{"id":"https://openalex.org/W2031865362","doi":"https://doi.org/10.1371/journal.pcbi.1003532","title":"Biophysical Properties of Intrinsically Disordered p130Cas Substrate Domain \u2014 Implication in Mechanosensing","display_name":"Biophysical Properties of Intrinsically Disordered p130Cas Substrate Domain \u2014 Implication in Mechanosensing","publication_year":2014,"publication_date":"2014-04-10","ids":{"openalex":"https://openalex.org/W2031865362","doi":"https://doi.org/10.1371/journal.pcbi.1003532","mag":"2031865362","pmid":"https://pubmed.ncbi.nlm.nih.gov/24722239"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1003532","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003532","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003532&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003532&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026142739","display_name":"Kinya Hotta","orcid":"https://orcid.org/0000-0002-9427-0081"},"institutions":[{"id":"https://openalex.org/I155043079","display_name":"University of Nottingham Malaysia Campus","ror":"https://ror.org/04mz9mt17","country_code":"MY","type":"education","lineage":["https://openalex.org/I142263535","https://openalex.org/I155043079"]},{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["MY","SG"],"is_corresponding":false,"raw_author_name":"Kinya Hotta","raw_affiliation_strings":["Department of Biological Sciences, National University of Singapore, Singapore; School of Biosciences, The University of Nottingham Malaysia Campus, Selangor, Malaysia","Department of Biological Sciences, National University of Singapore, Singapore","School of Biosciences, The University of Nottingham Malaysia Campus, Selangor, Malaysia"],"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, National University of Singapore, Singapore; School of Biosciences, The University of Nottingham Malaysia Campus, Selangor, Malaysia","institution_ids":[]},{"raw_affiliation_string":"Department of Biological Sciences, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]},{"raw_affiliation_string":"School of Biosciences, The University of Nottingham Malaysia Campus, Selangor, Malaysia","institution_ids":["https://openalex.org/I155043079"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006421687","display_name":"Soumya Ranganathan","orcid":"https://orcid.org/0000-0002-5655-223X"},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Soumya Ranganathan","raw_affiliation_strings":["Department of Biological Sciences, National University of Singapore, Singapore; Mechanobiology Institute, National University of Singapore, Singapore","Mechanobiology Institute, National University of Singapore, Singapore","Department of Biological Sciences, National University of Singapore, Singapore"],"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, National University of Singapore, Singapore; Mechanobiology Institute, National University of Singapore, Singapore","institution_ids":[]},{"raw_affiliation_string":"Mechanobiology Institute, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]},{"raw_affiliation_string":"Department of Biological Sciences, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5024595141","display_name":"Ruchuan Liu","orcid":"https://orcid.org/0000-0002-7468-7808"},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Ruchuan Liu","raw_affiliation_strings":["Mechanobiology Institute, National University of Singapore, Singapore; Department of Physics, National University of Singapore, Singapore","Department of Physics, National University of Singapore, Singapore","Mechanobiology Institute, National University of Singapore, Singapore"],"affiliations":[{"raw_affiliation_string":"Mechanobiology Institute, National University of Singapore, Singapore; Department of Physics, National University of Singapore, Singapore","institution_ids":[]},{"raw_affiliation_string":"Department of Physics, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]},{"raw_affiliation_string":"Mechanobiology Institute, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023518578","display_name":"Fei Wu","orcid":"https://orcid.org/0000-0003-4196-0289"},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Fei Wu","raw_affiliation_strings":["Department of Physics, National University of Singapore, Singapore"],"affiliations":[{"raw_affiliation_string":"Department of Physics, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023142901","display_name":"Hiroaki Machiyama","orcid":"https://orcid.org/0000-0002-5524-581X"},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Hiroaki Machiyama","raw_affiliation_strings":["Department of Biological Sciences, National University of Singapore, Singapore; Mechanobiology Institute, National University of Singapore, Singapore","Mechanobiology Institute, National University of Singapore, Singapore","Department of Biological Sciences, National University of Singapore, Singapore"],"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, National University of Singapore, Singapore; Mechanobiology Institute, National University of Singapore, Singapore","institution_ids":[]},{"raw_affiliation_string":"Mechanobiology Institute, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]},{"raw_affiliation_string":"Department of Biological Sciences, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101743626","display_name":"Rong Gao","orcid":"https://orcid.org/0000-0002-5495-2889"},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Rong Gao","raw_affiliation_strings":["Department of Biological Sciences, National University of Singapore, Singapore; Mechanobiology Institute, National University of Singapore, Singapore","Department of Biological Sciences, National University of Singapore, Singapore","Mechanobiology Institute, National University of Singapore, Singapore"],"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, National University of Singapore, Singapore; Mechanobiology Institute, National University of Singapore, Singapore","institution_ids":[]},{"raw_affiliation_string":"Department of Biological Sciences, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]},{"raw_affiliation_string":"Mechanobiology Institute, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089520394","display_name":"Hiroaki Hirata","orcid":"https://orcid.org/0000-0002-2604-9158"},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Hiroaki Hirata","raw_affiliation_strings":["Mechanobiology Institute, National University of Singapore, Singapore"],"affiliations":[{"raw_affiliation_string":"Mechanobiology Institute, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012258328","display_name":"Neelesh Soni","orcid":"https://orcid.org/0000-0002-9333-7491"},"institutions":[{"id":"https://openalex.org/I181996519","display_name":"Indian Institute of Science Education and Research Pune","ror":"https://ror.org/028qa3n13","country_code":"IN","type":"education","lineage":["https://openalex.org/I181996519"]}],"countries":["IN"],"is_corresponding":false,"raw_author_name":"Neelesh Soni","raw_affiliation_strings":["Indian Institute of Science Education and Research, Pune, India"],"affiliations":[{"raw_affiliation_string":"Indian Institute of Science Education and Research, Pune, India","institution_ids":["https://openalex.org/I181996519"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057867013","display_name":"Takashi Ohe","orcid":null},"institutions":[{"id":"https://openalex.org/I4210161310","display_name":"Nadogaya Hospital","ror":"https://ror.org/05xkjsd30","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210161310"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takashi Ohe","raw_affiliation_strings":["Locomotive Syndrome Research Institute, Nadogaya Hospital, Kashiwa, Japan"],"affiliations":[{"raw_affiliation_string":"Locomotive Syndrome Research Institute, Nadogaya Hospital, Kashiwa, Japan","institution_ids":["https://openalex.org/I4210161310"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084007105","display_name":"Christopher W.V. Hogue","orcid":"https://orcid.org/0000-0002-3107-5246"},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["SG"],"is_corresponding":false,"raw_author_name":"Christopher W. V. Hogue","raw_affiliation_strings":["Department of Biological Sciences, National University of Singapore, Singapore; Mechanobiology Institute, National University of Singapore, Singapore","Mechanobiology Institute, National University of Singapore, Singapore","Department of Biological Sciences, National University of Singapore, Singapore"],"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, National University of Singapore, Singapore; Mechanobiology Institute, National University of Singapore, Singapore","institution_ids":[]},{"raw_affiliation_string":"Mechanobiology Institute, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]},{"raw_affiliation_string":"Department of Biological Sciences, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070485625","display_name":"M. S. Madhusudhan","orcid":"https://orcid.org/0000-0002-2889-5884"},"institutions":[{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]},{"id":"https://openalex.org/I181996519","display_name":"Indian Institute of Science Education and Research Pune","ror":"https://ror.org/028qa3n13","country_code":"IN","type":"education","lineage":["https://openalex.org/I181996519"]},{"id":"https://openalex.org/I4210148498","display_name":"Bioinformatics Institute","ror":"https://ror.org/044w3nw43","country_code":"SG","type":"facility","lineage":["https://openalex.org/I115228651","https://openalex.org/I2801752549","https://openalex.org/I4210148498"]}],"countries":["IN","SG"],"is_corresponding":true,"raw_author_name":"M. S. Madhusudhan","raw_affiliation_strings":["Department of Biological Sciences, National University of Singapore, Singapore; Indian Institute of Science Education and Research, Pune, India; Bioinformatics Institute, Singapore","Department of Biological Sciences, National University of Singapore, Singapore","Indian Institute of Science Education and Research, Pune, India","Bioinformatics Institute, Singapore"],"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, National University of Singapore, Singapore; Indian Institute of Science Education and Research, Pune, India; Bioinformatics Institute, Singapore","institution_ids":[]},{"raw_affiliation_string":"Department of Biological Sciences, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]},{"raw_affiliation_string":"Indian Institute of Science Education and Research, Pune, India","institution_ids":["https://openalex.org/I181996519"]},{"raw_affiliation_string":"Bioinformatics Institute, Singapore","institution_ids":["https://openalex.org/I4210148498"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066018988","display_name":"Yasuhiro Sawada","orcid":"https://orcid.org/0000-0003-0625-3335"},"institutions":[{"id":"https://openalex.org/I4210161310","display_name":"Nadogaya Hospital","ror":"https://ror.org/05xkjsd30","country_code":"JP","type":"healthcare","lineage":["https://openalex.org/I4210161310"]},{"id":"https://openalex.org/I165932596","display_name":"National University of Singapore","ror":"https://ror.org/01tgyzw49","country_code":"SG","type":"education","lineage":["https://openalex.org/I165932596"]}],"countries":["JP","SG"],"is_corresponding":true,"raw_author_name":"Yasuhiro Sawada","raw_affiliation_strings":["Department of Biological Sciences, National University of Singapore, Singapore; Mechanobiology Institute, National University of Singapore, Singapore; Locomotive Syndrome Research Institute, Nadogaya Hospital, Kashiwa, Japan","Department of Biological Sciences, National University of Singapore, Singapore","Mechanobiology Institute, National University of Singapore, Singapore","Locomotive Syndrome Research Institute, Nadogaya Hospital, Kashiwa, Japan"],"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, National University of Singapore, Singapore; Mechanobiology Institute, National University of Singapore, Singapore; Locomotive Syndrome Research Institute, Nadogaya Hospital, Kashiwa, Japan","institution_ids":[]},{"raw_affiliation_string":"Department of Biological Sciences, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]},{"raw_affiliation_string":"Mechanobiology Institute, National University of Singapore, Singapore","institution_ids":["https://openalex.org/I165932596"]},{"raw_affiliation_string":"Locomotive Syndrome Research Institute, Nadogaya Hospital, Kashiwa, Japan","institution_ids":["https://openalex.org/I4210161310"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":12,"corresponding_author_ids":["https://openalex.org/A5066018988","https://openalex.org/A5070485625"],"corresponding_institution_ids":["https://openalex.org/I165932596","https://openalex.org/I181996519","https://openalex.org/I4210148498","https://openalex.org/I4210161310"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.2174,"has_fulltext":true,"cited_by_count":25,"citation_normalized_percentile":{"value":0.76236374,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":98},"biblio":{"volume":"10","issue":"4","first_page":"e1003532","last_page":"e1003532"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/intrinsically-disordered-proteins","display_name":"Intrinsically disordered proteins","score":0.749777615070343},{"id":"https://openalex.org/keywords/phosphorylation","display_name":"Phosphorylation","score":0.5683070421218872},{"id":"https://openalex.org/keywords/radius-of-gyration","display_name":"Radius of gyration","score":0.5644537210464478},{"id":"https://openalex.org/keywords/polyproline-helix","display_name":"Polyproline helix","score":0.5306103825569153},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.5167388319969177},{"id":"https://openalex.org/keywords/circular-dichroism","display_name":"Circular dichroism","score":0.4780850410461426},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.46478721499443054},{"id":"https://openalex.org/keywords/crystallography","display_name":"Crystallography","score":0.35165128111839294},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.22662746906280518},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.1800195276737213},{"id":"https://openalex.org/keywords/peptide","display_name":"Peptide","score":0.10967540740966797}],"concepts":[{"id":"https://openalex.org/C2778815515","wikidata":"https://www.wikidata.org/wiki/Q3408242","display_name":"Intrinsically disordered proteins","level":2,"score":0.749777615070343},{"id":"https://openalex.org/C11960822","wikidata":"https://www.wikidata.org/wiki/Q242736","display_name":"Phosphorylation","level":2,"score":0.5683070421218872},{"id":"https://openalex.org/C168568712","wikidata":"https://www.wikidata.org/wiki/Q909999","display_name":"Radius of gyration","level":3,"score":0.5644537210464478},{"id":"https://openalex.org/C109300003","wikidata":"https://www.wikidata.org/wiki/Q4384651","display_name":"Polyproline helix","level":3,"score":0.5306103825569153},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5167388319969177},{"id":"https://openalex.org/C133571119","wikidata":"https://www.wikidata.org/wiki/Q899102","display_name":"Circular dichroism","level":2,"score":0.4780850410461426},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.46478721499443054},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.35165128111839294},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.22662746906280518},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1800195276737213},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.10967540740966797},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001703","descriptor_name":"Biophysics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001703","descriptor_name":"Biophysics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001703","descriptor_name":"Biophysics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018625","descriptor_name":"Microscopy, Atomic Force","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018625","descriptor_name":"Microscopy, Atomic Force","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018625","descriptor_name":"Microscopy, Atomic Force","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D040542","descriptor_name":"Mechanotransduction, Cellular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D040542","descriptor_name":"Mechanotransduction, Cellular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D040542","descriptor_name":"Mechanotransduction, Cellular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D050719","descriptor_name":"Crk-Associated Substrate Protein","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D050719","descriptor_name":"Crk-Associated Substrate Protein","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D050719","descriptor_name":"Crk-Associated Substrate Protein","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D058767","descriptor_name":"Protein Unfolding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058767","descriptor_name":"Protein Unfolding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058767","descriptor_name":"Protein Unfolding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D064267","descriptor_name":"Intrinsically Disordered Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D064267","descriptor_name":"Intrinsically Disordered Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D064267","descriptor_name":"Intrinsically Disordered Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1003532","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003532","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003532&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:24722239","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24722239","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:5ef1f265b25545e49fcbeed1b7bc74e3","is_oa":true,"landing_page_url":"https://doaj.org/article/5ef1f265b25545e49fcbeed1b7bc74e3","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 10, Iss 4, p e1003532 (2014)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:2966303","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3983058","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/995112","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/_Biophysical_Properties_of_Intrinsically_Disordered_p130Cas_Substrate_Domain_8212_Implication_in_Mechanosensing_/995112","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1003532","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003532","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003532&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.5600000023841858,"display_name":"Life below water","id":"https://metadata.un.org/sdg/14"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320311904","display_name":"Wellcome Trust","ror":"https://ror.org/029chgv08"},{"id":"https://openalex.org/F4320320671","display_name":"National Research Foundation","ror":"https://ror.org/05s0g1g46"},{"id":"https://openalex.org/F4320320709","display_name":"National Research Foundation Singapore","ror":"https://ror.org/03cpyc314"},{"id":"https://openalex.org/F4320320717","display_name":"Department of Biotechnology, Ministry of Science and Technology, India","ror":"https://ror.org/03tjsyq23"},{"id":"https://openalex.org/F4320320766","display_name":"Nanyang Technological University","ror":"https://ror.org/02e7b5302"},{"id":"https://openalex.org/F4320324605","display_name":"Mechanobiology Institute, Singapore","ror":"https://ror.org/01tgyzw49"},{"id":"https://openalex.org/F4320325580","display_name":"The Wellcome Trust DBT India Alliance","ror":"https://ror.org/04reqzt68"},{"id":"https://openalex.org/F4320335846","display_name":"Biomedical Research Council","ror":"https://ror.org/03xy0wx88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2031865362.pdf","grobid_xml":"https://content.openalex.org/works/W2031865362.grobid-xml"},"referenced_works_count":77,"referenced_works":["https://openalex.org/W1491040459","https://openalex.org/W1539340892","https://openalex.org/W1571862608","https://openalex.org/W1792685479","https://openalex.org/W1965150025","https://openalex.org/W1966521458","https://openalex.org/W1972013995","https://openalex.org/W1974604735","https://openalex.org/W1975132186","https://openalex.org/W1975311020","https://openalex.org/W1975317507","https://openalex.org/W1976214697","https://openalex.org/W1980690799","https://openalex.org/W1980762494","https://openalex.org/W1982714879","https://openalex.org/W1982720620","https://openalex.org/W1983476134","https://openalex.org/W1988194926","https://openalex.org/W1989637102","https://openalex.org/W1990422473","https://openalex.org/W1990746199","https://openalex.org/W1991906934","https://openalex.org/W1994949724","https://openalex.org/W1997944423","https://openalex.org/W2004863845","https://openalex.org/W2006133276","https://openalex.org/W2006192061","https://openalex.org/W2012230802","https://openalex.org/W2014550271","https://openalex.org/W2019511236","https://openalex.org/W2023392069","https://openalex.org/W2025713519","https://openalex.org/W2034140083","https://openalex.org/W2035488660","https://openalex.org/W2036786219","https://openalex.org/W2039990215","https://openalex.org/W2040013838","https://openalex.org/W2040502656","https://openalex.org/W2048917256","https://openalex.org/W2049291900","https://openalex.org/W2052606462","https://openalex.org/W2059433877","https://openalex.org/W2061247427","https://openalex.org/W2066041565","https://openalex.org/W2067190679","https://openalex.org/W2069982947","https://openalex.org/W2076662394","https://openalex.org/W2078356159","https://openalex.org/W2085809843","https://openalex.org/W2086992732","https://openalex.org/W2089618587","https://openalex.org/W2096495474","https://openalex.org/W2098334414","https://openalex.org/W2100824350","https://openalex.org/W2102171946","https://openalex.org/W2102845147","https://openalex.org/W2111658087","https://openalex.org/W2117372001","https://openalex.org/W2118105104","https://openalex.org/W2119693327","https://openalex.org/W2122536893","https://openalex.org/W2126064524","https://openalex.org/W2130110320","https://openalex.org/W2131965976","https://openalex.org/W2133349905","https://openalex.org/W2137015675","https://openalex.org/W2149285542","https://openalex.org/W2149472608","https://openalex.org/W2150697021","https://openalex.org/W2153187042","https://openalex.org/W2153575042","https://openalex.org/W2156407548","https://openalex.org/W2156678798","https://openalex.org/W2157301325","https://openalex.org/W2158773789","https://openalex.org/W2166780974","https://openalex.org/W2328838412"],"related_works":["https://openalex.org/W3214935461","https://openalex.org/W2228302324","https://openalex.org/W2480602590","https://openalex.org/W2104623056","https://openalex.org/W3019026711","https://openalex.org/W2042218564","https://openalex.org/W2413435361","https://openalex.org/W3122645723","https://openalex.org/W2327483701","https://openalex.org/W2561683712"],"abstract_inverted_index":{"Mechanical":[0],"stretch-induced":[1],"tyrosine":[2,24,77],"phosphorylation":[3,25,213],"in":[4,30,60,113,130],"the":[5,39,63,125,140,149,155,176,182],"proline-rich":[6,64],"306-residue":[7],"substrate":[8,76],"domain":[9,202],"(CasSD)":[10],"of":[11,42,94,143,151,179,197,204,214],"p130Cas":[12,23],"(or":[13],"BCAR1)":[14],"has":[15,161],"eluded":[16],"an":[17,116],"experimentally":[18],"validated":[19],"structural":[20,177],"understanding.":[21],"Cellular":[22],"is":[26,49,137,167,186],"shown":[27],"to":[28,169,188,190,211],"function":[29,209],"areas":[31],"without":[32],"internal":[33],"actomyosin":[34],"contractility,":[35],"sensing":[36],"force":[37,88],"at":[38],"leading":[40],"edge":[41],"cell":[43],"migration.":[44],"Circular":[45],"dichroism":[46],"shows":[47],"CasSD":[48,84,112,160,180,199,215],"intrinsically":[50,107],"disordered":[51,108],"with":[52,70,115,124,132],"dominant":[53],"polyproline":[54],"type":[55],"II":[56],"conformations.":[57],"Strongly":[58],"conserved":[59],"placental":[61],"mammals,":[62],"sequence":[65],"exhibits":[66,90],"a":[67,105,195],"pseudo-repeat":[68],"unit":[69],"variation":[71],"hotspots":[72],"2-9":[73],"residues":[74],"before":[75],"residues.":[78],"Atomic-force":[79],"microscopy":[80],"pulling":[81],"experiments":[82],"show":[83,103],"requires":[85],"minimal":[86],"extension":[87],"and":[89,100,166,181,200,216],"infrequent,":[91],"random":[92],"regions":[93],"weak":[95],"stability.":[96],"Proteolysis,":[97],"light":[98],"scattering":[99],"ultracentrifugation":[101],"results":[102],"that":[104,159,184],"monomeric":[106],"form":[109],"persists":[110],"for":[111],"solution":[114],"expanded":[117],"hydrodynamic":[118],"radius.":[119],"All-atom":[120],"3D":[121],"conformer":[122],"sampling":[123,136],"TraDES":[126],"package":[127],"yields":[128],"ensembles":[129],"agreement":[131],"experiment":[133],"when":[134],"coil-biased":[135],"used,":[138],"matching":[139],"experimental":[141],"radius":[142],"gyration.":[144],"Increasing":[145],"\u03b2-sampling":[146],"propensities":[147],"increases":[148],"number":[150],"prolate":[152],"conformers.":[153],"Combining":[154],"results,":[156],"we":[157,193],"conclude":[158],"no":[162],"stable":[163],"compact":[164],"structure":[165],"unlikely":[168],"efficiently":[170],"autoinhibit":[171],"phosphorylation.":[172],"Taking":[173],"into":[174],"consideration":[175],"propensity":[178],"fact":[183],"it":[185],"known":[187],"bind":[189],"LIM":[191,201],"domains,":[192],"propose":[194],"model":[196],"how":[198],"family":[203],"transcription":[205],"factor":[206],"proteins":[207],"may":[208],"together":[210],"regulate":[212],"effect":[217],"machanosensing.":[218]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":4},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":2}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}