{"id":"https://openalex.org/W4285020551","doi":"https://doi.org/10.1371/journal.pcbi.1010294","title":"Thalamic deep brain stimulation paradigm to reduce consciousness: Cortico-striatal dynamics implicated in mechanisms of consciousness","display_name":"Thalamic deep brain stimulation paradigm to reduce consciousness: Cortico-striatal dynamics implicated in mechanisms of consciousness","publication_year":2022,"publication_date":"2022-07-11","ids":{"openalex":"https://openalex.org/W4285020551","doi":"https://doi.org/10.1371/journal.pcbi.1010294","pmid":"https://pubmed.ncbi.nlm.nih.gov/35816488"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1010294","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010294","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1010294&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1010294&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072106021","display_name":"Michelle J. Redinbaugh","orcid":"https://orcid.org/0000-0003-1367-8606"},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michelle J. Redinbaugh","raw_affiliation_strings":["Department of Psychology, University of Wisconsin-Madison, Madison, Wisconsin, United States of America"],"raw_orcid":"https://orcid.org/0000-0003-1367-8606","affiliations":[{"raw_affiliation_string":"Department of Psychology, University of Wisconsin-Madison, Madison, Wisconsin, United States of America","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040855288","display_name":"Mohsen Afrasiabi","orcid":"https://orcid.org/0000-0002-3114-5996"},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mohsen Afrasiabi","raw_affiliation_strings":["Department of Psychology, University of Wisconsin-Madison, Madison, Wisconsin, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-3114-5996","affiliations":[{"raw_affiliation_string":"Department of Psychology, University of Wisconsin-Madison, Madison, Wisconsin, United States of America","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046368518","display_name":"Jessica M. Phillips","orcid":"https://orcid.org/0000-0002-8240-7327"},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jessica M. Phillips","raw_affiliation_strings":["Department of Psychology, University of Wisconsin-Madison, Madison, Wisconsin, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-8240-7327","affiliations":[{"raw_affiliation_string":"Department of Psychology, University of Wisconsin-Madison, Madison, Wisconsin, United States of America","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063499239","display_name":"Niranjan A. Kambi","orcid":"https://orcid.org/0009-0007-8436-490X"},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Niranjan A. Kambi","raw_affiliation_strings":["Department of Psychology, University of Wisconsin-Madison, Madison, Wisconsin, United States of America"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychology, University of Wisconsin-Madison, Madison, Wisconsin, United States of America","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008586786","display_name":"Sounak Mohanta","orcid":"https://orcid.org/0000-0001-8169-446X"},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sounak Mohanta","raw_affiliation_strings":["Department of Psychology, University of Wisconsin-Madison, Madison, Wisconsin, United States of America"],"raw_orcid":"https://orcid.org/0000-0001-8169-446X","affiliations":[{"raw_affiliation_string":"Department of Psychology, University of Wisconsin-Madison, Madison, Wisconsin, United States of America","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044892576","display_name":"Aeyal Raz","orcid":"https://orcid.org/0000-0002-5253-7278"},"institutions":[{"id":"https://openalex.org/I174306211","display_name":"Technion \u2013 Israel Institute of Technology","ror":"https://ror.org/03qryx823","country_code":"IL","type":"education","lineage":["https://openalex.org/I174306211"]},{"id":"https://openalex.org/I2801301638","display_name":"Rambam Health Care Campus","ror":"https://ror.org/01fm87m50","country_code":"IL","type":"healthcare","lineage":["https://openalex.org/I2801301638"]},{"id":"https://openalex.org/I4210117163","display_name":"Rappaport Family Institute for Research in the Medical Sciences","ror":"https://ror.org/029hzjx43","country_code":"IL","type":"facility","lineage":["https://openalex.org/I4210117163"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Aeyal Raz","raw_affiliation_strings":["Department of Anesthesiology, Rambam Health Care Campus, Haifa, Israel; Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel","Department of Anesthesiology, Rambam Health Care Campus, Haifa, Israel","Ruth and Bruce Rappaport Faculty of Medicine, Technion\u2014Israel Institute of Technology, Haifa, Israel"],"raw_orcid":"https://orcid.org/0000-0002-5253-7278","affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Rambam Health Care Campus, Haifa, Israel; Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel","institution_ids":["https://openalex.org/I2801301638","https://openalex.org/I4210117163"]},{"raw_affiliation_string":"Department of Anesthesiology, Rambam Health Care Campus, Haifa, Israel","institution_ids":["https://openalex.org/I2801301638"]},{"raw_affiliation_string":"Ruth and Bruce Rappaport Faculty of Medicine, Technion\u2014Israel Institute of Technology, Haifa, Israel","institution_ids":["https://openalex.org/I174306211"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024140873","display_name":"Yuri B. Saalmann","orcid":"https://orcid.org/0000-0001-8880-6698"},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Yuri B. Saalmann","raw_affiliation_strings":["Department of Psychology, University of Wisconsin-Madison, Madison, Wisconsin, United States of America","Wisconsin National Primate Research Center, Madison, Wisconsin, United States of America"],"raw_orcid":"https://orcid.org/0000-0001-8880-6698","affiliations":[{"raw_affiliation_string":"Department of Psychology, University of Wisconsin-Madison, Madison, Wisconsin, United States of America","institution_ids":["https://openalex.org/I135310074"]},{"raw_affiliation_string":"Wisconsin National Primate Research Center, Madison, Wisconsin, United States of America","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5024140873","https://openalex.org/A5072106021"],"corresponding_institution_ids":["https://openalex.org/I135310074"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":4.3561,"has_fulltext":true,"cited_by_count":42,"citation_normalized_percentile":{"value":0.95416405,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"18","issue":"7","first_page":"e1010294","last_page":"e1010294"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10429","display_name":"EEG and Brain-Computer Interfaces","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10429","display_name":"EEG and Brain-Computer Interfaces","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10919","display_name":"Neurological disorders and treatments","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuroscience","display_name":"Neuroscience","score":0.7865983247756958},{"id":"https://openalex.org/keywords/consciousness","display_name":"Consciousness","score":0.7695763111114502},{"id":"https://openalex.org/keywords/neural-correlates-of-consciousness","display_name":"Neural correlates of consciousness","score":0.570254921913147},{"id":"https://openalex.org/keywords/deep-brain-stimulation","display_name":"Deep brain stimulation","score":0.5635496377944946},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.5402408242225647},{"id":"https://openalex.org/keywords/thalamus","display_name":"Thalamus","score":0.5272587537765503},{"id":"https://openalex.org/keywords/biological-neural-network","display_name":"Biological neural network","score":0.5023081302642822},{"id":"https://openalex.org/keywords/persistent-vegetative-state","display_name":"Persistent vegetative state","score":0.4848400354385376},{"id":"https://openalex.org/keywords/stimulation","display_name":"Stimulation","score":0.4645037353038788},{"id":"https://openalex.org/keywords/level-of-consciousness","display_name":"Level of consciousness","score":0.4270203113555908},{"id":"https://openalex.org/keywords/minimally-conscious-state","display_name":"Minimally conscious state","score":0.2589942216873169},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.23344719409942627},{"id":"https://openalex.org/keywords/parkinsons-disease","display_name":"Parkinson's disease","score":0.16912543773651123},{"id":"https://openalex.org/keywords/cognition","display_name":"Cognition","score":0.11821219325065613},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.07212209701538086},{"id":"https://openalex.org/keywords/developmental-psychology","display_name":"Developmental psychology","score":0.07179856300354004}],"concepts":[{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.7865983247756958},{"id":"https://openalex.org/C186720457","wikidata":"https://www.wikidata.org/wiki/Q7087","display_name":"Consciousness","level":2,"score":0.7695763111114502},{"id":"https://openalex.org/C129564537","wikidata":"https://www.wikidata.org/wiki/Q1460873","display_name":"Neural correlates of consciousness","level":3,"score":0.570254921913147},{"id":"https://openalex.org/C2778542668","wikidata":"https://www.wikidata.org/wiki/Q618076","display_name":"Deep brain stimulation","level":4,"score":0.5635496377944946},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.5402408242225647},{"id":"https://openalex.org/C2779246727","wikidata":"https://www.wikidata.org/wiki/Q184215","display_name":"Thalamus","level":2,"score":0.5272587537765503},{"id":"https://openalex.org/C118403218","wikidata":"https://www.wikidata.org/wiki/Q43283","display_name":"Biological neural network","level":2,"score":0.5023081302642822},{"id":"https://openalex.org/C2777938509","wikidata":"https://www.wikidata.org/wiki/Q139720","display_name":"Persistent vegetative state","level":4,"score":0.4848400354385376},{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.4645037353038788},{"id":"https://openalex.org/C171525899","wikidata":"https://www.wikidata.org/wiki/Q17029618","display_name":"Level of consciousness","level":2,"score":0.4270203113555908},{"id":"https://openalex.org/C2778170955","wikidata":"https://www.wikidata.org/wiki/Q1093388","display_name":"Minimally conscious state","level":3,"score":0.2589942216873169},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.23344719409942627},{"id":"https://openalex.org/C2779734285","wikidata":"https://www.wikidata.org/wiki/Q11085","display_name":"Parkinson's disease","level":3,"score":0.16912543773651123},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.11821219325065613},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.07212209701538086},{"id":"https://openalex.org/C138496976","wikidata":"https://www.wikidata.org/wiki/Q175002","display_name":"Developmental psychology","level":1,"score":0.07179856300354004},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D003243","descriptor_name":"Consciousness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003243","descriptor_name":"Consciousness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003243","descriptor_name":"Consciousness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003243","descriptor_name":"Consciousness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003342","descriptor_name":"Corpus Striatum","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003342","descriptor_name":"Corpus Striatum","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003342","descriptor_name":"Corpus Striatum","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003342","descriptor_name":"Corpus Striatum","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013788","descriptor_name":"Thalamus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013788","descriptor_name":"Thalamus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013788","descriptor_name":"Thalamus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013788","descriptor_name":"Thalamus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D046690","descriptor_name":"Deep Brain Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D046690","descriptor_name":"Deep Brain Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D046690","descriptor_name":"Deep Brain Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D046690","descriptor_name":"Deep Brain Stimulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1010294","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010294","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1010294&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:35816488","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35816488","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:111bf88af36d4e75ab7295edd14cde42","is_oa":true,"landing_page_url":"https://doaj.org/article/111bf88af36d4e75ab7295edd14cde42","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 18, Iss 7, p e1010294 (2022)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9321468","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9321468","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmh:oai:share.osf.io:E016D-F2E-67E","is_oa":false,"landing_page_url":"http://osf.io/nfa87/","pdf_url":null,"source":{"id":"https://openalex.org/S4306401127","display_name":"OSF Preprints (OSF Preprints)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2799848540","host_organization_name":"Center for Open Science","host_organization_lineage":["https://openalex.org/I2799848540"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"project"},{"id":"pmh:oai:share.osf.io:c9d8c217-8d19-4b93-92ce-9beb006f4068","is_oa":false,"landing_page_url":"https://osf.io/nfa87","pdf_url":null,"source":{"id":"https://openalex.org/S4306401127","display_name":"OSF Preprints (OSF Preprints)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I2799848540","host_organization_name":"Center for Open Science","host_organization_lineage":["https://openalex.org/I2799848540"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Project"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1010294","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010294","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1010294&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8100000023841858,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G1745149053","display_name":null,"funder_award_id":"2021011","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G6371322517","display_name":null,"funder_award_id":"R01MH110311","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6833382141","display_name":null,"funder_award_id":"201732","funder_id":"https://openalex.org/F4320308960","funder_display_name":"United States - Israel Binational Science Foundation"},{"id":"https://openalex.org/G8773890364","display_name":null,"funder_award_id":"P51OD011106","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320308960","display_name":"United States - Israel Binational Science Foundation","ror":"https://ror.org/00j8z2m73"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W4285020551.pdf","grobid_xml":"https://content.openalex.org/works/W4285020551.grobid-xml"},"referenced_works_count":110,"referenced_works":["https://openalex.org/W1511712482","https://openalex.org/W1517951919","https://openalex.org/W1558419262","https://openalex.org/W1583209675","https://openalex.org/W1601087798","https://openalex.org/W1607957700","https://openalex.org/W1723619723","https://openalex.org/W1808239140","https://openalex.org/W1950544107","https://openalex.org/W1966159115","https://openalex.org/W1967959295","https://openalex.org/W1969469858","https://openalex.org/W1970545979","https://openalex.org/W1970957555","https://openalex.org/W1973117088","https://openalex.org/W1978860717","https://openalex.org/W1988881714","https://openalex.org/W1991661804","https://openalex.org/W1991853590","https://openalex.org/W1993492847","https://openalex.org/W1993506942","https://openalex.org/W1993508839","https://openalex.org/W1994684268","https://openalex.org/W2000341627","https://openalex.org/W2000693195","https://openalex.org/W2001950078","https://openalex.org/W2012777073","https://openalex.org/W2015303758","https://openalex.org/W2027386783","https://openalex.org/W2029979531","https://openalex.org/W2034263079","https://openalex.org/W2036180872","https://openalex.org/W2038632582","https://openalex.org/W2038810510","https://openalex.org/W2043877765","https://openalex.org/W2048013965","https://openalex.org/W2051703153","https://openalex.org/W2062124861","https://openalex.org/W2064113649","https://openalex.org/W2067702957","https://openalex.org/W2069114395","https://openalex.org/W2075832530","https://openalex.org/W2082187992","https://openalex.org/W2096301242","https://openalex.org/W2097792392","https://openalex.org/W2102248966","https://openalex.org/W2102630578","https://openalex.org/W2104791598","https://openalex.org/W2105622546","https://openalex.org/W2108714018","https://openalex.org/W2109584604","https://openalex.org/W2109793051","https://openalex.org/W2111998656","https://openalex.org/W2114827170","https://openalex.org/W2114900706","https://openalex.org/W2118521279","https://openalex.org/W2125136217","https://openalex.org/W2127498969","https://openalex.org/W2132796361","https://openalex.org/W2133177004","https://openalex.org/W2135390742","https://openalex.org/W2135894974","https://openalex.org/W2138028423","https://openalex.org/W2140684369","https://openalex.org/W2142680372","https://openalex.org/W2147272268","https://openalex.org/W2148764920","https://openalex.org/W2151762048","https://openalex.org/W2152385686","https://openalex.org/W2153707769","https://openalex.org/W2155128430","https://openalex.org/W2157020359","https://openalex.org/W2158601670","https://openalex.org/W2159221444","https://openalex.org/W2168202614","https://openalex.org/W2180627541","https://openalex.org/W2193978670","https://openalex.org/W2217402295","https://openalex.org/W2242515881","https://openalex.org/W2272545495","https://openalex.org/W2274969970","https://openalex.org/W2278158700","https://openalex.org/W2319306748","https://openalex.org/W2421212092","https://openalex.org/W2433459962","https://openalex.org/W2491632063","https://openalex.org/W2514213849","https://openalex.org/W2756280986","https://openalex.org/W2773072410","https://openalex.org/W2787079105","https://openalex.org/W2793484468","https://openalex.org/W2811113323","https://openalex.org/W2888352380","https://openalex.org/W2911077895","https://openalex.org/W2911514809","https://openalex.org/W2939924174","https://openalex.org/W2941525855","https://openalex.org/W2952447148","https://openalex.org/W2962965717","https://openalex.org/W3005621022","https://openalex.org/W3007531339","https://openalex.org/W3009555114","https://openalex.org/W3038965741","https://openalex.org/W3100708443","https://openalex.org/W3110820786","https://openalex.org/W3137927330","https://openalex.org/W3159289346","https://openalex.org/W4211192417","https://openalex.org/W4386373863","https://openalex.org/W6648294141"],"related_works":["https://openalex.org/W3004867024","https://openalex.org/W2049529304","https://openalex.org/W1995044355","https://openalex.org/W4385665827","https://openalex.org/W2106629207","https://openalex.org/W2931803995","https://openalex.org/W4308727537","https://openalex.org/W3106732618","https://openalex.org/W176380218","https://openalex.org/W4380271832"],"abstract_inverted_index":{"Anesthetic":[0],"manipulations":[1],"provide":[2],"much-needed":[3],"causal":[4],"evidence":[5],"for":[6],"neural":[7,120,161],"correlates":[8],"of":[9,42,90,119,128,179,188,215,226],"consciousness,":[10,31,129],"but":[11],"non-specific":[12],"drug":[13],"effects":[14],"complicate":[15],"their":[16],"interpretation.":[17],"Evidence":[18],"suggests":[19],"that":[20,170],"thalamic":[21],"deep":[22],"brain":[23],"stimulation":[24,35,199],"(DBS)":[25],"can":[26,208],"either":[27],"increase":[28,202],"or":[29],"decrease":[30],"depending":[32],"on":[33],"the":[34,43,177],"target":[36,55],"and":[37,67,84,123,130,143,155,160,173,181],"parameters.":[38],"The":[39],"putative":[40],"role":[41],"central":[44],"lateral":[45],"thalamus":[46],"(CL)":[47],"in":[48,60,77,108,117,135,153,166,204],"consciousness":[49,66,102,159,203,216,228],"makes":[50],"it":[51,207],"an":[52],"ideal":[53],"DBS":[54,73,87,104,195],"to":[56,75,115,133,164,186,211],"manipulate":[57],"circuit-level":[58],"mechanisms":[59],"cortico-striato-thalamic":[61],"(CST)":[62],"systems,":[63],"thereby":[64],"influencing":[65],"related":[68],"processes.":[69],"We":[70],"used":[71,210],"multi-microelectrode":[72,194],"targeted":[74],"CL":[76],"macaques":[78],"while":[79],"recording":[80],"from":[81],"frontal,":[82],"parietal,":[83],"striatal":[85],"regions.":[86],"induced":[88],"episodes":[89],"abnormally":[91],"long,":[92],"vacant":[93],"staring":[94],"with":[95,217],"low-frequency":[96],"oscillations":[97],"here":[98],"termed":[99],"vacant,":[100],"perturbed":[101],"(VPC).":[103],"modulated":[105],"VPC":[106,112,180],"likelihood":[107],"a":[109],"frequency-specific":[110],"manner.":[111],"events":[113],"corresponded":[114,163],"decreases":[116],"measures":[118],"complexity":[121],"(entropy)":[122],"integration":[124,162],"(\u03a6*),":[125],"proposed":[126],"indices":[127],"substantial":[131],"changes":[132],"communication":[134],"CST":[136,150],"circuits.":[137],"During":[138],"VPC,":[139],"power":[140],"spectral":[141],"density":[142],"coherence":[144],"at":[145,197],"low":[146],"frequencies":[147],"increased":[148],"across":[149],"circuits,":[151],"especially":[152],"thalamo-parietal":[154],"cortico-striatal":[156,167],"pathways.":[157],"Decreased":[158],"shifts":[165],"network":[168],"configurations":[169],"dissociated":[171],"parietal":[172],"subcortical":[174],"structures.":[175],"Overall,":[176],"features":[178],"implicated":[182],"networks":[183],"were":[184],"similar":[185],"those":[187],"absence":[189],"epilepsy.":[190],"As":[191],"this":[192],"same":[193],"method-but":[196],"different":[198],"frequencies-can":[200],"also":[201],"anesthetized":[205],"macaques,":[206],"be":[209],"flexibly":[212],"address":[213],"questions":[214],"limited":[218],"confounds,":[219],"as":[220,222],"well":[221],"inform":[223],"clinical":[224],"investigations":[225],"other":[227],"disorders.":[229]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":16},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":2},{"year":2020,"cited_by_count":1}],"updated_date":"2026-03-27T05:58:40.876381","created_date":"2025-10-10T00:00:00"}