{"id":"https://openalex.org/W2091892056","doi":"https://doi.org/10.1371/journal.pcbi.1003899","title":"Immuno-epidemiological Modeling of HIV-1 Predicts High Heritability of the Set-Point Virus Load, while Selection for CTL Escape Dominates Virulence Evolution","display_name":"Immuno-epidemiological Modeling of HIV-1 Predicts High Heritability of the Set-Point Virus Load, while Selection for CTL Escape Dominates Virulence Evolution","publication_year":2014,"publication_date":"2014-12-18","ids":{"openalex":"https://openalex.org/W2091892056","doi":"https://doi.org/10.1371/journal.pcbi.1003899","mag":"2091892056","pmid":"https://pubmed.ncbi.nlm.nih.gov/25522184"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1003899","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003899","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003899&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003899&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023400595","display_name":"Christiaan H. van Dorp","orcid":"https://orcid.org/0000-0002-7504-9947"},"institutions":[{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]},{"id":"https://openalex.org/I4210104433","display_name":"National Institute for Public Health and the Environment","ror":"https://ror.org/01cesdt21","country_code":"NL","type":"facility","lineage":["https://openalex.org/I4210104433"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Christiaan H. van Dorp","raw_affiliation_strings":["Theoretical Biology and Bioinformatics, Universiteit Utrecht, Utrecht, The Netherlands; National Institute for Public Health and the Environment, Bilthoven, The Netherlands","National Institute for Public Health and the Environment, Bilthoven, The Netherlands","Theoretical Biology and Bioinformatics, Universiteit Utrecht, Utrecht, The Netherlands"],"affiliations":[{"raw_affiliation_string":"Theoretical Biology and Bioinformatics, Universiteit Utrecht, Utrecht, The Netherlands; National Institute for Public Health and the Environment, Bilthoven, The Netherlands","institution_ids":[]},{"raw_affiliation_string":"National Institute for Public Health and the Environment, Bilthoven, The Netherlands","institution_ids":["https://openalex.org/I4210104433"]},{"raw_affiliation_string":"Theoretical Biology and Bioinformatics, Universiteit Utrecht, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I193662353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066880216","display_name":"Michiel van Boven","orcid":"https://orcid.org/0000-0002-0841-2400"},"institutions":[{"id":"https://openalex.org/I4210104433","display_name":"National Institute for Public Health and the Environment","ror":"https://ror.org/01cesdt21","country_code":"NL","type":"facility","lineage":["https://openalex.org/I4210104433"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Michiel van Boven","raw_affiliation_strings":["National Institute for Public Health and the Environment, Bilthoven, The Netherlands"],"affiliations":[{"raw_affiliation_string":"National Institute for Public Health and the Environment, Bilthoven, The Netherlands","institution_ids":["https://openalex.org/I4210104433"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5053694044","display_name":"Rob J. de Boer","orcid":"https://orcid.org/0000-0002-2130-691X"},"institutions":[{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Rob J. de Boer","raw_affiliation_strings":["Theoretical Biology and Bioinformatics, Universiteit Utrecht, Utrecht, The Netherlands"],"affiliations":[{"raw_affiliation_string":"Theoretical Biology and Bioinformatics, Universiteit Utrecht, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I193662353"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5023400595"],"corresponding_institution_ids":["https://openalex.org/I193662353","https://openalex.org/I4210104433"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":2.1236,"has_fulltext":true,"cited_by_count":37,"citation_normalized_percentile":{"value":0.87659574,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"10","issue":"12","first_page":"e1003899","last_page":"e1003899"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10482","display_name":"Mathematical and Theoretical Epidemiology and Ecology Models","score":0.9947999715805054,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/heritability","display_name":"Heritability","score":0.7900879383087158},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.7193660736083984},{"id":"https://openalex.org/keywords/viral-evolution","display_name":"Viral evolution","score":0.6617459058761597},{"id":"https://openalex.org/keywords/transmission","display_name":"Transmission (telecommunications)","score":0.6296340227127075},{"id":"https://openalex.org/keywords/host","display_name":"Host (biology)","score":0.6160812973976135},{"id":"https://openalex.org/keywords/selection","display_name":"Selection (genetic algorithm)","score":0.6012195348739624},{"id":"https://openalex.org/keywords/virus","display_name":"Virus","score":0.5043736696243286},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.45956116914749146},{"id":"https://openalex.org/keywords/adaptation","display_name":"Adaptation (eye)","score":0.4576702117919922},{"id":"https://openalex.org/keywords/immune-system","display_name":"Immune system","score":0.43121927976608276},{"id":"https://openalex.org/keywords/evolutionary-biology","display_name":"Evolutionary biology","score":0.4311111867427826},{"id":"https://openalex.org/keywords/virology","display_name":"Virology","score":0.39401331543922424},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.38022059202194214},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.17525354027748108},{"id":"https://openalex.org/keywords/demography","display_name":"Demography","score":0.16031262278556824}],"concepts":[{"id":"https://openalex.org/C161890455","wikidata":"https://www.wikidata.org/wiki/Q1503548","display_name":"Heritability","level":2,"score":0.7900879383087158},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7193660736083984},{"id":"https://openalex.org/C8769409","wikidata":"https://www.wikidata.org/wiki/Q2066554","display_name":"Viral evolution","level":4,"score":0.6617459058761597},{"id":"https://openalex.org/C761482","wikidata":"https://www.wikidata.org/wiki/Q118093","display_name":"Transmission (telecommunications)","level":2,"score":0.6296340227127075},{"id":"https://openalex.org/C126831891","wikidata":"https://www.wikidata.org/wiki/Q221673","display_name":"Host (biology)","level":2,"score":0.6160812973976135},{"id":"https://openalex.org/C81917197","wikidata":"https://www.wikidata.org/wiki/Q628760","display_name":"Selection (genetic algorithm)","level":2,"score":0.6012195348739624},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.5043736696243286},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.45956116914749146},{"id":"https://openalex.org/C139807058","wikidata":"https://www.wikidata.org/wiki/Q352374","display_name":"Adaptation (eye)","level":2,"score":0.4576702117919922},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.43121927976608276},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.4311111867427826},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.39401331543922424},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.38022059202194214},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.17525354027748108},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.16031262278556824},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.0},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013602","descriptor_name":"T-Lymphocytes, Cytotoxic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013602","descriptor_name":"T-Lymphocytes, Cytotoxic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013602","descriptor_name":"T-Lymphocytes, Cytotoxic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":true},{"descriptor_ui":"D018448","descriptor_name":"Models, Immunological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018448","descriptor_name":"Models, Immunological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018448","descriptor_name":"Models, Immunological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019562","descriptor_name":"Viral Load","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D019562","descriptor_name":"Viral Load","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D019562","descriptor_name":"Viral Load","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D057131","descriptor_name":"Immune Evasion","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D057131","descriptor_name":"Immune Evasion","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D057131","descriptor_name":"Immune Evasion","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D057131","descriptor_name":"Immune Evasion","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D057131","descriptor_name":"Immune Evasion","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D057131","descriptor_name":"Immune Evasion","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1003899","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003899","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003899&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:25522184","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25522184","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:efae74bcb4534e9ebe3869e9988cc886","is_oa":true,"landing_page_url":"https://doaj.org/article/efae74bcb4534e9ebe3869e9988cc886","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 10, Iss 12, p e1003899 (2014)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:3241866","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4270429","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:rivm.openrepository.com:10029/647950","is_oa":false,"landing_page_url":"https://rivm.openrepository.com/handle/10029/647950","pdf_url":null,"source":{"id":"https://openalex.org/S4306401681","display_name":"Rivm (National Institute for Public Health and the Environment)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210104433","host_organization_name":"National Institute for Public Health and the Environment","host_organization_lineage":["https://openalex.org/I4210104433"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1003899","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003899","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003899&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.8500000238418579}],"awards":[{"id":"https://openalex.org/G7703678402","display_name":null,"funder_award_id":"www.nwo.nl","funder_id":"https://openalex.org/F4320321800","funder_display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek"},{"id":"https://openalex.org/G7988532870","display_name":null,"funder_award_id":"645.000.002","funder_id":"https://openalex.org/F4320321800","funder_display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek"}],"funders":[{"id":"https://openalex.org/F4320321800","display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","ror":"https://ror.org/04jsz6e67"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2091892056.pdf","grobid_xml":"https://content.openalex.org/works/W2091892056.grobid-xml"},"referenced_works_count":77,"referenced_works":["https://openalex.org/W16380243","https://openalex.org/W755194005","https://openalex.org/W1565963867","https://openalex.org/W1709821438","https://openalex.org/W1913957972","https://openalex.org/W1967714946","https://openalex.org/W1970963975","https://openalex.org/W1987891234","https://openalex.org/W2005364009","https://openalex.org/W2007445829","https://openalex.org/W2009082439","https://openalex.org/W2009307527","https://openalex.org/W2009784575","https://openalex.org/W2010218635","https://openalex.org/W2010313660","https://openalex.org/W2013602955","https://openalex.org/W2019559865","https://openalex.org/W2027549739","https://openalex.org/W2031754540","https://openalex.org/W2032099305","https://openalex.org/W2041572706","https://openalex.org/W2041795471","https://openalex.org/W2042021579","https://openalex.org/W2053002571","https://openalex.org/W2053978116","https://openalex.org/W2057912460","https://openalex.org/W2059707355","https://openalex.org/W2063485002","https://openalex.org/W2069926681","https://openalex.org/W2070649137","https://openalex.org/W2073257790","https://openalex.org/W2073542555","https://openalex.org/W2076225720","https://openalex.org/W2087484510","https://openalex.org/W2088129901","https://openalex.org/W2092061701","https://openalex.org/W2095983332","https://openalex.org/W2099364824","https://openalex.org/W2102048184","https://openalex.org/W2104343332","https://openalex.org/W2105538746","https://openalex.org/W2105940076","https://openalex.org/W2109130469","https://openalex.org/W2112680994","https://openalex.org/W2117737648","https://openalex.org/W2118619556","https://openalex.org/W2121634437","https://openalex.org/W2121776332","https://openalex.org/W2121984564","https://openalex.org/W2123252019","https://openalex.org/W2123584222","https://openalex.org/W2124627199","https://openalex.org/W2124704961","https://openalex.org/W2124969212","https://openalex.org/W2125377484","https://openalex.org/W2128528264","https://openalex.org/W2141634782","https://openalex.org/W2143598835","https://openalex.org/W2144882745","https://openalex.org/W2147134928","https://openalex.org/W2148686896","https://openalex.org/W2150412603","https://openalex.org/W2152534166","https://openalex.org/W2152719039","https://openalex.org/W2153778605","https://openalex.org/W2154499327","https://openalex.org/W2160226661","https://openalex.org/W2163036286","https://openalex.org/W2163591597","https://openalex.org/W2167155055","https://openalex.org/W2168688111","https://openalex.org/W2168776079","https://openalex.org/W2169096262","https://openalex.org/W2169404894","https://openalex.org/W2171141994","https://openalex.org/W3102284001","https://openalex.org/W4233223652"],"related_works":["https://openalex.org/W2281560785","https://openalex.org/W3152090159","https://openalex.org/W2258846206","https://openalex.org/W2110808585","https://openalex.org/W2329094632","https://openalex.org/W1994153931","https://openalex.org/W2986565703","https://openalex.org/W45701117","https://openalex.org/W2116885251","https://openalex.org/W1565428981"],"abstract_inverted_index":{"It":[0],"has":[1,6,103],"been":[2,104],"suggested":[3],"that":[4,30,92,131],"HIV-1":[5,59],"evolved":[7],"its":[8],"set-point":[9,26,125],"virus":[10,27,126],"load":[11,28,127],"to":[12,55,101],"be":[13,136],"optimized":[14],"for":[15,63,116,124],"transmission.":[16,70,117],"Previous":[17],"epidemiological":[18],"models":[19,78],"and":[20,53,68,76,86,129],"studies":[21],"into":[22],"the":[23,36,43,56,94,139,148],"heritability":[24,133],"of":[25,33,46,50,83,96],"confirm":[29],"this":[31],"mode":[32],"adaptation":[34],"within":[35,110],"human":[37],"population":[38],"is":[39,60,99,112],"feasible.":[40],"However,":[41],"during":[42],"many":[44],"cycles":[45],"replication":[47],"between":[48],"infection":[49],"a":[51],"host":[52],"transmission":[54],"next":[57],"host,":[58],"under":[61],"selection":[62,109,115],"escape":[64,98],"from":[65],"immune":[66,97,108,145],"responses,":[67],"not":[69],"Here":[71],"we":[72,119],"investigate":[73],"with":[74],"computational":[75],"mathematical":[77],"how":[79],"these":[80],"two":[81],"levels":[82],"selection,":[84],"within-host":[85],"between-host,":[87],"are":[88],"intertwined.":[89],"We":[90],"find":[91,121],"when":[93],"rate":[95],"comparable":[100],"what":[102],"observed":[105],"in":[106],"patients,":[107],"hosts":[111],"dominant":[113],"over":[114],"Surprisingly,":[118],"do":[120],"high":[122,132],"values":[123],"heritability,":[128],"argue":[130],"estimates":[134],"can":[135],"caused":[137],"by":[138,142],"'footprints'":[140],"left":[141],"differing":[143],"hosts'":[144],"systems":[146],"on":[147],"virus.":[149]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2023,"cited_by_count":4},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}