{"id":"https://openalex.org/W2027967402","doi":"https://doi.org/10.1371/journal.pcbi.1002263","title":"Computational Modeling and Analysis of Insulin Induced Eukaryotic Translation Initiation","display_name":"Computational Modeling and Analysis of Insulin Induced Eukaryotic Translation Initiation","publication_year":2011,"publication_date":"2011-11-10","ids":{"openalex":"https://openalex.org/W2027967402","doi":"https://doi.org/10.1371/journal.pcbi.1002263","mag":"2027967402","pmid":"https://pubmed.ncbi.nlm.nih.gov/22102801"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1002263","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002263","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002263&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002263&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5022576195","display_name":"Joshua Lequieu","orcid":"https://orcid.org/0000-0001-9480-0989"},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua Lequieu","raw_affiliation_strings":["School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, New York, United States of America"],"affiliations":[{"raw_affiliation_string":"School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, New York, United States of America","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020079717","display_name":"Anirikh Chakrabarti","orcid":"https://orcid.org/0000-0001-7804-209X"},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anirikh Chakrabarti","raw_affiliation_strings":["School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, New York, United States of America"],"affiliations":[{"raw_affiliation_string":"School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, New York, United States of America","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065041225","display_name":"Satyaprakash Nayak","orcid":"https://orcid.org/0000-0001-7225-1317"},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Satyaprakash Nayak","raw_affiliation_strings":["School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, New York, United States of America"],"affiliations":[{"raw_affiliation_string":"School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, New York, United States of America","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5003161155","display_name":"Jeffrey D. Varner","orcid":"https://orcid.org/0000-0002-2558-7026"},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Jeffrey D. Varner","raw_affiliation_strings":["School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, New York, United States of America"],"affiliations":[{"raw_affiliation_string":"School of Chemical and Biomolecular Engineering, Cornell University, Ithaca, New York, United States of America","institution_ids":["https://openalex.org/I205783295"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5003161155"],"corresponding_institution_ids":["https://openalex.org/I205783295"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.0673,"has_fulltext":true,"cited_by_count":23,"citation_normalized_percentile":{"value":0.75615754,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"7","issue":"11","first_page":"e1002263","last_page":"e1002263"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.9973999857902527,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11339","display_name":"Metabolism, Diabetes, and Cancer","score":0.9973999857902527,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.996999979019165,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.995199978351593,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/insulin","display_name":"Insulin","score":0.6775944232940674},{"id":"https://openalex.org/keywords/pi3k/akt/mtor-pathway","display_name":"PI3K/AKT/mTOR pathway","score":0.5116024613380432},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5055601596832275},{"id":"https://openalex.org/keywords/insulin-receptor","display_name":"Insulin receptor","score":0.47921544313430786},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3665277361869812},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.3254629969596863},{"id":"https://openalex.org/keywords/signal-transduction","display_name":"Signal transduction","score":0.2973840832710266},{"id":"https://openalex.org/keywords/endocrinology","display_name":"Endocrinology","score":0.2890055179595947},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"Insulin resistance","score":0.21788322925567627}],"concepts":[{"id":"https://openalex.org/C2779306644","wikidata":"https://www.wikidata.org/wiki/Q2002370","display_name":"Insulin","level":2,"score":0.6775944232940674},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.5116024613380432},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5055601596832275},{"id":"https://openalex.org/C112446052","wikidata":"https://www.wikidata.org/wiki/Q422579","display_name":"Insulin receptor","level":4,"score":0.47921544313430786},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3665277361869812},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3254629969596863},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.2973840832710266},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2890055179595947},{"id":"https://openalex.org/C2777391703","wikidata":"https://www.wikidata.org/wiki/Q1053470","display_name":"Insulin resistance","level":3,"score":0.21788322925567627}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007328","descriptor_name":"Insulin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010442","descriptor_name":"Peptide Chain Initiation, Translational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010442","descriptor_name":"Peptide Chain Initiation, Translational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010442","descriptor_name":"Peptide Chain Initiation, Translational","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051059","descriptor_name":"PTEN Phosphohydrolase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051059","descriptor_name":"PTEN Phosphohydrolase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051059","descriptor_name":"PTEN Phosphohydrolase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055504","descriptor_name":"Insulin Receptor Substrate Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055504","descriptor_name":"Insulin Receptor Substrate Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D055504","descriptor_name":"Insulin Receptor Substrate Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D056890","descriptor_name":"Eukaryota","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D056890","descriptor_name":"Eukaryota","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D056890","descriptor_name":"Eukaryota","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pcbi.1002263","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002263","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002263&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:22102801","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22102801","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.288.2763","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.288.2763","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/44/5f/PLoS_Comput_Biol_2011_Nov_10_7(11)_e1002263.tar.gz","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:f3c7eb76f0cb42c6b8f72aa5e7bbc89c","is_oa":true,"landing_page_url":"https://doaj.org/article/f3c7eb76f0cb42c6b8f72aa5e7bbc89c","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 7, Iss 11, p e1002263 (2011)","raw_type":"article"},{"id":"pmh:oai:ecommons.cornell.edu:1813/29361","is_oa":false,"landing_page_url":"https://hdl.handle.net/1813/29361","pdf_url":null,"source":{"id":"https://openalex.org/S4306400757","display_name":"eCommons (Cornell University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I205783295","host_organization_name":"Cornell University","host_organization_lineage":["https://openalex.org/I205783295"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"dissertation or thesis"},{"id":"pmh:oai:europepmc.org:2220530","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3213178","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/131576","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Computational_Modeling_and_Analysis_of_Insulin_Induced_Eukaryotic_Translation_Initiation/131576","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1002263","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002263","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002263&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.4699999988079071,"id":"https://metadata.un.org/sdg/3"}],"awards":[{"id":"https://openalex.org/G1037117416","display_name":null,"funder_award_id":"CA143876","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G1994966301","display_name":null,"funder_award_id":"CA143876","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7257766642","display_name":null,"funder_award_id":"U54CA143876","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G7595331413","display_name":null,"funder_award_id":"U54CA143876","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2027967402.pdf","grobid_xml":"https://content.openalex.org/works/W2027967402.grobid-xml"},"referenced_works_count":125,"referenced_works":["https://openalex.org/W64510277","https://openalex.org/W184238969","https://openalex.org/W187685575","https://openalex.org/W1536730736","https://openalex.org/W1555945582","https://openalex.org/W1585517331","https://openalex.org/W1591823948","https://openalex.org/W1612556207","https://openalex.org/W1637936532","https://openalex.org/W1680392829","https://openalex.org/W1964675052","https://openalex.org/W1968013733","https://openalex.org/W1970156673","https://openalex.org/W1970424517","https://openalex.org/W1971403296","https://openalex.org/W1974159373","https://openalex.org/W1975861025","https://openalex.org/W1977267072","https://openalex.org/W1978002465","https://openalex.org/W1978486653","https://openalex.org/W1981072221","https://openalex.org/W1983247384","https://openalex.org/W1983566775","https://openalex.org/W1984736455","https://openalex.org/W1988037647","https://openalex.org/W1989891233","https://openalex.org/W1995924881","https://openalex.org/W1995949259","https://openalex.org/W1998493448","https://openalex.org/W1999161065","https://openalex.org/W2001191754","https://openalex.org/W2002226709","https://openalex.org/W2003659422","https://openalex.org/W2006512810","https://openalex.org/W2006754176","https://openalex.org/W2006980279","https://openalex.org/W2008410413","https://openalex.org/W2009940763","https://openalex.org/W2011282245","https://openalex.org/W2012123054","https://openalex.org/W2014887370","https://openalex.org/W2016403730","https://openalex.org/W2021012077","https://openalex.org/W2023455728","https://openalex.org/W2023834045","https://openalex.org/W2024571181","https://openalex.org/W2025595745","https://openalex.org/W2031253131","https://openalex.org/W2032062076","https://openalex.org/W2032619610","https://openalex.org/W2034269086","https://openalex.org/W2036960789","https://openalex.org/W2041308494","https://openalex.org/W2043460027","https://openalex.org/W2046854548","https://openalex.org/W2050169071","https://openalex.org/W2056739666","https://openalex.org/W2059548072","https://openalex.org/W2066569500","https://openalex.org/W2066659565","https://openalex.org/W2067669512","https://openalex.org/W2068602646","https://openalex.org/W2073898739","https://openalex.org/W2074067471","https://openalex.org/W2075161553","https://openalex.org/W2077582389","https://openalex.org/W2078206056","https://openalex.org/W2080498142","https://openalex.org/W2080844337","https://openalex.org/W2082853003","https://openalex.org/W2083879234","https://openalex.org/W2084521532","https://openalex.org/W2087012714","https://openalex.org/W2089889881","https://openalex.org/W2092309107","https://openalex.org/W2092710950","https://openalex.org/W2094941511","https://openalex.org/W2096595244","https://openalex.org/W2101181377","https://openalex.org/W2107674876","https://openalex.org/W2110026982","https://openalex.org/W2111125738","https://openalex.org/W2114416343","https://openalex.org/W2114492564","https://openalex.org/W2115965551","https://openalex.org/W2117056464","https://openalex.org/W2123229219","https://openalex.org/W2126393987","https://openalex.org/W2126466006","https://openalex.org/W2127230663","https://openalex.org/W2127921048","https://openalex.org/W2129172946","https://openalex.org/W2129585918","https://openalex.org/W2133036743","https://openalex.org/W2136676465","https://openalex.org/W2137224863","https://openalex.org/W2137854471","https://openalex.org/W2138270253","https://openalex.org/W2138825607","https://openalex.org/W2138871725","https://openalex.org/W2139424276","https://openalex.org/W2141058339","https://openalex.org/W2142072523","https://openalex.org/W2143784594","https://openalex.org/W2144370915","https://openalex.org/W2146414563","https://openalex.org/W2149124745","https://openalex.org/W2149199536","https://openalex.org/W2150317682","https://openalex.org/W2150351516","https://openalex.org/W2153607816","https://openalex.org/W2156682654","https://openalex.org/W2156779720","https://openalex.org/W2159990074","https://openalex.org/W2160188132","https://openalex.org/W2161046976","https://openalex.org/W2165023381","https://openalex.org/W2165106082","https://openalex.org/W2166307667","https://openalex.org/W2167264968","https://openalex.org/W2168639189","https://openalex.org/W2232064591","https://openalex.org/W2261054240","https://openalex.org/W4238567307","https://openalex.org/W6680497045"],"related_works":["https://openalex.org/W1006589974","https://openalex.org/W1974250949","https://openalex.org/W2031281657","https://openalex.org/W1978608178","https://openalex.org/W155856152","https://openalex.org/W2898511335","https://openalex.org/W2037619920","https://openalex.org/W2013332593","https://openalex.org/W2094271071","https://openalex.org/W2146323830"],"abstract_inverted_index":{"Insulin,":[0],"the":[1,5,10,51,58,62,135,146,171,175,188,192,212,230,242],"primary":[2],"hormone":[3],"regulating":[4],"level":[6],"of":[7,15,33,53,61,81,84,106,134,145,174,182,194,198,214,233],"glucose":[8],"in":[9,20,191,211],"bloodstream,":[11],"modulates":[12],"a":[13,30,79,168,196],"variety":[14],"cellular":[16],"and":[17,22,77,132,151,179,200,235],"enzymatic":[18],"processes":[19,44],"normal":[21],"diseased":[23],"cells.":[24],"Insulin":[25],"signals":[26],"are":[27],"processed":[28],"by":[29,75],"complex":[31],"network":[32,91],"biochemical":[34],"interactions":[35],"which":[36],"ultimately":[37],"induce":[38],"gene":[39],"expression":[40],"programs":[41],"or":[42],"other":[43,189],"such":[45],"as":[46],"translation":[47,67,87,160],"initiation.":[48,88,161,186],"Surprisingly,":[49],"despite":[50],"wealth":[52],"literature":[54],"on":[55],"insulin":[56,65,85,90,195,222],"signaling,":[57],"relative":[59,231],"importance":[60,232],"components":[63],"linking":[64],"with":[66],"initiation":[68],"remains":[69],"unclear.":[70],"We":[71],"addressed":[72],"this":[73],"question":[74],"developing":[76],"interrogating":[78],"family":[80,105],"mathematical":[82],"models":[83],"induced":[86],"The":[89,127],"was":[92,109,208],"modeled":[93],"using":[94,119,141,149],"mass-action":[95],"kinetics":[96],"within":[97],"an":[98,113,155],"ordinary":[99],"differential":[100],"equation":[101],"(ODE)":[102],"framework.":[103],"A":[104],"model":[107,130,147],"parameters":[108],"estimated,":[110],"starting":[111],"from":[112,125],"initial":[114],"best":[115],"fit":[116],"parameter":[117],"set,":[118],"24":[120],"experimental":[121,136],"data":[122],"sets":[123],"taken":[124],"literature.":[126],"residual":[128],"between":[129,170],"simulations":[131],"each":[133],"constraints":[137],"were":[138],"simultaneously":[139],"minimized":[140],"multiobjective":[142],"optimization.":[143],"Interrogation":[144],"population,":[148],"sensitivity":[150],"robustness":[152],"analysis,":[153],"identified":[154],"insulin-dependent":[156],"switch":[157],"that":[158,165],"controlled":[159,184,203],"Our":[162],"analysis":[163],"suggested":[164],"without":[166],"insulin,":[167],"balance":[169],"pro-initiation":[172],"activity":[173,181,202],"GTP-binding":[176],"protein":[177],"Rheb":[178,201,236],"anti-initiation":[180],"PTEN":[183],"basal":[185],"On":[187],"hand,":[190],"presence":[193,213],"combination":[197],"PI3K":[199,207,234],"inducible":[204],"initiation,":[205],"where":[206],"only":[209],"critical":[210],"insulin.":[215],"Other":[216],"well":[217],"known":[218],"regulatory":[219],"mechanisms":[220],"governing":[221],"action,":[223],"for":[224],"example":[225],"IRS-1":[226],"negative":[227],"feedback,":[228],"modulated":[229],"but":[237],"did":[238],"not":[239],"fundamentally":[240],"change":[241],"signal":[243],"flow.":[244]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":3},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":4}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}