{"id":"https://openalex.org/W3094345105","doi":"https://doi.org/10.1371/journal.pcbi.1008258","title":"Misuse of the Michaelis\u2013Menten rate law for protein interaction networks and its remedy","display_name":"Misuse of the Michaelis\u2013Menten rate law for protein interaction networks and its remedy","publication_year":2020,"publication_date":"2020-10-22","ids":{"openalex":"https://openalex.org/W3094345105","doi":"https://doi.org/10.1371/journal.pcbi.1008258","mag":"3094345105","pmid":"https://pubmed.ncbi.nlm.nih.gov/33090989"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1008258","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008258","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008258&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"review","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008258&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067034493","display_name":"Jae Kyoung Kim","orcid":null},"institutions":[{"id":"https://openalex.org/I157485424","display_name":"Korea Advanced Institute of Science and Technology","ror":"https://ror.org/05apxxy63","country_code":"KR","type":"education","lineage":["https://openalex.org/I157485424"]}],"countries":["KR"],"is_corresponding":true,"raw_author_name":"Jae Kyoung Kim","raw_affiliation_strings":["Department of Mathematical Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea"],"raw_orcid":"https://orcid.org/0000-0001-7842-2172","affiliations":[{"raw_affiliation_string":"Department of Mathematical Sciences, Korea Advanced Institute of Science and Technology, Daejeon, Republic of Korea","institution_ids":["https://openalex.org/I157485424"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028908910","display_name":"John J. Tyson","orcid":"https://orcid.org/0000-0001-7560-6013"},"institutions":[{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John J. Tyson","raw_affiliation_strings":["Department of Biological Sciences, Virginia Tech, Blacksburg, Virginia, United States of America","Division of Systems Biology, Virginia Tech, Blacksburg, Virginia, United States of America"],"raw_orcid":"https://orcid.org/0000-0001-7560-6013","affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Virginia Tech, Blacksburg, Virginia, United States of America","institution_ids":["https://openalex.org/I859038795"]},{"raw_affiliation_string":"Division of Systems Biology, Virginia Tech, Blacksburg, Virginia, United States of America","institution_ids":["https://openalex.org/I859038795"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5067034493"],"corresponding_institution_ids":["https://openalex.org/I157485424"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":3.5111,"has_fulltext":true,"cited_by_count":80,"citation_normalized_percentile":{"value":0.93952735,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"16","issue":"10","first_page":"e1008258","last_page":"e1008258"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10621","display_name":"Gene Regulatory Network Analysis","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.996399998664856,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.9962999820709229,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bistability","display_name":"Bistability","score":0.6399182081222534},{"id":"https://openalex.org/keywords/context","display_name":"Context (archaeology)","score":0.6213160753250122},{"id":"https://openalex.org/keywords/rate-equation","display_name":"Rate equation","score":0.5649181008338928},{"id":"https://openalex.org/keywords/steady-state","display_name":"Steady state (chemistry)","score":0.5291041731834412},{"id":"https://openalex.org/keywords/statistical-physics","display_name":"Statistical physics","score":0.5209102034568787},{"id":"https://openalex.org/keywords/expression","display_name":"Expression (computer science)","score":0.45631229877471924},{"id":"https://openalex.org/keywords/law","display_name":"Law","score":0.40911269187927246},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4057621359825134},{"id":"https://openalex.org/keywords/applied-mathematics","display_name":"Applied mathematics","score":0.326811283826828},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.3034225106239319},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.24525994062423706},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.2321411371231079},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.15643620491027832},{"id":"https://openalex.org/keywords/classical-mechanics","display_name":"Classical mechanics","score":0.1508786678314209},{"id":"https://openalex.org/keywords/kinetics","display_name":"Kinetics","score":0.1103600263595581}],"concepts":[{"id":"https://openalex.org/C97292510","wikidata":"https://www.wikidata.org/wiki/Q2304620","display_name":"Bistability","level":2,"score":0.6399182081222534},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.6213160753250122},{"id":"https://openalex.org/C111163200","wikidata":"https://www.wikidata.org/wiki/Q904041","display_name":"Rate equation","level":3,"score":0.5649181008338928},{"id":"https://openalex.org/C8171440","wikidata":"https://www.wikidata.org/wiki/Q903414","display_name":"Steady state (chemistry)","level":2,"score":0.5291041731834412},{"id":"https://openalex.org/C121864883","wikidata":"https://www.wikidata.org/wiki/Q677916","display_name":"Statistical physics","level":1,"score":0.5209102034568787},{"id":"https://openalex.org/C90559484","wikidata":"https://www.wikidata.org/wiki/Q778379","display_name":"Expression (computer science)","level":2,"score":0.45631229877471924},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.40911269187927246},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4057621359825134},{"id":"https://openalex.org/C28826006","wikidata":"https://www.wikidata.org/wiki/Q33521","display_name":"Applied mathematics","level":1,"score":0.326811283826828},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.3034225106239319},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.24525994062423706},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2321411371231079},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.15643620491027832},{"id":"https://openalex.org/C74650414","wikidata":"https://www.wikidata.org/wiki/Q11397","display_name":"Classical mechanics","level":1,"score":0.1508786678314209},{"id":"https://openalex.org/C148898269","wikidata":"https://www.wikidata.org/wiki/Q1108792","display_name":"Kinetics","level":2,"score":0.1103600263595581},{"id":"https://openalex.org/C199360897","wikidata":"https://www.wikidata.org/wiki/Q9143","display_name":"Programming language","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1371/journal.pcbi.1008258","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008258","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008258&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:33090989","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/33090989","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:c780cc6c7c5445edb933f7ef531654cb","is_oa":true,"landing_page_url":"https://doaj.org/article/c780cc6c7c5445edb933f7ef531654cb","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 16, Iss 10, p e1008258 (2020)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7581366","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7581366","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1008258","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1008258","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1008258&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8100000023841858,"display_name":"Peace, Justice and strong institutions","id":"https://metadata.un.org/sdg/16"}],"awards":[{"id":"https://openalex.org/G1002502107","display_name":null,"funder_award_id":"NRF-2016 RICIB 3008468","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G2008413390","display_name":null,"funder_award_id":"2016 RICIB 3008468","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"},{"id":"https://openalex.org/G4244126222","display_name":null,"funder_award_id":"NRF-2016","funder_id":"https://openalex.org/F4320322120","funder_display_name":"National Research Foundation of Korea"}],"funders":[{"id":"https://openalex.org/F4320316819","display_name":"LG Yeonam Cultural Foundation","ror":null},{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320322120","display_name":"National Research Foundation of Korea","ror":"https://ror.org/013aysd81"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3094345105.pdf","grobid_xml":"https://content.openalex.org/works/W3094345105.grobid-xml"},"referenced_works_count":126,"referenced_works":["https://openalex.org/W567006062","https://openalex.org/W1564775231","https://openalex.org/W1599969036","https://openalex.org/W1645305843","https://openalex.org/W1869042642","https://openalex.org/W1932512987","https://openalex.org/W1964756055","https://openalex.org/W1967295320","https://openalex.org/W1971327350","https://openalex.org/W1973890190","https://openalex.org/W1974020517","https://openalex.org/W1977665132","https://openalex.org/W1980085157","https://openalex.org/W1985263169","https://openalex.org/W1989011389","https://openalex.org/W1992179397","https://openalex.org/W1992475241","https://openalex.org/W1992726958","https://openalex.org/W1994500037","https://openalex.org/W1995174791","https://openalex.org/W1996264210","https://openalex.org/W1998842497","https://openalex.org/W2000619385","https://openalex.org/W2002162541","https://openalex.org/W2002164453","https://openalex.org/W2006139156","https://openalex.org/W2007769474","https://openalex.org/W2008229310","https://openalex.org/W2010900077","https://openalex.org/W2010959934","https://openalex.org/W2018670096","https://openalex.org/W2019768978","https://openalex.org/W2021844372","https://openalex.org/W2023145868","https://openalex.org/W2024283669","https://openalex.org/W2026163190","https://openalex.org/W2026427707","https://openalex.org/W2029217862","https://openalex.org/W2030945597","https://openalex.org/W2031329949","https://openalex.org/W2036099201","https://openalex.org/W2037992356","https://openalex.org/W2038536277","https://openalex.org/W2041603328","https://openalex.org/W2050568471","https://openalex.org/W2053156756","https://openalex.org/W2054887782","https://openalex.org/W2055750802","https://openalex.org/W2057778468","https://openalex.org/W2058794142","https://openalex.org/W2064911508","https://openalex.org/W2067184822","https://openalex.org/W2072285397","https://openalex.org/W2072580718","https://openalex.org/W2075151302","https://openalex.org/W2075621480","https://openalex.org/W2077326330","https://openalex.org/W2079672230","https://openalex.org/W2090312078","https://openalex.org/W2094481611","https://openalex.org/W2095324538","https://openalex.org/W2096065176","https://openalex.org/W2102688834","https://openalex.org/W2104162805","https://openalex.org/W2106362845","https://openalex.org/W2115354930","https://openalex.org/W2124015059","https://openalex.org/W2132828256","https://openalex.org/W2133401281","https://openalex.org/W2135326887","https://openalex.org/W2138835511","https://openalex.org/W2139882086","https://openalex.org/W2142484802","https://openalex.org/W2143113504","https://openalex.org/W2145225614","https://openalex.org/W2147078972","https://openalex.org/W2150767223","https://openalex.org/W2151492171","https://openalex.org/W2153100796","https://openalex.org/W2153265394","https://openalex.org/W2155418451","https://openalex.org/W2159287491","https://openalex.org/W2159414118","https://openalex.org/W2160314966","https://openalex.org/W2164665803","https://openalex.org/W2165688051","https://openalex.org/W2165977465","https://openalex.org/W2174187976","https://openalex.org/W2186462130","https://openalex.org/W2323526584","https://openalex.org/W2380368735","https://openalex.org/W2414354733","https://openalex.org/W2517280042","https://openalex.org/W2528271650","https://openalex.org/W2554221761","https://openalex.org/W2559927712","https://openalex.org/W2570895165","https://openalex.org/W2580767461","https://openalex.org/W2604773806","https://openalex.org/W2609780203","https://openalex.org/W2622490204","https://openalex.org/W2727442359","https://openalex.org/W2741754189","https://openalex.org/W2766105307","https://openalex.org/W2789370962","https://openalex.org/W2789596542","https://openalex.org/W2791611289","https://openalex.org/W2803948731","https://openalex.org/W2950586838","https://openalex.org/W2952635753","https://openalex.org/W2952789681","https://openalex.org/W2956013039","https://openalex.org/W2963085788","https://openalex.org/W2963297079","https://openalex.org/W2963802777","https://openalex.org/W2979347585","https://openalex.org/W3006680225","https://openalex.org/W3011658201","https://openalex.org/W3013106498","https://openalex.org/W3018346404","https://openalex.org/W3037702397","https://openalex.org/W3104744823","https://openalex.org/W4231550443","https://openalex.org/W4250505175","https://openalex.org/W6674432084","https://openalex.org/W6775438838"],"related_works":["https://openalex.org/W4224217224","https://openalex.org/W3118640947","https://openalex.org/W4388308731","https://openalex.org/W2042003698","https://openalex.org/W1964519618","https://openalex.org/W2070681510","https://openalex.org/W2347334022","https://openalex.org/W1991851235","https://openalex.org/W2148382714","https://openalex.org/W2898285107"],"abstract_inverted_index":{"For":[0],"over":[1,58],"a":[2,133,164],"century,":[3],"the":[4,14,23,26,33,47,52,59,78,95,100,103,138,144,154,170,187],"Michaelis-Menten":[5],"(MM)":[6],"rate":[7,28,80,97,140,175],"law":[8,81,98],"has":[9,82],"been":[10,84],"used":[11,158],"to":[12,181,190],"describe":[13,125],"rates":[15],"of":[16,25,35,94,102,108,115,137,173],"enzyme-catalyzed":[17],"reactions":[18,38],"and":[19,111,122],"gene":[20],"expression.":[21],"Despite":[22],"ubiquity":[24],"MM":[27,79,96,139],"law,":[29,141],"it":[30,43],"accurately":[31],"captures":[32],"dynamics":[34,101],"underlying":[36],"biochemical":[37],"only":[39],"so":[40,73],"long":[41],"as":[42,119],"is":[44,54,69],"applied":[45],"under":[46],"right":[48,188],"condition,":[49],"namely,":[50],"that":[51,153],"substrate":[53],"in":[55,63,74,186,196],"large":[56],"excess":[57],"enzyme-substrate":[60],"complex.":[61],"Unfortunately,":[62],"circumstances":[64],"where":[65],"its":[66],"validity":[67],"condition":[68],"not":[70],"satisfied,":[71],"especially":[72],"protein":[75],"interaction":[76],"networks,":[77],"frequently":[83],"misused.":[85],"In":[86],"this":[87],"review,":[88],"we":[89,151],"illustrate":[90],"how":[91,126,180],"inappropriate":[92],"use":[93,182],"distorts":[99],"system,":[104],"provides":[105],"mistaken":[106],"estimates":[107],"parameter":[109],"values,":[110],"makes":[112],"false":[113],"predictions":[114],"dynamical":[116],"features":[117],"such":[118],"ultrasensitivity,":[120],"bistability,":[121],"oscillations.":[123],"We":[124],"these":[127],"problems":[128],"can":[129,156],"be":[130,157],"resolved":[131],"with":[132],"slightly":[134],"modified":[135],"form":[136],"based":[142],"on":[143],"total":[145],"quasi-steady":[146,183],"state":[147,184],"approximation":[148],"(tQSSA).":[149],"Furthermore,":[150],"show":[152],"tQSSA":[155],"for":[159],"accurate":[160],"stochastic":[161],"simulations":[162],"at":[163],"lower":[165],"computational":[166],"cost":[167],"than":[168],"using":[169],"full":[171],"set":[172],"mass-action":[174],"laws.":[176],"This":[177],"review":[178],"describes":[179],"approximations":[185],"context,":[189],"prevent":[191],"drawing":[192],"erroneous":[193],"conclusions":[194],"from":[195],"silico":[197],"simulations.":[198]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":18},{"year":2024,"cited_by_count":16},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":20},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":2}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}