{"id":"https://openalex.org/W1981915380","doi":"https://doi.org/10.1371/journal.pcbi.1002310","title":"Translating Clinical Findings into Knowledge in Drug Safety Evaluation - Drug Induced Liver Injury Prediction System (DILIps)","display_name":"Translating Clinical Findings into Knowledge in Drug Safety Evaluation - Drug Induced Liver Injury Prediction System (DILIps)","publication_year":2011,"publication_date":"2011-12-15","ids":{"openalex":"https://openalex.org/W1981915380","doi":"https://doi.org/10.1371/journal.pcbi.1002310","mag":"1981915380","pmid":"https://pubmed.ncbi.nlm.nih.gov/22194678"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1002310","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002310","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002310&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002310&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100459801","display_name":"Zhichao Liu","orcid":"https://orcid.org/0000-0002-3379-6258"},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhichao Liu","raw_affiliation_strings":["Division of Systems Biology, National Center for Toxicological Research, United States Food and Drug Administration, Jefferson, Arizona, USA"],"affiliations":[{"raw_affiliation_string":"Division of Systems Biology, National Center for Toxicological Research, United States Food and Drug Administration, Jefferson, Arizona, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043949763","display_name":"Qiang Shi","orcid":"https://orcid.org/0000-0002-9030-8572"},"institutions":[{"id":"https://openalex.org/I1304557061","display_name":"National Center for Toxicological Research","ror":"https://ror.org/05jmhh281","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1304557061","https://openalex.org/I1320320070"]},{"id":"https://openalex.org/I1320320070","display_name":"United States Food and Drug Administration","ror":"https://ror.org/034xvzb47","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1320320070"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Qiang Shi","raw_affiliation_strings":["Division of Systems Biology, National Center for Toxicological Research, United States Food and Drug Administration, Jefferson, Arizona, United States of America"],"affiliations":[{"raw_affiliation_string":"Division of Systems Biology, National Center for Toxicological Research, United States Food and Drug Administration, Jefferson, Arizona, United States of America","institution_ids":["https://openalex.org/I1304557061","https://openalex.org/I1320320070"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042841855","display_name":"Don Ding","orcid":null},"institutions":[{"id":"https://openalex.org/I1304557061","display_name":"National Center for Toxicological Research","ror":"https://ror.org/05jmhh281","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1304557061","https://openalex.org/I1320320070"]},{"id":"https://openalex.org/I61822063","display_name":"ICF International (United States)","ror":"https://ror.org/0156f0c06","country_code":"US","type":"company","lineage":["https://openalex.org/I61822063"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Don Ding","raw_affiliation_strings":["ICF International Company at FDA's National Center for Toxicological Research, Jefferson, Arizona, United States of America"],"affiliations":[{"raw_affiliation_string":"ICF International Company at FDA's National Center for Toxicological Research, Jefferson, Arizona, United States of America","institution_ids":["https://openalex.org/I1304557061","https://openalex.org/I61822063"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002993711","display_name":"Reagan Kelly","orcid":"https://orcid.org/0000-0002-5063-0655"},"institutions":[{"id":"https://openalex.org/I61822063","display_name":"ICF International (United States)","ror":"https://ror.org/0156f0c06","country_code":"US","type":"company","lineage":["https://openalex.org/I61822063"]},{"id":"https://openalex.org/I1304557061","display_name":"National Center for Toxicological Research","ror":"https://ror.org/05jmhh281","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1304557061","https://openalex.org/I1320320070"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Reagan Kelly","raw_affiliation_strings":["ICF International Company at FDA's National Center for Toxicological Research, Jefferson, Arizona, United States of America"],"affiliations":[{"raw_affiliation_string":"ICF International Company at FDA's National Center for Toxicological Research, Jefferson, Arizona, United States of America","institution_ids":["https://openalex.org/I1304557061","https://openalex.org/I61822063"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103228349","display_name":"Hong Fang","orcid":"https://orcid.org/0000-0002-2330-1469"},"institutions":[{"id":"https://openalex.org/I1304557061","display_name":"National Center for Toxicological Research","ror":"https://ror.org/05jmhh281","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1304557061","https://openalex.org/I1320320070"]},{"id":"https://openalex.org/I61822063","display_name":"ICF International (United States)","ror":"https://ror.org/0156f0c06","country_code":"US","type":"company","lineage":["https://openalex.org/I61822063"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hong Fang","raw_affiliation_strings":["ICF International Company at FDA's National Center for Toxicological Research, Jefferson, Arizona, United States of America"],"affiliations":[{"raw_affiliation_string":"ICF International Company at FDA's National Center for Toxicological Research, Jefferson, Arizona, United States of America","institution_ids":["https://openalex.org/I1304557061","https://openalex.org/I61822063"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5068886380","display_name":"Weida Tong","orcid":"https://orcid.org/0000-0003-3488-6148"},"institutions":[{"id":"https://openalex.org/I1320320070","display_name":"United States Food and Drug Administration","ror":"https://ror.org/034xvzb47","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1320320070"]},{"id":"https://openalex.org/I1304557061","display_name":"National Center for Toxicological Research","ror":"https://ror.org/05jmhh281","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1304557061","https://openalex.org/I1320320070"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Weida Tong","raw_affiliation_strings":["Division of Systems Biology, National Center for Toxicological Research, United States Food and Drug Administration, Jefferson, Arizona, United States of America"],"affiliations":[{"raw_affiliation_string":"Division of Systems Biology, National Center for Toxicological Research, United States Food and Drug Administration, Jefferson, Arizona, United States of America","institution_ids":["https://openalex.org/I1304557061","https://openalex.org/I1320320070"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5068886380"],"corresponding_institution_ids":["https://openalex.org/I1304557061","https://openalex.org/I1320320070"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":7.3078,"has_fulltext":true,"cited_by_count":96,"citation_normalized_percentile":{"value":0.96415416,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":99},"biblio":{"volume":"7","issue":"12","first_page":"e1002310","last_page":"e1002310"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10375","display_name":"Pharmacogenetics and Drug Metabolism","score":0.9972000122070312,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/drugbank","display_name":"DrugBank","score":0.9398841857910156},{"id":"https://openalex.org/keywords/in-silico","display_name":"In silico","score":0.7222810387611389},{"id":"https://openalex.org/keywords/drug","display_name":"Drug","score":0.721653938293457},{"id":"https://openalex.org/keywords/concordance","display_name":"Concordance","score":0.6700385808944702},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.6073431968688965},{"id":"https://openalex.org/keywords/predictive-value","display_name":"Predictive value","score":0.525928795337677},{"id":"https://openalex.org/keywords/drug-development","display_name":"Drug development","score":0.5177942514419556},{"id":"https://openalex.org/keywords/liver-toxicity","display_name":"Liver toxicity","score":0.5025670528411865},{"id":"https://openalex.org/keywords/drug-repositioning","display_name":"Drug repositioning","score":0.4651796221733093},{"id":"https://openalex.org/keywords/liver-injury","display_name":"Liver injury","score":0.4549330472946167},{"id":"https://openalex.org/keywords/drug-discovery","display_name":"Drug discovery","score":0.4126036465167999},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3996931314468384},{"id":"https://openalex.org/keywords/pharmacology","display_name":"Pharmacology","score":0.3933654725551605},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3831223249435425},{"id":"https://openalex.org/keywords/toxicity","display_name":"Toxicity","score":0.22018539905548096},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.18771246075630188},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.18171197175979614}],"concepts":[{"id":"https://openalex.org/C155261790","wikidata":"https://www.wikidata.org/wiki/Q1122544","display_name":"DrugBank","level":3,"score":0.9398841857910156},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.7222810387611389},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.721653938293457},{"id":"https://openalex.org/C160798450","wikidata":"https://www.wikidata.org/wiki/Q4230870","display_name":"Concordance","level":2,"score":0.6700385808944702},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6073431968688965},{"id":"https://openalex.org/C3019719930","wikidata":"https://www.wikidata.org/wiki/Q3910099","display_name":"Predictive value","level":2,"score":0.525928795337677},{"id":"https://openalex.org/C64903051","wikidata":"https://www.wikidata.org/wiki/Q2198549","display_name":"Drug development","level":3,"score":0.5177942514419556},{"id":"https://openalex.org/C2993709057","wikidata":"https://www.wikidata.org/wiki/Q1349821","display_name":"Liver toxicity","level":3,"score":0.5025670528411865},{"id":"https://openalex.org/C103637391","wikidata":"https://www.wikidata.org/wiki/Q5308921","display_name":"Drug repositioning","level":3,"score":0.4651796221733093},{"id":"https://openalex.org/C2776637226","wikidata":"https://www.wikidata.org/wiki/Q6658207","display_name":"Liver injury","level":2,"score":0.4549330472946167},{"id":"https://openalex.org/C74187038","wikidata":"https://www.wikidata.org/wiki/Q1418791","display_name":"Drug discovery","level":2,"score":0.4126036465167999},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3996931314468384},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3933654725551605},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3831223249435425},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.22018539905548096},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.18771246075630188},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.18171197175979614},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000890","descriptor_name":"Anti-Infective Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000890","descriptor_name":"Anti-Infective Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000890","descriptor_name":"Anti-Infective Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D000893","descriptor_name":"Anti-Inflammatory Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016208","descriptor_name":"Databases, Factual","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D056486","descriptor_name":"Chemical and Drug Induced Liver Injury","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D056486","descriptor_name":"Chemical and Drug Induced Liver Injury","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D056486","descriptor_name":"Chemical and Drug Induced Liver Injury","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D064420","descriptor_name":"Drug-Related Side Effects and Adverse Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D064420","descriptor_name":"Drug-Related Side Effects and Adverse Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D064420","descriptor_name":"Drug-Related Side Effects and Adverse Reactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pcbi.1002310","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002310","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002310&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:22194678","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22194678","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.287.49","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.287.49","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/cb/df/PLoS_Comput_Biol_2011_Dec_15_7(12)_e1002310.tar.gz","raw_type":"text"},{"id":"pmh:oai:RePEc:plo:pcbi00:1002310","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1002310","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:810332a8a7134103a7fa026e5f450908","is_oa":true,"landing_page_url":"https://doaj.org/article/810332a8a7134103a7fa026e5f450908","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 7, Iss 12, p e1002310 (2011)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/130432","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Translating_Clinical_Findings_into_Knowledge_in_Drug_Safety_Evaluation_Drug_Induced_Liver_Injury_Prediction_System_DILIps_/130432","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:3240589","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3240589","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1002310","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002310","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002310&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.7599999904632568,"id":"https://metadata.un.org/sdg/3"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320332163","display_name":"U.S. Food and Drug Administration","ror":"https://ror.org/034xvzb47"},{"id":"https://openalex.org/F4320332382","display_name":"Oak Ridge Institute for Science and Education","ror":"https://ror.org/0526p1y61"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1981915380.pdf","grobid_xml":"https://content.openalex.org/works/W1981915380.grobid-xml"},"referenced_works_count":50,"referenced_works":["https://openalex.org/W194123839","https://openalex.org/W1544009106","https://openalex.org/W1814520009","https://openalex.org/W1988680583","https://openalex.org/W1995042037","https://openalex.org/W2003268732","https://openalex.org/W2009313526","https://openalex.org/W2017783406","https://openalex.org/W2017946433","https://openalex.org/W2019431905","https://openalex.org/W2028132386","https://openalex.org/W2031374844","https://openalex.org/W2040135138","https://openalex.org/W2041295073","https://openalex.org/W2043014029","https://openalex.org/W2051143799","https://openalex.org/W2055128986","https://openalex.org/W2060192843","https://openalex.org/W2061290402","https://openalex.org/W2065261900","https://openalex.org/W2065961278","https://openalex.org/W2068075375","https://openalex.org/W2075455619","https://openalex.org/W2078154840","https://openalex.org/W2085426524","https://openalex.org/W2087561463","https://openalex.org/W2089013398","https://openalex.org/W2090773565","https://openalex.org/W2091905605","https://openalex.org/W2092058382","https://openalex.org/W2093117046","https://openalex.org/W2099536767","https://openalex.org/W2104209550","https://openalex.org/W2110820547","https://openalex.org/W2117906220","https://openalex.org/W2123759002","https://openalex.org/W2124012426","https://openalex.org/W2132272495","https://openalex.org/W2134956122","https://openalex.org/W2135302201","https://openalex.org/W2137052779","https://openalex.org/W2139196151","https://openalex.org/W2142462614","https://openalex.org/W2142572836","https://openalex.org/W2157437146","https://openalex.org/W2160121262","https://openalex.org/W2170146596","https://openalex.org/W2269544137","https://openalex.org/W2327070670","https://openalex.org/W4212885919"],"related_works":["https://openalex.org/W4387572939","https://openalex.org/W3114988578","https://openalex.org/W4385514295","https://openalex.org/W4322489931","https://openalex.org/W2797260394","https://openalex.org/W3035455406","https://openalex.org/W4200515792","https://openalex.org/W2769782375","https://openalex.org/W3177397016","https://openalex.org/W3036955211"],"abstract_inverted_index":{"Drug-induced":[0],"liver":[1,22,270],"injury":[2],"(DILI)":[3],"is":[4,205],"a":[5,92,132,245],"significant":[6],"concern":[7],"in":[8,34,45,50,75,120,128,168,175],"drug":[9,52,256,283],"development":[10,42],"due":[11],"to":[12,90,148,220,251,264,281],"the":[13,27,35,41,51,110,122,161,166,237,242,275],"poor":[14],"concordance":[15],"between":[16],"preclinical":[17],"and":[18,170,180,196,215,229,253],"clinical":[19],"findings":[20],"of":[21,43,81,114,124,177,239],"toxicity.":[23,271,291],"We":[24,55,72,186,210,272],"hypothesized":[25],"that":[26,116,188,217,222,267,274],"DILI":[28,70,93,119,173,224],"types":[29],"(hepatotoxic":[30],"side":[31,59,84],"effects)":[32],"seen":[33],"clinic":[36],"can":[37,277],"be":[38,278],"translated":[39],"into":[40],"predictive":[44,77,143],"silico":[46,76],"models":[47,78],"for":[48,64,68,79,103,112,193,202],"use":[49,195],"discovery":[53],"phase.":[54],"identified":[56,212],"13":[57,83,137],"hepatotoxic":[58],"effects":[60],"with":[61,207],"high":[62,141],"accuracy":[63,102],"classifying":[65],"marketed":[66,234],"drugs":[67,115,154,167,221,235],"their":[69,172],"potential.":[71],"then":[73],"developed":[74,127],"each":[80],"these":[82],"effects,":[85],"which":[86,204],"were":[87,200,236],"further":[88],"combined":[89],"construct":[91],"prediction":[94,101],"system":[95,198],"(DILIps).":[96],"The":[97],"DILIps":[98,129,243],"yielded":[99],"60-70%":[100],"three":[104,156],"independent":[105,157],"validation":[106],"sets.":[107],"To":[108],"enhance":[109],"confidence":[111],"identification":[113],"cause":[117,223,269],"severe":[118],"humans,":[121],"\"Rule":[123],"Three\"":[125],"was":[126],"by":[130,225],"using":[131,226],"consensus":[133],"strategy":[134],"based":[135],"on":[136],"models.":[138],"This":[139],"gave":[140],"positive":[142],"value":[144],"(91%)":[145],"when":[146],"applied":[147,280],"an":[149,248],"external":[150],"dataset":[151],"containing":[152],"206":[153],"from":[155],"literature":[158],"datasets.":[159],"Using":[160],"DILIps,":[162],"we":[163],"screened":[164],"all":[165],"DrugBank":[169],"investigated":[171],"potential":[174,246],"terms":[176],"protein":[178,213],"targets":[179,214],"therapeutic":[181,190],"categories":[182],"through":[183],"network":[184],"modeling.":[185],"demonstrated":[187],"two":[189],"categories,":[191],"anti-infectives":[192],"systemic":[194],"musculoskeletal":[197],"drugs,":[199],"enriched":[201],"DILI,":[203],"consistent":[206],"current":[208],"knowledge.":[209],"also":[211,279],"pathways":[216],"are":[218],"related":[219],"pathway":[227],"analysis":[228],"co-occurrence":[230],"text":[231],"mining.":[232],"While":[233],"focus":[238],"this":[240],"study,":[241],"has":[244],"as":[247,261,287],"evaluation":[249],"tool":[250],"screen":[252],"prioritize":[254],"new":[255],"candidates":[257],"or":[258,289],"chemicals,":[259,263],"such":[260,286],"environmental":[262],"avoid":[265],"those":[266],"might":[268],"expect":[273],"methodology":[276],"other":[282],"safety":[284],"endpoints,":[285],"renal":[288],"cardiovascular":[290]},"counts_by_year":[{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":7},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":8},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":4}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}
