{"id":"https://openalex.org/W3037518185","doi":"https://doi.org/10.1371/journal.pcbi.1007901","title":"A systematic approach to decipher crosstalk in the p53 signaling pathway using single cell dynamics","display_name":"A systematic approach to decipher crosstalk in the p53 signaling pathway using single cell dynamics","publication_year":2020,"publication_date":"2020-06-26","ids":{"openalex":"https://openalex.org/W3037518185","doi":"https://doi.org/10.1371/journal.pcbi.1007901","mag":"3037518185","pmid":"https://pubmed.ncbi.nlm.nih.gov/32589666"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1007901","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007901","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007901&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007901&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083286814","display_name":"Fabian Konrath","orcid":null},"institutions":[{"id":"https://openalex.org/I205582932","display_name":"Max Delbr\u00fcck Center","ror":"https://ror.org/04p5ggc03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I205582932"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Fabian Konrath","raw_affiliation_strings":["Mathematical Modelling of Cellular Processes, Max Delbrueck Center for Molecular Medicine, Berlin, Germany"],"raw_orcid":"https://orcid.org/0000-0002-6843-6252","affiliations":[{"raw_affiliation_string":"Mathematical Modelling of Cellular Processes, Max Delbrueck Center for Molecular Medicine, Berlin, Germany","institution_ids":["https://openalex.org/I205582932"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079425451","display_name":"Anna Mittermeier","orcid":"https://orcid.org/0000-0001-8439-4307"},"institutions":[{"id":"https://openalex.org/I31512782","display_name":"Technische Universit\u00e4t Darmstadt","ror":"https://ror.org/05n911h24","country_code":"DE","type":"education","lineage":["https://openalex.org/I31512782"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Anna Mittermeier","raw_affiliation_strings":["Systems Biology of the Stress Response, Department of Biology, Technische Universit\u00e4t Darmstadt, Darmstadt, Germany"],"raw_orcid":"https://orcid.org/0000-0001-8439-4307","affiliations":[{"raw_affiliation_string":"Systems Biology of the Stress Response, Department of Biology, Technische Universit\u00e4t Darmstadt, Darmstadt, Germany","institution_ids":["https://openalex.org/I31512782"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082969308","display_name":"Elena Cristiano","orcid":null},"institutions":[{"id":"https://openalex.org/I205582932","display_name":"Max Delbr\u00fcck Center","ror":"https://ror.org/04p5ggc03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I205582932"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Elena Cristiano","raw_affiliation_strings":["Signaling Dynamics in Single Cells, Berlin Institute for Medical Systems Biology, Max Delbrueck Center for Molecular Medicine, Berlin, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Signaling Dynamics in Single Cells, Berlin Institute for Medical Systems Biology, Max Delbrueck Center for Molecular Medicine, Berlin, Germany","institution_ids":["https://openalex.org/I205582932"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011931952","display_name":"Jana Wolf","orcid":"https://orcid.org/0000-0003-3254-5868"},"institutions":[{"id":"https://openalex.org/I205582932","display_name":"Max Delbr\u00fcck Center","ror":"https://ror.org/04p5ggc03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I205582932"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Jana Wolf","raw_affiliation_strings":["Mathematical Modelling of Cellular Processes, Max Delbrueck Center for Molecular Medicine, Berlin, Germany"],"raw_orcid":"https://orcid.org/0000-0003-3254-5868","affiliations":[{"raw_affiliation_string":"Mathematical Modelling of Cellular Processes, Max Delbrueck Center for Molecular Medicine, Berlin, Germany","institution_ids":["https://openalex.org/I205582932"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042093444","display_name":"Alexander Loewer","orcid":"https://orcid.org/0000-0002-8819-3040"},"institutions":[{"id":"https://openalex.org/I205582932","display_name":"Max Delbr\u00fcck Center","ror":"https://ror.org/04p5ggc03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I205582932"]},{"id":"https://openalex.org/I31512782","display_name":"Technische Universit\u00e4t Darmstadt","ror":"https://ror.org/05n911h24","country_code":"DE","type":"education","lineage":["https://openalex.org/I31512782"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Alexander Loewer","raw_affiliation_strings":["Signaling Dynamics in Single Cells, Berlin Institute for Medical Systems Biology, Max Delbrueck Center for Molecular Medicine, Berlin, Germany","Systems Biology of the Stress Response, Department of Biology, Technische Universit\u00e4t Darmstadt, Darmstadt, Germany"],"raw_orcid":"https://orcid.org/0000-0002-8819-3040","affiliations":[{"raw_affiliation_string":"Signaling Dynamics in Single Cells, Berlin Institute for Medical Systems Biology, Max Delbrueck Center for Molecular Medicine, Berlin, Germany","institution_ids":["https://openalex.org/I205582932"]},{"raw_affiliation_string":"Systems Biology of the Stress Response, Department of Biology, Technische Universit\u00e4t Darmstadt, Darmstadt, Germany","institution_ids":["https://openalex.org/I31512782"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5011931952","https://openalex.org/A5042093444"],"corresponding_institution_ids":["https://openalex.org/I205582932","https://openalex.org/I31512782"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2083,"currency":"EUR","value_usd":2246},"fwci":1.0888,"has_fulltext":true,"cited_by_count":19,"citation_normalized_percentile":{"value":0.79941153,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":98},"biblio":{"volume":"16","issue":"6","first_page":"e1007901","last_page":"e1007901"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.9969000220298767,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/crosstalk","display_name":"Crosstalk","score":0.9019221067428589},{"id":"https://openalex.org/keywords/transcription-factor","display_name":"Transcription factor","score":0.5579887628555298},{"id":"https://openalex.org/keywords/regulator","display_name":"Regulator","score":0.5524380803108215},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5478408932685852},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.49271252751350403},{"id":"https://openalex.org/keywords/cell-fate-determination","display_name":"Cell fate determination","score":0.47550612688064575},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"Signal transduction","score":0.47427043318748474},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.4648294448852539},{"id":"https://openalex.org/keywords/cell-signaling","display_name":"Cell signaling","score":0.42550429701805115},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4227806329727173},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.3756595253944397},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.22337722778320312},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.19971159100532532}],"concepts":[{"id":"https://openalex.org/C169822122","wikidata":"https://www.wikidata.org/wiki/Q230187","display_name":"Crosstalk","level":2,"score":0.9019221067428589},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.5579887628555298},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.5524380803108215},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5478408932685852},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.49271252751350403},{"id":"https://openalex.org/C163952510","wikidata":"https://www.wikidata.org/wiki/Q5058196","display_name":"Cell fate determination","level":4,"score":0.47550612688064575},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.47427043318748474},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.4648294448852539},{"id":"https://openalex.org/C150555746","wikidata":"https://www.wikidata.org/wiki/Q210973","display_name":"Cell signaling","level":3,"score":0.42550429701805115},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4227806329727173},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.3756595253944397},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.22337722778320312},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.19971159100532532},{"id":"https://openalex.org/C120665830","wikidata":"https://www.wikidata.org/wiki/Q14620","display_name":"Optics","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D008853","descriptor_name":"Microscopy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008853","descriptor_name":"Microscopy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008853","descriptor_name":"Microscopy","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1007901","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007901","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007901&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:32589666","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32589666","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:edoc.mdc-berlin.de:19090","is_oa":false,"landing_page_url":"http://edoc.mdc-berlin.de/19090/3/19090suppl.zip","pdf_url":null,"source":{"id":"https://openalex.org/S4306400224","display_name":"MDC Repository (Max-Delbrueck-Center for Molecular Medicine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:doaj.org/article:c75db1df7f4a4c2896588f994787f4d4","is_oa":true,"landing_page_url":"https://doaj.org/article/c75db1df7f4a4c2896588f994787f4d4","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 16, Iss 6, p e1007901 (2020)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:7319280","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7319280","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmh:oai:tubiblio.ulb.tu-darmstadt.de:121330","is_oa":false,"landing_page_url":"http://tubiblio.ulb.tu-darmstadt.de/121330/","pdf_url":null,"source":{"id":"https://openalex.org/S4377196390","display_name":"TUbilio (Technical University of Darmstadt)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I31512782","host_organization_name":"Technische Universit\u00e4t Darmstadt","host_organization_lineage":["https://openalex.org/I31512782"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Artikel"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1007901","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007901","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1007901&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G3584653315","display_name":null,"funder_award_id":"Graduiertenkolleg 1772","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G5294808123","display_name":null,"funder_award_id":"0316047A","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"},{"id":"https://openalex.org/G736588634","display_name":null,"funder_award_id":"111645","funder_id":"https://openalex.org/F4320323556","funder_display_name":"Deutsche Krebshilfe"}],"funders":[{"id":"https://openalex.org/F4320320876","display_name":"Helmholtz-Gemeinschaft","ror":"https://ror.org/0281dp749"},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320321114","display_name":"Bundesministerium f\u00fcr Bildung und Forschung","ror":"https://ror.org/04pz7b180"},{"id":"https://openalex.org/F4320323556","display_name":"Deutsche Krebshilfe","ror":"https://ror.org/01wxdd722"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3037518185.pdf","grobid_xml":"https://content.openalex.org/works/W3037518185.grobid-xml"},"referenced_works_count":71,"referenced_works":["https://openalex.org/W87058663","https://openalex.org/W144339231","https://openalex.org/W1661180389","https://openalex.org/W1822745879","https://openalex.org/W1881072801","https://openalex.org/W1972429412","https://openalex.org/W1975816997","https://openalex.org/W1978518304","https://openalex.org/W1979634817","https://openalex.org/W1990087549","https://openalex.org/W1991063693","https://openalex.org/W1997760180","https://openalex.org/W1998253936","https://openalex.org/W2003236156","https://openalex.org/W2003775478","https://openalex.org/W2008841385","https://openalex.org/W2010114834","https://openalex.org/W2012045589","https://openalex.org/W2013324041","https://openalex.org/W2025722611","https://openalex.org/W2027572713","https://openalex.org/W2037722096","https://openalex.org/W2040244459","https://openalex.org/W2043027414","https://openalex.org/W2043329242","https://openalex.org/W2044013267","https://openalex.org/W2045001281","https://openalex.org/W2046822015","https://openalex.org/W2057631551","https://openalex.org/W2063669247","https://openalex.org/W2066218351","https://openalex.org/W2068912983","https://openalex.org/W2077436902","https://openalex.org/W2082979850","https://openalex.org/W2083922442","https://openalex.org/W2084831115","https://openalex.org/W2088172210","https://openalex.org/W2091818021","https://openalex.org/W2092944644","https://openalex.org/W2094863064","https://openalex.org/W2095708527","https://openalex.org/W2097651998","https://openalex.org/W2102434872","https://openalex.org/W2107554012","https://openalex.org/W2110980999","https://openalex.org/W2111510713","https://openalex.org/W2112785503","https://openalex.org/W2114445658","https://openalex.org/W2120549828","https://openalex.org/W2124343538","https://openalex.org/W2129297473","https://openalex.org/W2130704889","https://openalex.org/W2133959309","https://openalex.org/W2134887638","https://openalex.org/W2141997480","https://openalex.org/W2152750766","https://openalex.org/W2159099751","https://openalex.org/W2159664830","https://openalex.org/W2167921512","https://openalex.org/W2179083909","https://openalex.org/W2262285937","https://openalex.org/W2267814167","https://openalex.org/W2411596856","https://openalex.org/W2507812261","https://openalex.org/W2608450331","https://openalex.org/W2752942423","https://openalex.org/W2784772328","https://openalex.org/W2903099223","https://openalex.org/W2950115754","https://openalex.org/W3148021032","https://openalex.org/W4212962560"],"related_works":["https://openalex.org/W3022555688","https://openalex.org/W4385588055","https://openalex.org/W2546463226","https://openalex.org/W2076883893","https://openalex.org/W2288499012","https://openalex.org/W4223418040","https://openalex.org/W4388293120","https://openalex.org/W3007366204","https://openalex.org/W2902329950","https://openalex.org/W2076754613"],"abstract_inverted_index":{"The":[0,109],"transcription":[1],"factors":[2],"NF-\u03baB":[3,53,62,120],"and":[4,14,64,100,106,125,161,180],"p53":[5,70,83,123,152,164],"are":[6,15],"key":[7],"regulators":[8],"in":[9,94,150,184],"the":[10,34,49,66,104,115,147,151,159,168,175,178],"genotoxic":[11,72],"stress":[12,73],"response":[13,68],"critical":[16,59],"for":[17,25,103],"tumor":[18],"development.":[19],"Although":[20],"there":[21],"is":[22,36,143],"ample":[23],"evidence":[24],"interactions":[26,47,129],"between":[27,48,130],"both":[28,131],"networks,":[29],"a":[30,41,58,95,137],"comprehensive":[31],"understanding":[32],"of":[33,61,69,118,140,163,170,177],"crosstalk":[35,179],"lacking.":[37],"Here,":[38],"we":[39,134,155],"developed":[40],"systematic":[42],"approach":[43,110],"to":[44,71,85,92,113,145],"identify":[45],"potential":[46,128,182],"pathways.":[50],"We":[51],"perturbed":[52,107],"signaling":[54,98],"by":[55],"inhibiting":[56],"IKK2,":[57],"regulator":[60],"activity,":[63],"monitored":[65],"altered":[67],"using":[74],"single":[75,88],"cell":[76,89],"time":[77],"lapse":[78],"microscopy.":[79],"Fitting":[80],"subpopulation-specific":[81],"computational":[82],"models":[84],"this":[86],"time-resolved":[87],"data":[90],"allowed":[91],"reproduce":[93],"quantitative":[96],"manner":[97],"dynamics":[99,124],"cellular":[101,186],"heterogeneity":[102],"unperturbed":[105],"conditions.":[108],"enabled":[111],"us":[112],"untangle":[114],"integrated":[116],"effects":[117],"IKK/":[119],"perturbation":[121,139],"on":[122],"thereby":[126],"derive":[127],"networks.":[132],"Intriguingly,":[133],"find":[135],"that":[136],"simultaneous":[138],"multiple":[141],"processes":[142],"necessary":[144],"explain":[146],"observed":[148],"changes":[149],"response.":[153],"Specifically,":[154],"show":[156],"interference":[157],"with":[158],"activation":[160],"degradation":[162,169],"as":[165,167],"well":[166],"Mdm2.":[171],"Our":[172],"results":[173],"highlight":[174],"importance":[176],"its":[181],"implications":[183],"p53-dependent":[185],"functions.":[187]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":5}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}