{"id":"https://openalex.org/W4225483981","doi":"https://doi.org/10.1371/journal.pcbi.1010021","title":"Computational drug repurposing against SARS-CoV-2 reveals plasma membrane cholesterol depletion as key factor of antiviral drug activity","display_name":"Computational drug repurposing against SARS-CoV-2 reveals plasma membrane cholesterol depletion as key factor of antiviral drug activity","publication_year":2022,"publication_date":"2022-04-11","ids":{"openalex":"https://openalex.org/W4225483981","doi":"https://doi.org/10.1371/journal.pcbi.1010021","pmid":"https://pubmed.ncbi.nlm.nih.gov/35404937"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1010021","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010021","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.pcbi.1010021","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046900456","display_name":"Szilvia Barsi","orcid":"https://orcid.org/0000-0002-8779-2383"},"institutions":[{"id":"https://openalex.org/I101202996","display_name":"Semmelweis University","ror":"https://ror.org/01g9ty582","country_code":"HU","type":"education","lineage":["https://openalex.org/I101202996"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Szilvia Barsi","raw_affiliation_strings":["Semmelweis University, Faculty of Medicine, Department of Physiology, Budapest, Hungary"],"raw_orcid":"https://orcid.org/0000-0002-8779-2383","affiliations":[{"raw_affiliation_string":"Semmelweis University, Faculty of Medicine, Department of Physiology, Budapest, Hungary","institution_ids":["https://openalex.org/I101202996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031984206","display_name":"Henrietta Papp","orcid":"https://orcid.org/0000-0003-3887-5657"},"institutions":[{"id":"https://openalex.org/I79741316","display_name":"University of Pecs","ror":"https://ror.org/037b5pv06","country_code":"HU","type":"education","lineage":["https://openalex.org/I79741316"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Henrietta Papp","raw_affiliation_strings":["Institute of Biology, Faculty of Sciences, University of P\u00e9cs, P\u00e9cs, Hungary","National Laboratory of Virology, University of P\u00e9cs, P\u00e9cs, Hungary"],"raw_orcid":"https://orcid.org/0000-0003-3887-5657","affiliations":[{"raw_affiliation_string":"Institute of Biology, Faculty of Sciences, University of P\u00e9cs, P\u00e9cs, Hungary","institution_ids":["https://openalex.org/I79741316"]},{"raw_affiliation_string":"National Laboratory of Virology, University of P\u00e9cs, P\u00e9cs, Hungary","institution_ids":["https://openalex.org/I79741316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065507596","display_name":"Alberto Valdeolivas","orcid":"https://orcid.org/0000-0001-5482-9023"},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Alberto Valdeolivas","raw_affiliation_strings":["Heidelberg University, Faculty of Medicine, and Heidelberg University Hospital, Institute for Computational Biomedicine, Bioquant, Heidelberg, Germany"],"raw_orcid":"https://orcid.org/0000-0001-5482-9023","affiliations":[{"raw_affiliation_string":"Heidelberg University, Faculty of Medicine, and Heidelberg University Hospital, Institute for Computational Biomedicine, Bioquant, Heidelberg, Germany","institution_ids":["https://openalex.org/I2802164966","https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082204743","display_name":"D\u00e1niel J. T\u00f3th","orcid":"https://orcid.org/0000-0001-6670-3348"},"institutions":[{"id":"https://openalex.org/I101202996","display_name":"Semmelweis University","ror":"https://ror.org/01g9ty582","country_code":"HU","type":"education","lineage":["https://openalex.org/I101202996"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"D\u00e1niel J. T\u00f3th","raw_affiliation_strings":["Semmelweis University, Faculty of Medicine, Department of Physiology, Budapest, Hungary"],"raw_orcid":"https://orcid.org/0000-0001-6670-3348","affiliations":[{"raw_affiliation_string":"Semmelweis University, Faculty of Medicine, Department of Physiology, Budapest, Hungary","institution_ids":["https://openalex.org/I101202996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020407813","display_name":"Anett Kuczmog","orcid":"https://orcid.org/0000-0002-5680-4951"},"institutions":[{"id":"https://openalex.org/I79741316","display_name":"University of Pecs","ror":"https://ror.org/037b5pv06","country_code":"HU","type":"education","lineage":["https://openalex.org/I79741316"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Anett Kuczmog","raw_affiliation_strings":["Institute of Biology, Faculty of Sciences, University of P\u00e9cs, P\u00e9cs, Hungary","National Laboratory of Virology, University of P\u00e9cs, P\u00e9cs, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biology, Faculty of Sciences, University of P\u00e9cs, P\u00e9cs, Hungary","institution_ids":["https://openalex.org/I79741316"]},{"raw_affiliation_string":"National Laboratory of Virology, University of P\u00e9cs, P\u00e9cs, Hungary","institution_ids":["https://openalex.org/I79741316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031739659","display_name":"M\u00f3nika Madai","orcid":null},"institutions":[{"id":"https://openalex.org/I79741316","display_name":"University of Pecs","ror":"https://ror.org/037b5pv06","country_code":"HU","type":"education","lineage":["https://openalex.org/I79741316"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"M\u00f3nika Madai","raw_affiliation_strings":["Institute of Biology, Faculty of Sciences, University of P\u00e9cs, P\u00e9cs, Hungary","National Laboratory of Virology, University of P\u00e9cs, P\u00e9cs, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biology, Faculty of Sciences, University of P\u00e9cs, P\u00e9cs, Hungary","institution_ids":["https://openalex.org/I79741316"]},{"raw_affiliation_string":"National Laboratory of Virology, University of P\u00e9cs, P\u00e9cs, Hungary","institution_ids":["https://openalex.org/I79741316"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010688747","display_name":"L\u00e1szl\u00f3 Hunyady","orcid":"https://orcid.org/0000-0002-8438-7251"},"institutions":[{"id":"https://openalex.org/I101202996","display_name":"Semmelweis University","ror":"https://ror.org/01g9ty582","country_code":"HU","type":"education","lineage":["https://openalex.org/I101202996"]},{"id":"https://openalex.org/I4210096417","display_name":"Institute of Materials and Environmental Chemistry","ror":"https://ror.org/00r71zw23","country_code":"HU","type":"facility","lineage":["https://openalex.org/I4210096417","https://openalex.org/I4387152226","https://openalex.org/I80251312"]},{"id":"https://openalex.org/I4210151515","display_name":"Institute of Molecular Life Sciences","ror":"https://ror.org/04t4pws42","country_code":"HU","type":"facility","lineage":["https://openalex.org/I4210151515","https://openalex.org/I4387152226","https://openalex.org/I80251312"]},{"id":"https://openalex.org/I80251312","display_name":"HUN-REN Research Centre for Natural Sciences","ror":"https://ror.org/03zwxja46","country_code":"HU","type":"facility","lineage":["https://openalex.org/I4387152226","https://openalex.org/I80251312"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"L\u00e1szl\u00f3 Hunyady","raw_affiliation_strings":["Institute of Enzymology, Research Centre for Natural Sciences, Budapest, Hungary","MTA-SE Laboratory of Molecular Physiology, Budapest, Hungary","Semmelweis University, Faculty of Medicine, Department of Physiology, Budapest, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Enzymology, Research Centre for Natural Sciences, Budapest, Hungary","institution_ids":["https://openalex.org/I4210151515","https://openalex.org/I80251312"]},{"raw_affiliation_string":"MTA-SE Laboratory of Molecular Physiology, Budapest, Hungary","institution_ids":["https://openalex.org/I4210096417"]},{"raw_affiliation_string":"Semmelweis University, Faculty of Medicine, Department of Physiology, Budapest, Hungary","institution_ids":["https://openalex.org/I101202996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026539610","display_name":"P\u00e9ter V\u00e1rnai","orcid":"https://orcid.org/0000-0002-7777-806X"},"institutions":[{"id":"https://openalex.org/I101202996","display_name":"Semmelweis University","ror":"https://ror.org/01g9ty582","country_code":"HU","type":"education","lineage":["https://openalex.org/I101202996"]},{"id":"https://openalex.org/I4210096417","display_name":"Institute of Materials and Environmental Chemistry","ror":"https://ror.org/00r71zw23","country_code":"HU","type":"facility","lineage":["https://openalex.org/I4210096417","https://openalex.org/I4387152226","https://openalex.org/I80251312"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"P\u00e9ter V\u00e1rnai","raw_affiliation_strings":["MTA-SE Laboratory of Molecular Physiology, Budapest, Hungary","Semmelweis University, Faculty of Medicine, Department of Physiology, Budapest, Hungary"],"raw_orcid":"https://orcid.org/0000-0002-7777-806X","affiliations":[{"raw_affiliation_string":"MTA-SE Laboratory of Molecular Physiology, Budapest, Hungary","institution_ids":["https://openalex.org/I4210096417"]},{"raw_affiliation_string":"Semmelweis University, Faculty of Medicine, Department of Physiology, Budapest, Hungary","institution_ids":["https://openalex.org/I101202996"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005499510","display_name":"Julio S\u00e1ez-Rodr\u00edguez","orcid":"https://orcid.org/0000-0002-8552-8976"},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I2802164966","display_name":"University Hospital Heidelberg","ror":"https://ror.org/013czdx64","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I2802164966"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Julio Saez-Rodriguez","raw_affiliation_strings":["Heidelberg University, Faculty of Medicine, and Heidelberg University Hospital, Institute for Computational Biomedicine, Bioquant, Heidelberg, Germany"],"raw_orcid":"https://orcid.org/0000-0002-8552-8976","affiliations":[{"raw_affiliation_string":"Heidelberg University, Faculty of Medicine, and Heidelberg University Hospital, Institute for Computational Biomedicine, Bioquant, Heidelberg, Germany","institution_ids":["https://openalex.org/I2802164966","https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038442611","display_name":"Ferenc Jakab","orcid":"https://orcid.org/0000-0002-3913-0430"},"institutions":[{"id":"https://openalex.org/I79741316","display_name":"University of Pecs","ror":"https://ror.org/037b5pv06","country_code":"HU","type":"education","lineage":["https://openalex.org/I79741316"]}],"countries":["HU"],"is_corresponding":false,"raw_author_name":"Ferenc Jakab","raw_affiliation_strings":["Institute of Biology, Faculty of Sciences, University of P\u00e9cs, P\u00e9cs, Hungary","National Laboratory of Virology, University of P\u00e9cs, P\u00e9cs, Hungary"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biology, Faculty of Sciences, University of P\u00e9cs, P\u00e9cs, Hungary","institution_ids":["https://openalex.org/I79741316"]},{"raw_affiliation_string":"National Laboratory of Virology, University of P\u00e9cs, P\u00e9cs, Hungary","institution_ids":["https://openalex.org/I79741316"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084722846","display_name":"Bence Szalai","orcid":"https://orcid.org/0000-0002-9320-5704"},"institutions":[{"id":"https://openalex.org/I101202996","display_name":"Semmelweis University","ror":"https://ror.org/01g9ty582","country_code":"HU","type":"education","lineage":["https://openalex.org/I101202996"]}],"countries":["HU"],"is_corresponding":true,"raw_author_name":"Bence Szalai","raw_affiliation_strings":["Semmelweis University, Faculty of Medicine, Department of Physiology, Budapest, Hungary"],"raw_orcid":"https://orcid.org/0000-0002-9320-5704","affiliations":[{"raw_affiliation_string":"Semmelweis University, Faculty of Medicine, Department of Physiology, Budapest, Hungary","institution_ids":["https://openalex.org/I101202996"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":11,"corresponding_author_ids":["https://openalex.org/A5084722846"],"corresponding_institution_ids":["https://openalex.org/I101202996"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.0093,"has_fulltext":false,"cited_by_count":13,"citation_normalized_percentile":{"value":0.76257521,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"18","issue":"4","first_page":"e1010021","last_page":"e1010021"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10118","display_name":"SARS-CoV-2 and COVID-19 Research","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11495","display_name":"Animal Virus Infections Studies","score":0.9915000200271606,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drug-repositioning","display_name":"Drug repositioning","score":0.8609716296195984},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.67745441198349},{"id":"https://openalex.org/keywords/repurposing","display_name":"Repurposing","score":0.5682197213172913},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.555770754814148},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"Drug discovery","score":0.5455446243286133},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.5282824635505676},{"id":"https://openalex.org/keywords/in-vitro","display_name":"In vitro","score":0.49706581234931946},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.4840671122074127},{"id":"https://openalex.org/keywords/cholesterol","display_name":"Cholesterol","score":0.45690101385116577},{"id":"https://openalex.org/keywords/antiviral-drug","display_name":"Antiviral drug","score":0.44058772921562195},{"id":"https://openalex.org/keywords/gene-expression-profiling","display_name":"Gene expression profiling","score":0.42301058769226074},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.35012903809547424},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.20617219805717468},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.169888436794281}],"concepts":[{"id":"https://openalex.org/C103637391","wikidata":"https://www.wikidata.org/wiki/Q5308921","display_name":"Drug repositioning","level":3,"score":0.8609716296195984},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.67745441198349},{"id":"https://openalex.org/C519536355","wikidata":"https://www.wikidata.org/wiki/Q21021151","display_name":"Repurposing","level":2,"score":0.5682197213172913},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.555770754814148},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.5455446243286133},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.5282824635505676},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.49706581234931946},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4840671122074127},{"id":"https://openalex.org/C2778163477","wikidata":"https://www.wikidata.org/wiki/Q43656","display_name":"Cholesterol","level":2,"score":0.45690101385116577},{"id":"https://openalex.org/C2779756493","wikidata":"https://www.wikidata.org/wiki/Q846227","display_name":"Antiviral drug","level":3,"score":0.44058772921562195},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.42301058769226074},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.35012903809547424},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.20617219805717468},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.169888436794281},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000086402","descriptor_name":"SARS-CoV-2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000093485","descriptor_name":"COVID-19 Drug Treatment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000093485","descriptor_name":"COVID-19 Drug Treatment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000093485","descriptor_name":"COVID-19 Drug Treatment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002462","descriptor_name":"Cell Membrane","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002784","descriptor_name":"Cholesterol","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D058492","descriptor_name":"Drug Repositioning","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1371/journal.pcbi.1010021","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010021","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:35404937","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35404937","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:ead04c612c984d5d8cd52b9ab306ee11","is_oa":true,"landing_page_url":"https://doaj.org/article/ead04c612c984d5d8cd52b9ab306ee11","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 18, Iss 4, p e1010021 (2022)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:9022874","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9022874","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1010021","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1010021","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8299999833106995}],"awards":[{"id":"https://openalex.org/G106760024","display_name":null,"funder_award_id":"EFOP-3.6.1","funder_id":"https://openalex.org/F4320338080","funder_display_name":"European Social Fund"},{"id":"https://openalex.org/G1927218007","display_name":null,"funder_award_id":"TKP2021-NVA-07","funder_id":"https://openalex.org/F4320335908","funder_display_name":"Nemzeti Kutat\u00e1si, Fejleszt\u00e9si \u00e9s Innovaci\u00f3s Alap"},{"id":"https://openalex.org/G2953162778","display_name":null,"funder_award_id":"TKP2021-NVA","funder_id":"https://openalex.org/F4320335908","funder_display_name":"Nemzeti Kutat\u00e1si, Fejleszt\u00e9si \u00e9s Innovaci\u00f3s Alap"},{"id":"https://openalex.org/G2984039750","display_name":null,"funder_award_id":"TUDFO/47138/2019-ITM","funder_id":"https://openalex.org/F4320328991","funder_display_name":"Innov\u00e1ci\u00f3s \u00e9s Technol\u00f3giai Miniszt\u00e9rium"},{"id":"https://openalex.org/G298428782","display_name":null,"funder_award_id":"TKP2021","funder_id":"https://openalex.org/F4320335908","funder_display_name":"Nemzeti Kutat\u00e1si, Fejleszt\u00e9si \u00e9s Innovaci\u00f3s Alap"},{"id":"https://openalex.org/G4562510306","display_name":null,"funder_award_id":"EFOP-3.6.1","funder_id":"https://openalex.org/F4320328991","funder_display_name":"Innov\u00e1ci\u00f3s \u00e9s Technol\u00f3giai Miniszt\u00e9rium"},{"id":"https://openalex.org/G4693063966","display_name":null,"funder_award_id":"EFOP-3","funder_id":"https://openalex.org/F4320338080","funder_display_name":"European Social Fund"},{"id":"https://openalex.org/G4978610471","display_name":null,"funder_award_id":"EFOP-3.6.1.-16-2016-00004","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"},{"id":"https://openalex.org/G5489890681","display_name":null,"funder_award_id":"TKP2021","funder_id":"https://openalex.org/F4320328991","funder_display_name":"Innov\u00e1ci\u00f3s \u00e9s Technol\u00f3giai Miniszt\u00e9rium"},{"id":"https://openalex.org/G5646108281","display_name":null,"funder_award_id":"K134357","funder_id":"https://openalex.org/F4320321994","funder_display_name":"Hungarian Scientific Research Fund"},{"id":"https://openalex.org/G5792602100","display_name":null,"funder_award_id":"EFOP-3.6.1.-16-2016-00004","funder_id":"https://openalex.org/F4320338080","funder_display_name":"European Social Fund"},{"id":"https://openalex.org/G6636759893","display_name":null,"funder_award_id":"EFOP-3.6.1.-16-2016-00004","funder_id":"https://openalex.org/F4320321994","funder_display_name":"Hungarian Scientific Research Fund"},{"id":"https://openalex.org/G6844412585","display_name":null,"funder_award_id":"460044","funder_id":"https://openalex.org/F4320322192","funder_display_name":"Magyar Tudom\u00e1nyos Akad\u00e9mia"},{"id":"https://openalex.org/G7478106387","display_name":null,"funder_award_id":"TKP2021-NVA","funder_id":"https://openalex.org/F4320328991","funder_display_name":"Innov\u00e1ci\u00f3s \u00e9s Technol\u00f3giai Miniszt\u00e9rium"},{"id":"https://openalex.org/G7798551118","display_name":null,"funder_award_id":"EFOP-3.6.1","funder_id":"https://openalex.org/F4320335908","funder_display_name":"Nemzeti Kutat\u00e1si, Fejleszt\u00e9si \u00e9s Innovaci\u00f3s Alap"},{"id":"https://openalex.org/G8604173349","display_name":null,"funder_award_id":"KH129599","funder_id":"https://openalex.org/F4320321994","funder_display_name":"Hungarian Scientific Research Fund"},{"id":"https://openalex.org/G8854761416","display_name":null,"funder_award_id":"EFOP-3.6.1","funder_id":"https://openalex.org/F4320320300","funder_display_name":"European Commission"}],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320321994","display_name":"Hungarian Scientific Research Fund","ror":"https://ror.org/00v349e63"},{"id":"https://openalex.org/F4320322192","display_name":"Magyar Tudom\u00e1nyos Akad\u00e9mia","ror":"https://ror.org/02ks8qq67"},{"id":"https://openalex.org/F4320328991","display_name":"Innov\u00e1ci\u00f3s \u00e9s Technol\u00f3giai Miniszt\u00e9rium","ror":"https://ror.org/02ey3ab96"},{"id":"https://openalex.org/F4320335908","display_name":"Nemzeti Kutat\u00e1si, Fejleszt\u00e9si \u00e9s Innovaci\u00f3s Alap","ror":null},{"id":"https://openalex.org/F4320338080","display_name":"European Social Fund","ror":"https://ror.org/00k4n6c32"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":81,"referenced_works":["https://openalex.org/W1852627342","https://openalex.org/W1988920565","https://openalex.org/W2009769910","https://openalex.org/W2016921919","https://openalex.org/W2019351415","https://openalex.org/W2051052628","https://openalex.org/W2099582158","https://openalex.org/W2101234009","https://openalex.org/W2111473164","https://openalex.org/W2133422078","https://openalex.org/W2135177247","https://openalex.org/W2137632714","https://openalex.org/W2146469651","https://openalex.org/W2146512944","https://openalex.org/W2146544786","https://openalex.org/W2150658610","https://openalex.org/W2161834691","https://openalex.org/W2179438025","https://openalex.org/W2191790139","https://openalex.org/W2209999571","https://openalex.org/W2416935803","https://openalex.org/W2472255748","https://openalex.org/W2593784999","https://openalex.org/W2612467560","https://openalex.org/W2734505834","https://openalex.org/W2772692099","https://openalex.org/W2792387716","https://openalex.org/W2896002881","https://openalex.org/W2905302554","https://openalex.org/W2908901070","https://openalex.org/W2935426292","https://openalex.org/W2952391626","https://openalex.org/W2964315448","https://openalex.org/W2972751199","https://openalex.org/W2975712044","https://openalex.org/W2986455832","https://openalex.org/W3003257820","https://openalex.org/W3005212621","https://openalex.org/W3008443627","https://openalex.org/W3011072970","https://openalex.org/W3011498764","https://openalex.org/W3016469012","https://openalex.org/W3016489853","https://openalex.org/W3017271475","https://openalex.org/W3017312007","https://openalex.org/W3019802146","https://openalex.org/W3022285953","https://openalex.org/W3023724901","https://openalex.org/W3025316617","https://openalex.org/W3036453504","https://openalex.org/W3037945517","https://openalex.org/W3040765027","https://openalex.org/W3043379468","https://openalex.org/W3045802278","https://openalex.org/W3046863270","https://openalex.org/W3047197438","https://openalex.org/W3049552342","https://openalex.org/W3086243616","https://openalex.org/W3087689951","https://openalex.org/W3093900830","https://openalex.org/W3102648521","https://openalex.org/W3103145119","https://openalex.org/W3105070128","https://openalex.org/W3109313148","https://openalex.org/W3110883951","https://openalex.org/W3111521801","https://openalex.org/W3111836713","https://openalex.org/W3128962620","https://openalex.org/W3130872060","https://openalex.org/W3134608058","https://openalex.org/W3138055079","https://openalex.org/W3156389344","https://openalex.org/W3158868742","https://openalex.org/W3173547614","https://openalex.org/W3174747632","https://openalex.org/W3188892819","https://openalex.org/W3192850761","https://openalex.org/W4252021281","https://openalex.org/W4283735086","https://openalex.org/W6675354045","https://openalex.org/W7027488492"],"related_works":["https://openalex.org/W2899096130","https://openalex.org/W3190782215","https://openalex.org/W2902729297","https://openalex.org/W3110500039","https://openalex.org/W4255531208","https://openalex.org/W4396858017","https://openalex.org/W4400165188","https://openalex.org/W4206422705","https://openalex.org/W4320009247","https://openalex.org/W3186872001"],"abstract_inverted_index":{"Comparing":[0],"SARS-CoV-2":[1,93],"infection-induced":[2,141],"gene":[3,9,87,98,142],"expression":[4,10,88,99,143],"signatures":[5,11,100],"to":[6,17,36,123,148,225],"drug":[7,28,73,139],"treatment-induced":[8],"is":[12,30],"a":[13,37,181,214],"promising":[14],"bioinformatic":[15],"tool":[16],"repurpose":[18,228],"existing":[19],"drugs":[20,32,102,121,190,230],"against":[21,48,231],"SARS-CoV-2.":[22],"The":[23],"general":[24],"hypothesis":[25],"of":[26,54,101,125,155,163,195],"signature-based":[27],"repurposing":[29],"that":[31,68,112,188],"with":[33,117,200],"inverse":[34,137],"similarity":[35],"disease":[38,42,75],"signature":[39,76],"can":[40,77,223],"reverse":[41],"phenotype":[43],"and":[44,74,97,115,130,140,233],"thus":[45],"be":[46,78],"effective":[47,72,120,177],"it.":[49],"However,":[50],"in":[51,91,118,151,175,204,217],"the":[52,69,134,150,168,192,203,209],"case":[53],"viral":[55],"infection":[56,114],"diseases,":[57],"like":[58,128],"SARS-CoV-2,":[59,232],"infected":[60,94],"cells":[61,199],"also":[62,158,234],"activate":[63],"adaptive,":[64],"antiviral":[65,126,153,178,206,240],"pathways,":[66],"so":[67],"relationship":[70],"between":[71],"more":[79,226],"ambiguous.":[80],"To":[81],"address":[82],"this":[83],"question,":[84],"we":[85,145,186],"analysed":[86],"data":[89],"from":[90],"vitro":[92,119,152,176,205],"cell":[95],"lines,":[96],"showing":[103],"anti-SARS-CoV-2":[104],"activity.":[105],"Our":[106,221],"extensive":[107],"functional":[108],"genomic":[109],"analysis":[110],"showed":[111,187],"both":[113],"treatment":[116],"leads":[122],"activation":[124],"pathways":[127],"NFkB":[129],"JAK-STAT.":[131],"Based":[132],"on":[133],"similarity-and":[135],"not":[136],"similarity-between":[138],"signatures,":[144],"were":[146],"able":[147],"predict":[149],"activity":[154],"drugs.":[156,179],"We":[157],"identified":[159],"SREBF1/2,":[160],"key":[161,215,236],"regulators":[162],"lipid":[164],"metabolising":[165],"enzymes,":[166],"as":[167],"most":[169],"activated":[170],"transcription":[171],"factors":[172],"by":[173],"several":[174],"Using":[180],"fluorescently":[182],"labeled":[183],"cholesterol":[184,193,201,212],"sensor,":[185],"these":[189],"decrease":[191],"levels":[194],"plasma-membrane.":[196],"Supplementing":[197],"drug-treated":[198],"reversed":[202],"effect,":[207],"suggesting":[208],"depleting":[210],"plasma-membrane":[211],"plays":[213],"role":[216],"virus":[218],"inhibitory":[219],"mechanism.":[220],"results":[222],"help":[224],"effectively":[227],"approved":[229],"highlights":[235],"mechanisms":[237],"behind":[238],"their":[239],"effect.":[241]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":2}],"updated_date":"2026-03-27T05:58:40.876381","created_date":"2025-10-10T00:00:00"}
