{"id":"https://openalex.org/W2063184115","doi":"https://doi.org/10.1371/journal.pcbi.1003478","title":"Computational Design of the Affinity and Specificity of a Therapeutic T Cell Receptor","display_name":"Computational Design of the Affinity and Specificity of a Therapeutic T Cell Receptor","publication_year":2014,"publication_date":"2014-02-13","ids":{"openalex":"https://openalex.org/W2063184115","doi":"https://doi.org/10.1371/journal.pcbi.1003478","mag":"2063184115"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1003478","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003478","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003478&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003478&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046287489","display_name":"Brian G. Pierce","orcid":"https://orcid.org/0000-0003-4821-0368"},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian G. Pierce","raw_affiliation_strings":["Program in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America"],"affiliations":[{"raw_affiliation_string":"Program in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America","institution_ids":["https://openalex.org/I166722992"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039193076","display_name":"Lance M. Hellman","orcid":"https://orcid.org/0000-0002-4938-6296"},"institutions":[{"id":"https://openalex.org/I107639228","display_name":"University of Notre Dame","ror":"https://ror.org/00mkhxb43","country_code":"US","type":"education","lineage":["https://openalex.org/I107639228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lance M. Hellman","raw_affiliation_strings":["Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana, United States of America","institution_ids":["https://openalex.org/I107639228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045444781","display_name":"Moushumi Hossain","orcid":null},"institutions":[{"id":"https://openalex.org/I107639228","display_name":"University of Notre Dame","ror":"https://ror.org/00mkhxb43","country_code":"US","type":"education","lineage":["https://openalex.org/I107639228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Moushumi Hossain","raw_affiliation_strings":["Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana, United States of America","institution_ids":["https://openalex.org/I107639228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101632047","display_name":"Nishant K. Singh","orcid":"https://orcid.org/0000-0002-2404-2024"},"institutions":[{"id":"https://openalex.org/I107639228","display_name":"University of Notre Dame","ror":"https://ror.org/00mkhxb43","country_code":"US","type":"education","lineage":["https://openalex.org/I107639228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nishant K. Singh","raw_affiliation_strings":["Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana, United States of America","institution_ids":["https://openalex.org/I107639228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080334304","display_name":"Craig W. Vander Kooi","orcid":"https://orcid.org/0000-0002-7463-3914"},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Craig W. Vander Kooi","raw_affiliation_strings":["Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, Kentucky, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, Kentucky, United States of America","institution_ids":["https://openalex.org/I143302722"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084369008","display_name":"Zhiping Weng","orcid":"https://orcid.org/0000-0002-3032-7966"},"institutions":[{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Zhiping Weng","raw_affiliation_strings":["Program in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America"],"affiliations":[{"raw_affiliation_string":"Program in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester, Massachusetts, United States of America","institution_ids":["https://openalex.org/I166722992"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082462618","display_name":"Brian M. Baker","orcid":"https://orcid.org/0000-0002-0864-0964"},"institutions":[{"id":"https://openalex.org/I107639228","display_name":"University of Notre Dame","ror":"https://ror.org/00mkhxb43","country_code":"US","type":"education","lineage":["https://openalex.org/I107639228"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Brian M. Baker","raw_affiliation_strings":["Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana, United States of America","Harper Cancer Research Institute, University of Notre Dame, Notre Dame, Indiana, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana, United States of America","institution_ids":["https://openalex.org/I107639228"]},{"raw_affiliation_string":"Harper Cancer Research Institute, University of Notre Dame, Notre Dame, Indiana, United States of America","institution_ids":["https://openalex.org/I107639228"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":["https://openalex.org/A5082462618","https://openalex.org/A5084369008"],"corresponding_institution_ids":["https://openalex.org/I107639228","https://openalex.org/I166722992"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":4.1825,"has_fulltext":true,"cited_by_count":83,"citation_normalized_percentile":{"value":0.95447608,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":99},"biblio":{"volume":"10","issue":"2","first_page":"e1003478","last_page":"e1003478"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9991999864578247,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12576","display_name":"vaccines and immunoinformatics approaches","score":0.9977999925613403,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9962000250816345,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/t-cell-receptor","display_name":"T-cell receptor","score":0.7699275016784668},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.7071720957756042},{"id":"https://openalex.org/keywords/epitope","display_name":"Epitope","score":0.6042397618293762},{"id":"https://openalex.org/keywords/major-histocompatibility-complex","display_name":"Major histocompatibility complex","score":0.5028693079948425},{"id":"https://openalex.org/keywords/rational-design","display_name":"Rational design","score":0.5028218626976013},{"id":"https://openalex.org/keywords/ligand","display_name":"Ligand (biochemistry)","score":0.4790940582752228},{"id":"https://openalex.org/keywords/peptide","display_name":"Peptide","score":0.46652114391326904},{"id":"https://openalex.org/keywords/affinity-maturation","display_name":"Affinity maturation","score":0.4407842457294464},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.43538662791252136},{"id":"https://openalex.org/keywords/protein-engineering","display_name":"Protein engineering","score":0.42774030566215515},{"id":"https://openalex.org/keywords/t-cell","display_name":"T cell","score":0.423372358083725},{"id":"https://openalex.org/keywords/receptor","display_name":"Receptor","score":0.40941286087036133},{"id":"https://openalex.org/keywords/antigen","display_name":"Antigen","score":0.3704506754875183},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.3462722897529602},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.31148597598075867},{"id":"https://openalex.org/keywords/immune-system","display_name":"Immune system","score":0.2068483531475067},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.15638577938079834},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.1281311810016632},{"id":"https://openalex.org/keywords/enzyme","display_name":"Enzyme","score":0.07822409272193909}],"concepts":[{"id":"https://openalex.org/C19317047","wikidata":"https://www.wikidata.org/wiki/Q412037","display_name":"T-cell receptor","level":4,"score":0.7699275016784668},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.7071720957756042},{"id":"https://openalex.org/C195616568","wikidata":"https://www.wikidata.org/wiki/Q128711","display_name":"Epitope","level":3,"score":0.6042397618293762},{"id":"https://openalex.org/C207936829","wikidata":"https://www.wikidata.org/wiki/Q423163","display_name":"Major histocompatibility complex","level":3,"score":0.5028693079948425},{"id":"https://openalex.org/C53105671","wikidata":"https://www.wikidata.org/wiki/Q14777816","display_name":"Rational design","level":2,"score":0.5028218626976013},{"id":"https://openalex.org/C116569031","wikidata":"https://www.wikidata.org/wiki/Q899107","display_name":"Ligand (biochemistry)","level":3,"score":0.4790940582752228},{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.46652114391326904},{"id":"https://openalex.org/C2781377902","wikidata":"https://www.wikidata.org/wiki/Q21418769","display_name":"Affinity maturation","level":3,"score":0.4407842457294464},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.43538662791252136},{"id":"https://openalex.org/C147816474","wikidata":"https://www.wikidata.org/wiki/Q169525","display_name":"Protein engineering","level":3,"score":0.42774030566215515},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.423372358083725},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.40941286087036133},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.3704506754875183},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3462722897529602},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.31148597598075867},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2068483531475067},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.15638577938079834},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.1281311810016632},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.07822409272193909}],"mesh":[],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pcbi.1003478","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003478","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003478&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmh:oai:escholarship.umassmed.edu:faculty_pubs-1416","is_oa":true,"landing_page_url":"https://escholarship.umassmed.edu/faculty_pubs/417","pdf_url":null,"source":{"id":"https://openalex.org/S4306400883","display_name":"The Journal of the American Medical Association (JAMA) Network (American Medical Association)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I173654999","host_organization_name":"American Medical Association","host_organization_lineage":["https://openalex.org/I173654999"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"University of Massachusetts Medical School Faculty Publications","raw_type":"text"},{"id":"pmh:oai:uknowledge.uky.edu:biochem_facpub-1041","is_oa":true,"landing_page_url":"https://uknowledge.uky.edu/biochem_facpub/42","pdf_url":null,"source":{"id":"https://openalex.org/S4306402623","display_name":"UKnowledge (University of Kentucky)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I143302722","host_organization_name":"University of Kentucky","host_organization_lineage":["https://openalex.org/I143302722"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Molecular and Cellular Biochemistry Faculty Publications","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:9a4c08b9b45e4c7ea4f396e85ae6b134","is_oa":true,"landing_page_url":"https://doaj.org/article/9a4c08b9b45e4c7ea4f396e85ae6b134","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 10, Iss 2, p e1003478 (2014)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:2909824","is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3923660","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/934571","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/_Computational_Design_of_the_Affinity_and_Specificity_of_a_Therapeutic_T_Cell_Receptor_/934571","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:3923660","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3923660","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1003478","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1003478","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1003478&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.4000000059604645,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G2395209334","display_name":null,"funder_award_id":"GM067079","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4359693134","display_name":null,"funder_award_id":"NIGMS","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G4994162000","display_name":null,"funder_award_id":"GM103773","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G5250288683","display_name":null,"funder_award_id":"GM084884","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6187660970","display_name":null,"funder_award_id":"103773","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G8224352852","display_name":null,"funder_award_id":"GM103773","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2063184115.pdf","grobid_xml":"https://content.openalex.org/works/W2063184115.grobid-xml"},"referenced_works_count":62,"referenced_works":["https://openalex.org/W255996521","https://openalex.org/W1541816872","https://openalex.org/W1922646908","https://openalex.org/W1971543858","https://openalex.org/W1974782594","https://openalex.org/W1976670151","https://openalex.org/W1980048816","https://openalex.org/W1993174731","https://openalex.org/W1993446370","https://openalex.org/W1997222968","https://openalex.org/W2003807422","https://openalex.org/W2008295690","https://openalex.org/W2014275356","https://openalex.org/W2020312840","https://openalex.org/W2021310372","https://openalex.org/W2039206013","https://openalex.org/W2050302632","https://openalex.org/W2051628563","https://openalex.org/W2068872497","https://openalex.org/W2071966111","https://openalex.org/W2074545819","https://openalex.org/W2075216746","https://openalex.org/W2075244544","https://openalex.org/W2076368535","https://openalex.org/W2084653587","https://openalex.org/W2089000345","https://openalex.org/W2094652659","https://openalex.org/W2097271989","https://openalex.org/W2097602001","https://openalex.org/W2099156986","https://openalex.org/W2101271238","https://openalex.org/W2103647145","https://openalex.org/W2106582884","https://openalex.org/W2115770884","https://openalex.org/W2117960073","https://openalex.org/W2117962428","https://openalex.org/W2120339346","https://openalex.org/W2121315503","https://openalex.org/W2129075135","https://openalex.org/W2129454543","https://openalex.org/W2131185370","https://openalex.org/W2132770291","https://openalex.org/W2132826139","https://openalex.org/W2140386129","https://openalex.org/W2144081223","https://openalex.org/W2146040535","https://openalex.org/W2146074801","https://openalex.org/W2146832462","https://openalex.org/W2148131811","https://openalex.org/W2150192011","https://openalex.org/W2152165755","https://openalex.org/W2152814571","https://openalex.org/W2153105219","https://openalex.org/W2153712501","https://openalex.org/W2154714625","https://openalex.org/W2154876959","https://openalex.org/W2155994234","https://openalex.org/W2159772201","https://openalex.org/W2164373210","https://openalex.org/W2164431424","https://openalex.org/W2165447245","https://openalex.org/W2167642721"],"related_works":["https://openalex.org/W2011835836","https://openalex.org/W2089872551","https://openalex.org/W1973836350","https://openalex.org/W2038509173","https://openalex.org/W2136036540","https://openalex.org/W2075125040","https://openalex.org/W2113488569","https://openalex.org/W3032468696","https://openalex.org/W2176905394","https://openalex.org/W2749706380"],"abstract_inverted_index":{"T":[0],"cell":[1],"receptors":[2],"(TCRs)":[3],"are":[4,10],"key":[5],"to":[6,38,73,153,196,229],"antigen-specific":[7],"immunity":[8],"and":[9,64,117,139,147,149,155,167,172,211],"increasingly":[11],"being":[12],"explored":[13,102],"as":[14,242,244],"therapeutics,":[15],"most":[16],"visibly":[17],"in":[18,44,52,74,84,98],"cancer":[19],"immunotherapy.":[20],"As":[21,71],"TCRs":[22,231,249],"typically":[23],"possess":[24],"only":[25],"low-to-moderate":[26],"affinity":[27,146,186,204],"for":[28,188,239,247],"their":[29],"peptide/MHC":[30],"(pMHC)":[31],"ligands,":[32],"there":[33],"is":[34],"a":[35,176],"recognized":[36],"need":[37],"develop":[39],"affinity-enhanced":[40],"TCR":[41,53,112],"variants.":[42],"Previous":[43],"vitro":[45,75],"engineering":[46],"efforts":[47],"have":[48],"yielded":[49],"remarkable":[50],"improvements":[51],"affinity,":[54,166,171],"yet":[55],"concerns":[56],"exist":[57],"about":[58],"the":[59,65,87,103,109,121,127,151,169,189,213,224],"maintenance":[60],"of":[61,68,90,105,175,201,216,226],"peptide":[62,91,240],"specificity":[63,92],"biological":[66],"impacts":[67,144],"ultra-high":[69],"affinity.":[70,99],"opposed":[72],"engineering,":[76],"computational":[77,106,227],"design":[78,107,228],"can":[79],"directly":[80],"address":[81],"these":[82],"issues,":[83],"theory":[85],"permitting":[86],"rational":[88],"control":[89],"together":[93],"with":[94,108,232,250],"relatively":[95],"controlled":[96],"increments":[97],"Here":[100],"we":[101],"efficacy":[104],"clinically":[110],"relevant":[111],"DMF5,":[113],"which":[114],"recognizes":[115],"nonameric":[116],"decameric":[118,190],"epitopes":[119],"from":[120],"melanoma-associated":[122],"Melan-A/MART-1":[123],"protein":[124],"presented":[125],"by":[126,137],"class":[128],"I":[129],"MHC":[130],"HLA-A2.":[131],"We":[132,159],"tested":[133],"multiple":[134,161],"mutations":[135,162],"selected":[136],"flexible":[138],"rigid":[140],"modeling":[141,218],"protocols,":[142],"assessed":[143],"on":[145],"specificity,":[148,241],"utilized":[150],"data":[152],"examine":[154],"improve":[156],"algorithmic":[157],"performance.":[158],"identified":[160],"that":[163,181],"improved":[164,233],"binding":[165,173,195],"characterized":[168],"structure,":[170],"kinetics":[174],"previously":[177],"reported":[178],"double":[179],"mutant":[180,205],"exhibits":[182],"an":[183],"impressive":[184],"400-fold":[185],"improvement":[187],"pMHC":[191,234],"ligand":[192],"without":[193],"detectable":[194],"non-cognate":[197],"ligands.":[198],"The":[199],"structure":[200],"this":[202],"high":[203,214],"indicated":[206],"very":[207],"little":[208],"conformational":[209],"consequences":[210],"emphasized":[212],"fidelity":[215],"our":[217,221],"procedure.":[219],"Overall,":[220],"work":[222],"showcases":[223],"capability":[225],"generate":[230],"affinities":[235],"while":[236],"explicitly":[237],"accounting":[238],"well":[243],"its":[245],"potential":[246],"generating":[248],"customized":[251],"antigen":[252],"targeting":[253],"capabilities.":[254]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":8},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":11},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":3}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}