.org/W2023324488","https://openalex.org/W2026880181","https://openalex.org/W2027899199","https://openalex.org/W2028973783","https://openalex.org/W2029766994","https://openalex.org/W2030322059","https://openalex.org/W2031573094","https://openalex.org/W2032109847","https://openalex.org/W2034516527","https://openalex.org/W2035619629","https://openalex.org/W2036555063","https://openalex.org/W2037112734","https://openalex.org/W2037119702","https://openalex.org/W2044709111","https://openalex.org/W2045303275","https://openalex.org/W2045680470","https://openalex.org/W2047283852","https://openalex.org/W2048225875","https://openalex.org/W2049634353","https://openalex.org/W2052413329","https://openalex.org/W2052623113","https://openalex.org/W2054217158","https://openalex.org/W2055355841","https://openalex.org/W2055612680","https://openalex.org/W2058279355","https://openalex.org/W2059361692","https://openalex.org/W2060629558","https://openalex.org/W2061786366","https://openalex.org/W2065037544","https://openalex.org/W2073558026","https://openalex.org/W2075683527","https://openalex.org/W2076639600","https://openalex.org/W2078442124","https://openalex.org/W2081499285","https://openalex.org/W2081874034","https://openalex.org/W2086658900","https://openalex.org/W2092701993","https://openalex.org/W2095102158","https://openalex.org/W2097166266","https://openalex.org/W2098636377","https://openalex.org/W2098644652","https://openalex.org/W2101450536","https://openalex.org/W2102967129","https://openalex.org/W2107372101","https://openalex.org/W2114497926","https://openalex.org/W2116413932","https://openalex.org/W2118587791","https://openalex.org/W2120062444","https://openalex.org/W2120067420","https://openalex.org/W2120863041","https://openalex.org/W2122341748","https://openalex.org/W2124316636","https://openalex.org/W2131598032","https://openalex.org/W2132812047","https://openalex.org/W2133847910","https://openalex.org/W2135748160","https://openalex.org/W2137740979","https://openalex.org/W2142961055","https://openalex.org/W2150018011","https://openalex.org/W2151421775","https://openalex.org/W2151743270","https://openalex.org/W2151943435","https://openalex.org/W2153709908","https://openalex.org/W2153937354","https://openalex.org/W2154684959","https://openalex.org/W2154863667","https://openalex.org/W2156557519","https://openalex.org/W2160851432","https://openalex.org/W2163224216","https://openalex.org/W2164631901","https://openalex.org/W2167218611","https://openalex.org/W2167691756","https://openalex.org/W2168002572","https://openalex.org/W2170237197","https://openalex.org/W2206931957","https://openalex.org/W2225473590","https://openalex.org/W2315162885","https://openalex.org/W2315439459","https://openalex.org/W2408763169","https://openalex.org/W2413031504","https://openalex.org/W2428033039","https://openalex.org/W2592859765","https://openalex.org/W2792546493","https://openalex.org/W2795624029","https://openalex.org/W2800855528","https://openalex.org/W2803806607","https://openalex.org/W2883478139","https://openalex.org/W2883899140","https://openalex.org/W2887512841","https://openalex.org/W2913263558","https://openalex.org/W3011105676","https://openalex.org/W3044344688","https://openalex.org/W3110963325","https://openalex.org/W3112785303","https://openalex.org/W3127848956","https://openalex.org/W3210356416","https://openalex.org/W4366774021","https://openalex.org/W4390875505","https://openalex.org/W4409156109","https://openalex.org/W7074118939"],"related_works":["https://openalex.org/W1995678847","https://openalex.org/W268425286","https://openalex.org/W2362817354","https://openalex.org/W2070387810","https://openalex.org/W3031209609","https://openalex.org/W3101126528","https://openalex.org/W2108883887","https://openalex.org/W2034991958","https://openalex.org/W2116535728","https://openalex.org/W4405421772"],"abstract_inverted_index":{"Primary":[0],"mitral":[1,40],"regurgitation":[2],"(MR)":[3],"is":[4,93,151,189],"a":[5,24,111,133,183,248,288],"pathology":[6],"that":[7,146,186],"alters":[8],"mechanical":[9,293],"loading":[10],"on":[11,120],"the":[12,57,75,82,86,100,155,174,238,253,271,280],"left":[13],"ventricle,":[14],"triggers":[15],"an":[16,159,257],"array":[17],"of":[18,49,60,64,81,88,102,137,177,201,211,232,234,240,256,270,273,283,290],"compensatory":[19],"neurohormonal":[20,156],"responses,":[21],"and":[22,52,97,126,128,292],"induces":[23],"distinctive":[25],"ventricular":[26,89],"remodeling":[27,170],"response":[28],"known":[29,254],"as":[30,228,230],"eccentric":[31],"hypertrophy.":[32],"Drug":[33],"therapies":[34],"may":[35],"alleviate":[36],"symptoms,":[37],"but":[38],"only":[39],"valve":[41],"repair":[42],"or":[43,216],"replacement":[44],"can":[45],"provide":[46],"significant":[47],"recovery":[48],"cardiac":[50,284],"function":[51],"dimensions.":[53],"Questions":[54],"remain":[55],"about":[56],"optimal":[58],"timing":[59],"surgery,":[61],"with":[62,158,182,219],"20%":[63],"patients":[65],"developing":[66],"systolic":[67],"dysfunction":[68],"post-operatively":[69],"despite":[70],"being":[71,166],"treated":[72],"according":[73],"to":[74,95,114,131,224,251,261,276],"current":[76],"guidelines.":[77],"Thus,":[78],"better":[79,98],"understanding":[80],"hypertrophic":[83,138,213],"process":[84],"in":[85,124,140,148,162,173,206,217,237,279],"setting":[87,239,282],"volume":[90,122,242],"overload":[91,123],"(VO)":[92],"needed":[94],"improve":[96],"personalize":[99],"management":[101],"MR.":[103],"To":[104],"address":[105],"this":[106,246],"knowledge":[107],"gap,":[108],"we":[109],"employ":[110],"Bayesian":[112],"approach":[113,250],"combine":[115],"data":[116],"from":[117,264],"70":[118],"studies":[119,203,266],"experimental":[121,149,241],"dogs":[125],"rats":[127],"use":[129],"it":[130],"calibrate":[132],"logic-based":[134],"network":[135,260],"model":[136,144,197],"signaling":[139,259],"myocytes.":[141],"The":[142,196],"calibrated":[143],"predicts":[145],"growth":[147],"VO":[150],"mostly":[152],"driven":[153,190,286],"by":[154,168,192,287],"response,":[157],"initial":[160],"increase":[161],"myocardial":[163],"tissue":[164],"stretch":[165],"compensated":[167],"subsequent":[169],"fairly":[171],"early":[172],"time":[175],"course":[176],"VO.":[178],"This":[179],"observation":[180],"contrasts":[181],"common":[184],"perception":[185],"volume-overload":[187],"hypertrophy":[188,285],"primarily":[191],"increased":[193],"myocyte":[194],"strain.":[195],"reproduces":[198],"many":[199],"aspects":[200],"43":[202],"not":[204],"used":[205],"its":[207],"calibration,":[208],"including":[209],"infusion":[210],"individual":[212],"agonists":[214],"alone":[215],"combination":[218,289],"various":[220],"drugs":[221,236],"commonly":[222],"employed":[223],"treat":[225],"heart":[226],"failure,":[227],"well":[229],"administration":[231],"some":[233],"those":[235],"overload.":[243],"We":[244],"believe":[245],"represents":[247],"promising":[249],"using":[252],"structure":[255],"intracellular":[258],"integrate":[262],"information":[263],"multiple":[265],"into":[267],"quantitative":[268],"predictions":[269],"range":[272],"expected":[274],"responses":[275],"potential":[277],"interventions":[278],"complex":[281],"hormonal":[291],"factors.":[294]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1}],"updated_date":"2026-04-16T08:26:57.006410","created_date":"2025-10-10T00:00:00"}