{"id":"https://openalex.org/W4221110364","doi":"https://doi.org/10.1371/journal.pcbi.1009395","title":"A network-based approach to integrate nutrient microenvironment in the prediction of synthetic lethality in cancer metabolism","display_name":"A network-based approach to integrate nutrient microenvironment in the prediction of synthetic lethality in cancer metabolism","publication_year":2022,"publication_date":"2022-03-14","ids":{"openalex":"https://openalex.org/W4221110364","doi":"https://doi.org/10.1371/journal.pcbi.1009395","pmid":"https://pubmed.ncbi.nlm.nih.gov/35286311"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1009395","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009395","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.pcbi.1009395","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091862892","display_name":"I\u00f1igo Apaolaza","orcid":"https://orcid.org/0000-0002-8961-4513"},"institutions":[{"id":"https://openalex.org/I88155538","display_name":"Universidad de Navarra","ror":"https://ror.org/02rxc7m23","country_code":"ES","type":"education","lineage":["https://openalex.org/I88155538"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"I\u00f1igo Apaolaza","raw_affiliation_strings":["Universidad de Navarra, Centro de Ingenier\u00eda Biom\u00e9dica, Pamplona, Spain","Universidad de Navarra, DATAI Instituto de Ciencia de los Datos e Inteligencia Artificial, Pamplona, Spain","Universidad de Navarra, Tecnun Escuela de Ingenier\u00eda, San Sebasti\u00e1n, Spain"],"raw_orcid":"https://orcid.org/0000-0002-8961-4513","affiliations":[{"raw_affiliation_string":"Universidad de Navarra, Centro de Ingenier\u00eda Biom\u00e9dica, Pamplona, Spain","institution_ids":["https://openalex.org/I88155538"]},{"raw_affiliation_string":"Universidad de Navarra, DATAI Instituto de Ciencia de los Datos e Inteligencia Artificial, Pamplona, Spain","institution_ids":["https://openalex.org/I88155538"]},{"raw_affiliation_string":"Universidad de Navarra, Tecnun Escuela de Ingenier\u00eda, San Sebasti\u00e1n, Spain","institution_ids":["https://openalex.org/I88155538"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048791177","display_name":"Edurne San Jos\u00e9\u2010Eneriz","orcid":"https://orcid.org/0000-0001-5786-5273"},"institutions":[{"id":"https://openalex.org/I4210112085","display_name":"Navarre Institute of Health Research","ror":"https://ror.org/023d5h353","country_code":"ES","type":"education","lineage":["https://openalex.org/I4210112085"]},{"id":"https://openalex.org/I4210158561","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer","ror":"https://ror.org/04hya7017","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210158561"]},{"id":"https://openalex.org/I88155538","display_name":"Universidad de Navarra","ror":"https://ror.org/02rxc7m23","country_code":"ES","type":"education","lineage":["https://openalex.org/I88155538"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Edurne San Jos\u00e9-En\u00e9riz","raw_affiliation_strings":["CIBERONC Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer, Pamplona, Spain","IdiSNA Instituto de Investigaci\u00f3n Sanitaria de Navarra, Pamplona, Spain","Universidad de Navarra, CIMA Centro de Investigaci\u00f3n de Medicina Aplicada, Pamplona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CIBERONC Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer, Pamplona, Spain","institution_ids":["https://openalex.org/I4210158561"]},{"raw_affiliation_string":"IdiSNA Instituto de Investigaci\u00f3n Sanitaria de Navarra, Pamplona, Spain","institution_ids":["https://openalex.org/I4210112085"]},{"raw_affiliation_string":"Universidad de Navarra, CIMA Centro de Investigaci\u00f3n de Medicina Aplicada, Pamplona, Spain","institution_ids":["https://openalex.org/I88155538"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040584996","display_name":"Luis V. Valc\u00e1rcel","orcid":"https://orcid.org/0000-0003-3769-5419"},"institutions":[{"id":"https://openalex.org/I4210112085","display_name":"Navarre Institute of Health Research","ror":"https://ror.org/023d5h353","country_code":"ES","type":"education","lineage":["https://openalex.org/I4210112085"]},{"id":"https://openalex.org/I88155538","display_name":"Universidad de Navarra","ror":"https://ror.org/02rxc7m23","country_code":"ES","type":"education","lineage":["https://openalex.org/I88155538"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Luis V. Valcarcel","raw_affiliation_strings":["IdiSNA Instituto de Investigaci\u00f3n Sanitaria de Navarra, Pamplona, Spain","Universidad de Navarra, CIMA Centro de Investigaci\u00f3n de Medicina Aplicada, Pamplona, Spain","Universidad de Navarra, Tecnun Escuela de Ingenier\u00eda, San Sebasti\u00e1n, Spain"],"raw_orcid":"https://orcid.org/0000-0003-3769-5419","affiliations":[{"raw_affiliation_string":"IdiSNA Instituto de Investigaci\u00f3n Sanitaria de Navarra, Pamplona, Spain","institution_ids":["https://openalex.org/I4210112085"]},{"raw_affiliation_string":"Universidad de Navarra, CIMA Centro de Investigaci\u00f3n de Medicina Aplicada, Pamplona, Spain","institution_ids":["https://openalex.org/I88155538"]},{"raw_affiliation_string":"Universidad de Navarra, Tecnun Escuela de Ingenier\u00eda, San Sebasti\u00e1n, Spain","institution_ids":["https://openalex.org/I88155538"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049487102","display_name":"Xabier Agirre","orcid":"https://orcid.org/0000-0002-6558-9560"},"institutions":[{"id":"https://openalex.org/I4210112085","display_name":"Navarre Institute of Health Research","ror":"https://ror.org/023d5h353","country_code":"ES","type":"education","lineage":["https://openalex.org/I4210112085"]},{"id":"https://openalex.org/I4210158561","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer","ror":"https://ror.org/04hya7017","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210158561"]},{"id":"https://openalex.org/I88155538","display_name":"Universidad de Navarra","ror":"https://ror.org/02rxc7m23","country_code":"ES","type":"education","lineage":["https://openalex.org/I88155538"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Xabier Agirre","raw_affiliation_strings":["CIBERONC Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer, Pamplona, Spain","IdiSNA Instituto de Investigaci\u00f3n Sanitaria de Navarra, Pamplona, Spain","Universidad de Navarra, CIMA Centro de Investigaci\u00f3n de Medicina Aplicada, Pamplona, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CIBERONC Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer, Pamplona, Spain","institution_ids":["https://openalex.org/I4210158561"]},{"raw_affiliation_string":"IdiSNA Instituto de Investigaci\u00f3n Sanitaria de Navarra, Pamplona, Spain","institution_ids":["https://openalex.org/I4210112085"]},{"raw_affiliation_string":"Universidad de Navarra, CIMA Centro de Investigaci\u00f3n de Medicina Aplicada, Pamplona, Spain","institution_ids":["https://openalex.org/I88155538"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016030888","display_name":"Felipe Pr\u00f3sper","orcid":"https://orcid.org/0000-0001-6115-8790"},"institutions":[{"id":"https://openalex.org/I4210112085","display_name":"Navarre Institute of Health Research","ror":"https://ror.org/023d5h353","country_code":"ES","type":"education","lineage":["https://openalex.org/I4210112085"]},{"id":"https://openalex.org/I4210135003","display_name":"Clinica Universidad de Navarra","ror":"https://ror.org/03phm3r45","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210135003"]},{"id":"https://openalex.org/I4210158561","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer","ror":"https://ror.org/04hya7017","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210158561"]},{"id":"https://openalex.org/I88155538","display_name":"Universidad de Navarra","ror":"https://ror.org/02rxc7m23","country_code":"ES","type":"education","lineage":["https://openalex.org/I88155538"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Felipe Prosper","raw_affiliation_strings":["CIBERONC Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer, Pamplona, Spain","Cl\u00ednica Universidad de Navarra, Pamplona, Spain","IdiSNA Instituto de Investigaci\u00f3n Sanitaria de Navarra, Pamplona, Spain","Universidad de Navarra, CIMA Centro de Investigaci\u00f3n de Medicina Aplicada, Pamplona, Spain"],"raw_orcid":"https://orcid.org/0000-0001-6115-8790","affiliations":[{"raw_affiliation_string":"CIBERONC Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer, Pamplona, Spain","institution_ids":["https://openalex.org/I4210158561"]},{"raw_affiliation_string":"Cl\u00ednica Universidad de Navarra, Pamplona, Spain","institution_ids":["https://openalex.org/I4210135003"]},{"raw_affiliation_string":"IdiSNA Instituto de Investigaci\u00f3n Sanitaria de Navarra, Pamplona, Spain","institution_ids":["https://openalex.org/I4210112085"]},{"raw_affiliation_string":"Universidad de Navarra, CIMA Centro de Investigaci\u00f3n de Medicina Aplicada, Pamplona, Spain","institution_ids":["https://openalex.org/I88155538"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010754980","display_name":"Francisco J. Planes","orcid":"https://orcid.org/0000-0003-1155-3105"},"institutions":[{"id":"https://openalex.org/I88155538","display_name":"Universidad de Navarra","ror":"https://ror.org/02rxc7m23","country_code":"ES","type":"education","lineage":["https://openalex.org/I88155538"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Francisco J. Planes","raw_affiliation_strings":["Universidad de Navarra, Centro de Ingenier\u00eda Biom\u00e9dica, Pamplona, Spain","Universidad de Navarra, DATAI Instituto de Ciencia de los Datos e Inteligencia Artificial, Pamplona, Spain","Universidad de Navarra, Tecnun Escuela de Ingenier\u00eda, San Sebasti\u00e1n, Spain"],"raw_orcid":"https://orcid.org/0000-0003-1155-3105","affiliations":[{"raw_affiliation_string":"Universidad de Navarra, Centro de Ingenier\u00eda Biom\u00e9dica, Pamplona, Spain","institution_ids":["https://openalex.org/I88155538"]},{"raw_affiliation_string":"Universidad de Navarra, DATAI Instituto de Ciencia de los Datos e Inteligencia Artificial, Pamplona, Spain","institution_ids":["https://openalex.org/I88155538"]},{"raw_affiliation_string":"Universidad de Navarra, Tecnun Escuela de Ingenier\u00eda, San Sebasti\u00e1n, Spain","institution_ids":["https://openalex.org/I88155538"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5010754980"],"corresponding_institution_ids":["https://openalex.org/I88155538"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.868,"has_fulltext":false,"cited_by_count":12,"citation_normalized_percentile":{"value":0.70530437,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":99},"biblio":{"volume":"18","issue":"3","first_page":"e1009395","last_page":"e1009395"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9954000115394592,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/synthetic-lethality","display_name":"Synthetic lethality","score":0.8050118684768677},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.653404712677002},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5915377140045166},{"id":"https://openalex.org/keywords/cancer-cell","display_name":"Cancer cell","score":0.590136706829071},{"id":"https://openalex.org/keywords/function","display_name":"Function (biology)","score":0.551593542098999},{"id":"https://openalex.org/keywords/cancer","display_name":"Cancer","score":0.5453783869743347},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.5352922677993774},{"id":"https://openalex.org/keywords/lethality","display_name":"Lethality","score":0.49729683995246887},{"id":"https://openalex.org/keywords/metabolism","display_name":"Metabolism","score":0.45887672901153564},{"id":"https://openalex.org/keywords/phenotype","display_name":"Phenotype","score":0.413652241230011},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3834259808063507},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3406522870063782},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.2023392915725708},{"id":"https://openalex.org/keywords/dna-repair","display_name":"DNA repair","score":0.15351933240890503}],"concepts":[{"id":"https://openalex.org/C2778502085","wikidata":"https://www.wikidata.org/wiki/Q7662767","display_name":"Synthetic lethality","level":4,"score":0.8050118684768677},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.653404712677002},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5915377140045166},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.590136706829071},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.551593542098999},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5453783869743347},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5352922677993774},{"id":"https://openalex.org/C20379349","wikidata":"https://www.wikidata.org/wiki/Q1720706","display_name":"Lethality","level":2,"score":0.49729683995246887},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.45887672901153564},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.413652241230011},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3834259808063507},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3406522870063782},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2023392915725708},{"id":"https://openalex.org/C134935766","wikidata":"https://www.wikidata.org/wiki/Q210538","display_name":"DNA repair","level":3,"score":0.15351933240890503}],"mesh":[{"descriptor_ui":"D000072020","descriptor_name":"Synthetic Lethal Mutations","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000072020","descriptor_name":"Synthetic Lethal Mutations","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000072020","descriptor_name":"Synthetic Lethal Mutations","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000072020","descriptor_name":"Synthetic Lethal Mutations","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000078622","descriptor_name":"Nutrients","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000078622","descriptor_name":"Nutrients","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000078622","descriptor_name":"Nutrients","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000078622","descriptor_name":"Nutrients","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059016","descriptor_name":"Tumor Microenvironment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1009395","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009395","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:35286311","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/35286311","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:dadun.unav.edu:10171/64806","is_oa":true,"landing_page_url":"https://hdl.handle.net/10171/64806","pdf_url":null,"source":{"id":"https://openalex.org/S4306401514","display_name":"Deposito Adademico Digital Universidad De Navarra (University of Navarra)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I88155538","host_organization_name":"Universidad de Navarra","host_organization_lineage":["https://openalex.org/I88155538"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:077e783ad3e448e29da2dd4895c48394","is_oa":true,"landing_page_url":"https://doaj.org/article/077e783ad3e448e29da2dd4895c48394","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 18, Iss 3, p e1009395 (2022)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:8947600","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8947600","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1009395","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1009395","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2","score":0.6200000047683716}],"awards":[{"id":"https://openalex.org/G1061961021","display_name":null,"funder_award_id":"FI17/00297","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"},{"id":"https://openalex.org/G1075404386","display_name":null,"funder_award_id":"PI16/","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"},{"id":"https://openalex.org/G1694771286","display_name":null,"funder_award_id":"PI16/02024, PI17/00701, PI19/01352, PI20/01306","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"},{"id":"https://openalex.org/G2941146511","display_name":null,"funder_award_id":"KK-2020/00008","funder_id":"https://openalex.org/F4320321705","funder_display_name":"Eusko Jaurlaritza"},{"id":"https://openalex.org/G2993968861","display_name":null,"funder_award_id":"PI19/01352","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"},{"id":"https://openalex.org/G3893204708","display_name":null,"funder_award_id":"PIBA_2020_01_0055","funder_id":"https://openalex.org/F4320321705","funder_display_name":"Eusko Jaurlaritza"},{"id":"https://openalex.org/G3935185363","display_name":null,"funder_award_id":"KK-2020/00008","funder_id":"https://openalex.org/F4320323050","funder_display_name":"Ekonomiaren Garapen eta Lehiakortasun Saila, Eusko Jaurlaritza"},{"id":"https://openalex.org/G4160457854","display_name":null,"funder_award_id":"PI16/02024","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"},{"id":"https://openalex.org/G4237316828","display_name":null,"funder_award_id":"CB16/12/00489","funder_id":"https://openalex.org/F4320328325","funder_display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer"},{"id":"https://openalex.org/G4975135759","display_name":null,"funder_award_id":"PI20/01306","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"},{"id":"https://openalex.org/G5449442125","display_name":null,"funder_award_id":"PID2019-110344RB-I00","funder_id":"https://openalex.org/F4320321837","funder_display_name":"Ministerio de Econom\u00eda y Competitividad"},{"id":"https://openalex.org/G6732693109","display_name":null,"funder_award_id":"C355/A26819","funder_id":"https://openalex.org/F4320319985","funder_display_name":"Cancer Research UK"},{"id":"https://openalex.org/G7301387230","display_name":null,"funder_award_id":"PI17/00701","funder_id":"https://openalex.org/F4320334923","funder_display_name":"Instituto de Salud Carlos III"}],"funders":[{"id":"https://openalex.org/F4320310214","display_name":"Fundaci\u00f3n Ram\u00f3n Areces","ror":"https://ror.org/04ra91131"},{"id":"https://openalex.org/F4320319985","display_name":"Cancer Research UK","ror":"https://ror.org/054225q67"},{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"},{"id":"https://openalex.org/F4320321705","display_name":"Eusko Jaurlaritza","ror":"https://ror.org/00pz2fp31"},{"id":"https://openalex.org/F4320321837","display_name":"Ministerio de Econom\u00eda y Competitividad","ror":"https://ror.org/034900433"},{"id":"https://openalex.org/F4320323050","display_name":"Ekonomiaren Garapen eta Lehiakortasun Saila, Eusko Jaurlaritza","ror":"https://ror.org/007xj0t96"},{"id":"https://openalex.org/F4320328325","display_name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de C\u00e1ncer","ror":null},{"id":"https://openalex.org/F4320334923","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W1483430612","https://openalex.org/W1496283020","https://openalex.org/W1524699018","https://openalex.org/W1895317372","https://openalex.org/W1966182052","https://openalex.org/W1979971674","https://openalex.org/W1986631073","https://openalex.org/W1996307147","https://openalex.org/W2036181747","https://openalex.org/W2045953361","https://openalex.org/W2080051364","https://openalex.org/W2099787654","https://openalex.org/W2131719921","https://openalex.org/W2520159331","https://openalex.org/W2524141079","https://openalex.org/W2560197991","https://openalex.org/W2587946751","https://openalex.org/W2606441315","https://openalex.org/W2607135274","https://openalex.org/W2739511077","https://openalex.org/W2741508285","https://openalex.org/W2752877365","https://openalex.org/W2758067903","https://openalex.org/W2762019694","https://openalex.org/W2766663708","https://openalex.org/W2766955181","https://openalex.org/W2767683865","https://openalex.org/W2777635596","https://openalex.org/W2789128799","https://openalex.org/W2805761162","https://openalex.org/W2884231179","https://openalex.org/W2902258211","https://openalex.org/W2911647752","https://openalex.org/W2928947573","https://openalex.org/W2944477354","https://openalex.org/W2944723276","https://openalex.org/W2944727022","https://openalex.org/W2948469290","https://openalex.org/W2948963323","https://openalex.org/W2949189298","https://openalex.org/W2950705205","https://openalex.org/W2950983102","https://openalex.org/W2980457945","https://openalex.org/W2997778794","https://openalex.org/W3001275089","https://openalex.org/W3146811394","https://openalex.org/W3198992047","https://openalex.org/W4220756632","https://openalex.org/W4226230015"],"related_works":["https://openalex.org/W2116506288","https://openalex.org/W3093199425","https://openalex.org/W4391952194","https://openalex.org/W1508071893","https://openalex.org/W3097247875","https://openalex.org/W4280520494","https://openalex.org/W2161566038","https://openalex.org/W2950148520","https://openalex.org/W2518938096","https://openalex.org/W4362639343"],"abstract_inverted_index":{"Synthetic":[0],"Lethality":[1],"(SL)":[2],"is":[3,58,138,206,223],"currently":[4],"defined":[5],"as":[6,238],"a":[7,59,104,159],"type":[8],"of":[9,16,18,20,32,75,106,132,163,176,181,196,212,230],"genetic":[10,120,146,170],"interaction":[11],"in":[12,27,62,72,115,129,183,217,241],"which":[13,49],"the":[14,41,73,80,96,119,130,184,210],"loss":[15,175],"function":[17],"either":[19],"two":[21],"genes":[22,34],"individually":[23],"has":[24,68],"limited":[25],"effect":[26],"cell":[28,38],"viability":[29],"but":[30],"inactivation":[31],"both":[33],"simultaneously":[35],"leads":[36],"to":[37,79,112,135,139,153,191,225],"death.":[39],"Given":[40],"profound":[42],"genomic":[43],"aberrations":[44],"acquired":[45],"by":[46],"tumor":[47,142,231],"cells,":[48,232],"can":[50],"be":[51],"systematically":[52,140],"identified":[53],"with":[54],"-omics":[55],"data,":[56],"SL":[57,67,114,133,164],"promising":[60],"concept":[61],"cancer":[63,76,116,136,166],"research.":[64],"In":[65],"particular,":[66],"received":[69],"much":[70],"attention":[71],"area":[74],"metabolism,":[77,117],"due":[78],"fact":[81],"that":[82,91,145,168],"relevant":[83],"functional":[84],"alterations":[85],"concentrate":[86],"on":[87],"key":[88],"metabolic":[89,102,197],"pathways":[90],"promote":[92],"cellular":[93],"proliferation.":[94,155],"With":[95],"extensive":[97],"prior":[98],"knowledge":[99],"about":[100],"human":[101],"networks,":[103],"number":[105],"computational":[107,202],"methods":[108],"have":[109],"been":[110],"developed":[111],"predict":[113],"including":[118],"Minimal":[121],"Cut":[122],"Sets":[123],"(gMCSs)":[124],"approach.":[125],"A":[126,201],"major":[127],"challenge":[128],"application":[131],"approaches":[134],"metabolism":[137,167],"integrate":[141],"microenvironment,":[143],"given":[144],"interactions":[147],"and":[148,171,179,203,235],"nutritional":[149],"availability":[150],"are":[151],"interconnected":[152],"support":[154],"Here,":[156],"we":[157],"propose":[158],"more":[160],"general":[161],"definition":[162],"for":[165,208],"combines":[169],"environmental":[172],"interactions,":[173],"namely":[174],"gene":[177],"functions":[178],"absence":[180],"nutrients":[182],"environment.":[185],"We":[186],"extend":[187],"our":[188,221],"gMCSs":[189],"approach":[190,222],"determine":[192],"this":[193],"new":[194],"family":[195],"synthetic":[198],"lethal":[199],"interactions.":[200],"experimental":[204],"proof-of-concept":[205],"presented":[207],"predicting":[209],"lethality":[211],"dihydrofolate":[213],"reductase":[214],"(DHFR)":[215],"inhibition":[216],"different":[218,242],"environments.":[219],"Finally,":[220],"applied":[224],"identify":[226],"extracellular":[227],"nutrient":[228],"dependences":[229],"elucidating":[233],"cholesterol":[234],"myo-inositol":[236],"depletion":[237],"potential":[239],"vulnerabilities":[240],"malignancies.":[243]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":4}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}
