{"id":"https://openalex.org/W4307698885","doi":"https://doi.org/10.1371/journal.pcbi.1010674","title":"Controlling microbial co-culture based on substrate pulsing can lead to stability through differential fitness advantages","display_name":"Controlling microbial co-culture based on substrate pulsing can lead to stability through differential fitness advantages","publication_year":2022,"publication_date":"2022-10-31","ids":{"openalex":"https://openalex.org/W4307698885","doi":"https://doi.org/10.1371/journal.pcbi.1010674","pmid":"https://pubmed.ncbi.nlm.nih.gov/36315576"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1010674","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010674","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.pcbi.1010674","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012311587","display_name":"Juan A. Mart\u00ednez","orcid":"https://orcid.org/0000-0002-2331-5369"},"institutions":[{"id":"https://openalex.org/I157674565","display_name":"University of Li\u00e8ge","ror":"https://ror.org/00afp2z80","country_code":"BE","type":"education","lineage":["https://openalex.org/I157674565"]},{"id":"https://openalex.org/I27895137","display_name":"Gembloux Agro-Bio Tech","ror":"https://ror.org/00bmzhb16","country_code":"BE","type":"education","lineage":["https://openalex.org/I157674565","https://openalex.org/I27895137"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"J. Andres Martinez","raw_affiliation_strings":["TERRA Research and Teaching Centre, Microbial Processes and Interactions (MiPI), Gembloux Agro-Bio Tech, University of Li\u00e9ge, Gembloux, Belgium"],"raw_orcid":"https://orcid.org/0000-0002-2331-5369","affiliations":[{"raw_affiliation_string":"TERRA Research and Teaching Centre, Microbial Processes and Interactions (MiPI), Gembloux Agro-Bio Tech, University of Li\u00e9ge, Gembloux, Belgium","institution_ids":["https://openalex.org/I27895137","https://openalex.org/I157674565"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009023973","display_name":"Math\u00e9o Delvenne","orcid":"https://orcid.org/0000-0001-5893-5405"},"institutions":[{"id":"https://openalex.org/I157674565","display_name":"University of Li\u00e8ge","ror":"https://ror.org/00afp2z80","country_code":"BE","type":"education","lineage":["https://openalex.org/I157674565"]},{"id":"https://openalex.org/I27895137","display_name":"Gembloux Agro-Bio Tech","ror":"https://ror.org/00bmzhb16","country_code":"BE","type":"education","lineage":["https://openalex.org/I157674565","https://openalex.org/I27895137"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Matheo Delvenne","raw_affiliation_strings":["TERRA Research and Teaching Centre, Microbial Processes and Interactions (MiPI), Gembloux Agro-Bio Tech, University of Li\u00e9ge, Gembloux, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TERRA Research and Teaching Centre, Microbial Processes and Interactions (MiPI), Gembloux Agro-Bio Tech, University of Li\u00e9ge, Gembloux, Belgium","institution_ids":["https://openalex.org/I27895137","https://openalex.org/I157674565"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057612346","display_name":"Lucas Henrion","orcid":"https://orcid.org/0000-0003-1696-7657"},"institutions":[{"id":"https://openalex.org/I157674565","display_name":"University of Li\u00e8ge","ror":"https://ror.org/00afp2z80","country_code":"BE","type":"education","lineage":["https://openalex.org/I157674565"]},{"id":"https://openalex.org/I27895137","display_name":"Gembloux Agro-Bio Tech","ror":"https://ror.org/00bmzhb16","country_code":"BE","type":"education","lineage":["https://openalex.org/I157674565","https://openalex.org/I27895137"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Lucas Henrion","raw_affiliation_strings":["TERRA Research and Teaching Centre, Microbial Processes and Interactions (MiPI), Gembloux Agro-Bio Tech, University of Li\u00e9ge, Gembloux, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TERRA Research and Teaching Centre, Microbial Processes and Interactions (MiPI), Gembloux Agro-Bio Tech, University of Li\u00e9ge, Gembloux, Belgium","institution_ids":["https://openalex.org/I27895137","https://openalex.org/I157674565"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048093211","display_name":"Fabi\u00e1n Moreno","orcid":"https://orcid.org/0000-0001-7364-1704"},"institutions":[{"id":"https://openalex.org/I157674565","display_name":"University of Li\u00e8ge","ror":"https://ror.org/00afp2z80","country_code":"BE","type":"education","lineage":["https://openalex.org/I157674565"]},{"id":"https://openalex.org/I27895137","display_name":"Gembloux Agro-Bio Tech","ror":"https://ror.org/00bmzhb16","country_code":"BE","type":"education","lineage":["https://openalex.org/I157674565","https://openalex.org/I27895137"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Fabian Moreno","raw_affiliation_strings":["TERRA Research and Teaching Centre, Microbial Processes and Interactions (MiPI), Gembloux Agro-Bio Tech, University of Li\u00e9ge, Gembloux, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TERRA Research and Teaching Centre, Microbial Processes and Interactions (MiPI), Gembloux Agro-Bio Tech, University of Li\u00e9ge, Gembloux, Belgium","institution_ids":["https://openalex.org/I27895137","https://openalex.org/I157674565"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017776332","display_name":"Samuel Telek","orcid":"https://orcid.org/0000-0001-8115-0964"},"institutions":[{"id":"https://openalex.org/I157674565","display_name":"University of Li\u00e8ge","ror":"https://ror.org/00afp2z80","country_code":"BE","type":"education","lineage":["https://openalex.org/I157674565"]},{"id":"https://openalex.org/I27895137","display_name":"Gembloux Agro-Bio Tech","ror":"https://ror.org/00bmzhb16","country_code":"BE","type":"education","lineage":["https://openalex.org/I157674565","https://openalex.org/I27895137"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Samuel Telek","raw_affiliation_strings":["TERRA Research and Teaching Centre, Microbial Processes and Interactions (MiPI), Gembloux Agro-Bio Tech, University of Li\u00e9ge, Gembloux, Belgium"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TERRA Research and Teaching Centre, Microbial Processes and Interactions (MiPI), Gembloux Agro-Bio Tech, University of Li\u00e9ge, Gembloux, Belgium","institution_ids":["https://openalex.org/I27895137","https://openalex.org/I157674565"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061467562","display_name":"Christian Dusny","orcid":"https://orcid.org/0000-0002-4653-4951"},"institutions":[{"id":"https://openalex.org/I137479271","display_name":"Helmholtz Centre for Environmental Research","ror":"https://ror.org/000h6jb29","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I137479271"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Christian Dusny","raw_affiliation_strings":["Microscale Analysis and Engineering, Department of Solar Materials, Helmholtz-Centre for Environmental Research- UFZ Leipzig, Leipzig, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microscale Analysis and Engineering, Department of Solar Materials, Helmholtz-Centre for Environmental Research- UFZ Leipzig, Leipzig, Germany","institution_ids":["https://openalex.org/I137479271"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077784420","display_name":"Frank Delvigne","orcid":"https://orcid.org/0000-0002-1679-1914"},"institutions":[{"id":"https://openalex.org/I157674565","display_name":"University of Li\u00e8ge","ror":"https://ror.org/00afp2z80","country_code":"BE","type":"education","lineage":["https://openalex.org/I157674565"]},{"id":"https://openalex.org/I27895137","display_name":"Gembloux Agro-Bio Tech","ror":"https://ror.org/00bmzhb16","country_code":"BE","type":"education","lineage":["https://openalex.org/I157674565","https://openalex.org/I27895137"]}],"countries":["BE"],"is_corresponding":true,"raw_author_name":"Frank Delvigne","raw_affiliation_strings":["TERRA Research and Teaching Centre, Microbial Processes and Interactions (MiPI), Gembloux Agro-Bio Tech, University of Li\u00e9ge, Gembloux, Belgium"],"raw_orcid":"https://orcid.org/0000-0002-1679-1914","affiliations":[{"raw_affiliation_string":"TERRA Research and Teaching Centre, Microbial Processes and Interactions (MiPI), Gembloux Agro-Bio Tech, University of Li\u00e9ge, Gembloux, Belgium","institution_ids":["https://openalex.org/I27895137","https://openalex.org/I157674565"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5077784420"],"corresponding_institution_ids":["https://openalex.org/I157674565","https://openalex.org/I27895137"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2802,"currency":"EUR","value_usd":3021},"fwci":2.2567,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.88998867,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"18","issue":"10","first_page":"e1010674","last_page":"e1010674"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9975000023841858,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/yeast","display_name":"Yeast","score":0.5994036197662354},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.5805197358131409},{"id":"https://openalex.org/keywords/biochemical-engineering","display_name":"Biochemical engineering","score":0.5350640416145325},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5233994126319885},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.5227180123329163},{"id":"https://openalex.org/keywords/bioreactor","display_name":"Bioreactor","score":0.5158399939537048},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.48825743794441223},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.44260966777801514},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.29669705033302307},{"id":"https://openalex.org/keywords/engineering","display_name":"Engineering","score":0.09088784456253052}],"concepts":[{"id":"https://openalex.org/C2779222958","wikidata":"https://www.wikidata.org/wiki/Q45422","display_name":"Yeast","level":2,"score":0.5994036197662354},{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.5805197358131409},{"id":"https://openalex.org/C183696295","wikidata":"https://www.wikidata.org/wiki/Q2487696","display_name":"Biochemical engineering","level":1,"score":0.5350640416145325},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5233994126319885},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5227180123329163},{"id":"https://openalex.org/C168170006","wikidata":"https://www.wikidata.org/wiki/Q864699","display_name":"Bioreactor","level":2,"score":0.5158399939537048},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.48825743794441223},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.44260966777801514},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.29669705033302307},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.09088784456253052},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018920","descriptor_name":"Coculture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018920","descriptor_name":"Coculture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018920","descriptor_name":"Coculture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019149","descriptor_name":"Bioreactors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019149","descriptor_name":"Bioreactors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019149","descriptor_name":"Bioreactors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1371/journal.pcbi.1010674","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010674","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:36315576","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36315576","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:orbi.ulg.ac.be:2268/316101","is_oa":true,"landing_page_url":"https://orbi.uliege.be/handle/2268/316101","pdf_url":null,"source":{"id":"https://openalex.org/S4306400651","display_name":"Open Repository and Bibliography (University of Li\u00e8ge)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I157674565","host_organization_name":"University of Li\u00e8ge","host_organization_lineage":["https://openalex.org/I157674565"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, 18 (10), e1010674 (2022-10)","raw_type":"peer reviewed"},{"id":"pmh:oai:pubmedcentral.nih.gov:9648842","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9648842","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1010674","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010674","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/15","display_name":"Life in Land","score":0.4699999988079071}],"awards":[],"funders":[{"id":"https://openalex.org/F4320321390","display_name":"Fonds De La Recherche Scientifique - FNRS","ror":"https://ror.org/03q83t159"},{"id":"https://openalex.org/F4320332999","display_name":"Horizon 2020 Framework Programme","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320334840","display_name":"Fonds pour la Formation \u00e0 la Recherche dans l\u2019Industrie et dans l\u2019Agriculture","ror":"https://ror.org/03q83t159"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":70,"referenced_works":["https://openalex.org/W1938292773","https://openalex.org/W1967330678","https://openalex.org/W1969951124","https://openalex.org/W1997890865","https://openalex.org/W2007805261","https://openalex.org/W2022616740","https://openalex.org/W2031861189","https://openalex.org/W2036173715","https://openalex.org/W2043487490","https://openalex.org/W2044082313","https://openalex.org/W2053016491","https://openalex.org/W2056228650","https://openalex.org/W2061832011","https://openalex.org/W2066038887","https://openalex.org/W2081475396","https://openalex.org/W2084338561","https://openalex.org/W2095355446","https://openalex.org/W2096015757","https://openalex.org/W2101442503","https://openalex.org/W2108048122","https://openalex.org/W2113106276","https://openalex.org/W2114628897","https://openalex.org/W2118672678","https://openalex.org/W2145352273","https://openalex.org/W2149181149","https://openalex.org/W2152146387","https://openalex.org/W2168317391","https://openalex.org/W2346788556","https://openalex.org/W2397945787","https://openalex.org/W2512750018","https://openalex.org/W2609618150","https://openalex.org/W2618954563","https://openalex.org/W2723535088","https://openalex.org/W2794647037","https://openalex.org/W2804076141","https://openalex.org/W2897377645","https://openalex.org/W2898796967","https://openalex.org/W2900016502","https://openalex.org/W2902798368","https://openalex.org/W2912599612","https://openalex.org/W2918059589","https://openalex.org/W2940709722","https://openalex.org/W2946268652","https://openalex.org/W2949808248","https://openalex.org/W2952890242","https://openalex.org/W2953949104","https://openalex.org/W2958731503","https://openalex.org/W2971658418","https://openalex.org/W2972369164","https://openalex.org/W2974481407","https://openalex.org/W2991644079","https://openalex.org/W3005423028","https://openalex.org/W3016575427","https://openalex.org/W3021904993","https://openalex.org/W3032530297","https://openalex.org/W3088277963","https://openalex.org/W3094021115","https://openalex.org/W3097349386","https://openalex.org/W3102402181","https://openalex.org/W3112224415","https://openalex.org/W3156565840","https://openalex.org/W3160173019","https://openalex.org/W3164388438","https://openalex.org/W3190028726","https://openalex.org/W3197419749","https://openalex.org/W3200688828","https://openalex.org/W3209527983","https://openalex.org/W3213284397","https://openalex.org/W4225369947","https://openalex.org/W4280567920"],"related_works":["https://openalex.org/W2028107853","https://openalex.org/W1982584572","https://openalex.org/W4210617669","https://openalex.org/W4232406862","https://openalex.org/W2397070560","https://openalex.org/W4402640375","https://openalex.org/W1980740090","https://openalex.org/W2818141943","https://openalex.org/W4285187183","https://openalex.org/W2552994593"],"abstract_inverted_index":{"Microbial":[0],"consortia":[1],"are":[2,43],"an":[3,171],"exciting":[4],"alternative":[5],"for":[6,12,119],"increasing":[7],"the":[8,13,20,31,95,114,134,167,187,190,194],"performances":[9],"of":[10,15,23,66,116,136,189,193],"bioprocesses":[11],"production":[14],"complex":[16,32,54],"metabolic":[17,191],"products.":[18],"However,":[19],"functional":[21],"properties":[22],"microbial":[24,38,41],"communities":[25,42],"remain":[26],"challenging":[27],"to":[28,49,86,94,112,132,139,142],"control,":[29],"considering":[30],"interaction":[33],"mechanisms":[34],"occurring":[35],"between":[36],"co-cultured":[37],"species.":[39],"Indeed,":[40],"highly":[44],"dynamic":[45],"and":[46,69],"can":[47],"adapt":[48],"changing":[50],"environmental":[51],"conditions":[52],"through":[53],"mechanisms,":[55],"such":[56],"as":[57],"phenotypic":[58,173],"diversification.":[59],"We":[60],"focused":[61],"on":[62,98,123,160],"stabilizing":[63],"a":[64,99,124,161],"co-culture":[65,88,144,177],"Saccharomyces":[67],"cerevisiae":[68],"Escherichia":[70],"coli":[71],"in":[72,152,176],"continuous":[73,153],"cultures.":[74],"Our":[75],"preliminary":[76],"data":[77],"pointed":[78],"out":[79],"that":[80,166,182],"transient":[81],"diauxic":[82,117,137],"shifts":[83],"could":[84,185],"lead":[85],"stable":[87],"by":[89],"providing":[90],"periodic":[91],"fitness":[92,192],"advantages":[93],"yeast.":[96,195],"Based":[97],"computational":[100],"toolbox":[101,128],"called":[102],"MONCKS":[103],"(for":[104],"MONod-type":[105],"Co-culture":[106],"Kinetic":[107],"Simulation),":[108],"we":[109,164],"were":[110,148],"able":[111],"predict":[113,133],"dynamics":[115],"shift":[118,138],"both":[120],"species":[121],"based":[122,159],"cybernetic":[125],"approach.":[126],"This":[127],"was":[129],"further":[130],"used":[131],"frequency":[135],"be":[140,186],"applied":[141],"reach":[143],"stability.":[145],"These":[146],"simulations":[147],"successfully":[149],"reproduced":[150],"experimentally":[151],"bioreactors":[154],"with":[155,179],"glucose":[156],"pulsing.":[157],"Finally,":[158],"bet-hedging":[162],"reporter,":[163],"observed":[165],"yeast":[168],"population":[169],"exhibited":[170],"increased":[172],"diversification":[174],"process":[175],"compared":[178],"mono-culture,":[180],"suggesting":[181],"this":[183],"mechanism":[184],"basis":[188]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":2}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}
