{"id":"https://openalex.org/W2080960587","doi":"https://doi.org/10.1371/journal.pcbi.1003518","title":"Environmental and State-Level Regulatory Factors Affect the Incidence of Autism and Intellectual Disability","display_name":"Environmental and State-Level Regulatory Factors Affect the Incidence of Autism and Intellectual Disability","publication_year":2014,"publication_date":"2014-03-13","ids":{"openalex":"https://openalex.org/W2080960587","doi":"https://doi.org/10.1371/journal.pcbi.1003518","mag":"2080960587","pmid":"https://pubmed.ncbi.nlm.nih.gov/24625521"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1003518","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003518","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003518&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003518&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004739989","display_name":"Andrey Rzhetsky","orcid":"https://orcid.org/0000-0001-6959-7405"},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Andrey Rzhetsky","raw_affiliation_strings":["Department of Medicine, the University of Chicago, Chicago, Illinois, United States of America; Institute for Genomics and Systems Biology, the University of Chicago, Chicago, Illinois, United States of America; Computation Institute, Department of Human Genetics, the University of Chicago, Chicago, Illinois, United States of America","Department of Medicine, the University of Chicago, Chicago, Illinois, United States of America","Institute for Genomics and Systems Biology, the University of Chicago, Chicago, Illinois, United States of America","Computation Institute, Department of Human Genetics, the University of Chicago, Chicago, Illinois, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Medicine, the University of Chicago, Chicago, Illinois, United States of America; Institute for Genomics and Systems Biology, the University of Chicago, Chicago, Illinois, United States of America; Computation Institute, Department of Human Genetics, the University of Chicago, Chicago, Illinois, United States of America","institution_ids":[]},{"raw_affiliation_string":"Department of Medicine, the University of Chicago, Chicago, Illinois, United States of America","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"Institute for Genomics and Systems Biology, the University of Chicago, Chicago, Illinois, United States of America","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"Computation Institute, Department of Human Genetics, the University of Chicago, Chicago, Illinois, United States of America","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004081066","display_name":"Steven C. Bagley","orcid":"https://orcid.org/0000-0003-2187-7955"},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Steven C. Bagley","raw_affiliation_strings":["Department of Genetics, Stanford University, Stanford, California, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Genetics, Stanford University, Stanford, California, United States of America","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017476704","display_name":"Kanix Wang","orcid":"https://orcid.org/0000-0003-1355-577X"},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kanix Wang","raw_affiliation_strings":["Institute for Genomics and Systems Biology, the University of Chicago, Chicago, Illinois, United States of America; Committee on Genetics, Genomics, and Systems Biology, the University of Chicago, Chicago, Illinois, United States of America","Committee on Genetics, Genomics, and Systems Biology, the University of Chicago, Chicago, Illinois, United States of America","Institute for Genomics and Systems Biology, the University of Chicago, Chicago, Illinois, United States of America"],"affiliations":[{"raw_affiliation_string":"Institute for Genomics and Systems Biology, the University of Chicago, Chicago, Illinois, United States of America; Committee on Genetics, Genomics, and Systems Biology, the University of Chicago, Chicago, Illinois, United States of America","institution_ids":[]},{"raw_affiliation_string":"Committee on Genetics, Genomics, and Systems Biology, the University of Chicago, Chicago, Illinois, United States of America","institution_ids":["https://openalex.org/I40347166"]},{"raw_affiliation_string":"Institute for Genomics and Systems Biology, the University of Chicago, Chicago, Illinois, United States of America","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064689190","display_name":"Christopher S. Lyttle","orcid":"https://orcid.org/0000-0002-5202-5838"},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christopher S. Lyttle","raw_affiliation_strings":["The Center for Health and the Social Sciences, the University of Chicago, Chicago, Illinois, United States of America"],"affiliations":[{"raw_affiliation_string":"The Center for Health and the Social Sciences, the University of Chicago, Chicago, Illinois, United States of America","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002090056","display_name":"Edwin H. Cook","orcid":"https://orcid.org/0000-0002-5848-5114"},"institutions":[{"id":"https://openalex.org/I39422238","display_name":"University of Illinois Chicago","ror":"https://ror.org/02mpq6x41","country_code":"US","type":"education","lineage":["https://openalex.org/I39422238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edwin H. Cook","raw_affiliation_strings":["Department of Psychiatry, Institute for Juvenile Research, University of Illinois at Chicago, Chicago, Illinois, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Psychiatry, Institute for Juvenile Research, University of Illinois at Chicago, Chicago, Illinois, United States of America","institution_ids":["https://openalex.org/I39422238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084043782","display_name":"Russ B. Altman","orcid":"https://orcid.org/0000-0003-3859-2905"},"institutions":[{"id":"https://openalex.org/I97018004","display_name":"Stanford University","ror":"https://ror.org/00f54p054","country_code":"US","type":"education","lineage":["https://openalex.org/I97018004"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Russ B. Altman","raw_affiliation_strings":["Departments of Bioengineering, Genetics, Medicine, and Computer Science, Stanford University, Stanford, California, United States of America"],"affiliations":[{"raw_affiliation_string":"Departments of Bioengineering, Genetics, Medicine, and Computer Science, Stanford University, Stanford, California, United States of America","institution_ids":["https://openalex.org/I97018004"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5030674909","display_name":"Robert D. Gibbons","orcid":"https://orcid.org/0000-0002-6463-2280"},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]},{"id":"https://openalex.org/I169222155","display_name":"Chicago Department of Public Health","ror":"https://ror.org/045v7ay82","country_code":"US","type":"government","lineage":["https://openalex.org/I169222155"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Robert D. Gibbons","raw_affiliation_strings":["Departments of Medicine and Health Studies, the University of Chicago, Center for Health Statistics, Chicago, Illinois, United States of America"],"affiliations":[{"raw_affiliation_string":"Departments of Medicine and Health Studies, the University of Chicago, Center for Health Statistics, Chicago, Illinois, United States of America","institution_ids":["https://openalex.org/I169222155","https://openalex.org/I40347166"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5004739989"],"corresponding_institution_ids":["https://openalex.org/I40347166"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":4.3889,"has_fulltext":true,"cited_by_count":59,"citation_normalized_percentile":{"value":0.94926932,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"10","issue":"3","first_page":"e1003518","last_page":"e1003518"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10106","display_name":"Autism Spectrum Disorder Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10106","display_name":"Autism Spectrum Disorder Research","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13393","display_name":"Child Nutrition and Feeding Issues","score":0.9248999953269958,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10537","display_name":"Attention Deficit Hyperactivity Disorder","score":0.9065999984741211,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/affect","display_name":"Affect (linguistics)","score":0.7609238624572754},{"id":"https://openalex.org/keywords/autism","display_name":"Autism","score":0.6640743613243103},{"id":"https://openalex.org/keywords/intellectual-disability","display_name":"Intellectual disability","score":0.5931113362312317},{"id":"https://openalex.org/keywords/incidence","display_name":"Incidence (geometry)","score":0.5021045207977295},{"id":"https://openalex.org/keywords/environmental-health","display_name":"Environmental health","score":0.3586632013320923},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.3473196029663086},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.2889322340488434},{"id":"https://openalex.org/keywords/psychiatry","display_name":"Psychiatry","score":0.2415996491909027},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.06981927156448364}],"concepts":[{"id":"https://openalex.org/C2776035688","wikidata":"https://www.wikidata.org/wiki/Q1606558","display_name":"Affect (linguistics)","level":2,"score":0.7609238624572754},{"id":"https://openalex.org/C205778803","wikidata":"https://www.wikidata.org/wiki/Q38404","display_name":"Autism","level":2,"score":0.6640743613243103},{"id":"https://openalex.org/C551499885","wikidata":"https://www.wikidata.org/wiki/Q183560","display_name":"Intellectual disability","level":2,"score":0.5931113362312317},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.5021045207977295},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.3586632013320923},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3473196029663086},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.2889322340488434},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.2415996491909027},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.06981927156448364},{"id":"https://openalex.org/C46312422","wikidata":"https://www.wikidata.org/wiki/Q11024","display_name":"Communication","level":1,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000013","descriptor_name":"Congenital Abnormalities","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D000013","descriptor_name":"Congenital Abnormalities","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D000013","descriptor_name":"Congenital Abnormalities","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D000013","descriptor_name":"Congenital Abnormalities","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D000013","descriptor_name":"Congenital Abnormalities","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D000013","descriptor_name":"Congenital Abnormalities","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001321","descriptor_name":"Autistic Disorder","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D001321","descriptor_name":"Autistic Disorder","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D001321","descriptor_name":"Autistic Disorder","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D001321","descriptor_name":"Autistic Disorder","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D001321","descriptor_name":"Autistic Disorder","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D001321","descriptor_name":"Autistic Disorder","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D004777","descriptor_name":"Environment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004777","descriptor_name":"Environment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004777","descriptor_name":"Environment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007345","descriptor_name":"Insurance Claim Review","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007345","descriptor_name":"Insurance Claim Review","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007345","descriptor_name":"Insurance Claim Review","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008607","descriptor_name":"Intellectual Disability","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D008607","descriptor_name":"Intellectual Disability","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D008607","descriptor_name":"Intellectual Disability","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D008607","descriptor_name":"Intellectual Disability","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D008607","descriptor_name":"Intellectual Disability","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D008607","descriptor_name":"Intellectual Disability","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":false},{"descriptor_ui":"D009010","descriptor_name":"Monte Carlo Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009010","descriptor_name":"Monte Carlo Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009010","descriptor_name":"Monte Carlo Method","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014481","descriptor_name":"United States","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015994","descriptor_name":"Incidence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015994","descriptor_name":"Incidence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015994","descriptor_name":"Incidence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016000","descriptor_name":"Cluster Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016012","descriptor_name":"Poisson Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016012","descriptor_name":"Poisson Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016012","descriptor_name":"Poisson Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1003518","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003518","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003518&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:24625521","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24625521","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:uchicago.tind.io:8409","is_oa":true,"landing_page_url":"http://knowledge.uchicago.edu/record/8409","pdf_url":null,"source":{"id":"https://openalex.org/S4306402460","display_name":"Knowledge@UChicago (University of Chicago)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I40347166","host_organization_name":"University of Chicago","host_organization_lineage":["https://openalex.org/I40347166"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://knowledge.uchicago.edu/record/8409","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.712.5114","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.712.5114","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www.contechicago.org/sites/www.contechicago.org/files/assets/2014%20Rzhetsky%20AUT_Environmental%20PlosCompBiol.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:ee079b49409043d8aa8e98c030fd3739","is_oa":true,"landing_page_url":"https://doaj.org/article/ee079b49409043d8aa8e98c030fd3739","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 10, Iss 3, p e1003518 (2014)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:2936610","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3952819","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1003518","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003518","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003518&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.4399999976158142,"id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G3663312919","display_name":null,"funder_award_id":"1P50MH094267","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4807971456","display_name":null,"funder_award_id":"U01HL108634","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6062123810","display_name":null,"funder_award_id":"P50MH094267","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7154406597","display_name":null,"funder_award_id":"U01HL108634-01","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8284505361","display_name":null,"funder_award_id":"HL108634","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320317058","display_name":"Chicago Biomedical Consortium","ror":null},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2080960587.pdf","grobid_xml":"https://content.openalex.org/works/W2080960587.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W416868322","https://openalex.org/W639084255","https://openalex.org/W1572327520","https://openalex.org/W1592873960","https://openalex.org/W1670429687","https://openalex.org/W1895131631","https://openalex.org/W1964444099","https://openalex.org/W1967824856","https://openalex.org/W1979345196","https://openalex.org/W1986931515","https://openalex.org/W1991331455","https://openalex.org/W1995854593","https://openalex.org/W2008426586","https://openalex.org/W2015083300","https://openalex.org/W2026074212","https://openalex.org/W2029578107","https://openalex.org/W2058268658","https://openalex.org/W2058879265","https://openalex.org/W2065418093","https://openalex.org/W2070181285","https://openalex.org/W2070534968","https://openalex.org/W2073271531","https://openalex.org/W2085198610","https://openalex.org/W2090604654","https://openalex.org/W2094675182","https://openalex.org/W2097360283","https://openalex.org/W2103590803","https://openalex.org/W2115007568","https://openalex.org/W2126758977","https://openalex.org/W2127810832","https://openalex.org/W2131104106","https://openalex.org/W2137085014","https://openalex.org/W2141326368","https://openalex.org/W2141789480","https://openalex.org/W2144673831","https://openalex.org/W2147977360","https://openalex.org/W2163272098","https://openalex.org/W2165026341","https://openalex.org/W2169155903","https://openalex.org/W2239406506","https://openalex.org/W2336021483","https://openalex.org/W2582743722","https://openalex.org/W4240048682","https://openalex.org/W4250609975","https://openalex.org/W4251790175","https://openalex.org/W4298357390","https://openalex.org/W4300998128"],"related_works":["https://openalex.org/W4280602684","https://openalex.org/W4310092953","https://openalex.org/W2227393071","https://openalex.org/W4402326599","https://openalex.org/W1995350144","https://openalex.org/W2082102603","https://openalex.org/W2166141227","https://openalex.org/W3133980636","https://openalex.org/W4378085486","https://openalex.org/W4366602711"],"abstract_inverted_index":{"Many":[0],"factors":[1,25,283],"affect":[2,161],"the":[3,33,51,59,65,91,105,155,182,197,230,248,292,299,317],"risks":[4],"for":[5,71,84,117,136,194,315],"neurodevelopmental":[6],"maladies":[7],"such":[8],"as":[9,68,279],"autism":[10],"spectrum":[11],"disorders":[12],"(ASD)":[13],"and":[14,23,39,88,172,209,220,237,244,296],"intellectual":[15],"disability":[16],"(ID).":[17],"To":[18],"compare":[19],"environmental,":[20],"phenotypic,":[21],"socioeconomic":[22],"state-policy":[24],"in":[26,108,112,121,150,196,207],"a":[27,69,190,204],"unified":[28],"geospatial":[29],"framework,":[30],"we":[31,57,289],"analyzed":[32],"spatial":[34,232,273],"incidence":[35,93,114,122,211],"patterns":[36],"of":[37,50,61,64,74,101,104,123,185,187,203,234,250,252,263,278,294],"ASD":[38,92,113,165,188,208,238,295],"ID":[40,137,174,210,236,297],"using":[41],"an":[42],"insurance":[43],"claims":[44],"dataset":[45],"covering":[46],"nearly":[47],"one":[48],"third":[49],"US":[52],"population.":[53],"Following":[54],"epidemiologic":[55],"evidence,":[56],"used":[58],"rate":[60,166,175],"congenital":[62,102,131,148],"malformations":[63,103,132,149],"reproductive":[66,106,156],"system":[67,107,200],"surrogate":[70],"environmental":[72,243,254],"exposure":[73],"parents":[75],"to":[76,98,159],"unmeasured":[77],"developmental":[78],"risk":[79],"factors,":[80,90],"including":[81],"toxins.":[82],"Adjusted":[83],"gender,":[85],"ethnic,":[86],"socioeconomic,":[87],"geopolitical":[89],"rates":[94,100,212,239,293],"were":[95,133,302],"strongly":[96,275],"linked":[97],"population-normalized":[99],"males":[109,151],"(an":[110],"increase":[111,120,167,176],"by":[115,189],"283%":[116],"every":[118],"percent":[119],"malformations,":[124],"95%":[125,140],"CI:":[126,141,214,222],"[91%,":[127],"576%],":[128],"p<6\u00d710(-5)).":[129,180],"Such":[130],"barely":[134],"significant":[135],"(94%":[138],"increase,":[139],"[1%,":[142],"250%],":[143],"p":[144,217,225,311],"=":[145,218,226,312],"0.0384).":[146],"Other":[147],"(excluding":[152],"those":[153],"affecting":[154],"system)":[157],"appeared":[158],"significantly":[160,305],"both":[162,235],"phenotypes:":[163],"31.8%":[164],"(CI:":[168,177],"[12%,":[169],"52%],":[170],"p<6\u00d710(-5)),":[171],"43%":[173],"[23%,":[178],"67%],":[179],"Furthermore,":[181],"state-mandated":[183],"rigor":[184],"diagnosis":[186],"pediatrician":[191],"or":[192],"clinician":[193],"consideration":[195],"special":[198],"education":[199],"was":[201,256,319],"predictive":[202],"considerable":[205],"decrease":[206],"(98.6%,":[213],"[28%,":[215],"99.99%],":[216,224],"0.02475":[219],"99%":[221],"[68%,":[223],"0.00637":[227],"respectively).":[228],"Thus,":[229],"observed":[231],"variability":[233],"is":[240],"associated":[241],"with":[242],"state-level":[245,264],"regulatory":[246],"factors;":[247],"magnitude":[249],"influence":[251],"compound":[253],"predictors":[255],"approximately":[257],"three":[258],"times":[259],"greater":[260],"than":[261],"that":[262,291],"incentives.":[265],"The":[266],"estimated":[267],"county-level":[268],"random":[269],"effects":[270],"exhibited":[271],"marked":[272],"clustering,":[274],"indicating":[276],"existence":[277],"yet":[280],"unidentified":[281],"localized":[282],"driving":[284],"apparent":[285],"disease":[286],"incidence.":[287],"Finally,":[288],"found":[290],"at":[298],"county":[300],"level":[301],"weakly":[303],"but":[304],"correlated":[306],"(Pearson":[307],"product-moment":[308],"correlation":[309,318],"0.0589,":[310],"0.00101),":[313],"while":[314],"females":[316],"much":[320],"stronger":[321],"(0.197,":[322],"p<2.26\u00d710(-16)).":[323]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":6}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}
