{"id":"https://openalex.org/W2110582765","doi":"https://doi.org/10.1371/journal.pcbi.1003814","title":"Characterizing Protein Interactions Employing a Genome-Wide siRNA Cellular Phenotyping Screen","display_name":"Characterizing Protein Interactions Employing a Genome-Wide siRNA Cellular Phenotyping Screen","publication_year":2014,"publication_date":"2014-09-25","ids":{"openalex":"https://openalex.org/W2110582765","doi":"https://doi.org/10.1371/journal.pcbi.1003814","mag":"2110582765","pmid":"https://pubmed.ncbi.nlm.nih.gov/25255318"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1003814","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003814","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003814&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003814&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013067913","display_name":"Apichat Suratanee","orcid":"https://orcid.org/0000-0002-3439-6619"},"institutions":[{"id":"https://openalex.org/I82828225","display_name":"King Mongkut's University of Technology North Bangkok","ror":"https://ror.org/04fy6jb97","country_code":"TH","type":"education","lineage":["https://openalex.org/I82828225"]}],"countries":["TH"],"is_corresponding":false,"raw_author_name":"Apichat Suratanee","raw_affiliation_strings":["Department of Mathematics, Faculty of Applied Science, King Mongkut's University of Technology North Bangkok, Bangsue, Bangkok, Thailand"],"affiliations":[{"raw_affiliation_string":"Department of Mathematics, Faculty of Applied Science, King Mongkut's University of Technology North Bangkok, Bangsue, Bangkok, Thailand","institution_ids":["https://openalex.org/I82828225"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032142988","display_name":"Martin H. Schaefer","orcid":"https://orcid.org/0000-0001-7503-6364"},"institutions":[{"id":"https://openalex.org/I4210137962","display_name":"Centre for Genomic Regulation","ror":"https://ror.org/03wyzt892","country_code":"ES","type":"funder","lineage":["https://openalex.org/I4210132884","https://openalex.org/I4210137962","https://openalex.org/I4387153040"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Martin H. Schaefer","raw_affiliation_strings":["EMBL/CRG Systems Biology Research Unit, Center for Genomic Regulation, Barcelona, Spain"],"affiliations":[{"raw_affiliation_string":"EMBL/CRG Systems Biology Research Unit, Center for Genomic Regulation, Barcelona, Spain","institution_ids":["https://openalex.org/I4210137962"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040703948","display_name":"Matthew J. Betts","orcid":"https://orcid.org/0000-0003-4583-9814"},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Matthew J. Betts","raw_affiliation_strings":["Robert B. Russell, Cell Networks Protein Evolution, BioQuant, University of Heidelberg, Heidelberg, Germany"],"affiliations":[{"raw_affiliation_string":"Robert B. Russell, Cell Networks Protein Evolution, BioQuant, University of Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062633175","display_name":"Zita Soons","orcid":"https://orcid.org/0000-0002-0767-8856"},"institutions":[{"id":"https://openalex.org/I4210162077","display_name":"Leibniz-Institut f\u00fcr Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Kn\u00f6ll-Institut (HKI)","ror":"https://ror.org/055s37c97","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210162077"]},{"id":"https://openalex.org/I34352273","display_name":"Maastricht University","ror":"https://ror.org/02jz4aj89","country_code":"NL","type":"education","lineage":["https://openalex.org/I34352273"]},{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE","NL"],"is_corresponding":false,"raw_author_name":"Zita Soons","raw_affiliation_strings":["Network Modeling, Leibniz Institute for Natural Product Research and Infection Biology - Hans Kn\u00f6ll Institute Jena, Jena, Germany; Department of Knowledge Engineering, Maastricht University, Maastricht, The Netherlands; Theoretical Bioinformatics, German Cancer Research Center, Heidelberg, Germany","Theoretical Bioinformatics, German Cancer Research Center, Heidelberg, Germany","Network Modeling, Leibniz Institute for Natural Product Research and Infection Biology - Hans Kn\u00f6ll Institute Jena, Jena, Germany","Department of Knowledge Engineering, Maastricht University, Maastricht, The Netherlands"],"affiliations":[{"raw_affiliation_string":"Network Modeling, Leibniz Institute for Natural Product Research and Infection Biology - Hans Kn\u00f6ll Institute Jena, Jena, Germany; Department of Knowledge Engineering, Maastricht University, Maastricht, The Netherlands; Theoretical Bioinformatics, German Cancer Research Center, Heidelberg, Germany","institution_ids":[]},{"raw_affiliation_string":"Theoretical Bioinformatics, German Cancer Research Center, Heidelberg, Germany","institution_ids":["https://openalex.org/I17937529","https://openalex.org/I223822909"]},{"raw_affiliation_string":"Network Modeling, Leibniz Institute for Natural Product Research and Infection Biology - Hans Kn\u00f6ll Institute Jena, Jena, Germany","institution_ids":["https://openalex.org/I4210162077"]},{"raw_affiliation_string":"Department of Knowledge Engineering, Maastricht University, Maastricht, The Netherlands","institution_ids":["https://openalex.org/I34352273"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022507691","display_name":"Heiko Mannsperger","orcid":null},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Heiko Mannsperger","raw_affiliation_strings":["Theoretical Bioinformatics, German Cancer Research Center, Heidelberg, Germany"],"affiliations":[{"raw_affiliation_string":"Theoretical Bioinformatics, German Cancer Research Center, Heidelberg, Germany","institution_ids":["https://openalex.org/I17937529","https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074570986","display_name":"Nathalie Harder","orcid":"https://orcid.org/0000-0002-6171-6462"},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Nathalie Harder","raw_affiliation_strings":["Theoretical Bioinformatics, German Cancer Research Center, Heidelberg, Germany; Department of Bioinformatics and Functional Genomics, Institute of Pharmacy and Molecular Biotechnology, BioQuant, University of Heidelberg, Heidelberg, Germany","Theoretical Bioinformatics, German Cancer Research Center, Heidelberg, Germany","Department of Bioinformatics and Functional Genomics, Institute of Pharmacy and Molecular Biotechnology, BioQuant, University of Heidelberg, Heidelberg, Germany"],"affiliations":[{"raw_affiliation_string":"Theoretical Bioinformatics, German Cancer Research Center, Heidelberg, Germany; Department of Bioinformatics and Functional Genomics, Institute of Pharmacy and Molecular Biotechnology, BioQuant, University of Heidelberg, Heidelberg, Germany","institution_ids":[]},{"raw_affiliation_string":"Theoretical Bioinformatics, German Cancer Research Center, Heidelberg, Germany","institution_ids":["https://openalex.org/I17937529","https://openalex.org/I223822909"]},{"raw_affiliation_string":"Department of Bioinformatics and Functional Genomics, Institute of Pharmacy and Molecular Biotechnology, BioQuant, University of Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084196031","display_name":"Marcus Oswald","orcid":"https://orcid.org/0000-0002-0740-7343"},"institutions":[{"id":"https://openalex.org/I4210134900","display_name":"Jena University Hospital","ror":"https://ror.org/035rzkx15","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210134900"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I4210162077","display_name":"Leibniz-Institut f\u00fcr Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Kn\u00f6ll-Institut (HKI)","ror":"https://ror.org/055s37c97","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210162077"]},{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Marcus Oswald","raw_affiliation_strings":["Network Modeling, Leibniz Institute for Natural Product Research and Infection Biology - Hans Kn\u00f6ll Institute Jena, Jena, Germany; Integrated Research and Treatment Center, Center for Sepsis Control and Care (CSCC), Jena University Hospital, Jena, Germany; Theoretical Bioinformatics, German Cancer Research Center, Heidelberg, Germany","Integrated Research and Treatment Center, Center for Sepsis Control and Care (CSCC), Jena University Hospital, Jena, Germany","Network Modeling, Leibniz Institute for Natural Product Research and Infection Biology - Hans Kn\u00f6ll Institute Jena, Jena, Germany","Theoretical Bioinformatics, German Cancer Research Center, Heidelberg, Germany"],"affiliations":[{"raw_affiliation_string":"Network Modeling, Leibniz Institute for Natural Product Research and Infection Biology - Hans Kn\u00f6ll Institute Jena, Jena, Germany; Integrated Research and Treatment Center, Center for Sepsis Control and Care (CSCC), Jena University Hospital, Jena, Germany; Theoretical Bioinformatics, German Cancer Research Center, Heidelberg, Germany","institution_ids":[]},{"raw_affiliation_string":"Integrated Research and Treatment Center, Center for Sepsis Control and Care (CSCC), Jena University Hospital, Jena, Germany","institution_ids":["https://openalex.org/I4210134900"]},{"raw_affiliation_string":"Network Modeling, Leibniz Institute for Natural Product Research and Infection Biology - Hans Kn\u00f6ll Institute Jena, Jena, Germany","institution_ids":["https://openalex.org/I4210162077"]},{"raw_affiliation_string":"Theoretical Bioinformatics, German Cancer Research Center, Heidelberg, Germany","institution_ids":["https://openalex.org/I17937529","https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077927851","display_name":"Markus Gipp","orcid":null},"institutions":[{"id":"https://openalex.org/I177802217","display_name":"University of Mannheim","ror":"https://ror.org/031bsb921","country_code":"DE","type":"education","lineage":["https://openalex.org/I177802217"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Markus Gipp","raw_affiliation_strings":["Department of Computer Science V, Institute of Computer Engineering, University of Mannheim, Mannheim, Germany"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science V, Institute of Computer Engineering, University of Mannheim, Mannheim, Germany","institution_ids":["https://openalex.org/I177802217"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073966744","display_name":"Ellen Ramminger","orcid":null},"institutions":[{"id":"https://openalex.org/I205582932","display_name":"Max Delbr\u00fcck Center","ror":"https://ror.org/04p5ggc03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I205582932"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ellen Ramminger","raw_affiliation_strings":["AG Neuroproteomics, Max Delbrueck Center for Molecular Medicine, Berlin, Germany"],"affiliations":[{"raw_affiliation_string":"AG Neuroproteomics, Max Delbrueck Center for Molecular Medicine, Berlin, Germany","institution_ids":["https://openalex.org/I205582932"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071888649","display_name":"Guillermo Marcus","orcid":"https://orcid.org/0000-0003-4270-4359"},"institutions":[{"id":"https://openalex.org/I177802217","display_name":"University of Mannheim","ror":"https://ror.org/031bsb921","country_code":"DE","type":"education","lineage":["https://openalex.org/I177802217"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Guillermo Marcus","raw_affiliation_strings":["Department of Computer Science V, Institute of Computer Engineering, University of Mannheim, Mannheim, Germany"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science V, Institute of Computer Engineering, University of Mannheim, Mannheim, Germany","institution_ids":["https://openalex.org/I177802217"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109312690","display_name":"Reinhard M\u00e4nner","orcid":null},"institutions":[{"id":"https://openalex.org/I177802217","display_name":"University of Mannheim","ror":"https://ror.org/031bsb921","country_code":"DE","type":"education","lineage":["https://openalex.org/I177802217"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Reinhard M\u00e4nner","raw_affiliation_strings":["Department of Computer Science V, Institute of Computer Engineering, University of Mannheim, Mannheim, Germany"],"affiliations":[{"raw_affiliation_string":"Department of Computer Science V, Institute of Computer Engineering, University of Mannheim, Mannheim, Germany","institution_ids":["https://openalex.org/I177802217"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105166471","display_name":"Karl Rohr","orcid":null},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]},{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Karl Rohr","raw_affiliation_strings":["Theoretical Bioinformatics, German Cancer Research Center, Heidelberg, Germany; Department of Bioinformatics and Functional Genomics, Institute of Pharmacy and Molecular Biotechnology, BioQuant, University of Heidelberg, Heidelberg, Germany","Theoretical Bioinformatics, German Cancer Research Center, Heidelberg, Germany","Department of Bioinformatics and Functional Genomics, Institute of Pharmacy and Molecular Biotechnology, BioQuant, University of Heidelberg, Heidelberg, Germany"],"affiliations":[{"raw_affiliation_string":"Theoretical Bioinformatics, German Cancer Research Center, Heidelberg, Germany; Department of Bioinformatics and Functional Genomics, Institute of Pharmacy and Molecular Biotechnology, BioQuant, University of Heidelberg, Heidelberg, Germany","institution_ids":[]},{"raw_affiliation_string":"Theoretical Bioinformatics, German Cancer Research Center, Heidelberg, Germany","institution_ids":["https://openalex.org/I17937529","https://openalex.org/I223822909"]},{"raw_affiliation_string":"Department of Bioinformatics and Functional Genomics, Institute of Pharmacy and Molecular Biotechnology, BioQuant, University of Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014950513","display_name":"Erich E. Wanker","orcid":"https://orcid.org/0000-0001-8072-1630"},"institutions":[{"id":"https://openalex.org/I205582932","display_name":"Max Delbr\u00fcck Center","ror":"https://ror.org/04p5ggc03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I205582932"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Erich Wanker","raw_affiliation_strings":["AG Neuroproteomics, Max Delbrueck Center for Molecular Medicine, Berlin, Germany"],"affiliations":[{"raw_affiliation_string":"AG Neuroproteomics, Max Delbrueck Center for Molecular Medicine, Berlin, Germany","institution_ids":["https://openalex.org/I205582932"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108001959","display_name":"Robert B. Russell","orcid":"https://orcid.org/0000-0002-1905-4717"},"institutions":[{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Robert B. Russell","raw_affiliation_strings":["Robert B. Russell, Cell Networks Protein Evolution, BioQuant, University of Heidelberg, Heidelberg, Germany"],"affiliations":[{"raw_affiliation_string":"Robert B. Russell, Cell Networks Protein Evolution, BioQuant, University of Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010178662","display_name":"Miguel A. Andrade\u2010Navarro","orcid":"https://orcid.org/0000-0001-6650-1711"},"institutions":[{"id":"https://openalex.org/I205582932","display_name":"Max Delbr\u00fcck Center","ror":"https://ror.org/04p5ggc03","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I205582932"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Miguel A. Andrade-Navarro","raw_affiliation_strings":["Computational Biology and Data Mining Group, Max Delbrueck Center for Molecular Medicine, Berlin, Germany"],"affiliations":[{"raw_affiliation_string":"Computational Biology and Data Mining Group, Max Delbrueck Center for Molecular Medicine, Berlin, Germany","institution_ids":["https://openalex.org/I205582932"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044191947","display_name":"Roland Eils","orcid":"https://orcid.org/0000-0002-0034-4036"},"institutions":[{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Roland Eils","raw_affiliation_strings":["Theoretical Bioinformatics, German Cancer Research Center, Heidelberg, Germany; Department of Bioinformatics and Functional Genomics, Institute of Pharmacy and Molecular Biotechnology, BioQuant, University of Heidelberg, Heidelberg, Germany","Department of Bioinformatics and Functional Genomics, Institute of Pharmacy and Molecular Biotechnology, BioQuant, University of Heidelberg, Heidelberg, Germany","Theoretical Bioinformatics, German Cancer Research Center, Heidelberg, Germany"],"affiliations":[{"raw_affiliation_string":"Theoretical Bioinformatics, German Cancer Research Center, Heidelberg, Germany; Department of Bioinformatics and Functional Genomics, Institute of Pharmacy and Molecular Biotechnology, BioQuant, University of Heidelberg, Heidelberg, Germany","institution_ids":[]},{"raw_affiliation_string":"Department of Bioinformatics and Functional Genomics, Institute of Pharmacy and Molecular Biotechnology, BioQuant, University of Heidelberg, Heidelberg, Germany","institution_ids":["https://openalex.org/I223822909"]},{"raw_affiliation_string":"Theoretical Bioinformatics, German Cancer Research Center, Heidelberg, Germany","institution_ids":["https://openalex.org/I17937529","https://openalex.org/I223822909"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5077200146","display_name":"Rainer K\u00f6nig","orcid":null},"institutions":[{"id":"https://openalex.org/I4210134900","display_name":"Jena University Hospital","ror":"https://ror.org/035rzkx15","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210134900"]},{"id":"https://openalex.org/I17937529","display_name":"German Cancer Research Center","ror":"https://ror.org/04cdgtt98","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I17937529"]},{"id":"https://openalex.org/I4210162077","display_name":"Leibniz-Institut f\u00fcr Naturstoff-Forschung und Infektionsbiologie e. V. - Hans-Kn\u00f6ll-Institut (HKI)","ror":"https://ror.org/055s37c97","country_code":"DE","type":"facility","lineage":["https://openalex.org/I315704651","https://openalex.org/I4210162077"]},{"id":"https://openalex.org/I223822909","display_name":"Heidelberg University","ror":"https://ror.org/038t36y30","country_code":"DE","type":"education","lineage":["https://openalex.org/I223822909"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Rainer K\u00f6nig","raw_affiliation_strings":["Network Modeling, Leibniz Institute for Natural Product Research and Infection Biology - Hans Kn\u00f6ll Institute Jena, Jena, Germany; Integrated Research and Treatment Center, Center for Sepsis Control and Care (CSCC), Jena University Hospital, Jena, Germany; Theoretical Bioinformatics, German Cancer Research Center, Heidelberg, Germany","Integrated Research and Treatment Center, Center for Sepsis Control and Care (CSCC), Jena University Hospital, Jena, Germany","Network Modeling, Leibniz Institute for Natural Product Research and Infection Biology - Hans Kn\u00f6ll Institute Jena, Jena, Germany","Theoretical Bioinformatics, German Cancer Research Center, Heidelberg, Germany"],"affiliations":[{"raw_affiliation_string":"Network Modeling, Leibniz Institute for Natural Product Research and Infection Biology - Hans Kn\u00f6ll Institute Jena, Jena, Germany; Integrated Research and Treatment Center, Center for Sepsis Control and Care (CSCC), Jena University Hospital, Jena, Germany; Theoretical Bioinformatics, German Cancer Research Center, Heidelberg, Germany","institution_ids":[]},{"raw_affiliation_string":"Integrated Research and Treatment Center, Center for Sepsis Control and Care (CSCC), Jena University Hospital, Jena, Germany","institution_ids":["https://openalex.org/I4210134900"]},{"raw_affiliation_string":"Network Modeling, Leibniz Institute for Natural Product Research and Infection Biology - Hans Kn\u00f6ll Institute Jena, Jena, Germany","institution_ids":["https://openalex.org/I4210162077"]},{"raw_affiliation_string":"Theoretical Bioinformatics, German Cancer Research Center, Heidelberg, Germany","institution_ids":["https://openalex.org/I17937529","https://openalex.org/I223822909"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":17,"corresponding_author_ids":["https://openalex.org/A5044191947","https://openalex.org/A5077200146"],"corresponding_institution_ids":["https://openalex.org/I17937529","https://openalex.org/I223822909","https://openalex.org/I4210134900","https://openalex.org/I4210162077"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.713,"has_fulltext":true,"cited_by_count":19,"citation_normalized_percentile":{"value":0.70690951,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"10","issue":"9","first_page":"e1003814","last_page":"e1003814"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9993000030517578,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.998199999332428,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9979000091552734,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gene-knockdown","display_name":"Gene knockdown","score":0.8047170639038086},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6708439588546753},{"id":"https://openalex.org/keywords/rna-interference","display_name":"RNA interference","score":0.5420334339141846},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5128384232521057},{"id":"https://openalex.org/keywords/kegg","display_name":"KEGG","score":0.5005218982696533},{"id":"https://openalex.org/keywords/protein\u2013protein-interaction","display_name":"Protein\u2013protein interaction","score":0.48777133226394653},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.4875158965587616},{"id":"https://openalex.org/keywords/phenotype","display_name":"Phenotype","score":0.463532954454422},{"id":"https://openalex.org/keywords/biological-pathway","display_name":"Biological pathway","score":0.45774051547050476},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.43965384364128113},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"Signal transduction","score":0.42979463934898376},{"id":"https://openalex.org/keywords/function","display_name":"Function (biology)","score":0.41835135221481323},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.27987635135650635},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.2669055461883545},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.13937190175056458},{"id":"https://openalex.org/keywords/rna","display_name":"RNA","score":0.11844232678413391},{"id":"https://openalex.org/keywords/gene-ontology","display_name":"Gene ontology","score":0.09527003765106201}],"concepts":[{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.8047170639038086},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6708439588546753},{"id":"https://openalex.org/C166703698","wikidata":"https://www.wikidata.org/wiki/Q201993","display_name":"RNA interference","level":4,"score":0.5420334339141846},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5128384232521057},{"id":"https://openalex.org/C152724338","wikidata":"https://www.wikidata.org/wiki/Q909442","display_name":"KEGG","level":5,"score":0.5005218982696533},{"id":"https://openalex.org/C11804247","wikidata":"https://www.wikidata.org/wiki/Q896177","display_name":"Protein\u2013protein interaction","level":2,"score":0.48777133226394653},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.4875158965587616},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.463532954454422},{"id":"https://openalex.org/C9927688","wikidata":"https://www.wikidata.org/wiki/Q4915012","display_name":"Biological pathway","level":4,"score":0.45774051547050476},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.43965384364128113},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.42979463934898376},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.41835135221481323},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.27987635135650635},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2669055461883545},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.13937190175056458},{"id":"https://openalex.org/C67705224","wikidata":"https://www.wikidata.org/wiki/Q11053","display_name":"RNA","level":3,"score":0.11844232678413391},{"id":"https://openalex.org/C2987395477","wikidata":"https://www.wikidata.org/wiki/Q135085","display_name":"Gene ontology","level":4,"score":0.09527003765106201}],"mesh":[{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012372","descriptor_name":"ROC Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D023281","descriptor_name":"Genomics","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D034741","descriptor_name":"RNA, Small Interfering","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D055785","descriptor_name":"Gene Knockdown Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055785","descriptor_name":"Gene Knockdown Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055785","descriptor_name":"Gene Knockdown Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060066","descriptor_name":"Protein Interaction Maps","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":8,"locations":[{"id":"doi:10.1371/journal.pcbi.1003814","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003814","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003814&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:25255318","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25255318","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:cris.maastrichtuniversity.nl:openaire/367248cb-f770-49d5-a6f3-7946d58f798c","is_oa":true,"landing_page_url":"https://cris.maastrichtuniversity.nl/en/publications/367248cb-f770-49d5-a6f3-7946d58f798c","pdf_url":null,"source":{"id":"https://openalex.org/S4306402616","display_name":"Research Publications (Maastricht University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I34352273","host_organization_name":"Maastricht University","host_organization_lineage":["https://openalex.org/I34352273"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Suratanee, A, Schaefer, M H, Betts, M J, Soons, Z, Mannsperger, H, Harder, N, Oswald, M, Gipp, M, Ramminger, E, Marcus, G, Maenner, R, Rohr, K, Wanker, E, Russell, R B, Andrade-Navarro, M A, Eils, R & Koenig, R 2014, 'Characterizing Protein Interactions Employing a Genome-Wide siRNA Cellular Phenotyping Screen', PLoS Computational Biology, vol. 10, no. 9, 1003814. https://doi.org/10.1371/journal.pcbi.1003814","raw_type":"info:eu-repo/semantics/publishedVersion"},{"id":"pmh:oai:edoc.mdc-berlin.de:14366","is_oa":false,"landing_page_url":null,"pdf_url":null,"source":{"id":"https://openalex.org/S4306400224","display_name":"MDC Repository (Max-Delbrueck-Center for Molecular Medicine)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I149899117","host_organization_name":"Max Planck Society","host_organization_lineage":["https://openalex.org/I149899117"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.792.551","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.792.551","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/3f/20/pcbi.1003814.PMC4178005.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:e01205940d804bc0bcc38759f7abd7ed","is_oa":true,"landing_page_url":"https://doaj.org/article/e01205940d804bc0bcc38759f7abd7ed","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 10, Iss 9, p e1003814 (2014)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:3156210","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4178005","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/1182103","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/_Characterizing_Protein_Interactions_Employing_a_Genome_Wide_siRNA_Cellular_Phenotyping_Screen_/1182103","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1003814","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003814","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003814&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G3236928039","display_name":null,"funder_award_id":"01EO1002","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"},{"id":"https://openalex.org/G4662980202","display_name":null,"funder_award_id":"SFB618","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G4821459042","display_name":null,"funder_award_id":"0316168","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"},{"id":"https://openalex.org/G4917316984","display_name":null,"funder_award_id":"01EO1002","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"},{"id":"https://openalex.org/G5298580630","display_name":"Verbundprojekt: Neuroblastom: \" Zellen-Bildanalyse f\u00fcr verfeinerte Selektion von Arzneimitteln und ihren Targets\"","funder_award_id":"01GS0898","funder_id":"https://openalex.org/F4320321114","funder_display_name":"Bundesministerium f\u00fcr Bildung und Forschung"},{"id":"https://openalex.org/G884619906","display_name":null,"funder_award_id":"SFB740","funder_id":"https://openalex.org/F4320320879","funder_display_name":"Deutsche Forschungsgemeinschaft"}],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320321114","display_name":"Bundesministerium f\u00fcr Bildung und Forschung","ror":"https://ror.org/04pz7b180"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2110582765.pdf","grobid_xml":"https://content.openalex.org/works/W2110582765.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W1487944143","https://openalex.org/W1974482866","https://openalex.org/W1986986419","https://openalex.org/W1993369755","https://openalex.org/W1995372789","https://openalex.org/W1997580772","https://openalex.org/W1999776252","https://openalex.org/W2002582122","https://openalex.org/W2011340259","https://openalex.org/W2021724420","https://openalex.org/W2049101886","https://openalex.org/W2057545775","https://openalex.org/W2065455422","https://openalex.org/W2067803871","https://openalex.org/W2073327370","https://openalex.org/W2075744820","https://openalex.org/W2085963663","https://openalex.org/W2093442991","https://openalex.org/W2098223746","https://openalex.org/W2101181377","https://openalex.org/W2103579660","https://openalex.org/W2106248311","https://openalex.org/W2107249189","https://openalex.org/W2122863289","https://openalex.org/W2123060905","https://openalex.org/W2130561514","https://openalex.org/W2132992030","https://openalex.org/W2141885858","https://openalex.org/W2152853006","https://openalex.org/W2154947819","https://openalex.org/W2170066434","https://openalex.org/W2915108429","https://openalex.org/W4320301318"],"related_works":["https://openalex.org/W4391126805","https://openalex.org/W2093213574","https://openalex.org/W2076785949","https://openalex.org/W2167306613","https://openalex.org/W1963563485","https://openalex.org/W2129321041","https://openalex.org/W1974857950","https://openalex.org/W2529615212","https://openalex.org/W3107361973","https://openalex.org/W3087561174"],"abstract_inverted_index":{"Characterizing":[0],"the":[1,16,48,73,108,140,146,166,186,199,210,220,227],"activating":[2,74,117,129,187],"and":[3,70,75,118,130,151,153,206],"inhibiting":[4,76,119,131,189],"effect":[5,49,190],"of":[6,20,26,42,50,64,78,89,107,145,149,176,185,191,201,204,212,223,226,230],"protein-protein":[7],"interactions":[8],"(PPI)":[9],"is":[10,44],"fundamental":[11],"to":[12,31,46,85,172],"gain":[13],"insight":[14],"into":[15],"complex":[17],"signaling":[18,143,224],"system":[19,229],"a":[21,37,56,65,86,97,160],"human":[22],"cell.":[23],"A":[24],"plethora":[25],"methods":[27],"has":[28],"been":[29],"suggested":[30],"infer":[32],"PPI":[33],"from":[34],"data":[35],"on":[36],"large":[38,202],"scale,":[39],"but":[40],"none":[41],"them":[43],"able":[45],"characterize":[47],"this":[51],"interaction.":[52],"Here,":[53],"we":[54,81,101],"present":[55],"novel":[57],"computational":[58],"development":[59],"that":[60,165],"employs":[61],"mitotic":[62],"phenotypes":[63],"genome-wide":[66],"RNAi":[67],"knockdown":[68,87,174],"screen":[69,88],"enables":[71],"identifying":[72],"effects":[77,132,168],"PPIs.":[79],"Exemplarily,":[80],"applied":[82],"our":[83],"technique":[84],"HeLa":[90,137],"cells":[91,138],"cultivated":[92],"at":[93],"standard":[94],"conditions.":[95],"Using":[96],"machine":[98],"learning":[99],"approach,":[100],"obtained":[102],"high":[103],"accuracy":[104],"(82%":[105],"AUC":[106],"receiver":[109],"operating":[110],"characteristics)":[111],"by":[112],"cross-validation":[113],"using":[114],"6,870":[115],"known":[116],"PPIs":[120,135,193,205,213],"as":[121,214],"gold":[122],"standard.":[123],"We":[124,162],"predicted":[125,167],"de":[126],"novo":[127],"unknown":[128],"for":[133,198,218],"1,954":[134],"in":[136,159,180],"covering":[139],"ten":[141],"major":[142],"pathways":[144,225],"Kyoto":[147],"Encyclopedia":[148],"Genes":[150],"Genomes,":[152],"made":[154],"these":[155],"predictions":[156],"publicly":[157],"available":[158],"database.":[161],"finally":[163],"demonstrate":[164],"can":[169],"be":[170],"used":[171],"cluster":[173],"genes":[175],"similar":[177],"biological":[178],"processes":[179],"coherent":[181],"subgroups.":[182],"The":[183],"characterization":[184],"or":[188],"individual":[192],"opens":[194],"up":[195],"new":[196],"perspectives":[197],"interpretation":[200],"datasets":[203],"thus":[207],"considerably":[208],"increases":[209],"value":[211],"an":[215],"integrated":[216],"resource":[217],"studying":[219],"detailed":[221],"function":[222],"cellular":[228],"interest.":[231]},"counts_by_year":[{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}
