{"id":"https://openalex.org/W2037048830","doi":"https://doi.org/10.1371/journal.pcbi.1003592","title":"Determining Effects of Non-synonymous SNPs on Protein-Protein Interactions using Supervised and Semi-supervised Learning","display_name":"Determining Effects of Non-synonymous SNPs on Protein-Protein Interactions using Supervised and Semi-supervised Learning","publication_year":2014,"publication_date":"2014-05-01","ids":{"openalex":"https://openalex.org/W2037048830","doi":"https://doi.org/10.1371/journal.pcbi.1003592","mag":"2037048830","pmid":"https://pubmed.ncbi.nlm.nih.gov/24784581"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1003592","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003592","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003592&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003592&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5028509888","display_name":"Nan Zhao","orcid":"https://orcid.org/0000-0002-7897-2374"},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nan Zhao","raw_affiliation_strings":["Informatics Institute, University of Missouri, Columbia, Missouri, United States of America"],"affiliations":[{"raw_affiliation_string":"Informatics Institute, University of Missouri, Columbia, Missouri, United States of America","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101147774","display_name":"Jing Han","orcid":null},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jing Ginger Han","raw_affiliation_strings":["Informatics Institute, University of Missouri, Columbia, Missouri, United States of America"],"affiliations":[{"raw_affiliation_string":"Informatics Institute, University of Missouri, Columbia, Missouri, United States of America","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013031415","display_name":"Chi\u2010Ren Shyu","orcid":"https://orcid.org/0000-0001-9197-9522"},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chi-Ren Shyu","raw_affiliation_strings":["Informatics Institute, University of Missouri, Columbia, Missouri, United States of America; Department of Computer Science, University of Missouri, Columbia, Missouri, United States of America","Department of Computer Science, University of Missouri, Columbia, Missouri, United States of America","Informatics Institute, University of Missouri, Columbia, Missouri, United States of America"],"affiliations":[{"raw_affiliation_string":"Informatics Institute, University of Missouri, Columbia, Missouri, United States of America; Department of Computer Science, University of Missouri, Columbia, Missouri, United States of America","institution_ids":[]},{"raw_affiliation_string":"Department of Computer Science, University of Missouri, Columbia, Missouri, United States of America","institution_ids":["https://openalex.org/I76835614"]},{"raw_affiliation_string":"Informatics Institute, University of Missouri, Columbia, Missouri, United States of America","institution_ids":["https://openalex.org/I76835614"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5022192689","display_name":"Dmitry Korkin","orcid":"https://orcid.org/0000-0002-3875-9085"},"institutions":[{"id":"https://openalex.org/I76835614","display_name":"University of Missouri","ror":"https://ror.org/02ymw8z06","country_code":"US","type":"education","lineage":["https://openalex.org/I76835614"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Dmitry Korkin","raw_affiliation_strings":["Informatics Institute, University of Missouri, Columbia, Missouri, United States of America; Department of Computer Science, University of Missouri, Columbia, Missouri, United States of America; Bond Life Science Center, University of Missouri, Columbia, Missouri, United States of America","Department of Computer Science, University of Missouri, Columbia, Missouri, United States of America","Bond Life Science Center, University of Missouri, Columbia, Missouri, United States of America","Informatics Institute, University of Missouri, Columbia, Missouri, United States of America"],"affiliations":[{"raw_affiliation_string":"Informatics Institute, University of Missouri, Columbia, Missouri, United States of America; Department of Computer Science, University of Missouri, Columbia, Missouri, United States of America; Bond Life Science Center, University of Missouri, Columbia, Missouri, United States of America","institution_ids":[]},{"raw_affiliation_string":"Department of Computer Science, University of Missouri, Columbia, Missouri, United States of America","institution_ids":["https://openalex.org/I76835614"]},{"raw_affiliation_string":"Bond Life Science Center, University of Missouri, Columbia, Missouri, United States of America","institution_ids":["https://openalex.org/I76835614"]},{"raw_affiliation_string":"Informatics Institute, University of Missouri, Columbia, Missouri, United States of America","institution_ids":["https://openalex.org/I76835614"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5022192689"],"corresponding_institution_ids":["https://openalex.org/I76835614"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":4.2784,"has_fulltext":true,"cited_by_count":85,"citation_normalized_percentile":{"value":0.95070305,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":100},"biblio":{"volume":"10","issue":"5","first_page":"e1003592","last_page":"e1003592"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12254","display_name":"Machine Learning in Bioinformatics","score":0.9980999827384949,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/single-nucleotide-polymorphism","display_name":"Single-nucleotide polymorphism","score":0.6191445589065552},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.577666163444519},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.5488463640213013},{"id":"https://openalex.org/keywords/classifier","display_name":"Classifier (UML)","score":0.5024588108062744},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.47736048698425293},{"id":"https://openalex.org/keywords/supervised-learning","display_name":"Supervised learning","score":0.4756447970867157},{"id":"https://openalex.org/keywords/snp","display_name":"SNP","score":0.46927228569984436},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4300297796726227},{"id":"https://openalex.org/keywords/missense-mutation","display_name":"Missense mutation","score":0.42283159494400024},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.4113644063472748},{"id":"https://openalex.org/keywords/mutation","display_name":"Mutation","score":0.3766123950481415},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3470200300216675},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.2386704385280609},{"id":"https://openalex.org/keywords/artificial-neural-network","display_name":"Artificial neural network","score":0.20986145734786987}],"concepts":[{"id":"https://openalex.org/C153209595","wikidata":"https://www.wikidata.org/wiki/Q501128","display_name":"Single-nucleotide polymorphism","level":4,"score":0.6191445589065552},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.577666163444519},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.5488463640213013},{"id":"https://openalex.org/C95623464","wikidata":"https://www.wikidata.org/wiki/Q1096149","display_name":"Classifier (UML)","level":2,"score":0.5024588108062744},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.47736048698425293},{"id":"https://openalex.org/C136389625","wikidata":"https://www.wikidata.org/wiki/Q334384","display_name":"Supervised learning","level":3,"score":0.4756447970867157},{"id":"https://openalex.org/C139275648","wikidata":"https://www.wikidata.org/wiki/Q17134011","display_name":"SNP","level":5,"score":0.46927228569984436},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4300297796726227},{"id":"https://openalex.org/C75563809","wikidata":"https://www.wikidata.org/wiki/Q2656896","display_name":"Missense mutation","level":4,"score":0.42283159494400024},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4113644063472748},{"id":"https://openalex.org/C501734568","wikidata":"https://www.wikidata.org/wiki/Q42918","display_name":"Mutation","level":3,"score":0.3766123950481415},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3470200300216675},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.2386704385280609},{"id":"https://openalex.org/C50644808","wikidata":"https://www.wikidata.org/wiki/Q192776","display_name":"Artificial neural network","level":2,"score":0.20986145734786987},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D003920","descriptor_name":"Diabetes Mellitus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010363","descriptor_name":"Pattern Recognition, Automated","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D010363","descriptor_name":"Pattern Recognition, Automated","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D010363","descriptor_name":"Pattern Recognition, Automated","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020543","descriptor_name":"Proteome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020641","descriptor_name":"Polymorphism, Single Nucleotide","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D056726","descriptor_name":"Genetic Association Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056726","descriptor_name":"Genetic Association Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056726","descriptor_name":"Genetic Association Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1003592","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003592","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003592&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:24784581","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24784581","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:26f56d67535b4510b5cb6ffd036dc219","is_oa":true,"landing_page_url":"https://doaj.org/article/26f56d67535b4510b5cb6ffd036dc219","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 10, Iss 5, p e1003592 (2014)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:2992359","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4006705","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/1013300","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/_Determining_Effects_of_Non_synonymous_SNPs_on_Protein_Protein_Interactions_using_Supervised_and_Semi_supervised_Learning_/1013300","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1003592","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003592","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003592&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/15","display_name":"Life in Land","score":0.6399999856948853}],"awards":[{"id":"https://openalex.org/G1896484428","display_name":null,"funder_award_id":"IOS-1126992","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G5866030102","display_name":"CAREER:    A Computational Approach to Study Molecular Mimicry in Host-Pathogen Interactions","funder_award_id":"0845196","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G6342935115","display_name":null,"funder_award_id":"DBI-0845196","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G8548363660","display_name":"Systems Analysis of Protein Interactome in Cytosol and Nuclei of Developing Soybean and Rapeseed Embryos","funder_award_id":"1126992","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2037048830.pdf","grobid_xml":"https://content.openalex.org/works/W2037048830.grobid-xml"},"referenced_works_count":92,"referenced_works":["https://openalex.org/W39276116","https://openalex.org/W92894758","https://openalex.org/W1595347157","https://openalex.org/W1782769401","https://openalex.org/W1840508780","https://openalex.org/W1915490970","https://openalex.org/W1963697504","https://openalex.org/W1964444099","https://openalex.org/W1971938921","https://openalex.org/W1972702506","https://openalex.org/W1973181481","https://openalex.org/W1980120676","https://openalex.org/W1980759842","https://openalex.org/W1987242394","https://openalex.org/W1987507232","https://openalex.org/W1988739180","https://openalex.org/W1989613054","https://openalex.org/W1990334093","https://openalex.org/W1990537176","https://openalex.org/W2003341701","https://openalex.org/W2006249058","https://openalex.org/W2023490488","https://openalex.org/W2025943989","https://openalex.org/W2027134752","https://openalex.org/W2028203395","https://openalex.org/W2038132549","https://openalex.org/W2038297271","https://openalex.org/W2043916285","https://openalex.org/W2046032690","https://openalex.org/W2046247026","https://openalex.org/W2049275721","https://openalex.org/W2051322491","https://openalex.org/W2051391520","https://openalex.org/W2051710717","https://openalex.org/W2052868118","https://openalex.org/W2058539819","https://openalex.org/W2059145105","https://openalex.org/W2061008984","https://openalex.org/W2067721032","https://openalex.org/W2080310417","https://openalex.org/W2082020870","https://openalex.org/W2086358562","https://openalex.org/W2088608587","https://openalex.org/W2090013396","https://openalex.org/W2097271989","https://openalex.org/W2098949725","https://openalex.org/W2104703176","https://openalex.org/W2105833751","https://openalex.org/W2107008379","https://openalex.org/W2107889007","https://openalex.org/W2107916366","https://openalex.org/W2109336567","https://openalex.org/W2111326065","https://openalex.org/W2115694019","https://openalex.org/W2117541321","https://openalex.org/W2118517681","https://openalex.org/W2122732537","https://openalex.org/W2123850444","https://openalex.org/W2127981150","https://openalex.org/W2128302979","https://openalex.org/W2128995100","https://openalex.org/W2129018774","https://openalex.org/W2131709305","https://openalex.org/W2131822674","https://openalex.org/W2133621813","https://openalex.org/W2133990480","https://openalex.org/W2134024404","https://openalex.org/W2137167381","https://openalex.org/W2138913459","https://openalex.org/W2140574901","https://openalex.org/W2140883620","https://openalex.org/W2141014201","https://openalex.org/W2146208101","https://openalex.org/W2152116196","https://openalex.org/W2152416668","https://openalex.org/W2153969263","https://openalex.org/W2154110104","https://openalex.org/W2154714967","https://openalex.org/W2156167884","https://openalex.org/W2156269526","https://openalex.org/W2157735020","https://openalex.org/W2157807259","https://openalex.org/W2162128823","https://openalex.org/W2166735471","https://openalex.org/W2167965498","https://openalex.org/W2172129621","https://openalex.org/W2258454327","https://openalex.org/W2328290467","https://openalex.org/W2911964244","https://openalex.org/W4210997624","https://openalex.org/W4254753097","https://openalex.org/W6639710061"],"related_works":["https://openalex.org/W2164855536","https://openalex.org/W1997352593","https://openalex.org/W4206968815","https://openalex.org/W2143489661","https://openalex.org/W3016573916","https://openalex.org/W2070581548","https://openalex.org/W1511048503","https://openalex.org/W3206555169","https://openalex.org/W3157359833","https://openalex.org/W4281711902"],"abstract_inverted_index":{"Single":[0],"nucleotide":[1],"polymorphisms":[2],"(SNPs)":[3],"are":[4,130],"among":[5],"the":[6,23,29,35,51,93,104,111,150,202,214,224,228,241,251,272],"most":[7,215],"common":[8],"types":[9],"of":[10,20,26,106,136,149,223,243,254,263,274,286],"genetic":[11,15],"variation":[12],"in":[13,197],"complex":[14],"disorders.":[16],"A":[17],"growing":[18],"number":[19],"studies":[21,139],"link":[22],"functional":[24,284],"role":[25],"SNPs":[27,43],"with":[28,144,201],"networks":[30],"and":[31,74,86,117,152,176,189,194,260,279],"pathways":[32],"mediated":[33],"by":[34],"disease-associated":[36,287],"genes.":[37],"For":[38],"example,":[39],"many":[40],"non-synonymous":[41],"missense":[42],"(nsSNPs)":[44],"have":[45],"been":[46],"found":[47],"near":[48],"or":[49,62],"inside":[50],"protein-protein":[52,276],"interaction":[53,277],"(PPI)":[54],"interfaces.":[55],"Determining":[56],"whether":[57],"such":[58],"nsSNP":[59],"will":[60],"disrupt":[61],"preserve":[63],"a":[64,67,88,134,161,174,178,198,295],"PPI":[65,142,165],"is":[66,291],"challenging":[68,216],"task":[69,80],"to":[70,211,249,270],"address,":[71],"both":[72],"experimentally":[73,145],"computationally.":[75],"Here,":[76],"we":[77,231],"present":[78],"this":[79],"as":[81,294],"three":[82],"related":[83],"classification":[84,156,180],"problems,":[85],"develop":[87],"new":[89,123],"computational":[90],"method,":[91],"called":[92],"SNP-IN":[94,244,264],"tool":[95,265,290],"(non-synonymous":[96],"SNP":[97],"INteraction":[98],"effect":[99],"predictor).":[100],"Our":[101],"method":[102],"predicts":[103],"effects":[105],"nsSNPs":[107],"on":[108,133],"PPIs,":[109],"given":[110],"interaction's":[112],"structure.":[113],"It":[114],"leverages":[115],"supervised":[116,188],"semi-supervised":[118,190],"feature-based":[119],"classifiers,":[120],"including":[121],"our":[122],"Random":[124],"Forest":[125],"self-learning":[126],"protocol.":[127],"The":[128,258],"classifiers":[129,191,226],"trained":[131,193],"based":[132],"dataset":[135],"comprehensive":[137],"mutagenesis":[138],"for":[140,208,213,236,283],"151":[141],"complexes,":[143],"determined":[146],"binding":[147],"affinities":[148],"mutant":[151],"wild-type":[153],"interactions.":[154],"Three":[155],"problems":[157],"were":[158,192],"considered:":[159],"(1)":[160],"2-class":[162,169,225],"problem":[163,170],"(strengthening/weakening":[164],"mutations),":[166],"(2)":[167],"another":[168],"(mutations":[171],"that":[172],"disrupt/preserve":[173],"PPI),":[175],"(3)":[177],"3-class":[179,229],"(detrimental/neutral/beneficial":[181],"mutation":[182],"effects).":[183],"In":[184],"total,":[185],"11":[186],"different":[187],"assessed":[195],"resulting":[196],"promising":[199],"performance,":[200],"weighted":[203],"f-measure":[204],"ranging":[205],"from":[206],"0.87":[207],"Problem":[209,217,237],"1":[210],"0.70":[212],"3.":[218,238],"By":[219],"integrating":[220],"prediction":[221],"results":[222],"into":[227],"classifier,":[230],"further":[232],"improved":[233],"its":[234],"performance":[235,262],"To":[239],"demonstrate":[240],"utility":[242],"tool,":[245],"it":[246,267],"was":[247],"applied":[248],"study":[250,271],"nsSNP-induced":[252],"rewiring":[253,273],"two":[255],"disease-centered":[256],"networks.":[257],"accurate":[259],"balanced":[261],"makes":[266],"readily":[268],"available":[269],"large-scale":[275],"networks,":[278],"can":[280],"be":[281],"useful":[282],"annotation":[285],"SNPs.":[288],"SNIP-IN":[289],"freely":[292],"accessible":[293],"web-server":[296],"at":[297],"http://korkinlab.org/snpintool/.":[298]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":10},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":16},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":2}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}