{"id":"https://openalex.org/W1879820513","doi":"https://doi.org/10.1371/journal.pcbi.1004398","title":"An Integrated Framework Advancing Membrane Protein Modeling and Design","display_name":"An Integrated Framework Advancing Membrane Protein Modeling and Design","publication_year":2015,"publication_date":"2015-09-01","ids":{"openalex":"https://openalex.org/W1879820513","doi":"https://doi.org/10.1371/journal.pcbi.1004398","mag":"1879820513","pmid":"https://pubmed.ncbi.nlm.nih.gov/26325167"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1004398","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1004398","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004398&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004398&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5040720163","display_name":"Rebecca F. Alford","orcid":"https://orcid.org/0000-0003-0306-8476"},"institutions":[{"id":"https://openalex.org/I74973139","display_name":"Carnegie Mellon University","ror":"https://ror.org/05x2bcf33","country_code":"US","type":"education","lineage":["https://openalex.org/I74973139"]},{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rebecca F. Alford","raw_affiliation_strings":["Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, Maryland, United States of America; Department of Chemistry, Carnegie Mellon University, Pittsburgh, Pennsylvania, United States of America","Department of Chemistry, Carnegie Mellon University, Pittsburgh, Pennsylvania, United States of America","Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, Maryland, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, Maryland, United States of America; Department of Chemistry, Carnegie Mellon University, Pittsburgh, Pennsylvania, United States of America","institution_ids":[]},{"raw_affiliation_string":"Department of Chemistry, Carnegie Mellon University, Pittsburgh, Pennsylvania, United States of America","institution_ids":["https://openalex.org/I74973139"]},{"raw_affiliation_string":"Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, Maryland, United States of America","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006314973","display_name":"Julia Koehler Leman","orcid":"https://orcid.org/0000-0002-5693-3593"},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julia Koehler Leman","raw_affiliation_strings":["Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, Maryland, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, Maryland, United States of America","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068514328","display_name":"Brian D. Weitzner","orcid":"https://orcid.org/0000-0002-1909-0961"},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian D. Weitzner","raw_affiliation_strings":["Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, Maryland, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, Maryland, United States of America","institution_ids":["https://openalex.org/I145311948"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048269783","display_name":"Amanda M. Duran","orcid":"https://orcid.org/0000-0003-2305-1049"},"institutions":[{"id":"https://openalex.org/I200719446","display_name":"Vanderbilt University","ror":"https://ror.org/02vm5rt34","country_code":"US","type":"education","lineage":["https://openalex.org/I200719446"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Amanda M. Duran","raw_affiliation_strings":["Center for Structural Biology, Department of Chemistry, Vanderbilt University, Nashville, Tennessee, United States of America"],"affiliations":[{"raw_affiliation_string":"Center for Structural Biology, Department of Chemistry, Vanderbilt University, Nashville, Tennessee, United States of America","institution_ids":["https://openalex.org/I200719446"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5069278741","display_name":"Drew C. Tilley","orcid":"https://orcid.org/0000-0002-5616-2661"},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Drew C. Tilley","raw_affiliation_strings":["Department of Physiology and Membrane Biology, University of California, Davis, Davis, California, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Physiology and Membrane Biology, University of California, Davis, Davis, California, United States of America","institution_ids":["https://openalex.org/I84218800"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075658127","display_name":"Assaf Elazar","orcid":"https://orcid.org/0000-0002-5281-0908"},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Assaf Elazar","raw_affiliation_strings":["Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel"],"affiliations":[{"raw_affiliation_string":"Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel","institution_ids":["https://openalex.org/I53964585"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5009383312","display_name":"Jeffrey J. Gray","orcid":"https://orcid.org/0000-0001-6380-2324"},"institutions":[{"id":"https://openalex.org/I145311948","display_name":"Johns Hopkins University","ror":"https://ror.org/00za53h95","country_code":"US","type":"education","lineage":["https://openalex.org/I145311948"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jeffrey J. Gray","raw_affiliation_strings":["Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, Maryland, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Chemical and Biomolecular Engineering, Johns Hopkins University, Baltimore, Maryland, United States of America","institution_ids":["https://openalex.org/I145311948"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5009383312"],"corresponding_institution_ids":["https://openalex.org/I145311948"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":5.5836,"has_fulltext":true,"cited_by_count":184,"citation_normalized_percentile":{"value":0.9657341,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":100},"biblio":{"volume":"11","issue":"9","first_page":"e1004398","last_page":"e1004398"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.57057785987854},{"id":"https://openalex.org/keywords/membrane-protein","display_name":"Membrane protein","score":0.5267407298088074},{"id":"https://openalex.org/keywords/protein-structure-prediction","display_name":"Protein structure prediction","score":0.5190311670303345},{"id":"https://openalex.org/keywords/protein-design","display_name":"Protein design","score":0.5150184631347656},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.45387449860572815},{"id":"https://openalex.org/keywords/protein-structure","display_name":"Protein structure","score":0.4432043135166168},{"id":"https://openalex.org/keywords/representation","display_name":"Representation (politics)","score":0.43045875430107117},{"id":"https://openalex.org/keywords/structural-biology","display_name":"Structural biology","score":0.4299051761627197},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3373497724533081},{"id":"https://openalex.org/keywords/membrane","display_name":"Membrane","score":0.25538575649261475},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.22231867909431458},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.13069704174995422}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.57057785987854},{"id":"https://openalex.org/C144647389","wikidata":"https://www.wikidata.org/wiki/Q423042","display_name":"Membrane protein","level":3,"score":0.5267407298088074},{"id":"https://openalex.org/C18051474","wikidata":"https://www.wikidata.org/wiki/Q899656","display_name":"Protein structure prediction","level":3,"score":0.5190311670303345},{"id":"https://openalex.org/C152769699","wikidata":"https://www.wikidata.org/wiki/Q410814","display_name":"Protein design","level":3,"score":0.5150184631347656},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.45387449860572815},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.4432043135166168},{"id":"https://openalex.org/C2776359362","wikidata":"https://www.wikidata.org/wiki/Q2145286","display_name":"Representation (politics)","level":3,"score":0.43045875430107117},{"id":"https://openalex.org/C191120209","wikidata":"https://www.wikidata.org/wiki/Q908902","display_name":"Structural biology","level":2,"score":0.4299051761627197},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3373497724533081},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.25538575649261475},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22231867909431458},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13069704174995422},{"id":"https://openalex.org/C17744445","wikidata":"https://www.wikidata.org/wiki/Q36442","display_name":"Political science","level":0,"score":0.0},{"id":"https://openalex.org/C94625758","wikidata":"https://www.wikidata.org/wiki/Q7163","display_name":"Politics","level":2,"score":0.0},{"id":"https://openalex.org/C199539241","wikidata":"https://www.wikidata.org/wiki/Q7748","display_name":"Law","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015202","descriptor_name":"Protein Engineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D015202","descriptor_name":"Protein Engineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D015202","descriptor_name":"Protein Engineering","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1004398","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1004398","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004398&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:26325167","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26325167","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:45cd5c8bb06d426491edd64a873144c7","is_oa":true,"landing_page_url":"https://doaj.org/article/45cd5c8bb06d426491edd64a873144c7","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 11, Iss 9, p e1004398 (2015)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:3541542","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4556676","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/1532727","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/_An_Integrated_Framework_Advancing_Membrane_Protein_Modeling_and_Design_/1532727","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1004398","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1004398","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1004398&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G8288036582","display_name":null,"funder_award_id":"NIH R01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1879820513.pdf","grobid_xml":"https://content.openalex.org/works/W1879820513.grobid-xml"},"referenced_works_count":86,"referenced_works":["https://openalex.org/W255996521","https://openalex.org/W1495306623","https://openalex.org/W1540308607","https://openalex.org/W1548178570","https://openalex.org/W1605284188","https://openalex.org/W1968682237","https://openalex.org/W1974312616","https://openalex.org/W1977214956","https://openalex.org/W1982583124","https://openalex.org/W1990122271","https://openalex.org/W1996478334","https://openalex.org/W1999102577","https://openalex.org/W1999648327","https://openalex.org/W2000443388","https://openalex.org/W2001708863","https://openalex.org/W2005578523","https://openalex.org/W2013425283","https://openalex.org/W2015279104","https://openalex.org/W2019215286","https://openalex.org/W2020469935","https://openalex.org/W2030119097","https://openalex.org/W2032919961","https://openalex.org/W2034736596","https://openalex.org/W2035503835","https://openalex.org/W2035571517","https://openalex.org/W2037312364","https://openalex.org/W2039246561","https://openalex.org/W2043284163","https://openalex.org/W2045732940","https://openalex.org/W2046785470","https://openalex.org/W2049357350","https://openalex.org/W2054467356","https://openalex.org/W2059551149","https://openalex.org/W2060055736","https://openalex.org/W2074713036","https://openalex.org/W2077178410","https://openalex.org/W2078705445","https://openalex.org/W2080850697","https://openalex.org/W2082351355","https://openalex.org/W2083412408","https://openalex.org/W2084246486","https://openalex.org/W2084493621","https://openalex.org/W2088945858","https://openalex.org/W2091038315","https://openalex.org/W2092705888","https://openalex.org/W2097775366","https://openalex.org/W2101810621","https://openalex.org/W2101934167","https://openalex.org/W2105537627","https://openalex.org/W2107520340","https://openalex.org/W2110434926","https://openalex.org/W2111387452","https://openalex.org/W2112846165","https://openalex.org/W2125872855","https://openalex.org/W2127268158","https://openalex.org/W2129414710","https://openalex.org/W2130479394","https://openalex.org/W2132820240","https://openalex.org/W2134059200","https://openalex.org/W2137827030","https://openalex.org/W2139447922","https://openalex.org/W2139754669","https://openalex.org/W2140831051","https://openalex.org/W2141216359","https://openalex.org/W2143632667","https://openalex.org/W2147691794","https://openalex.org/W2150192011","https://openalex.org/W2151156268","https://openalex.org/W2151322913","https://openalex.org/W2151363352","https://openalex.org/W2151581834","https://openalex.org/W2153457180","https://openalex.org/W2153654642","https://openalex.org/W2154882487","https://openalex.org/W2155201844","https://openalex.org/W2155839962","https://openalex.org/W2160983910","https://openalex.org/W2162274915","https://openalex.org/W2164437435","https://openalex.org/W2166701319","https://openalex.org/W2168282547","https://openalex.org/W2170670602","https://openalex.org/W2201713963","https://openalex.org/W2259375290","https://openalex.org/W2331714967","https://openalex.org/W2385691987"],"related_works":["https://openalex.org/W2946599741","https://openalex.org/W2095673458","https://openalex.org/W2368468053","https://openalex.org/W4387310732","https://openalex.org/W1564749278","https://openalex.org/W3216044760","https://openalex.org/W2013950502","https://openalex.org/W2402250173","https://openalex.org/W2607853144","https://openalex.org/W2171208795"],"abstract_inverted_index":{"Membrane":[0],"proteins":[1],"are":[2,44],"critical":[3],"functional":[4],"molecules":[5],"in":[6,18,27,63,157],"the":[7,19,79,87,123,158,187,191,195,201],"human":[8,20],"body,":[9],"constituting":[10],"more":[11],"than":[12],"30%":[13],"of":[14,25,56,91,125,136,152,193,198,203],"open":[15],"reading":[16],"frames":[17],"genome.":[21],"Unfortunately,":[22],"a":[23,68,99],"myriad":[24],"difficulties":[26],"overexpression":[28],"and":[29,60,75,109,149,171,183,211],"reconstitution":[30],"into":[31],"membrane":[32,48,57,72,83,101,159,208],"mimetics":[33],"severely":[34],"limit":[35],"our":[36,54],"ability":[37],"to":[38,47,117,179,206],"determine":[39],"their":[40,61],"structures.":[41,172],"Computational":[42],"tools":[43],"therefore":[45],"instrumental":[46],"protein":[49,58,73,84,154,209],"structure":[50],"prediction,":[51],"consequently":[52],"increasing":[53],"understanding":[55],"function":[59],"role":[62],"disease.":[64],"Here,":[65],"we":[66,128],"describe":[67],"general":[69,100],"framework":[70],"facilitating":[71],"modeling":[74,85,210],"design":[76],"that":[77,103,112,164],"combines":[78],"scientific":[80],"principles":[81],"for":[82,133],"with":[86,105,200],"flexible":[88,196],"software":[89],"architecture":[90],"Rosetta3.":[92],"This":[93],"new":[94,119],"framework,":[95],"called":[96],"RosettaMP,":[97],"provides":[98],"representation":[102],"interfaces":[104],"scoring,":[106],"conformational":[107],"sampling,":[108],"mutation":[110],"routines":[111,182],"can":[113,167],"be":[114],"easily":[115],"combined":[116],"create":[118],"protocols.":[120],"To":[121],"demonstrate":[122,190],"capabilities":[124],"this":[126],"implementation,":[127],"developed":[129],"four":[130],"proof-of-concept":[131],"applications":[132,188],"(1)":[134],"prediction":[135],"free":[137],"energy":[138],"changes":[139],"upon":[140],"mutation;":[141],"(2)":[142],"high-resolution":[143],"structural":[144],"refinement;":[145],"(3)":[146],"protein-protein":[147],"docking;":[148],"(4)":[150],"assembly":[151],"symmetric":[153],"complexes,":[155],"all":[156],"environment.":[160],"Preliminary":[161],"data":[162,174],"show":[163],"these":[165],"algorithms":[166,205],"produce":[168],"meaningful":[169],"scores":[170],"The":[173],"also":[175],"suggest":[176],"needed":[177],"improvements":[178],"both":[180],"sampling":[181],"score":[184],"functions.":[185],"Importantly,":[186],"collectively":[189],"potential":[192],"combining":[194],"nature":[197],"RosettaMP":[199],"power":[202],"Rosetta":[204],"facilitate":[207],"design.":[212]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":17},{"year":2023,"cited_by_count":19},{"year":2022,"cited_by_count":17},{"year":2021,"cited_by_count":36},{"year":2020,"cited_by_count":25},{"year":2019,"cited_by_count":24},{"year":2018,"cited_by_count":14},{"year":2017,"cited_by_count":13},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":1}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}