{"id":"https://openalex.org/W2094683075","doi":"https://doi.org/10.1371/journal.pcbi.1002048","title":"Quantitative Epistasis Analysis and Pathway Inference from Genetic Interaction Data","display_name":"Quantitative Epistasis Analysis and Pathway Inference from Genetic Interaction Data","publication_year":2011,"publication_date":"2011-05-12","ids":{"openalex":"https://openalex.org/W2094683075","doi":"https://doi.org/10.1371/journal.pcbi.1002048","mag":"2094683075","pmid":"https://pubmed.ncbi.nlm.nih.gov/21589890"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1002048","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002048","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002048&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002048&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026871523","display_name":"Hilary Phenix","orcid":null},"institutions":[{"id":"https://openalex.org/I153718931","display_name":"University of Ottawa","ror":"https://ror.org/03c4mmv16","country_code":"CA","type":"education","lineage":["https://openalex.org/I153718931"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Hilary Phenix","raw_affiliation_strings":["Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, Ontario, Canada","Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada"],"affiliations":[{"raw_affiliation_string":"Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, Ontario, Canada","institution_ids":["https://openalex.org/I153718931"]},{"raw_affiliation_string":"Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada","institution_ids":["https://openalex.org/I153718931"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022801195","display_name":"Katy Morin","orcid":null},"institutions":[{"id":"https://openalex.org/I153718931","display_name":"University of Ottawa","ror":"https://ror.org/03c4mmv16","country_code":"CA","type":"education","lineage":["https://openalex.org/I153718931"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Katy Morin","raw_affiliation_strings":["Department of Biochemistry, Immunology and Microbiology, University of Ottawa, Ottawa, Ontario, Canada,","Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, Ontario, Canada,","Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, Ontario, Canada","Department of Biochemistry, Immunology and Microbiology, University of Ottawa, Ottawa, Ontario, Canada"],"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Immunology and Microbiology, University of Ottawa, Ottawa, Ontario, Canada,","institution_ids":["https://openalex.org/I153718931"]},{"raw_affiliation_string":"Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, Ontario, Canada,","institution_ids":["https://openalex.org/I153718931"]},{"raw_affiliation_string":"Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, Ontario, Canada","institution_ids":["https://openalex.org/I153718931"]},{"raw_affiliation_string":"Department of Biochemistry, Immunology and Microbiology, University of Ottawa, Ottawa, Ontario, Canada","institution_ids":["https://openalex.org/I153718931"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013163191","display_name":"Cory Batenchuk","orcid":null},"institutions":[{"id":"https://openalex.org/I153718931","display_name":"University of Ottawa","ror":"https://ror.org/03c4mmv16","country_code":"CA","type":"education","lineage":["https://openalex.org/I153718931"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Cory Batenchuk","raw_affiliation_strings":["Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada,","Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, Ontario, Canada,","Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada","Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, Ontario, Canada"],"affiliations":[{"raw_affiliation_string":"Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada,","institution_ids":["https://openalex.org/I153718931"]},{"raw_affiliation_string":"Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, Ontario, Canada,","institution_ids":["https://openalex.org/I153718931"]},{"raw_affiliation_string":"Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada","institution_ids":["https://openalex.org/I153718931"]},{"raw_affiliation_string":"Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, Ontario, Canada","institution_ids":["https://openalex.org/I153718931"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063059245","display_name":"Jacob J. Parker","orcid":"https://orcid.org/0000-0001-9425-6418"},"institutions":[{"id":"https://openalex.org/I151746483","display_name":"University of Waterloo","ror":"https://ror.org/01aff2v68","country_code":"CA","type":"education","lineage":["https://openalex.org/I151746483"]},{"id":"https://openalex.org/I2800722420","display_name":"Ottawa Hospital","ror":"https://ror.org/03c62dg59","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2800722420"]},{"id":"https://openalex.org/I4388482656","display_name":"Ottawa Hospital Research Institute","ror":"https://ror.org/05jtef216","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I153718931","https://openalex.org/I2800722420","https://openalex.org/I4388482656"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Jacob Parker","raw_affiliation_strings":["Department of Applied Mathematics, University of Waterloo, Waterloo, Ontario, Canada,","Ottawa Hospital Research Institute, Ottawa, Ontario, Canada,","Department of Applied Mathematics, University of Waterloo, Waterloo, Ontario, Canada","Ottawa Hospital Research Institute, Ottawa, Ontario, Canada"],"affiliations":[{"raw_affiliation_string":"Department of Applied Mathematics, University of Waterloo, Waterloo, Ontario, Canada,","institution_ids":["https://openalex.org/I151746483"]},{"raw_affiliation_string":"Ottawa Hospital Research Institute, Ottawa, Ontario, Canada,","institution_ids":["https://openalex.org/I2800722420","https://openalex.org/I4388482656"]},{"raw_affiliation_string":"Department of Applied Mathematics, University of Waterloo, Waterloo, Ontario, Canada","institution_ids":["https://openalex.org/I151746483"]},{"raw_affiliation_string":"Ottawa Hospital Research Institute, Ottawa, Ontario, Canada","institution_ids":["https://openalex.org/I2800722420","https://openalex.org/I4388482656"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057855237","display_name":"Vida Abedi","orcid":"https://orcid.org/0000-0001-7689-933X"},"institutions":[{"id":"https://openalex.org/I153718931","display_name":"University of Ottawa","ror":"https://ror.org/03c4mmv16","country_code":"CA","type":"education","lineage":["https://openalex.org/I153718931"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Vida Abedi","raw_affiliation_strings":["Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada,","Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, Ontario, Canada,","Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, Ontario, Canada","Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada"],"affiliations":[{"raw_affiliation_string":"Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada,","institution_ids":["https://openalex.org/I153718931"]},{"raw_affiliation_string":"Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, Ontario, Canada,","institution_ids":["https://openalex.org/I153718931"]},{"raw_affiliation_string":"Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, Ontario, Canada","institution_ids":["https://openalex.org/I153718931"]},{"raw_affiliation_string":"Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada","institution_ids":["https://openalex.org/I153718931"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028874350","display_name":"Yang Liu","orcid":"https://orcid.org/0000-0003-2486-5765"},"institutions":[{"id":"https://openalex.org/I151746483","display_name":"University of Waterloo","ror":"https://ror.org/01aff2v68","country_code":"CA","type":"education","lineage":["https://openalex.org/I151746483"]},{"id":"https://openalex.org/I153718931","display_name":"University of Ottawa","ror":"https://ror.org/03c4mmv16","country_code":"CA","type":"education","lineage":["https://openalex.org/I153718931"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Liu Yang","raw_affiliation_strings":["Department of Applied Mathematics, University of Waterloo, Waterloo, Ontario, Canada","Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada","Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, Ontario, Canada"],"affiliations":[{"raw_affiliation_string":"Department of Applied Mathematics, University of Waterloo, Waterloo, Ontario, Canada","institution_ids":["https://openalex.org/I151746483"]},{"raw_affiliation_string":"Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada","institution_ids":["https://openalex.org/I153718931"]},{"raw_affiliation_string":"Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, Ontario, Canada","institution_ids":["https://openalex.org/I153718931"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021709097","display_name":"Lioudmila Tepliakova","orcid":null},"institutions":[{"id":"https://openalex.org/I153718931","display_name":"University of Ottawa","ror":"https://ror.org/03c4mmv16","country_code":"CA","type":"education","lineage":["https://openalex.org/I153718931"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Lioudmila Tepliakova","raw_affiliation_strings":["Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada,","Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, Ontario, Canada,","Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, Ontario, Canada","Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada"],"affiliations":[{"raw_affiliation_string":"Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada,","institution_ids":["https://openalex.org/I153718931"]},{"raw_affiliation_string":"Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, Ontario, Canada,","institution_ids":["https://openalex.org/I153718931"]},{"raw_affiliation_string":"Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, Ontario, Canada","institution_ids":["https://openalex.org/I153718931"]},{"raw_affiliation_string":"Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada","institution_ids":["https://openalex.org/I153718931"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009680404","display_name":"Theodore J. Perkins","orcid":"https://orcid.org/0000-0002-6622-8003"},"institutions":[{"id":"https://openalex.org/I153718931","display_name":"University of Ottawa","ror":"https://ror.org/03c4mmv16","country_code":"CA","type":"education","lineage":["https://openalex.org/I153718931"]},{"id":"https://openalex.org/I2800722420","display_name":"Ottawa Hospital","ror":"https://ror.org/03c62dg59","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I2800722420"]},{"id":"https://openalex.org/I4388482656","display_name":"Ottawa Hospital Research Institute","ror":"https://ror.org/05jtef216","country_code":null,"type":"healthcare","lineage":["https://openalex.org/I153718931","https://openalex.org/I2800722420","https://openalex.org/I4388482656"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Theodore J. Perkins","raw_affiliation_strings":["Department of Biochemistry, Immunology and Microbiology, University of Ottawa, Ottawa, Ontario, Canada,","Ottawa Hospital Research Institute, Ottawa, Ontario, Canada,","Ottawa Hospital Research Institute, Ottawa, Ontario, Canada","Department of Biochemistry, Immunology and Microbiology, University of Ottawa, Ottawa, Ontario, Canada"],"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, Immunology and Microbiology, University of Ottawa, Ottawa, Ontario, Canada,","institution_ids":["https://openalex.org/I153718931"]},{"raw_affiliation_string":"Ottawa Hospital Research Institute, Ottawa, Ontario, Canada,","institution_ids":["https://openalex.org/I2800722420","https://openalex.org/I4388482656"]},{"raw_affiliation_string":"Ottawa Hospital Research Institute, Ottawa, Ontario, Canada","institution_ids":["https://openalex.org/I2800722420","https://openalex.org/I4388482656"]},{"raw_affiliation_string":"Department of Biochemistry, Immunology and Microbiology, University of Ottawa, Ottawa, Ontario, Canada","institution_ids":["https://openalex.org/I153718931"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5057807980","display_name":"Mads K\u00e6rn","orcid":"https://orcid.org/0000-0002-9371-666X"},"institutions":[{"id":"https://openalex.org/I153718931","display_name":"University of Ottawa","ror":"https://ror.org/03c4mmv16","country_code":"CA","type":"education","lineage":["https://openalex.org/I153718931"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Mads K\u00e6rn","raw_affiliation_strings":["Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada","Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, Ontario, Canada","Department of Physics, University of Ottawa, Ottawa, Ontario, Canada"],"affiliations":[{"raw_affiliation_string":"Department of Cellular and Molecular Medicine, University of Ottawa, Ottawa, Ontario, Canada","institution_ids":["https://openalex.org/I153718931"]},{"raw_affiliation_string":"Ottawa Institute of Systems Biology, University of Ottawa, Ottawa, Ontario, Canada","institution_ids":["https://openalex.org/I153718931"]},{"raw_affiliation_string":"Department of Physics, University of Ottawa, Ottawa, Ontario, Canada","institution_ids":["https://openalex.org/I153718931"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":9,"corresponding_author_ids":["https://openalex.org/A5057807980"],"corresponding_institution_ids":["https://openalex.org/I153718931"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.667,"has_fulltext":true,"cited_by_count":19,"citation_normalized_percentile":{"value":0.69172673,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"7","issue":"5","first_page":"e1002048","last_page":"e1002048"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/epistasis","display_name":"Epistasis","score":0.8417538404464722},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.6860213279724121},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.6634591817855835},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.5771809816360474},{"id":"https://openalex.org/keywords/inference","display_name":"Inference","score":0.5083298087120056},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.5036546587944031},{"id":"https://openalex.org/keywords/false-positive-paradox","display_name":"False positive paradox","score":0.4881740212440491},{"id":"https://openalex.org/keywords/genetic-architecture","display_name":"Genetic architecture","score":0.4788670241832733},{"id":"https://openalex.org/keywords/saccharomyces-cerevisiae","display_name":"Saccharomyces cerevisiae","score":0.4785785675048828},{"id":"https://openalex.org/keywords/quantitative-trait-locus","display_name":"Quantitative trait locus","score":0.46601489186286926},{"id":"https://openalex.org/keywords/systems-biology","display_name":"Systems biology","score":0.42884647846221924},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.4263717532157898},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.2870342433452606},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.23401853442192078},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.16375836730003357},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.13645848631858826}],"concepts":[{"id":"https://openalex.org/C61727976","wikidata":"https://www.wikidata.org/wiki/Q751748","display_name":"Epistasis","level":3,"score":0.8417538404464722},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6860213279724121},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6634591817855835},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.5771809816360474},{"id":"https://openalex.org/C2776214188","wikidata":"https://www.wikidata.org/wiki/Q408386","display_name":"Inference","level":2,"score":0.5083298087120056},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5036546587944031},{"id":"https://openalex.org/C64869954","wikidata":"https://www.wikidata.org/wiki/Q1859747","display_name":"False positive paradox","level":2,"score":0.4881740212440491},{"id":"https://openalex.org/C9287583","wikidata":"https://www.wikidata.org/wiki/Q5532883","display_name":"Genetic architecture","level":4,"score":0.4788670241832733},{"id":"https://openalex.org/C2777576037","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Saccharomyces cerevisiae","level":3,"score":0.4785785675048828},{"id":"https://openalex.org/C81941488","wikidata":"https://www.wikidata.org/wiki/Q853421","display_name":"Quantitative trait locus","level":3,"score":0.46601489186286926},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.42884647846221924},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4263717532157898},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2870342433452606},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.23401853442192078},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.16375836730003357},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.13645848631858826}],"mesh":[{"descriptor_ui":"D004843","descriptor_name":"Epistasis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004843","descriptor_name":"Epistasis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004843","descriptor_name":"Epistasis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D004843","descriptor_name":"Epistasis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005690","descriptor_name":"Galactose","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005690","descriptor_name":"Galactose","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005690","descriptor_name":"Galactose","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005690","descriptor_name":"Galactose","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005690","descriptor_name":"Galactose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005690","descriptor_name":"Galactose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005690","descriptor_name":"Galactose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005690","descriptor_name":"Galactose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005800","descriptor_name":"Genes, Fungal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005800","descriptor_name":"Genes, Fungal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005800","descriptor_name":"Genes, Fungal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005800","descriptor_name":"Genes, Fungal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015966","descriptor_name":"Gene Expression Regulation, Fungal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015966","descriptor_name":"Gene Expression Regulation, Fungal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015966","descriptor_name":"Gene Expression Regulation, Fungal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015966","descriptor_name":"Gene Expression Regulation, Fungal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017353","descriptor_name":"Gene Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017353","descriptor_name":"Gene Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017353","descriptor_name":"Gene Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017353","descriptor_name":"Gene Deletion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pcbi.1002048","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002048","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002048&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:21589890","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21589890","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.806.5474","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.806.5474","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/a0/75/pcbi.1002048.PMC3093353.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:44582b5da47d4f9b8a6daa90782662e7","is_oa":true,"landing_page_url":"https://doaj.org/article/44582b5da47d4f9b8a6daa90782662e7","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 7, Iss 5, p e1002048 (2011)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/136828","is_oa":true,"landing_page_url":"https://figshare.com/articles/Quantitative_Epistasis_Analysis_and_Pathway_Inference_from_Genetic_Interaction_Data/136828","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:3093353","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3093353","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmh:oai:ruor.uottawa.ca:10393/20021","is_oa":false,"landing_page_url":"http://hdl.handle.net/10393/20021","pdf_url":null,"source":{"id":"https://openalex.org/S4306400902","display_name":"uO Research (University of Ottawa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I153718931","host_organization_name":"University of Ottawa","host_organization_lineage":["https://openalex.org/I153718931"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1002048","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1002048","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1002048&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G8644429313","display_name":null,"funder_award_id":"328154","funder_id":"https://openalex.org/F4320334593","funder_display_name":"Natural Sciences and Engineering Research Council of Canada"},{"id":"https://openalex.org/G8942627049","display_name":"Systems biology and biological information processing","funder_award_id":"328154-2009","funder_id":"https://openalex.org/F4320334593","funder_display_name":"Natural Sciences and Engineering Research Council of Canada"}],"funders":[{"id":"https://openalex.org/F4320322675","display_name":"Mitacs","ror":"https://ror.org/00cjrc276"},{"id":"https://openalex.org/F4320334593","display_name":"Natural Sciences and Engineering Research Council of Canada","ror":"https://ror.org/01h531d29"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2094683075.pdf","grobid_xml":"https://content.openalex.org/works/W2094683075.grobid-xml"},"referenced_works_count":39,"referenced_works":["https://openalex.org/W1587089803","https://openalex.org/W1601258312","https://openalex.org/W1898792859","https://openalex.org/W1966072209","https://openalex.org/W1972946410","https://openalex.org/W1973179872","https://openalex.org/W1974317514","https://openalex.org/W1981704956","https://openalex.org/W1988263223","https://openalex.org/W1988624915","https://openalex.org/W1992452843","https://openalex.org/W1996234405","https://openalex.org/W2007871023","https://openalex.org/W2008609077","https://openalex.org/W2024002487","https://openalex.org/W2026813804","https://openalex.org/W2034608799","https://openalex.org/W2037165519","https://openalex.org/W2042688172","https://openalex.org/W2062185406","https://openalex.org/W2084377907","https://openalex.org/W2095722471","https://openalex.org/W2110920860","https://openalex.org/W2115606218","https://openalex.org/W2117033519","https://openalex.org/W2125858955","https://openalex.org/W2127073167","https://openalex.org/W2130139983","https://openalex.org/W2133102806","https://openalex.org/W2133992568","https://openalex.org/W2148641007","https://openalex.org/W2153134824","https://openalex.org/W2158383746","https://openalex.org/W2159460045","https://openalex.org/W2161297153","https://openalex.org/W2163296115","https://openalex.org/W2168846334","https://openalex.org/W2169875902","https://openalex.org/W3099289621"],"related_works":["https://openalex.org/W1988072872","https://openalex.org/W3150638776","https://openalex.org/W2113244577","https://openalex.org/W4393427313","https://openalex.org/W2416919291","https://openalex.org/W2162555644","https://openalex.org/W4213127452","https://openalex.org/W1996840382","https://openalex.org/W2140140747","https://openalex.org/W2402496592"],"abstract_inverted_index":{"Inferring":[0],"regulatory":[1,185,188],"and":[2,51,139,148,167,190],"metabolic":[3,165,172],"network":[4,86],"models":[5],"from":[6],"quantitative":[7,23,73],"genetic":[8,85],"interaction":[9],"data":[10],"remains":[11],"a":[12,21,53,76,113,117],"major":[13],"challenge":[14],"in":[15,127],"systems":[16],"biology.":[17],"Here,":[18],"we":[19,133],"present":[20],"novel":[22],"model":[24,36],"for":[25],"interpreting":[26],"epistasis":[27],"within":[28,64],"pathways":[29],"responding":[30],"to":[31,44,58,81,84,91,158],"an":[32,41],"external":[33],"signal.":[34],"The":[35,66],"provides":[37],"the":[38,46,60,70,95,109,123,135,162,168,175,181,196,199,204,210],"basis":[39],"of":[40,48,56,62,72,79,97,116,137,164,170,177,183,198,209],"experimental":[42],"method":[43,67,110,157,205],"determine":[45],"architecture":[47],"such":[49],"pathways,":[50],"establishes":[52],"new":[54,77],"set":[55],"rules":[57],"infer":[59],"order":[61,163,182],"genes":[63],"them.":[65],"also":[68],"allows":[69],"extraction":[71],"parameters":[74],"enabling":[75],"level":[78],"information":[80],"be":[82,102],"added":[83],"models.":[87],"It":[88],"is":[89],"applicable":[90],"any":[92,214],"system":[93],"where":[94],"impact":[96],"combinatorial":[98],"loss-of-function":[99],"mutations":[100],"can":[101],"quantified":[103],"with":[104],"sufficient":[105],"accuracy.":[106],"We":[107,152],"test":[108],"by":[111],"conducting":[112],"systematic":[114],"analysis":[115,176],"thoroughly":[118],"characterized":[119],"eukaryotic":[120],"gene":[121,141,150],"network,":[122],"galactose":[124],"utilization":[125],"pathway":[126],"Saccharomyces":[128],"cerevisiae.":[129],"For":[130],"this":[131],"purpose,":[132],"quantify":[134],"effects":[136,169],"single":[138],"double":[140],"deletions":[142],"on":[143],"two":[144,200],"phenotypic":[145],"traits,":[146],"fitness":[147,159],"reporter":[149],"expression.":[151],"show":[153],"that":[154],"applying":[155],"our":[156],"traits":[160,179,201],"reveals":[161,180],"enzymes":[166],"accumulating":[171],"intermediates.":[173],"Conversely,":[174],"expression":[178],"transcriptional":[184],"genes,":[186],"secondary":[187],"signals":[189],"their":[191],"relative":[192],"strength.":[193],"Strikingly,":[194],"when":[195],"analyses":[197],"are":[202],"combined,":[203],"correctly":[206],"infers":[207],"~80%":[208],"known":[211],"relationships":[212],"without":[213],"false":[215],"positives.":[216]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}
