{"id":"https://openalex.org/W2045221992","doi":"https://doi.org/10.1371/journal.pcbi.1003701","title":"Computational Modeling and Analysis of Iron Release from Macrophages","display_name":"Computational Modeling and Analysis of Iron Release from Macrophages","publication_year":2014,"publication_date":"2014-07-03","ids":{"openalex":"https://openalex.org/W2045221992","doi":"https://doi.org/10.1371/journal.pcbi.1003701","mag":"2045221992","pmid":"https://pubmed.ncbi.nlm.nih.gov/24991925"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1003701","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003701","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003701&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003701&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017176596","display_name":"Alka A. Potdar","orcid":"https://orcid.org/0000-0002-1877-0172"},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]},{"id":"https://openalex.org/I2799343972","display_name":"University Hospitals of Cleveland","ror":"https://ror.org/0130jk839","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2799343972"]},{"id":"https://openalex.org/I36373038","display_name":"Cleveland Clinic Lerner College of Medicine","ror":"https://ror.org/02x4b0932","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750","https://openalex.org/I36373038"]},{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Alka A. Potdar","raw_affiliation_strings":["Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, United States of America; Department of Cellular and Molecular Medicine, Cleveland Clinic, Cleveland, Ohio, United States of America","Department of Cellular and Molecular Medicine, Cleveland Clinic, Cleveland, Ohio, United States of America","Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, United States of America; Department of Cellular and Molecular Medicine, Cleveland Clinic, Cleveland, Ohio, United States of America","institution_ids":["https://openalex.org/I58956616","https://openalex.org/I36373038","https://openalex.org/I2799343972"]},{"raw_affiliation_string":"Department of Cellular and Molecular Medicine, Cleveland Clinic, Cleveland, Ohio, United States of America","institution_ids":["https://openalex.org/I1316902750"]},{"raw_affiliation_string":"Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, United States of America","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005301360","display_name":"Joydeep Sarkar","orcid":null},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joydeep Sarkar","raw_affiliation_strings":["Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, United States of America","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049287730","display_name":"Nupur K. Das","orcid":"https://orcid.org/0000-0002-5652-1134"},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nupur K. Das","raw_affiliation_strings":["Department of Cellular and Molecular Medicine, Cleveland Clinic, Cleveland, Ohio, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Cellular and Molecular Medicine, Cleveland Clinic, Cleveland, Ohio, United States of America","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024573826","display_name":"Paroma Ghosh","orcid":null},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paroma Ghosh","raw_affiliation_strings":["Department of Cellular and Molecular Medicine, Cleveland Clinic, Cleveland, Ohio, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Cellular and Molecular Medicine, Cleveland Clinic, Cleveland, Ohio, United States of America","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003821715","display_name":"Mikl\u00f3s Gratzl","orcid":"https://orcid.org/0000-0001-8798-7394"},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Miklos Gratzl","raw_affiliation_strings":["Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, United States of America","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086615981","display_name":"Paul L. Fox","orcid":"https://orcid.org/0000-0002-6033-1528"},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul L. Fox","raw_affiliation_strings":["Department of Cellular and Molecular Medicine, Cleveland Clinic, Cleveland, Ohio, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Cellular and Molecular Medicine, Cleveland Clinic, Cleveland, Ohio, United States of America","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050315994","display_name":"Gerald M. Saidel","orcid":"https://orcid.org/0000-0003-2159-2343"},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Gerald M. Saidel","raw_affiliation_strings":["Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, United States of America","institution_ids":["https://openalex.org/I58956616"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5050315994"],"corresponding_institution_ids":["https://openalex.org/I58956616"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.9688,"has_fulltext":true,"cited_by_count":17,"citation_normalized_percentile":{"value":0.76196769,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"10","issue":"7","first_page":"e1003701","last_page":"e1003701"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10915","display_name":"Trace Elements in Health","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2916","display_name":"Nutrition and Dietetics"},"field":{"id":"https://openalex.org/fields/29","display_name":"Nursing"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.9972000122070312,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ferrous","display_name":"Ferrous","score":0.8760690689086914},{"id":"https://openalex.org/keywords/transferrin","display_name":"Transferrin","score":0.8065440654754639},{"id":"https://openalex.org/keywords/ceruloplasmin","display_name":"Ceruloplasmin","score":0.7269865870475769},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.7140716910362244},{"id":"https://openalex.org/keywords/ferric","display_name":"Ferric","score":0.7131505608558655},{"id":"https://openalex.org/keywords/ferroportin","display_name":"Ferroportin","score":0.6930415630340576},{"id":"https://openalex.org/keywords/ferritin","display_name":"Ferritin","score":0.652434766292572},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.5825833082199097},{"id":"https://openalex.org/keywords/transferrin-receptor","display_name":"Transferrin receptor","score":0.5468341112136841},{"id":"https://openalex.org/keywords/intracellular","display_name":"Intracellular","score":0.5316708087921143},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.47177696228027344},{"id":"https://openalex.org/keywords/transporter","display_name":"Transporter","score":0.4713149666786194},{"id":"https://openalex.org/keywords/metabolism","display_name":"Metabolism","score":0.45075178146362305},{"id":"https://openalex.org/keywords/macrophage","display_name":"Macrophage","score":0.44035622477531433},{"id":"https://openalex.org/keywords/inorganic-chemistry","display_name":"Inorganic chemistry","score":0.1968504786491394},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.13758200407028198},{"id":"https://openalex.org/keywords/iron-homeostasis","display_name":"Iron homeostasis","score":0.0880674421787262},{"id":"https://openalex.org/keywords/organic-chemistry","display_name":"Organic chemistry","score":0.06508567929267883}],"concepts":[{"id":"https://openalex.org/C2775832776","wikidata":"https://www.wikidata.org/wiki/Q65122087","display_name":"Ferrous","level":2,"score":0.8760690689086914},{"id":"https://openalex.org/C22814914","wikidata":"https://www.wikidata.org/wiki/Q410473","display_name":"Transferrin","level":2,"score":0.8065440654754639},{"id":"https://openalex.org/C28452662","wikidata":"https://www.wikidata.org/wiki/Q422752","display_name":"Ceruloplasmin","level":2,"score":0.7269865870475769},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7140716910362244},{"id":"https://openalex.org/C2780534640","wikidata":"https://www.wikidata.org/wiki/Q3233795","display_name":"Ferric","level":2,"score":0.7131505608558655},{"id":"https://openalex.org/C2776710925","wikidata":"https://www.wikidata.org/wiki/Q24777245","display_name":"Ferroportin","level":4,"score":0.6930415630340576},{"id":"https://openalex.org/C2778319317","wikidata":"https://www.wikidata.org/wiki/Q22327449","display_name":"Ferritin","level":2,"score":0.652434766292572},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5825833082199097},{"id":"https://openalex.org/C32264632","wikidata":"https://www.wikidata.org/wiki/Q1134983","display_name":"Transferrin receptor","level":3,"score":0.5468341112136841},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.5316708087921143},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.47177696228027344},{"id":"https://openalex.org/C149011108","wikidata":"https://www.wikidata.org/wiki/Q652985","display_name":"Transporter","level":3,"score":0.4713149666786194},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.45075178146362305},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.44035622477531433},{"id":"https://openalex.org/C179104552","wikidata":"https://www.wikidata.org/wiki/Q11165","display_name":"Inorganic chemistry","level":1,"score":0.1968504786491394},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.13758200407028198},{"id":"https://openalex.org/C2911035656","wikidata":"https://www.wikidata.org/wiki/Q5925744","display_name":"Iron homeostasis","level":3,"score":0.0880674421787262},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.06508567929267883},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007501","descriptor_name":"Iron","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007501","descriptor_name":"Iron","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007501","descriptor_name":"Iron","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042541","descriptor_name":"Intracellular Space","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042541","descriptor_name":"Intracellular Space","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042541","descriptor_name":"Intracellular Space","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pcbi.1003701","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003701","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003701&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:24991925","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24991925","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.817.6616","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.817.6616","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/10/2c/pcbi.1003701.PMC4083485.pdf","raw_type":"text"},{"id":"pmh:oai:RePEc:plo:pcbi00:1003701","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1003701","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:186cc27ae09e49d4a2d31164fdb932ff","is_oa":true,"landing_page_url":"https://doaj.org/article/186cc27ae09e49d4a2d31164fdb932ff","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 10, Iss 7, p e1003701 (2014)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/1093460","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/_Computational_Modeling_and_Analysis_of_Iron_Release_from_Macrophages_/1093460","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:4083485","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4083485","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1003701","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003701","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003701&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/6","display_name":"Clean water and sanitation","score":0.4699999988079071}],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2045221992.pdf","grobid_xml":"https://content.openalex.org/works/W2045221992.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W73808988","https://openalex.org/W147406974","https://openalex.org/W599716399","https://openalex.org/W1480892230","https://openalex.org/W1508143080","https://openalex.org/W1565446694","https://openalex.org/W1569685525","https://openalex.org/W1601203296","https://openalex.org/W1979156128","https://openalex.org/W1980042430","https://openalex.org/W1998213544","https://openalex.org/W2005488179","https://openalex.org/W2015248217","https://openalex.org/W2019465667","https://openalex.org/W2020656528","https://openalex.org/W2023081611","https://openalex.org/W2035390231","https://openalex.org/W2036615604","https://openalex.org/W2046761464","https://openalex.org/W2054390592","https://openalex.org/W2059632153","https://openalex.org/W2063617352","https://openalex.org/W2070771807","https://openalex.org/W2076136219","https://openalex.org/W2084072384","https://openalex.org/W2092322458","https://openalex.org/W2101071630","https://openalex.org/W2107704801","https://openalex.org/W2118745767","https://openalex.org/W2132040328","https://openalex.org/W2143798060","https://openalex.org/W2164481110","https://openalex.org/W4245239268"],"related_works":["https://openalex.org/W2095988872","https://openalex.org/W2014488879","https://openalex.org/W1985279299","https://openalex.org/W2305395223","https://openalex.org/W2027213379","https://openalex.org/W2143662073","https://openalex.org/W2013658748","https://openalex.org/W1991250386","https://openalex.org/W2001564713","https://openalex.org/W2050769195"],"abstract_inverted_index":{"A":[0,70,208],"major":[1],"process":[2,32],"of":[3,13,18,53,74,83,115,137,143,155,162,179,188,210,258,295],"iron":[4,8,14,54,68,75,86,117,151,180,224,236,248,285,296],"homeostasis":[5],"in":[6,118,265],"whole-body":[7,293],"metabolism":[9],"is":[10,37,65,197,288],"the":[11,16,19,33,40,58,91,94,98,112,119,132,135,141,146,150,160,176,186,189,205,218,235,241,250,256,266,271,276],"release":[12,76,144,181,237,277],"from":[15,140,182],"macrophages":[17,183],"reticuloendothelial":[20],"system.":[21],"Macrophages":[22],"recognize":[23],"and":[24,127,170,192,287],"phagocytose":[25],"senescent":[26],"or":[27],"damaged":[28],"erythrocytes.":[29],"Then,":[30],"they":[31],"heme":[34],"iron,":[35],"which":[36],"returned":[38],"to":[39,57,107,124,131,240,249,262,270],"circulation":[41],"for":[42,61,204,290],"reutilization":[43],"by":[44],"red":[45],"blood":[46],"cell":[47],"precursors":[48],"during":[49,67],"erythropoiesis.":[50],"The":[51,194],"amount":[52,59],"released,":[55],"compared":[56],"shunted":[60],"storage":[62],"as":[63],"ferritin,":[64],"greater":[66],"deficiency.":[69],"currently":[71],"accepted":[72],"model":[73,196,203,214,220,229,280,294],"assumes":[77],"a":[78,100,201,227],"passive-gradient":[79,133,195,219],"with":[80,213,231],"free":[81],"diffusion":[82],"intracellular":[84,244],"labile":[85,247],"(Fe2+)":[87],"through":[88],"ferroportin":[89],"(FPN),":[90],"transporter":[92],"on":[93,185],"plasma":[95],"membrane.":[96,252],"Outside":[97],"cell,":[99],"multi-copper":[101],"ferroxidase,":[102],"ceruloplasmin":[103],"(Cp),":[104],"oxidizes":[105],"ferrous":[106,138,259,273],"ferric":[108,122],"ion.":[109],"Apo-transferrin":[110],"(Tf),":[111],"primary":[113],"carrier":[114],"soluble":[116],"plasma,":[120],"binds":[121,269],"ion":[123,139,260],"form":[125],"mono-ferric":[126],"di-ferric":[128],"transferrin.":[129],"According":[130,239],"model,":[134,243],"removal":[136],"site":[142],"sustains":[145],"gradient":[147],"that":[148,159,217],"maintains":[149],"release.":[152,225],"Subcellular":[153],"localization":[154],"FPN,":[156],"however,":[157],"indicates":[158],"role":[161],"FPN":[163,191,232,245],"may":[164],"be":[165],"more":[166],"complex.":[167],"By":[168],"experiments":[169],"mathematical":[171,202],"modeling,":[172],"we":[173],"have":[174],"investigated":[175],"detailed":[177],"mechanism":[178],"focusing":[184],"roles":[187],"Cp,":[190],"apo-Tf.":[193],"quantitatively":[198],"analyzed":[199],"using":[200],"first":[206],"time.":[207],"comparison":[209],"experimental":[211],"data":[212],"simulations":[215],"shows":[216],"cannot":[221],"explain":[222,234],"macrophage":[223,251],"However,":[226],"facilitated-transport":[228,242],"associated":[230],"can":[233,281],"mechanism.":[238],"carries":[246],"Extracellular":[253],"Cp":[254],"accelerates":[255],"oxidation":[257],"bound":[261],"FPN.":[263],"Apo-Tf":[264],"extracellular":[267],"environment":[268],"oxidized":[272],"ion,":[274],"completing":[275],"process.":[278],"Facilitated-transport":[279],"correctly":[282],"predict":[283],"cellular":[284],"efflux":[286],"essential":[289],"physiologically":[291],"relevant":[292],"metabolism.":[297]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2014,"cited_by_count":1}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}