{"id":"https://openalex.org/W2460375631","doi":"https://doi.org/10.1371/journal.pcbi.1004968","title":"Electrophysiology of Heart Failure Using a Rabbit Model: From the Failing Myocyte to Ventricular Fibrillation","display_name":"Electrophysiology of Heart Failure Using a Rabbit Model: From the Failing Myocyte to Ventricular Fibrillation","publication_year":2016,"publication_date":"2016-06-23","ids":{"openalex":"https://openalex.org/W2460375631","doi":"https://doi.org/10.1371/journal.pcbi.1004968","mag":"2460375631","pmid":"https://pubmed.ncbi.nlm.nih.gov/27336310"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1004968","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1004968","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004968&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004968&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068367178","display_name":"Aditya V. S. Ponnaluri","orcid":null},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aditya V. S. Ponnaluri","raw_affiliation_strings":["Department of Mechanical and Aerospace Engineering, University of California Los Angeles, Los Angeles, California, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Mechanical and Aerospace Engineering, University of California Los Angeles, Los Angeles, California, United States of America","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022700306","display_name":"Luigi E. Perotti","orcid":"https://orcid.org/0000-0002-9010-2144"},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Luigi E. Perotti","raw_affiliation_strings":["Department of Radiological Sciences and Department of Bioengineering, University of California Los Angeles, Los Angeles, California, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Radiological Sciences and Department of Bioengineering, University of California Los Angeles, Los Angeles, California, United States of America","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100333906","display_name":"Michael Liu","orcid":"https://orcid.org/0000-0001-8860-0251"},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael Liu","raw_affiliation_strings":["Department of Medicine - Division of Cardiology, University of California Los Angeles, Los Angeles, California, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Medicine - Division of Cardiology, University of California Los Angeles, Los Angeles, California, United States of America","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051699207","display_name":"Zhilin Qu","orcid":"https://orcid.org/0000-0001-5217-6022"},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhilin Qu","raw_affiliation_strings":["Department of Medicine - Division of Cardiology, University of California Los Angeles, Los Angeles, California, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Medicine - Division of Cardiology, University of California Los Angeles, Los Angeles, California, United States of America","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009561014","display_name":"James N. Weiss","orcid":"https://orcid.org/0000-0002-8622-6427"},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James N. Weiss","raw_affiliation_strings":["Department of Medicine - Division of Cardiology, University of California Los Angeles, Los Angeles, California, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Medicine - Division of Cardiology, University of California Los Angeles, Los Angeles, California, United States of America","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083732002","display_name":"Daniel B. Ennis","orcid":"https://orcid.org/0000-0001-7435-1311"},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel B. Ennis","raw_affiliation_strings":["Department of Radiological Sciences and Department of Bioengineering, University of California Los Angeles, Los Angeles, California, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Radiological Sciences and Department of Bioengineering, University of California Los Angeles, Los Angeles, California, United States of America","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027146833","display_name":"William S. Klug","orcid":null},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William S. Klug","raw_affiliation_strings":["Department of Mechanical and Aerospace Engineering, University of California Los Angeles, Los Angeles, California, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Mechanical and Aerospace Engineering, University of California Los Angeles, Los Angeles, California, United States of America","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033787067","display_name":"Alan Garfinkel","orcid":"https://orcid.org/0000-0002-0500-3740"},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Alan Garfinkel","raw_affiliation_strings":["Department of Integrative Biology and Physiology, University of California Los Angeles, Los Angeles, California, United States of America","Department of Medicine - Division of Cardiology, University of California Los Angeles, Los Angeles, California, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Integrative Biology and Physiology, University of California Los Angeles, Los Angeles, California, United States of America","institution_ids":["https://openalex.org/I161318765"]},{"raw_affiliation_string":"Department of Medicine - Division of Cardiology, University of California Los Angeles, Los Angeles, California, United States of America","institution_ids":["https://openalex.org/I161318765"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5033787067"],"corresponding_institution_ids":["https://openalex.org/I161318765"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.9799,"has_fulltext":true,"cited_by_count":22,"citation_normalized_percentile":{"value":0.87551856,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"12","issue":"6","first_page":"e1004968","last_page":"e1004968"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10217","display_name":"Cardiac electrophysiology and arrhythmias","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11601","display_name":"Neuroscience and Neural Engineering","score":0.9952999949455261,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9918000102043152,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heart-failure","display_name":"Heart failure","score":0.8408757448196411},{"id":"https://openalex.org/keywords/cardiology","display_name":"Cardiology","score":0.7204465866088867},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.6663131713867188},{"id":"https://openalex.org/keywords/electrophysiology","display_name":"Electrophysiology","score":0.6186378002166748},{"id":"https://openalex.org/keywords/qrs-complex","display_name":"QRS complex","score":0.5791189670562744},{"id":"https://openalex.org/keywords/repolarization","display_name":"Repolarization","score":0.5542482733726501},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.5299649834632874},{"id":"https://openalex.org/keywords/cardiac-electrophysiology","display_name":"Cardiac electrophysiology","score":0.5264502167701721},{"id":"https://openalex.org/keywords/optical-mapping","display_name":"Optical mapping","score":0.518193781375885},{"id":"https://openalex.org/keywords/fibrillation","display_name":"Fibrillation","score":0.5051470398902893},{"id":"https://openalex.org/keywords/connexin","display_name":"Connexin","score":0.4986307621002197},{"id":"https://openalex.org/keywords/ventricular-fibrillation","display_name":"Ventricular fibrillation","score":0.44863858819007874},{"id":"https://openalex.org/keywords/nerve-conduction-velocity","display_name":"Nerve conduction velocity","score":0.41688936948776245},{"id":"https://openalex.org/keywords/gap-junction","display_name":"Gap junction","score":0.40027812123298645},{"id":"https://openalex.org/keywords/atrial-fibrillation","display_name":"Atrial fibrillation","score":0.3820817768573761},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.1812443733215332}],"concepts":[{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.8408757448196411},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.7204465866088867},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6663131713867188},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.6186378002166748},{"id":"https://openalex.org/C111773187","wikidata":"https://www.wikidata.org/wiki/Q1969239","display_name":"QRS complex","level":2,"score":0.5791189670562744},{"id":"https://openalex.org/C146403970","wikidata":"https://www.wikidata.org/wiki/Q205729","display_name":"Repolarization","level":3,"score":0.5542482733726501},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5299649834632874},{"id":"https://openalex.org/C61381695","wikidata":"https://www.wikidata.org/wiki/Q3302130","display_name":"Cardiac electrophysiology","level":3,"score":0.5264502167701721},{"id":"https://openalex.org/C28289500","wikidata":"https://www.wikidata.org/wiki/Q7098868","display_name":"Optical mapping","level":2,"score":0.518193781375885},{"id":"https://openalex.org/C2777356233","wikidata":"https://www.wikidata.org/wiki/Q1001150","display_name":"Fibrillation","level":3,"score":0.5051470398902893},{"id":"https://openalex.org/C2780228694","wikidata":"https://www.wikidata.org/wiki/Q423489","display_name":"Connexin","level":4,"score":0.4986307621002197},{"id":"https://openalex.org/C2781005686","wikidata":"https://www.wikidata.org/wiki/Q848662","display_name":"Ventricular fibrillation","level":2,"score":0.44863858819007874},{"id":"https://openalex.org/C179253579","wikidata":"https://www.wikidata.org/wiki/Q6276958","display_name":"Nerve conduction velocity","level":2,"score":0.41688936948776245},{"id":"https://openalex.org/C158157758","wikidata":"https://www.wikidata.org/wiki/Q232438","display_name":"Gap junction","level":3,"score":0.40027812123298645},{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.3820817768573761},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.1812443733215332},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006329","descriptor_name":"Heart Conduction System","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006329","descriptor_name":"Heart Conduction System","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006329","descriptor_name":"Heart Conduction System","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006329","descriptor_name":"Heart Conduction System","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008955","descriptor_name":"Models, Cardiovascular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014693","descriptor_name":"Ventricular Fibrillation","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D014693","descriptor_name":"Ventricular Fibrillation","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D014693","descriptor_name":"Ventricular Fibrillation","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D014693","descriptor_name":"Ventricular Fibrillation","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D055724","descriptor_name":"Electrophysiological Phenomena","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D055724","descriptor_name":"Electrophysiological Phenomena","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D055724","descriptor_name":"Electrophysiological Phenomena","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D055724","descriptor_name":"Electrophysiological Phenomena","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1004968","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1004968","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004968&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:27336310","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/27336310","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:RePEc:plo:pcbi00:1004968","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1004968","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:f215a631c14e4539a9d2a107fa41b34e","is_oa":true,"landing_page_url":"https://doaj.org/article/f215a631c14e4539a9d2a107fa41b34e","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 12, Iss 6, p e1004968 (2016)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:3903695","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4919062","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/3927078","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Electrophysiology_of_Heart_Failure_Using_a_Rabbit_Model_From_the_Failing_Myocyte_to_Ventricular_Fibrillation/3927078","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1004968","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1004968","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004968&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8700000047683716,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G344179415","display_name":null,"funder_award_id":"14POST19890027","funder_id":"https://openalex.org/F4320306230","funder_display_name":"American Heart Association"},{"id":"https://openalex.org/G583259481","display_name":null,"funder_award_id":"P01 HL78931","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2460375631.pdf","grobid_xml":"https://content.openalex.org/works/W2460375631.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W1495686042","https://openalex.org/W1597781658","https://openalex.org/W1660719507","https://openalex.org/W1850486727","https://openalex.org/W1914803846","https://openalex.org/W1989538619","https://openalex.org/W1991781357","https://openalex.org/W1998337984","https://openalex.org/W1999195342","https://openalex.org/W2009537432","https://openalex.org/W2010261299","https://openalex.org/W2042998312","https://openalex.org/W2043276871","https://openalex.org/W2047309639","https://openalex.org/W2058903192","https://openalex.org/W2059976733","https://openalex.org/W2072142813","https://openalex.org/W2077129671","https://openalex.org/W2077590638","https://openalex.org/W2084265884","https://openalex.org/W2085591768","https://openalex.org/W2098044063","https://openalex.org/W2102489764","https://openalex.org/W2106351593","https://openalex.org/W2110019686","https://openalex.org/W2112522502","https://openalex.org/W2113979526","https://openalex.org/W2115928923","https://openalex.org/W2117689702","https://openalex.org/W2127926880","https://openalex.org/W2130137227","https://openalex.org/W2131295262","https://openalex.org/W2133082972","https://openalex.org/W2134426004","https://openalex.org/W2139351974","https://openalex.org/W2142432219","https://openalex.org/W2143421921","https://openalex.org/W2143679973","https://openalex.org/W2144975424","https://openalex.org/W2146053060","https://openalex.org/W2156291625","https://openalex.org/W2162228881","https://openalex.org/W2162834159","https://openalex.org/W2163511605","https://openalex.org/W2167525963","https://openalex.org/W2171077730","https://openalex.org/W2210629408","https://openalex.org/W2255703453","https://openalex.org/W2918005975","https://openalex.org/W3150383941","https://openalex.org/W3176319765","https://openalex.org/W6797678356"],"related_works":["https://openalex.org/W4386255712","https://openalex.org/W2018592912","https://openalex.org/W2593616078","https://openalex.org/W3203549897","https://openalex.org/W4220658095","https://openalex.org/W2031070609","https://openalex.org/W4385988880","https://openalex.org/W2506298170","https://openalex.org/W4205981914","https://openalex.org/W2010452265"],"abstract_inverted_index":{"Heart":[0],"failure":[1,32,45,67,143,174],"is":[2,47,212,297],"a":[3,23,28,51,57,259,301,315],"leading":[4],"cause":[5],"of":[6,30,39,100,114,141,156,172,227,249,257,303],"death,":[7],"yet":[8],"its":[9,35],"underlying":[10],"electrophysiological":[11],"(EP)":[12],"mechanisms":[13],"are":[14],"not":[15,252,298],"well":[16],"understood.":[17],"In":[18],"this":[19],"study,":[20],"we":[21,69,86,107,146],"use":[22],"multiscale":[24],"approach":[25],"to":[26,37,98,168,282,300,314],"analyze":[27],"model":[29,46,55,122,164],"heart":[31,44,66,142,173,192,200],"and":[33,79,93,111,133,137,158,190,240,273,285],"connect":[34],"results":[36],"features":[38],"the":[40,65,71,83,88,104,109,128,148,170,188,198,217,231,243,247,264,271,278,291,304],"electrocardiogram":[41],"(ECG).":[42],"The":[43,119,161,267],"derived":[48],"by":[49,74,126],"modifying":[50],"previously":[52],"validated":[53,125,162],"electrophysiology":[54],"for":[56],"healthy":[58,157],"rabbit":[59,180],"heart.":[60,219,233,245],"Specifically,":[61],"in":[62,152,175,216,230,242,294,309],"accordance":[63],"with":[64,254],"literature,":[68],"modified":[70],"cell":[72,121,163,272],"EP":[73,171],"changing":[75],"both":[76,187],"membrane":[77],"currents":[78],"calcium":[80,135],"handling.":[81],"At":[82,103,220],"tissue":[84,274],"level,":[85,106],"modeled":[87],"increased":[89,277],"gap":[90],"junction":[91],"lateralization":[92],"lower":[94,134],"conduction":[95,228],"velocity":[96],"due":[97,299],"downregulation":[99],"Connexin":[101],"43.":[102],"biventricular":[105,179],"reduced":[108],"apex-to-base":[110],"transmural":[112],"gradients":[113],"action":[115,130],"potential":[116,260,296],"duration":[117],"(APD).":[118],"failing":[120,159,191,199,218,232,244,279],"was":[123,165,251],"first":[124],"reproducing":[127],"longer":[129],"potential,":[131],"slower":[132],"transient,":[136],"earlier":[138],"alternans":[139,203,211],"characteristic":[140],"EP.":[144],"Subsequently,":[145],"compared":[147],"electrical":[149],"wave":[150,238],"propagation":[151],"one":[153],"dimensional":[154],"cables":[155],"cells.":[160],"then":[166],"used":[167],"simulate":[169],"an":[176,255],"anatomically":[177],"accurate":[178],"model.":[181],"As":[182],"pacing":[183,236],"cycle":[184],"length":[185],"decreases,":[186],"normal":[189],"develop":[193],"T-wave":[194,210],"alternans,":[195],"but":[196,312],"only":[197],"shows":[201],"QRS":[202],"(although":[204],"moderate)":[205],"at":[206,270],"rapid":[207,221,288],"pacing.":[208,289],"Moreover,":[209],"significantly":[213],"more":[214],"pronounced":[215],"pacing,":[222],"APD":[223],"maps":[224],"show":[225],"areas":[226],"block":[229],"Finally,":[234],"accelerated":[235],"initiated":[237],"reentry":[239],"breakup":[241],"Further,":[246],"onset":[248],"VF":[250],"observed":[253,292],"upregulation":[256],"SERCA,":[258],"drug":[261],"therapy,":[262],"using":[263],"same":[265],"protocol.":[266],"changes":[268],"introduced":[269],"level":[275],"have":[276],"heart's":[280],"susceptibility":[281],"dynamic":[283],"instabilities":[284],"arrhythmias":[286],"under":[287],"However,":[290],"increase":[293],"arrhythmogenic":[295],"steepening":[302],"restitution":[305],"curve":[306],"(not":[307],"present":[308],"our":[310],"model),":[311],"rather":[313],"novel":[316],"blocking":[317],"mechanism.":[318]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1}],"updated_date":"2026-01-13T01:12:25.745995","created_date":"2025-10-10T00:00:00"}