{"id":"https://openalex.org/W2012137498","doi":"https://doi.org/10.1371/journal.pcbi.1003630","title":"Quantifying and Predicting the Effect of Exogenous Interleukin-7 on CD4+T Cells in HIV-1 Infection","display_name":"Quantifying and Predicting the Effect of Exogenous Interleukin-7 on CD4+T Cells in HIV-1 Infection","publication_year":2014,"publication_date":"2014-05-22","ids":{"openalex":"https://openalex.org/W2012137498","doi":"https://doi.org/10.1371/journal.pcbi.1003630","mag":"2012137498","pmid":"https://pubmed.ncbi.nlm.nih.gov/24853554"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1003630","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003630","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003630&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003630&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022077216","display_name":"Rodolphe Thi\u00e9baut","orcid":"https://orcid.org/0000-0002-5235-3962"},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"funder","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I1326498283","display_name":"Institut national de recherche en informatique et en automatique","ror":"https://ror.org/02kvxyf05","country_code":"FR","type":"funder","lineage":["https://openalex.org/I1326498283"]},{"id":"https://openalex.org/I15057530","display_name":"Universit\u00e9 de Bordeaux","ror":"https://ror.org/057qpr032","country_code":"FR","type":"education","lineage":["https://openalex.org/I15057530"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Rodolphe Thi\u00e9baut","raw_affiliation_strings":["INSERM, ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux, France; Univ. Bordeaux, ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux, France; INRIA, SISTM team, Bordeaux, France","INRIA, SISTM team, Bordeaux, France","INSERM, ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux, France","Univ. Bordeaux, ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux, France"],"affiliations":[{"raw_affiliation_string":"INSERM, ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux, France; Univ. Bordeaux, ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux, France; INRIA, SISTM team, Bordeaux, France","institution_ids":[]},{"raw_affiliation_string":"INRIA, SISTM team, Bordeaux, France","institution_ids":["https://openalex.org/I1326498283"]},{"raw_affiliation_string":"INSERM, ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"Univ. Bordeaux, ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I15057530"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052925574","display_name":"Julia Drylewicz","orcid":"https://orcid.org/0000-0002-9434-8459"},"institutions":[{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"funder","lineage":["https://openalex.org/I3018483916"]},{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Julia Drylewicz","raw_affiliation_strings":["Laboratory for Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands; Theoretical Biology and Bioinformatics, Department of Biology, Utrecht University, Utrecht, The Netherlands","Laboratory for Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands","Theoretical Biology and Bioinformatics, Department of Biology, Utrecht University, Utrecht, The Netherlands"],"affiliations":[{"raw_affiliation_string":"Laboratory for Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands; Theoretical Biology and Bioinformatics, Department of Biology, Utrecht University, Utrecht, The Netherlands","institution_ids":[]},{"raw_affiliation_string":"Laboratory for Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I3018483916"]},{"raw_affiliation_string":"Theoretical Biology and Bioinformatics, Department of Biology, Utrecht University, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I193662353"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037536070","display_name":"M\u00e9lanie Prague","orcid":"https://orcid.org/0000-0001-9809-7848"},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"funder","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I1326498283","display_name":"Institut national de recherche en informatique et en automatique","ror":"https://ror.org/02kvxyf05","country_code":"FR","type":"funder","lineage":["https://openalex.org/I1326498283"]},{"id":"https://openalex.org/I15057530","display_name":"Universit\u00e9 de Bordeaux","ror":"https://ror.org/057qpr032","country_code":"FR","type":"education","lineage":["https://openalex.org/I15057530"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"M\u00e9lanie Prague","raw_affiliation_strings":["INSERM, ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux, France; Univ. Bordeaux, ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux, France; INRIA, SISTM team, Bordeaux, France","INSERM, ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux, France","Univ. Bordeaux, ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux, France","INRIA, SISTM team, Bordeaux, France"],"affiliations":[{"raw_affiliation_string":"INSERM, ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux, France; Univ. Bordeaux, ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux, France; INRIA, SISTM team, Bordeaux, France","institution_ids":[]},{"raw_affiliation_string":"INSERM, ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"Univ. Bordeaux, ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I15057530"]},{"raw_affiliation_string":"INRIA, SISTM team, Bordeaux, France","institution_ids":["https://openalex.org/I1326498283"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091028608","display_name":"Christine Lacabaratz","orcid":"https://orcid.org/0000-0001-6925-0225"},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"funder","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Christine Lacabaratz","raw_affiliation_strings":["INSERM, Unit\u00e9 U955, Cr\u00e9teil, France; Universit\u00e9 Paris-Est, Facult\u00e9 de M\u00e9decine, UMR-S955 Creteil, France","Universit\u00e9 Paris-Est, Facult\u00e9 de M\u00e9decine, UMR-S955 Creteil, France","INSERM, Unit\u00e9 U955, Cr\u00e9teil, France"],"affiliations":[{"raw_affiliation_string":"INSERM, Unit\u00e9 U955, Cr\u00e9teil, France; Universit\u00e9 Paris-Est, Facult\u00e9 de M\u00e9decine, UMR-S955 Creteil, France","institution_ids":[]},{"raw_affiliation_string":"Universit\u00e9 Paris-Est, Facult\u00e9 de M\u00e9decine, UMR-S955 Creteil, France","institution_ids":[]},{"raw_affiliation_string":"INSERM, Unit\u00e9 U955, Cr\u00e9teil, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011869192","display_name":"St\u00e9phanie Beq","orcid":null},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"St\u00e9phanie Beq","raw_affiliation_strings":["CYTHERIS, Issy Les Moulineaux, France"],"affiliations":[{"raw_affiliation_string":"CYTHERIS, Issy Les Moulineaux, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111734777","display_name":"Ana Jarn\u00e9","orcid":null},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"funder","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I15057530","display_name":"Universit\u00e9 de Bordeaux","ror":"https://ror.org/057qpr032","country_code":"FR","type":"education","lineage":["https://openalex.org/I15057530"]},{"id":"https://openalex.org/I1326498283","display_name":"Institut national de recherche en informatique et en automatique","ror":"https://ror.org/02kvxyf05","country_code":"FR","type":"funder","lineage":["https://openalex.org/I1326498283"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Ana Jarne","raw_affiliation_strings":["INSERM, ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux, France; Univ. Bordeaux, ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux, France; INRIA, SISTM team, Bordeaux, France","INSERM, ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux, France","Univ. Bordeaux, ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux, France","INRIA, SISTM team, Bordeaux, France"],"affiliations":[{"raw_affiliation_string":"INSERM, ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux, France; Univ. Bordeaux, ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux, France; INRIA, SISTM team, Bordeaux, France","institution_ids":[]},{"raw_affiliation_string":"INSERM, ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"Univ. Bordeaux, ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I15057530"]},{"raw_affiliation_string":"INRIA, SISTM team, Bordeaux, France","institution_ids":["https://openalex.org/I1326498283"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008727148","display_name":"Th\u00e9r\u00e8se Croughs","orcid":"https://orcid.org/0000-0003-0246-7619"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Th\u00e9r\u00e8se Croughs","raw_affiliation_strings":["CYTHERIS, Issy Les Moulineaux, France"],"affiliations":[{"raw_affiliation_string":"CYTHERIS, Issy Les Moulineaux, France","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040099496","display_name":"Rafick\u2010Pierre S\u00e9kaly","orcid":"https://orcid.org/0000-0002-7816-4828"},"institutions":[{"id":"https://openalex.org/I4210131476","display_name":"Vaccine & Gene Therapy Institute of Florida","ror":"https://ror.org/03ez2en98","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210131476"]},{"id":"https://openalex.org/I4392738146","display_name":"Vaccine and Gene Therapy Institute","ror":"https://ror.org/00d4pqn65","country_code":null,"type":"facility","lineage":["https://openalex.org/I165690674","https://openalex.org/I4392738146"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rafick-Pierre Sekaly","raw_affiliation_strings":["Vaccine and Gene Therapy Institute-Florida, Port St. Lucie, Florida, United States of America"],"affiliations":[{"raw_affiliation_string":"Vaccine and Gene Therapy Institute-Florida, Port St. Lucie, Florida, United States of America","institution_ids":["https://openalex.org/I4210131476","https://openalex.org/I4392738146"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072899489","display_name":"Michael M. Lederman","orcid":"https://orcid.org/0000-0001-9247-8025"},"institutions":[{"id":"https://openalex.org/I58956616","display_name":"Case Western Reserve University","ror":"https://ror.org/051fd9666","country_code":"US","type":"education","lineage":["https://openalex.org/I58956616"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael M. Lederman","raw_affiliation_strings":["Case Western Reserve University/University Hospitals/Case Medical Center, Cleveland, Ohio, United States of America"],"affiliations":[{"raw_affiliation_string":"Case Western Reserve University/University Hospitals/Case Medical Center, Cleveland, Ohio, United States of America","institution_ids":["https://openalex.org/I58956616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089780095","display_name":"Irini Sereti","orcid":"https://orcid.org/0000-0002-0076-0224"},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210134534","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210134534"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Irini Sereti","raw_affiliation_strings":["National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America"],"affiliations":[{"raw_affiliation_string":"National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, United States of America","institution_ids":["https://openalex.org/I4210134534","https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010295552","display_name":"Daniel Commenges","orcid":"https://orcid.org/0000-0001-8988-9114"},"institutions":[{"id":"https://openalex.org/I15057530","display_name":"Universit\u00e9 de Bordeaux","ror":"https://ror.org/057qpr032","country_code":"FR","type":"education","lineage":["https://openalex.org/I15057530"]},{"id":"https://openalex.org/I1326498283","display_name":"Institut national de recherche en informatique et en automatique","ror":"https://ror.org/02kvxyf05","country_code":"FR","type":"funder","lineage":["https://openalex.org/I1326498283"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"funder","lineage":["https://openalex.org/I154526488"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Daniel Commenges","raw_affiliation_strings":["INSERM, ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux, France; Univ. Bordeaux, ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux, France; INRIA, SISTM team, Bordeaux, France","INRIA, SISTM team, Bordeaux, France","Univ. Bordeaux, ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux, France","INSERM, ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux, France"],"affiliations":[{"raw_affiliation_string":"INSERM, ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux, France; Univ. Bordeaux, ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux, France; INRIA, SISTM team, Bordeaux, France","institution_ids":[]},{"raw_affiliation_string":"INRIA, SISTM team, Bordeaux, France","institution_ids":["https://openalex.org/I1326498283"]},{"raw_affiliation_string":"Univ. Bordeaux, ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux, France","institution_ids":["https://openalex.org/I154526488","https://openalex.org/I15057530"]},{"raw_affiliation_string":"INSERM, ISPED, Centre INSERM U897-Epidemiologie-Biostatistique, Bordeaux, France","institution_ids":["https://openalex.org/I154526488"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111926131","display_name":"Yves L\u00e9vy","orcid":null},"institutions":[{"id":"https://openalex.org/I4210156254","display_name":"H\u00f4pital Albert-Chenevier","ror":"https://ror.org/0511th722","country_code":"FR","type":"healthcare","lineage":["https://openalex.org/I4210097159","https://openalex.org/I4210156254"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"funder","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210097159","display_name":"Assistance Publique \u2013 H\u00f4pitaux de Paris","ror":"https://ror.org/00pg5jh14","country_code":"FR","type":"funder","lineage":["https://openalex.org/I4210097159"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Yves L\u00e9vy","raw_affiliation_strings":["INSERM, Unit\u00e9 U955, Cr\u00e9teil, France; Universit\u00e9 Paris-Est, Facult\u00e9 de M\u00e9decine, UMR-S955 Creteil, France; AP-HP, Groupe Henri-Mondor Albert-Chenevier, Immunologie Clinique, Creteil, France","INSERM, Unit\u00e9 U955, Cr\u00e9teil, France","AP-HP, Groupe Henri-Mondor Albert-Chenevier, Immunologie Clinique, Creteil, France","Universit\u00e9 Paris-Est, Facult\u00e9 de M\u00e9decine, UMR-S955 Creteil, France"],"affiliations":[{"raw_affiliation_string":"INSERM, Unit\u00e9 U955, Cr\u00e9teil, France; Universit\u00e9 Paris-Est, Facult\u00e9 de M\u00e9decine, UMR-S955 Creteil, France; AP-HP, Groupe Henri-Mondor Albert-Chenevier, Immunologie Clinique, Creteil, France","institution_ids":[]},{"raw_affiliation_string":"INSERM, Unit\u00e9 U955, Cr\u00e9teil, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"AP-HP, Groupe Henri-Mondor Albert-Chenevier, Immunologie Clinique, Creteil, France","institution_ids":["https://openalex.org/I4210156254","https://openalex.org/I4210097159"]},{"raw_affiliation_string":"Universit\u00e9 Paris-Est, Facult\u00e9 de M\u00e9decine, UMR-S955 Creteil, France","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":12,"corresponding_author_ids":["https://openalex.org/A5022077216"],"corresponding_institution_ids":["https://openalex.org/I1326498283","https://openalex.org/I15057530","https://openalex.org/I154526488"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.6685,"has_fulltext":true,"cited_by_count":21,"citation_normalized_percentile":{"value":0.83268085,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"10","issue":"5","first_page":"e1003630","last_page":"e1003630"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/antiretroviral-therapy","display_name":"Antiretroviral therapy","score":0.6719319820404053},{"id":"https://openalex.org/keywords/cd4-t-cell","display_name":"Cd4 t cell","score":0.6253837943077087},{"id":"https://openalex.org/keywords/human-immunodeficiency-virus","display_name":"Human immunodeficiency virus (HIV)","score":0.6068591475486755},{"id":"https://openalex.org/keywords/immune-system","display_name":"Immune system","score":0.5925371646881104},{"id":"https://openalex.org/keywords/t-cell","display_name":"T cell","score":0.5300697088241577},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.5296069383621216},{"id":"https://openalex.org/keywords/interleukin","display_name":"Interleukin","score":0.5189392566680908},{"id":"https://openalex.org/keywords/interleukin-4","display_name":"Interleukin 4","score":0.44913023710250854},{"id":"https://openalex.org/keywords/interleukin-2","display_name":"Interleukin 2","score":0.43887633085250854},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.43875303864479065},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.415962815284729},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.37490957975387573},{"id":"https://openalex.org/keywords/viral-load","display_name":"Viral load","score":0.24218550324440002},{"id":"https://openalex.org/keywords/cytokine","display_name":"Cytokine","score":0.23834913969039917}],"concepts":[{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.6719319820404053},{"id":"https://openalex.org/C2993178667","wikidata":"https://www.wikidata.org/wiki/Q632518","display_name":"Cd4 t cell","level":4,"score":0.6253837943077087},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.6068591475486755},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5925371646881104},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.5300697088241577},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5296069383621216},{"id":"https://openalex.org/C74172505","wikidata":"https://www.wikidata.org/wiki/Q194908","display_name":"Interleukin","level":3,"score":0.5189392566680908},{"id":"https://openalex.org/C191732599","wikidata":"https://www.wikidata.org/wiki/Q14865947","display_name":"Interleukin 4","level":3,"score":0.44913023710250854},{"id":"https://openalex.org/C2777371288","wikidata":"https://www.wikidata.org/wiki/Q410130","display_name":"Interleukin 2","level":3,"score":0.43887633085250854},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.43875303864479065},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.415962815284729},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37490957975387573},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.24218550324440002},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.23834913969039917},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015496","descriptor_name":"CD4-Positive T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015497","descriptor_name":"HIV-1","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015851","descriptor_name":"Interleukin-7","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015851","descriptor_name":"Interleukin-7","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015851","descriptor_name":"Interleukin-7","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018448","descriptor_name":"Models, Immunological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018448","descriptor_name":"Models, Immunological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018448","descriptor_name":"Models, Immunological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019394","descriptor_name":"Ki-67 Antigen","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D019394","descriptor_name":"Ki-67 Antigen","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D019394","descriptor_name":"Ki-67 Antigen","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pcbi.1003630","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003630","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003630&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:24853554","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24853554","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:HAL:hal-01108204v1","is_oa":false,"landing_page_url":"https://inria.hal.science/hal-01108204","pdf_url":null,"source":{"id":"https://openalex.org/S4406922466","display_name":"SPIRE - Sciences Po Institutional REpository","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, 2014, 10 (5), pp.e1003630. ⟨10.1371/journal.pcbi.1003630⟩","raw_type":"Journal articles"},{"id":"pmh:oai:RePEc:plo:pcbi00:1003630","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1003630","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:c2686c9e352e4e8a8a992c7f7a8d279d","is_oa":true,"landing_page_url":"https://doaj.org/article/c2686c9e352e4e8a8a992c7f7a8d279d","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 10, Iss 5, p e1003630 (2014)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:3008999","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4031052","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/1034579","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Quantifying_and_Predicting_the_Effect_of_Exogenous_Interleukin_7_on_CD4_T_Cells_in_HIV_1_Infection/1034579","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1003630","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003630","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003630&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8299999833106995,"display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2012137498.pdf","grobid_xml":"https://content.openalex.org/works/W2012137498.grobid-xml"},"referenced_works_count":61,"referenced_works":["https://openalex.org/W85833199","https://openalex.org/W572213268","https://openalex.org/W1509269909","https://openalex.org/W1580217007","https://openalex.org/W1596727920","https://openalex.org/W1938018184","https://openalex.org/W1965612904","https://openalex.org/W1970082645","https://openalex.org/W1970635924","https://openalex.org/W1974104246","https://openalex.org/W1974208182","https://openalex.org/W1988495621","https://openalex.org/W1992031335","https://openalex.org/W1994844769","https://openalex.org/W2002051431","https://openalex.org/W2004049598","https://openalex.org/W2009012723","https://openalex.org/W2010234200","https://openalex.org/W2040870229","https://openalex.org/W2048417224","https://openalex.org/W2056644883","https://openalex.org/W2069043306","https://openalex.org/W2069331773","https://openalex.org/W2070439685","https://openalex.org/W2073848442","https://openalex.org/W2080181628","https://openalex.org/W2082797461","https://openalex.org/W2095985058","https://openalex.org/W2098152992","https://openalex.org/W2099088219","https://openalex.org/W2102369355","https://openalex.org/W2105011122","https://openalex.org/W2105646872","https://openalex.org/W2110938611","https://openalex.org/W2111888415","https://openalex.org/W2121841446","https://openalex.org/W2123434358","https://openalex.org/W2124114936","https://openalex.org/W2126815715","https://openalex.org/W2127652935","https://openalex.org/W2134377316","https://openalex.org/W2135813534","https://openalex.org/W2146666488","https://openalex.org/W2147468547","https://openalex.org/W2148047471","https://openalex.org/W2149851148","https://openalex.org/W2150645158","https://openalex.org/W2157191575","https://openalex.org/W2159004702","https://openalex.org/W2159958805","https://openalex.org/W2161179658","https://openalex.org/W2161334033","https://openalex.org/W2165981943","https://openalex.org/W2167148984","https://openalex.org/W2167370485","https://openalex.org/W2168016523","https://openalex.org/W2171907379","https://openalex.org/W2171970710","https://openalex.org/W2316986106","https://openalex.org/W2430517988","https://openalex.org/W4242140596"],"related_works":["https://openalex.org/W2127830638","https://openalex.org/W2144596714","https://openalex.org/W4253361592","https://openalex.org/W2073655058","https://openalex.org/W2160715338","https://openalex.org/W2383711492","https://openalex.org/W2462542604","https://openalex.org/W4246272606","https://openalex.org/W2014074050","https://openalex.org/W2057073952"],"abstract_inverted_index":{"Exogenous":[0],"Interleukin-7":[1],"(IL-7),":[2],"in":[3,19,63,91,179],"supplement":[4],"to":[5,9,97,168],"antiretroviral":[6,187],"therapy,":[7],"leads":[8],"a":[10,41,76,88,134,152],"substantial":[11],"increase":[12,78],"of":[13,27,32,34,44,47,79,102,106,126,154,160],"all":[14],"CD4+":[15,51,92,109,139,171],"T":[16,52,93,110,140,172],"cell":[17,94,111,141,173],"subsets":[18],"HIV-1":[20,59,180],"infected":[21,60,181],"patients.":[22],"However,":[23],"the":[24,28,103,107,113,164],"quantitative":[25],"contribution":[26],"several":[29],"potential":[30,165],"mechanisms":[31],"action":[33],"IL-7":[35,82,167,177],"is":[36,112],"unknown.":[37],"We":[38,72],"have":[39],"performed":[40],"mathematical":[42],"analysis":[43,159],"repeated":[45,124],"measurements":[46],"total":[48,108],"and":[49,54],"naive":[50],"cells":[53],"their":[55],"Ki67":[56],"expression":[57],"from":[58],"patients":[61,182],"involved":[62],"three":[64],"phase":[65],"I/II":[66],"studies":[67],"(N":[68],"=":[69],"53":[70],"patients).":[71],"show":[73],"that,":[74],"besides":[75],"transient":[77],"peripheral":[80],"proliferation,":[81],"exerts":[83],"additional":[84],"effects":[85],"that":[86,132],"play":[87],"significant":[89],"role":[90],"dynamics":[95],"up":[96],"52":[98],"weeks.":[99],"A":[100],"decrease":[101],"loss":[104],"rate":[105],"most":[114],"probable":[115],"explanation.":[116],"If":[117],"this":[118],"effect":[119],"could":[120],"be":[121],"maintained":[122],"during":[123],"administration":[125],"IL-7,":[127],"our":[128],"simulation":[129],"study":[130],"shows":[131],"such":[133],"strategy":[135],"may":[136],"allow":[137],"maintaining":[138],"counts":[142],"above":[143],"500":[144],"cells/\u00b5L":[145],"with":[146,175,183],"4":[147],"cycles":[148],"or":[149],"fewer":[150],"over":[151],"period":[153],"two":[155],"years.":[156],"This":[157],"in-depth":[158],"clinical":[161],"data":[162],"revealed":[163],"for":[166],"achieve":[169],"sustained":[170],"restoration":[174],"limited":[176],"exposure":[178],"immune":[184],"failure":[185],"despite":[186],"therapy.":[188]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3}],"updated_date":"2026-04-06T07:47:59.780226","created_date":"2025-10-10T00:00:00"}