{"id":"https://openalex.org/W4296794115","doi":"https://doi.org/10.1371/journal.pcbi.1010529","title":"Identification of key somatic oncogenic mutation based on a confounder-free causal inference model","display_name":"Identification of key somatic oncogenic mutation based on a confounder-free causal inference model","publication_year":2022,"publication_date":"2022-09-22","ids":{"openalex":"https://openalex.org/W4296794115","doi":"https://doi.org/10.1371/journal.pcbi.1010529","pmid":"https://pubmed.ncbi.nlm.nih.gov/36137089"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1010529","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010529","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.pcbi.1010529","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5104287422","display_name":"Yijun Liu","orcid":"https://orcid.org/0009-0000-5612-7666"},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yijun Liu","raw_affiliation_strings":["School of Artificial Intelligence, Jilin University, Changchun, Jilin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Artificial Intelligence, Jilin University, Changchun, Jilin, China","institution_ids":["https://openalex.org/I194450716"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048169544","display_name":"Ji Sun","orcid":"https://orcid.org/0000-0001-5085-4803"},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ji Sun","raw_affiliation_strings":["School of Artificial Intelligence, Jilin University, Changchun, Jilin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Artificial Intelligence, Jilin University, Changchun, Jilin, China","institution_ids":["https://openalex.org/I194450716"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022806069","display_name":"Huiyan Sun","orcid":null},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]},{"id":"https://openalex.org/I4210164189","display_name":"Jilin International Studies University","ror":"https://ror.org/05mvcw862","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210164189"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Huiyan Sun","raw_affiliation_strings":["International Center of Future Science, Jilin University, Changchun, Jilin, China","School of Artificial Intelligence, Jilin University, Changchun, Jilin, China"],"raw_orcid":"https://orcid.org/0000-0002-4664-7147","affiliations":[{"raw_affiliation_string":"International Center of Future Science, Jilin University, Changchun, Jilin, China","institution_ids":["https://openalex.org/I4210164189","https://openalex.org/I194450716"]},{"raw_affiliation_string":"School of Artificial Intelligence, Jilin University, Changchun, Jilin, China","institution_ids":["https://openalex.org/I194450716"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5029392006","display_name":"Yi Chang","orcid":"https://orcid.org/0000-0003-2697-8093"},"institutions":[{"id":"https://openalex.org/I194450716","display_name":"Jilin University","ror":"https://ror.org/00js3aw79","country_code":"CN","type":"education","lineage":["https://openalex.org/I194450716"]},{"id":"https://openalex.org/I4210164189","display_name":"Jilin International Studies University","ror":"https://ror.org/05mvcw862","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210164189"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yi Chang","raw_affiliation_strings":["International Center of Future Science, Jilin University, Changchun, Jilin, China","School of Artificial Intelligence, Jilin University, Changchun, Jilin, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"International Center of Future Science, Jilin University, Changchun, Jilin, China","institution_ids":["https://openalex.org/I4210164189","https://openalex.org/I194450716"]},{"raw_affiliation_string":"School of Artificial Intelligence, Jilin University, Changchun, Jilin, China","institution_ids":["https://openalex.org/I194450716"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5022806069","https://openalex.org/A5029392006"],"corresponding_institution_ids":["https://openalex.org/I194450716","https://openalex.org/I4210164189"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.3797,"has_fulltext":false,"cited_by_count":4,"citation_normalized_percentile":{"value":0.5424482,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":91,"max":97},"biblio":{"volume":"18","issue":"9","first_page":"e1010529","last_page":"e1010529"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11287","display_name":"Cancer Genomics and Diagnostics","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":0.9972000122070312,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9955999851226807,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/causal-inference","display_name":"Causal inference","score":0.671404242515564},{"id":"https://openalex.org/keywords/inference","display_name":"Inference","score":0.5771201848983765},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.571759819984436},{"id":"https://openalex.org/keywords/confounding","display_name":"Confounding","score":0.5583136081695557},{"id":"https://openalex.org/keywords/mutation","display_name":"Mutation","score":0.5518525242805481},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5447744131088257},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.5295839309692383},{"id":"https://openalex.org/keywords/autoencoder","display_name":"Autoencoder","score":0.4959498345851898},{"id":"https://openalex.org/keywords/causality","display_name":"Causality (physics)","score":0.4288562834262848},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3971540629863739},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.2741277813911438},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.26397040486335754},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.2251223623752594},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.177133709192276},{"id":"https://openalex.org/keywords/econometrics","display_name":"Econometrics","score":0.14311152696609497},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.12347754836082458},{"id":"https://openalex.org/keywords/deep-learning","display_name":"Deep learning","score":0.11974591016769409}],"concepts":[{"id":"https://openalex.org/C158600405","wikidata":"https://www.wikidata.org/wiki/Q5054566","display_name":"Causal inference","level":2,"score":0.671404242515564},{"id":"https://openalex.org/C2776214188","wikidata":"https://www.wikidata.org/wiki/Q408386","display_name":"Inference","level":2,"score":0.5771201848983765},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.571759819984436},{"id":"https://openalex.org/C77350462","wikidata":"https://www.wikidata.org/wiki/Q1125472","display_name":"Confounding","level":2,"score":0.5583136081695557},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.5518525242805481},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5447744131088257},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5295839309692383},{"id":"https://openalex.org/C101738243","wikidata":"https://www.wikidata.org/wiki/Q786435","display_name":"Autoencoder","level":3,"score":0.4959498345851898},{"id":"https://openalex.org/C64357122","wikidata":"https://www.wikidata.org/wiki/Q1149766","display_name":"Causality (physics)","level":2,"score":0.4288562834262848},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3971540629863739},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2741277813911438},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.26397040486335754},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.2251223623752594},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.177133709192276},{"id":"https://openalex.org/C149782125","wikidata":"https://www.wikidata.org/wiki/Q160039","display_name":"Econometrics","level":1,"score":0.14311152696609497},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12347754836082458},{"id":"https://openalex.org/C108583219","wikidata":"https://www.wikidata.org/wiki/Q197536","display_name":"Deep learning","level":2,"score":0.11974591016769409},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.0},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009857","descriptor_name":"Oncogenes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009857","descriptor_name":"Oncogenes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009857","descriptor_name":"Oncogenes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015982","descriptor_name":"Bias","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015982","descriptor_name":"Bias","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015982","descriptor_name":"Bias","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015984","descriptor_name":"Causality","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015984","descriptor_name":"Causality","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015984","descriptor_name":"Causality","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063646","descriptor_name":"Carcinogenesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D063646","descriptor_name":"Carcinogenesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D063646","descriptor_name":"Carcinogenesis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1371/journal.pcbi.1010529","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010529","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:36137089","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/36137089","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:215612afacc3444d9731fe107fff8a46","is_oa":true,"landing_page_url":"https://doaj.org/article/215612afacc3444d9731fe107fff8a46","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 18, Iss 9, p e1010529 (2022)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9499235","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9499235","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1010529","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010529","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G3014971928","display_name":null,"funder_award_id":"61902144","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G524871825","display_name":null,"funder_award_id":"61976102","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G7138386155","display_name":null,"funder_award_id":"U19A2065","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":59,"referenced_works":["https://openalex.org/W1512072225","https://openalex.org/W1520852255","https://openalex.org/W1522301498","https://openalex.org/W1544362532","https://openalex.org/W1920914663","https://openalex.org/W1959608418","https://openalex.org/W1974843841","https://openalex.org/W1984675437","https://openalex.org/W1996016456","https://openalex.org/W2038251519","https://openalex.org/W2055130200","https://openalex.org/W2058000497","https://openalex.org/W2060252723","https://openalex.org/W2068751029","https://openalex.org/W2084831115","https://openalex.org/W2111862142","https://openalex.org/W2120396011","https://openalex.org/W2125348377","https://openalex.org/W2129973040","https://openalex.org/W2130410032","https://openalex.org/W2132623845","https://openalex.org/W2139227366","https://openalex.org/W2141410747","https://openalex.org/W2143891888","https://openalex.org/W2151432963","https://openalex.org/W2158485828","https://openalex.org/W2164411392","https://openalex.org/W2166771322","https://openalex.org/W2176412452","https://openalex.org/W2271840356","https://openalex.org/W2329659234","https://openalex.org/W2436745791","https://openalex.org/W2514108517","https://openalex.org/W2611387862","https://openalex.org/W2620040559","https://openalex.org/W2620393362","https://openalex.org/W2726542547","https://openalex.org/W2757487320","https://openalex.org/W2767399544","https://openalex.org/W2784142616","https://openalex.org/W2868860358","https://openalex.org/W2888725209","https://openalex.org/W2915168078","https://openalex.org/W2919691581","https://openalex.org/W2942797919","https://openalex.org/W2963285578","https://openalex.org/W3008182829","https://openalex.org/W3024000868","https://openalex.org/W3041426930","https://openalex.org/W3047825284","https://openalex.org/W3080838508","https://openalex.org/W3094278623","https://openalex.org/W3109762849","https://openalex.org/W3186405496","https://openalex.org/W3187973486","https://openalex.org/W4295097398","https://openalex.org/W6631190155","https://openalex.org/W6640963894","https://openalex.org/W6780235739"],"related_works":["https://openalex.org/W3023719900","https://openalex.org/W4287798354","https://openalex.org/W3035083705","https://openalex.org/W2030287811","https://openalex.org/W4386534229","https://openalex.org/W3002087755","https://openalex.org/W4386150491","https://openalex.org/W3080342542","https://openalex.org/W2806152055","https://openalex.org/W1547624382"],"abstract_inverted_index":{"Abnormal":[0],"cell":[1,151],"proliferation":[2,152],"and":[3,15,59,94,105,114,153,159,184],"epithelial-mesenchymal":[4],"transition":[5],"(EMT)":[6],"are":[7,178],"the":[8,54,79,98,144,195],"essential":[9],"events":[10],"that":[11,167],"induce":[12,81],"cancer":[13,21,92,139,183,186],"initiation":[14,93],"progression.":[16],"A":[17],"fundamental":[18],"goal":[19],"in":[20,62,181,194],"research":[22],"is":[23],"to":[24,29,44,77,102,130,137,203],"develop":[25],"an":[26],"efficient":[27],"method":[28,142],"detect":[30],"mutational":[31],"genes":[32,168],"capable":[33],"of":[34,50,83,91,147,197],"driving":[35],"cancer.":[36],"Although":[37],"several":[38],"computational":[39],"methods":[40],"have":[41],"been":[42],"proposed":[43],"identify":[45,131,204],"these":[46],"key":[47,132],"mutations,":[48],"many":[49],"them":[51],"focus":[52],"on":[53,87,125,150],"association":[55],"between":[56],"genetic":[57,148],"mutations":[58,104,149],"functional":[60],"changes":[61],"relevant":[63],"biological":[64,89],"processes,":[65],"but":[66],"not":[67,174],"their":[68],"real":[69,80],"causality.":[70],"Causal":[71],"effect":[72,82,146],"inference":[73,122,202],"provides":[74],"a":[75,84,119,126,192],"way":[76],"estimate":[78],"certain":[85],"mutation":[86,171],"vital":[88],"processes":[90],"progression,":[95],"through":[96],"addressing":[97],"confounder":[99],"bias":[100],"due":[101],"neutral":[103],"unobserved":[106,160],"latent":[107],"variables.":[108],"In":[109],"this":[110],"study,":[111],"integrating":[112],"genomic":[113],"transcriptomic":[115],"data,":[116],"we":[117],"construct":[118],"novel":[120],"causal":[121,145,201],"model":[123],"based":[124],"deep":[127],"variational":[128],"autoencoder":[129],"oncogenic":[133,205],"somatic":[134],"mutations.":[135,206],"Applied":[136],"10":[138],"types,":[140],"our":[141,189],"quantifies":[143],"EMT":[154],"by":[155],"reducing":[156],"both":[157],"observed":[158],"confounding":[161],"biases.":[162],"The":[163],"experimental":[164],"results":[165],"indicate":[166],"with":[169],"higher":[170],"frequency":[172],"do":[173],"necessarily":[175],"mean":[176],"they":[177],"more":[179],"potent":[180],"inducing":[182],"promoting":[185],"development.":[187],"Moreover,":[188],"study":[190],"fills":[191],"gap":[193],"use":[196],"machine":[198],"learning":[199],"for":[200]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}
