{"id":"https://openalex.org/W3016916364","doi":"https://doi.org/10.1371/journal.pcbi.1007768","title":"High-dimensional mediation analysis in survival models","display_name":"High-dimensional mediation analysis in survival models","publication_year":2020,"publication_date":"2020-04-17","ids":{"openalex":"https://openalex.org/W3016916364","doi":"https://doi.org/10.1371/journal.pcbi.1007768","mag":"3016916364","pmid":"https://pubmed.ncbi.nlm.nih.gov/32302299"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1007768","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007768","pdf_url":"https://storage.googleapis.com/plos-corpus-prod/10.1371/journal.pcbi.1007768/2/pcbi.1007768.pdf?X-Goog-Algorithm=GOOG4-RSA-SHA256&X-Goog-Credential=wombat-sa%40plos-prod.iam.gserviceaccount.com%2F20210217%2Fauto%2Fstorage%2Fgoog4_request&X-Goog-Date=20210217T071400Z&X-Goog-Expires=3600&X-Goog-SignedHeaders=host&X-Goog-Signature=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","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://storage.googleapis.com/plos-corpus-prod/10.1371/journal.pcbi.1007768/2/pcbi.1007768.pdf?X-Goog-Algorithm=GOOG4-RSA-SHA256&X-Goog-Credential=wombat-sa%40plos-prod.iam.gserviceaccount.com%2F20210217%2Fauto%2Fstorage%2Fgoog4_request&X-Goog-Date=20210217T071400Z&X-Goog-Expires=3600&X-Goog-SignedHeaders=host&X-Goog-Signature=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","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5084324157","display_name":"Chengwen Luo","orcid":"https://orcid.org/0000-0002-9544-9921"},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Chengwen Luo","raw_affiliation_strings":["Department of Bioinformatics and Biostatistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China","SJTU-Yale Joint Center for Biostatistics, Shanghai Jiao Tong University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics and Biostatistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China","institution_ids":["https://openalex.org/I183067930"]},{"raw_affiliation_string":"SJTU-Yale Joint Center for Biostatistics, Shanghai Jiao Tong University, Shanghai, China","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041867840","display_name":"Botao Fa","orcid":"https://orcid.org/0009-0009-0973-9366"},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Botao Fa","raw_affiliation_strings":["Department of Bioinformatics and Biostatistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China","SJTU-Yale Joint Center for Biostatistics, Shanghai Jiao Tong University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics and Biostatistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China","institution_ids":["https://openalex.org/I183067930"]},{"raw_affiliation_string":"SJTU-Yale Joint Center for Biostatistics, Shanghai Jiao Tong University, Shanghai, China","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074352094","display_name":"Yuting Yan","orcid":"https://orcid.org/0000-0002-9355-2984"},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuting Yan","raw_affiliation_strings":["SJTU-Yale Joint Center for Biostatistics, Shanghai Jiao Tong University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"SJTU-Yale Joint Center for Biostatistics, Shanghai Jiao Tong University, Shanghai, China","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100754169","display_name":"Yang Wang","orcid":"https://orcid.org/0000-0002-6948-0909"},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yang Wang","raw_affiliation_strings":["SJTU-Yale Joint Center for Biostatistics, Shanghai Jiao Tong University, Shanghai, China"],"raw_orcid":"https://orcid.org/0000-0002-6948-0909","affiliations":[{"raw_affiliation_string":"SJTU-Yale Joint Center for Biostatistics, Shanghai Jiao Tong University, Shanghai, China","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018749493","display_name":"Yiwang Zhou","orcid":"https://orcid.org/0000-0002-8023-205X"},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210111179","display_name":"Michigan United","ror":"https://ror.org/0291ys696","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210111179"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yiwang Zhou","raw_affiliation_strings":["Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, United States of America"],"raw_orcid":"https://orcid.org/0000-0002-8023-205X","affiliations":[{"raw_affiliation_string":"Department of Biostatistics, University of Michigan, Ann Arbor, Michigan, United States of America","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210111179"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100333678","display_name":"Yue Zhang","orcid":"https://orcid.org/0000-0002-0603-6536"},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yue Zhang","raw_affiliation_strings":["Department of Bioinformatics and Biostatistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China","SJTU-Yale Joint Center for Biostatistics, Shanghai Jiao Tong University, Shanghai, China"],"raw_orcid":"https://orcid.org/0000-0002-0603-6536","affiliations":[{"raw_affiliation_string":"Department of Bioinformatics and Biostatistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China","institution_ids":["https://openalex.org/I183067930"]},{"raw_affiliation_string":"SJTU-Yale Joint Center for Biostatistics, Shanghai Jiao Tong University, Shanghai, China","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5086936559","display_name":"Zhangsheng Yu","orcid":"https://orcid.org/0000-0002-8189-5330"},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhangsheng Yu","raw_affiliation_strings":["Department of Bioinformatics and Biostatistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China","SJTU-Yale Joint Center for Biostatistics, Shanghai Jiao Tong University, Shanghai, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics and Biostatistics, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China","institution_ids":["https://openalex.org/I183067930"]},{"raw_affiliation_string":"SJTU-Yale Joint Center for Biostatistics, Shanghai Jiao Tong University, Shanghai, China","institution_ids":["https://openalex.org/I183067930"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5086936559"],"corresponding_institution_ids":["https://openalex.org/I183067930"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":5.0749,"has_fulltext":false,"cited_by_count":45,"citation_normalized_percentile":{"value":0.96292274,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"16","issue":"4","first_page":"e1007768","last_page":"e1007768"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10845","display_name":"Advanced Causal Inference Techniques","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10845","display_name":"Advanced Causal Inference Techniques","score":0.989300012588501,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.9843999743461609,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10136","display_name":"Statistical Methods and Inference","score":0.9811000227928162,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.6168904900550842},{"id":"https://openalex.org/keywords/oncology","display_name":"Oncology","score":0.5959110260009766},{"id":"https://openalex.org/keywords/proportional-hazards-model","display_name":"Proportional hazards model","score":0.5847859978675842},{"id":"https://openalex.org/keywords/lung-cancer","display_name":"Lung cancer","score":0.5376710891723633},{"id":"https://openalex.org/keywords/mediation","display_name":"Mediation","score":0.5064517259597778},{"id":"https://openalex.org/keywords/epigenetics","display_name":"Epigenetics","score":0.49166566133499146},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.4836350679397583},{"id":"https://openalex.org/keywords/survival-analysis","display_name":"Survival analysis","score":0.47022247314453125},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.4147101938724518},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.38795164227485657},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.36668938398361206},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.3207783102989197},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.20856037735939026},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.1584112048149109}],"concepts":[{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.6168904900550842},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.5959110260009766},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.5847859978675842},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.5376710891723633},{"id":"https://openalex.org/C179420905","wikidata":"https://www.wikidata.org/wiki/Q223871","display_name":"Mediation","level":2,"score":0.5064517259597778},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.49166566133499146},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4836350679397583},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.47022247314453125},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4147101938724518},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.38795164227485657},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36668938398361206},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3207783102989197},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.20856037735939026},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1584112048149109},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012907","descriptor_name":"Smoking","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012907","descriptor_name":"Smoking","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012907","descriptor_name":"Smoking","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012907","descriptor_name":"Smoking","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012907","descriptor_name":"Smoking","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D012907","descriptor_name":"Smoking","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D012907","descriptor_name":"Smoking","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D012907","descriptor_name":"Smoking","qualifier_ui":"Q000401","qualifier_name":"mortality","is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D057890","descriptor_name":"Epigenomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057890","descriptor_name":"Epigenomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057890","descriptor_name":"Epigenomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D057890","descriptor_name":"Epigenomics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1007768","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007768","pdf_url":"https://storage.googleapis.com/plos-corpus-prod/10.1371/journal.pcbi.1007768/2/pcbi.1007768.pdf?X-Goog-Algorithm=GOOG4-RSA-SHA256&X-Goog-Credential=wombat-sa%40plos-prod.iam.gserviceaccount.com%2F20210217%2Fauto%2Fstorage%2Fgoog4_request&X-Goog-Date=20210217T071400Z&X-Goog-Expires=3600&X-Goog-SignedHeaders=host&X-Goog-Signature=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","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:32302299","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/32302299","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:RePEc:plo:pcbi00:1007768","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1007768","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:b9c6225c4fc748e7acf9dc46689d0a30","is_oa":true,"landing_page_url":"https://doaj.org/article/b9c6225c4fc748e7acf9dc46689d0a30","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 16, Iss 4, p e1007768 (2020)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/12148287","is_oa":true,"landing_page_url":null,"pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:7190184","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7190184","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1007768","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1007768","pdf_url":"https://storage.googleapis.com/plos-corpus-prod/10.1371/journal.pcbi.1007768/2/pcbi.1007768.pdf?X-Goog-Algorithm=GOOG4-RSA-SHA256&X-Goog-Credential=wombat-sa%40plos-prod.iam.gserviceaccount.com%2F20210217%2Fauto%2Fstorage%2Fgoog4_request&X-Goog-Date=20210217T071400Z&X-Goog-Expires=3600&X-Goog-SignedHeaders=host&X-Goog-Signature=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","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8799999952316284}],"awards":[{"id":"https://openalex.org/G4599811421","display_name":null,"funder_award_id":"11671256(Yu)","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6981488226","display_name":null,"funder_award_id":"2016YFC0902403(Yu)","funder_id":"https://openalex.org/F4320321540","funder_display_name":"Ministry of Science and Technology of the People's Republic of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321540","display_name":"Ministry of Science and Technology of the People's Republic of China","ror":"https://ror.org/027s68j25"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W3016916364.pdf","grobid_xml":"https://content.openalex.org/works/W3016916364.grobid-xml"},"referenced_works_count":62,"referenced_works":["https://openalex.org/W1580788756","https://openalex.org/W1640894779","https://openalex.org/W1918724965","https://openalex.org/W1929501557","https://openalex.org/W1937592784","https://openalex.org/W1943668628","https://openalex.org/W1965125844","https://openalex.org/W1971440513","https://openalex.org/W1973285887","https://openalex.org/W1973627705","https://openalex.org/W1976765441","https://openalex.org/W1976876708","https://openalex.org/W1979362779","https://openalex.org/W1993211119","https://openalex.org/W1997824331","https://openalex.org/W2001820152","https://openalex.org/W2006345816","https://openalex.org/W2009754435","https://openalex.org/W2017502278","https://openalex.org/W2019774106","https://openalex.org/W2033207105","https://openalex.org/W2038702827","https://openalex.org/W2042408865","https://openalex.org/W2056947824","https://openalex.org/W2058028273","https://openalex.org/W2061693044","https://openalex.org/W2068719957","https://openalex.org/W2078159349","https://openalex.org/W2082405562","https://openalex.org/W2104616002","https://openalex.org/W2121046269","https://openalex.org/W2123901033","https://openalex.org/W2132617827","https://openalex.org/W2149144946","https://openalex.org/W2149199519","https://openalex.org/W2153307798","https://openalex.org/W2154560360","https://openalex.org/W2160680909","https://openalex.org/W2307827365","https://openalex.org/W2474105078","https://openalex.org/W2566863750","https://openalex.org/W2595179827","https://openalex.org/W2610860393","https://openalex.org/W2625629732","https://openalex.org/W2761773932","https://openalex.org/W2770715274","https://openalex.org/W2783523809","https://openalex.org/W2789589248","https://openalex.org/W2807747040","https://openalex.org/W2894522712","https://openalex.org/W2897491575","https://openalex.org/W2952076147","https://openalex.org/W2963060335","https://openalex.org/W2970305451","https://openalex.org/W3001510540","https://openalex.org/W3049340299","https://openalex.org/W3098306969","https://openalex.org/W3104192544","https://openalex.org/W3106108064","https://openalex.org/W3121505931","https://openalex.org/W3147894994","https://openalex.org/W4292811746"],"related_works":["https://openalex.org/W2214376880","https://openalex.org/W3212149434","https://openalex.org/W2073893804","https://openalex.org/W2291484187","https://openalex.org/W2797301068","https://openalex.org/W2010631330","https://openalex.org/W2006470775","https://openalex.org/W2581226876","https://openalex.org/W4225134093","https://openalex.org/W4380448775"],"abstract_inverted_index":{"Mediation":[0,140],"analysis":[1,27,34,56,141,245],"with":[2,28,74,170,202],"high-dimensional":[3,29,32,54,243],"DNA":[4,132],"methylation":[5,163,188],"markers":[6,164,231],"is":[7],"important":[8],"in":[9,93,134,191,250],"identifying":[10,94],"epigenetic":[11,230],"pathways":[12],"between":[13],"environmental":[14],"exposures":[15],"and":[16,66,77,101,168,181,216,234,253],"health":[17],"outcomes.":[18],"There":[19],"have":[20,152,196,218],"been":[21,197,220],"some":[22],"methodology":[23],"developments":[24],"of":[25,84,105,159,174,236],"mediation":[26,33,55,244],"mediators.":[30],"However,":[31,209],"methods":[35],"for":[36,58,71,81],"time-to-event":[37],"outcome":[38],"data":[39],"are":[40,223],"still":[41],"yet":[42],"to":[43,114,121,199],"be":[44,200],"developed.":[45],"To":[46],"address":[47],"these":[48],"challenges,":[49],"we":[50],"propose":[51],"a":[52,143],"new":[53],"procedure":[57,246],"survival":[59,123,235],"models":[60],"by":[61,130],"incorporating":[62],"sure":[63],"independent":[64],"screening":[65],"minimax":[67],"concave":[68],"penalty":[69],"techniques":[70],"variable":[72],"selection,":[73],"the":[75,78,106,116,135,157,192,210,227,241],"Sobel":[76],"joint":[79],"method":[80],"significance":[82],"test":[83],"indirect":[85,254],"effect.":[86],"The":[87,186],"simulation":[88],"studies":[89],"show":[90],"good":[91,248],"performance":[92,249],"correct":[95],"biomarkers,":[96],"false":[97],"discovery":[98],"rate":[99],"control,":[100],"minimum":[102],"estimation":[103],"bias":[104],"proposed":[107,242],"procedure.":[108],"We":[109],"also":[110],"apply":[111],"this":[112],"approach":[113],"study":[115],"causal":[117],"pathway":[118],"from":[119],"smoking":[120,154,233],"overall":[122,207],"among":[124],"lung":[125,137,160,203,237],"cancer":[126,138,161,204,238],"patients":[127,150],"potentially":[128],"mediated":[129],"365,307":[131],"methylations":[133],"TCGA":[136],"cohort.":[139],"using":[142],"Cox":[144],"proportional":[145],"hazards":[146],"model":[147],"estimates":[148],"that":[149],"who":[151],"serious":[153],"history":[155],"increase":[156],"risk":[158],"through":[162],"including":[165],"cg21926276,":[166],"cg27042065,":[167],"cg26387355":[169],"significant":[171],"hazard":[172],"ratios":[173],"1.2497(95%CI:":[175],"1.1121,":[176],"1.4045),":[177],"1.0920(95%CI:":[178],"1.0170,":[179],"1.1726),":[180],"1.1489(95%CI:":[182],"1.0518,":[183],"1.2550),":[184],"respectively.":[185],"three":[187,193,211],"sites":[189,213],"locate":[190],"genes":[194],"which":[195,222],"showed":[198],"associated":[201],"event":[205],"or":[206],"survival.":[208],"CpG":[212],"(cg21926276,":[214],"cg27042065":[215],"cg26387355)":[217],"not":[219],"reported,":[221],"newly":[224],"identified":[225],"as":[226],"potential":[228],"novel":[229],"linking":[232],"patients.":[239],"Collectively,":[240],"has":[247],"mediator":[251],"selection":[252],"effect":[255],"estimation.":[256]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":8},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":10}],"updated_date":"2026-03-27T05:58:40.876381","created_date":"2025-10-10T00:00:00"}
