{"id":"https://openalex.org/W2036573968","doi":"https://doi.org/10.1371/journal.pcbi.1003528","title":"Identification of New I\u03baB\u03b1 Complexes by an Iterative Experimental and Mathematical Modeling Approach","display_name":"Identification of New I\u03baB\u03b1 Complexes by an Iterative Experimental and Mathematical Modeling Approach","publication_year":2014,"publication_date":"2014-03-27","ids":{"openalex":"https://openalex.org/W2036573968","doi":"https://doi.org/10.1371/journal.pcbi.1003528","mag":"2036573968","pmid":"https://pubmed.ncbi.nlm.nih.gov/24675998"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1003528","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003528","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003528&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003528&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5083286814","display_name":"Fabian Konrath","orcid":"https://orcid.org/0000-0002-6843-6252"},"institutions":[{"id":"https://openalex.org/I100066346","display_name":"University of Stuttgart","ror":"https://ror.org/04vnq7t77","country_code":"DE","type":"education","lineage":["https://openalex.org/I100066346"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Fabian Konrath","raw_affiliation_strings":["Institute of Cell Biology and Immunology, University of Stuttgart, Stuttgart, Germany; Institute for System Dynamics, University of Stuttgart, Stuttgart, Germany","Institute of Cell Biology and Immunology, University of Stuttgart, Stuttgart, Germany","Institute for System Dynamics, University of Stuttgart, Stuttgart, Germany"],"affiliations":[{"raw_affiliation_string":"Institute of Cell Biology and Immunology, University of Stuttgart, Stuttgart, Germany; Institute for System Dynamics, University of Stuttgart, Stuttgart, Germany","institution_ids":[]},{"raw_affiliation_string":"Institute of Cell Biology and Immunology, University of Stuttgart, Stuttgart, Germany","institution_ids":["https://openalex.org/I100066346"]},{"raw_affiliation_string":"Institute for System Dynamics, University of Stuttgart, Stuttgart, Germany","institution_ids":["https://openalex.org/I100066346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109207446","display_name":"Johannes Witt","orcid":null},"institutions":[{"id":"https://openalex.org/I100066346","display_name":"University of Stuttgart","ror":"https://ror.org/04vnq7t77","country_code":"DE","type":"education","lineage":["https://openalex.org/I100066346"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Johannes Witt","raw_affiliation_strings":["Institute for System Dynamics, University of Stuttgart, Stuttgart, Germany"],"affiliations":[{"raw_affiliation_string":"Institute for System Dynamics, University of Stuttgart, Stuttgart, Germany","institution_ids":["https://openalex.org/I100066346"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050871083","display_name":"Thomas Sauter","orcid":"https://orcid.org/0000-0001-8225-2954"},"institutions":[{"id":"https://openalex.org/I186903577","display_name":"University of Luxembourg","ror":"https://ror.org/036x5ad56","country_code":"LU","type":"education","lineage":["https://openalex.org/I186903577"]}],"countries":["LU"],"is_corresponding":false,"raw_author_name":"Thomas Sauter","raw_affiliation_strings":["Life Sciences Research Unit, University of Luxembourg, Luxembourg, Luxembourg"],"affiliations":[{"raw_affiliation_string":"Life Sciences Research Unit, University of Luxembourg, Luxembourg, Luxembourg","institution_ids":["https://openalex.org/I186903577"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073671212","display_name":"Dagmar Kulms","orcid":"https://orcid.org/0000-0001-6874-0548"},"institutions":[{"id":"https://openalex.org/I78650965","display_name":"TU Dresden","ror":"https://ror.org/042aqky30","country_code":"DE","type":"education","lineage":["https://openalex.org/I78650965"]},{"id":"https://openalex.org/I100066346","display_name":"University of Stuttgart","ror":"https://ror.org/04vnq7t77","country_code":"DE","type":"education","lineage":["https://openalex.org/I100066346"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Dagmar Kulms","raw_affiliation_strings":["Institute of Cell Biology and Immunology, University of Stuttgart, Stuttgart, Germany; Experimental Dermatology, Department of Dermatology, TU-Dresden, Dresden, Germany","Experimental Dermatology, Department of Dermatology, TU-Dresden, Dresden, Germany","Institute of Cell Biology and Immunology, University of Stuttgart, Stuttgart, Germany"],"affiliations":[{"raw_affiliation_string":"Institute of Cell Biology and Immunology, University of Stuttgart, Stuttgart, Germany; Experimental Dermatology, Department of Dermatology, TU-Dresden, Dresden, Germany","institution_ids":[]},{"raw_affiliation_string":"Experimental Dermatology, Department of Dermatology, TU-Dresden, Dresden, Germany","institution_ids":["https://openalex.org/I78650965"]},{"raw_affiliation_string":"Institute of Cell Biology and Immunology, University of Stuttgart, Stuttgart, Germany","institution_ids":["https://openalex.org/I100066346"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5073671212"],"corresponding_institution_ids":["https://openalex.org/I100066346","https://openalex.org/I78650965"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.7781,"has_fulltext":true,"cited_by_count":12,"citation_normalized_percentile":{"value":0.70632579,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":97},"biblio":{"volume":"10","issue":"3","first_page":"e1003528","last_page":"e1003528"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11385","display_name":"Natural product bioactivities and synthesis","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/transcription-factor","display_name":"Transcription factor","score":0.6369987726211548},{"id":"https://openalex.org/keywords/i\u03bab-kinase","display_name":"I\u03baB kinase","score":0.6368609666824341},{"id":"https://openalex.org/keywords/regulator","display_name":"Regulator","score":0.5540621280670166},{"id":"https://openalex.org/keywords/nf-\u03bab","display_name":"NF-\u03baB","score":0.5112886428833008},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.4980645179748535},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4886046051979065},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"Signal transduction","score":0.45614832639694214},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.42876237630844116},{"id":"https://openalex.org/keywords/nfkb1","display_name":"NFKB1","score":0.4145451486110687},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.41368696093559265},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3498968780040741},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.23696169257164001},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.12963014841079712}],"concepts":[{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.6369987726211548},{"id":"https://openalex.org/C100175707","wikidata":"https://www.wikidata.org/wiki/Q6103519","display_name":"I\u03baB kinase","level":4,"score":0.6368609666824341},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.5540621280670166},{"id":"https://openalex.org/C2777730290","wikidata":"https://www.wikidata.org/wiki/Q411114","display_name":"NF-\u03baB","level":3,"score":0.5112886428833008},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.4980645179748535},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4886046051979065},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.45614832639694214},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.42876237630844116},{"id":"https://openalex.org/C123298856","wikidata":"https://www.wikidata.org/wiki/Q15317427","display_name":"NFKB1","level":4,"score":0.4145451486110687},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41368696093559265},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3498968780040741},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23696169257164001},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.12963014841079712}],"mesh":[{"descriptor_ui":"D000072000","descriptor_name":"NF-KappaB Inhibitor alpha","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072000","descriptor_name":"NF-KappaB Inhibitor alpha","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000072000","descriptor_name":"NF-KappaB Inhibitor alpha","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001671","descriptor_name":"Biochemistry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D001671","descriptor_name":"Biochemistry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D001671","descriptor_name":"Biochemistry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002467","descriptor_name":"Cell Nucleus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003600","descriptor_name":"Cytosol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003600","descriptor_name":"Cytosol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003600","descriptor_name":"Cytosol","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014638","descriptor_name":"Vanadates","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014638","descriptor_name":"Vanadates","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014638","descriptor_name":"Vanadates","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020672","descriptor_name":"I-kappa B Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020672","descriptor_name":"I-kappa B Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020672","descriptor_name":"I-kappa B Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":9,"locations":[{"id":"doi:10.1371/journal.pcbi.1003528","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003528","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003528&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:24675998","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24675998","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:orbilu.uni.lu:10993/16286","is_oa":true,"landing_page_url":"https://orbilu.uni.lu/handle/10993/16286","pdf_url":"http://orbilu.uni.lu/handle/10993/16286","source":{"id":"https://openalex.org/S4306401815","display_name":"Open Repository and Bibliography (University of Luxembourg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I186903577","host_organization_name":"University of Luxembourg","host_organization_lineage":["https://openalex.org/I186903577"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"PLoS Computational Biology, 10 (3), e1003528 (2014)","raw_type":"peer reviewed"},{"id":"pmh:oai:orbilu.uni.lu:10993/16286","is_oa":true,"landing_page_url":"http://orbilu.uni.lu/handle/10993/16286","pdf_url":"http://orbilu.uni.lu/handle/10993/16286","source":{"id":"https://openalex.org/S4306401815","display_name":"Open Repository and Bibliography (University of Luxembourg)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I186903577","host_organization_name":"University of Luxembourg","host_organization_lineage":["https://openalex.org/I186903577"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS computational biology, 10(3), 1003528. United States (2014).","raw_type":null},{"id":"pmh:oai:RePEc:plo:pcbi00:1003528","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1003528","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:dc042349a89c4c7887cbf6fdb2b89a8b","is_oa":true,"landing_page_url":"https://doaj.org/article/dc042349a89c4c7887cbf6fdb2b89a8b","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 10, Iss 3, p e1003528 (2014)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:2954217","is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3967930","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/976885","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/_Identification_of_New_I_954_B_945_Complexes_by_an_Iterative_Experimental_and_Mathematical_Modeling_Approach_/976885","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:3967930","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3967930","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1003528","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003528","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003528&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.5699999928474426}],"awards":[],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2036573968.pdf","grobid_xml":"https://content.openalex.org/works/W2036573968.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W20888715","https://openalex.org/W1499561015","https://openalex.org/W1547109494","https://openalex.org/W1641228030","https://openalex.org/W1661180389","https://openalex.org/W1911781926","https://openalex.org/W1949280308","https://openalex.org/W1977147193","https://openalex.org/W1980919524","https://openalex.org/W1981497128","https://openalex.org/W1982528660","https://openalex.org/W1993262772","https://openalex.org/W1998463022","https://openalex.org/W1998626820","https://openalex.org/W2002629524","https://openalex.org/W2006322387","https://openalex.org/W2007875429","https://openalex.org/W2008392297","https://openalex.org/W2019656867","https://openalex.org/W2024696581","https://openalex.org/W2027534342","https://openalex.org/W2032408313","https://openalex.org/W2068895616","https://openalex.org/W2069988274","https://openalex.org/W2074097004","https://openalex.org/W2082789114","https://openalex.org/W2087984134","https://openalex.org/W2088469845","https://openalex.org/W2104182199","https://openalex.org/W2108902725","https://openalex.org/W2119027455","https://openalex.org/W2120884489","https://openalex.org/W2121316694","https://openalex.org/W2127094826","https://openalex.org/W2128316422","https://openalex.org/W2133554538","https://openalex.org/W2138876537","https://openalex.org/W2154401739","https://openalex.org/W2166071821","https://openalex.org/W2169668745","https://openalex.org/W2275490491","https://openalex.org/W2335925695"],"related_works":["https://openalex.org/W2552495559","https://openalex.org/W2565946308","https://openalex.org/W1588163428","https://openalex.org/W2743272905","https://openalex.org/W1572734717","https://openalex.org/W2069649695","https://openalex.org/W2898273603","https://openalex.org/W2417377041","https://openalex.org/W2893438736","https://openalex.org/W2310354646"],"abstract_inverted_index":{"The":[0],"transcription":[1],"factor":[2,4],"nuclear":[3],"kappa-B":[5],"(NF\u03baB)":[6],"is":[7,32,72,99],"a":[8,40,51,140,162],"key":[9],"regulator":[10],"of":[11,25,43,67,175],"pro-inflammatory":[12],"and":[13,53,91,147,220],"pro-proliferative":[14],"processes.":[15],"Accordingly,":[16],"uncontrolled":[17],"NF\u03baB":[18,35,93,110,131,216],"activity":[19],"may":[20,79,106,195,206],"contribute":[21],"to":[22,74,119,130,144,172,213],"the":[23,29,108,126,149,173,197,211],"development":[24],"severe":[26],"diseases":[27],"when":[28],"regulatory":[30],"system":[31],"impaired.":[33],"Since":[34],"can":[36],"be":[37],"triggered":[38],"by":[39],"huge":[41],"variety":[42],"inflammatory,":[44],"pro-and":[45],"anti-apoptotic":[46],"stimuli,":[47],"its":[48],"activation":[49,94,217],"underlies":[50],"complex":[52,69,179,204],"tightly":[54],"regulated":[55],"signaling":[56,70],"network":[57,71,151],"that":[58,78,105,180,188,194],"also":[59],"includes":[60],"multi-layered":[61],"negative":[62],"feedback":[63],"mechanisms.":[64],"Detailed":[65],"understanding":[66],"this":[68],"mandatory":[73],"identify":[75],"sensitive":[76],"parameters":[77],"serve":[80,207],"as":[81,135,208],"targets":[82],"for":[83,210],"therapeutic":[84],"interventions.":[85],"While":[86],"many":[87],"details":[88],"about":[89,101],"canonical":[90,191],"non-canonical":[92],"have":[95],"been":[96,117],"investigated,":[97],"less":[98],"known":[100],"cellular":[102,109,198],"I\u03baB\u03b1":[103,112,178,199],"pools":[104],"tune":[107],"levels.":[111],"has":[113],"so":[114],"far":[115],"exclusively":[116],"described":[118],"exist":[120,193],"in":[121],"two":[122],"different":[123],"forms":[124],"within":[125],"cell:":[127],"stably":[128],"bound":[129],"or,":[132],"very":[133],"transiently,":[134],"unbound":[136],"protein.":[137],"We":[138,185],"created":[139],"detailed":[141],"mathematical":[142],"model":[143,165],"quantitatively":[145],"capture":[146],"analyze":[148],"time-resolved":[150],"behavior.":[152],"By":[153],"iterative":[154],"refinement":[155],"with":[156,166],"numerous":[157],"biological":[158],"experiments,":[159],"we":[160],"yielded":[161],"highly":[163],"identifiable":[164],"superior":[167],"predictive":[168],"power":[169],"which":[170],"led":[171],"hypothesis":[174],"an":[176],"NF\u03baB-lacking":[177],"contains":[181],"stabilizing":[182],"IKK":[183],"subunits.":[184],"provide":[186],"evidence":[187],"other":[189],"but":[190],"pathways":[192],"affect":[196],"status.":[200],"This":[201],"additional":[202],"I\u03baB\u03b1:IKK\u03b3":[203],"revealed":[205],"storage":[209],"inhibitor":[212],"antagonize":[214],"undesired":[215],"under":[218],"physiological":[219],"pathophysiological":[221],"conditions.":[222]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2016-06-24T00:00:00"}
