{"id":"https://openalex.org/W2124252812","doi":"https://doi.org/10.1371/journal.pcbi.1001058","title":"Stochastic Theory of Early Viral Infection: Continuous versus Burst Production of Virions","display_name":"Stochastic Theory of Early Viral Infection: Continuous versus Burst Production of Virions","publication_year":2011,"publication_date":"2011-02-03","ids":{"openalex":"https://openalex.org/W2124252812","doi":"https://doi.org/10.1371/journal.pcbi.1001058","mag":"2124252812","pmid":"https://pubmed.ncbi.nlm.nih.gov/21304934"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1001058","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1001058","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1001058&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1001058&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067076584","display_name":"John E. Pearson","orcid":"https://orcid.org/0000-0001-7552-9353"},"institutions":[{"id":"https://openalex.org/I1343871089","display_name":"Los Alamos National Laboratory","ror":"https://ror.org/01e41cf67","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I1343871089","https://openalex.org/I198811213","https://openalex.org/I4210120050"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John E. Pearson","raw_affiliation_strings":["Theoretical Biology & Biophysics, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America"],"affiliations":[{"raw_affiliation_string":"Theoretical Biology & Biophysics, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America","institution_ids":["https://openalex.org/I1343871089"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032602392","display_name":"P. L. Krapivsky","orcid":"https://orcid.org/0000-0003-3470-5095"},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Paul Krapivsky","raw_affiliation_strings":["Department of Physics, Boston University, Boston, Massachusetts, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Physics, Boston University, Boston, Massachusetts, United States of America","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058338534","display_name":"Alan S. Perelson","orcid":"https://orcid.org/0000-0002-2455-0002"},"institutions":[{"id":"https://openalex.org/I1343871089","display_name":"Los Alamos National Laboratory","ror":"https://ror.org/01e41cf67","country_code":"US","type":"facility","lineage":["https://openalex.org/I1330989302","https://openalex.org/I1343871089","https://openalex.org/I198811213","https://openalex.org/I4210120050"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Alan S. Perelson","raw_affiliation_strings":["Theoretical Biology & Biophysics, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America"],"affiliations":[{"raw_affiliation_string":"Theoretical Biology & Biophysics, Los Alamos National Laboratory, Los Alamos, New Mexico, United States of America","institution_ids":["https://openalex.org/I1343871089"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5058338534"],"corresponding_institution_ids":["https://openalex.org/I1343871089"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":11.3169,"has_fulltext":true,"cited_by_count":140,"citation_normalized_percentile":{"value":0.98698122,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"7","issue":"2","first_page":"e1001058","last_page":"e1001058"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10482","display_name":"Mathematical and Theoretical Epidemiology and Ecology Models","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10482","display_name":"Mathematical and Theoretical Epidemiology and Ecology Models","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9958999752998352,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10410","display_name":"COVID-19 epidemiological studies","score":0.991100013256073,"subfield":{"id":"https://openalex.org/subfields/2611","display_name":"Modeling and Simulation"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.5762473940849304},{"id":"https://openalex.org/keywords/viral-infection","display_name":"Viral infection","score":0.5649096965789795},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5189740061759949},{"id":"https://openalex.org/keywords/extinction","display_name":"Extinction (optical mineralogy)","score":0.5129227638244629},{"id":"https://openalex.org/keywords/production","display_name":"Production (economics)","score":0.4959000051021576},{"id":"https://openalex.org/keywords/dynamics","display_name":"Dynamics (music)","score":0.4944441318511963},{"id":"https://openalex.org/keywords/virology","display_name":"Virology","score":0.4510178565979004},{"id":"https://openalex.org/keywords/steady-state","display_name":"Steady state (chemistry)","score":0.4399715065956116},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.4220535159111023},{"id":"https://openalex.org/keywords/viral-replication","display_name":"Viral replication","score":0.41971972584724426},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.33960282802581787},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.3279881477355957},{"id":"https://openalex.org/keywords/virus","display_name":"Virus","score":0.31675201654434204},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.1884617805480957}],"concepts":[{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5762473940849304},{"id":"https://openalex.org/C2994541485","wikidata":"https://www.wikidata.org/wiki/Q1928978","display_name":"Viral infection","level":3,"score":0.5649096965789795},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5189740061759949},{"id":"https://openalex.org/C101991246","wikidata":"https://www.wikidata.org/wiki/Q5422078","display_name":"Extinction (optical mineralogy)","level":2,"score":0.5129227638244629},{"id":"https://openalex.org/C2778348673","wikidata":"https://www.wikidata.org/wiki/Q739302","display_name":"Production (economics)","level":2,"score":0.4959000051021576},{"id":"https://openalex.org/C145912823","wikidata":"https://www.wikidata.org/wiki/Q113558","display_name":"Dynamics (music)","level":2,"score":0.4944441318511963},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4510178565979004},{"id":"https://openalex.org/C8171440","wikidata":"https://www.wikidata.org/wiki/Q903414","display_name":"Steady state (chemistry)","level":2,"score":0.4399715065956116},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.4220535159111023},{"id":"https://openalex.org/C140704245","wikidata":"https://www.wikidata.org/wiki/Q3933202","display_name":"Viral replication","level":3,"score":0.41971972584724426},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.33960282802581787},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3279881477355957},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.31675201654434204},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.1884617805480957},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.0},{"id":"https://openalex.org/C147789679","wikidata":"https://www.wikidata.org/wiki/Q11372","display_name":"Physical chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C144024400","wikidata":"https://www.wikidata.org/wiki/Q21201","display_name":"Sociology","level":0,"score":0.0},{"id":"https://openalex.org/C139719470","wikidata":"https://www.wikidata.org/wiki/Q39680","display_name":"Macroeconomics","level":1,"score":0.0},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006678","descriptor_name":"HIV","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006678","descriptor_name":"HIV","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006678","descriptor_name":"HIV","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013269","descriptor_name":"Stochastic Processes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014771","descriptor_name":"Virion","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014771","descriptor_name":"Virion","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014771","descriptor_name":"Virion","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014777","descriptor_name":"Virus Diseases","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D014777","descriptor_name":"Virus Diseases","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D014777","descriptor_name":"Virus Diseases","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D014777","descriptor_name":"Virus Diseases","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D014777","descriptor_name":"Virus Diseases","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D014777","descriptor_name":"Virus Diseases","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014779","descriptor_name":"Virus Replication","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015302","descriptor_name":"Simian Immunodeficiency Virus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015302","descriptor_name":"Simian Immunodeficiency Virus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015302","descriptor_name":"Simian Immunodeficiency Virus","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D016097","descriptor_name":"Simian Acquired Immunodeficiency Syndrome","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D016097","descriptor_name":"Simian Acquired Immunodeficiency Syndrome","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D016097","descriptor_name":"Simian Acquired Immunodeficiency Syndrome","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D016097","descriptor_name":"Simian Acquired Immunodeficiency Syndrome","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D016097","descriptor_name":"Simian Acquired Immunodeficiency Syndrome","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D016097","descriptor_name":"Simian Acquired Immunodeficiency Syndrome","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019562","descriptor_name":"Viral Load","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019562","descriptor_name":"Viral Load","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019562","descriptor_name":"Viral Load","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055641","descriptor_name":"Mathematical Concepts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055641","descriptor_name":"Mathematical Concepts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055641","descriptor_name":"Mathematical Concepts","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pcbi.1001058","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1001058","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1001058&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:21304934","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21304934","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.293.3348","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.293.3348","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/bb/d1/PLoS_Comput_Biol_2011_Feb_3_7(2)_e1001058.tar.gz","raw_type":"text"},{"id":"pmh:oai:RePEc:plo:pcbi00:1001058","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1001058","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:9a45836e1e074b57902f14e833104524","is_oa":true,"landing_page_url":"https://doaj.org/article/9a45836e1e074b57902f14e833104524","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 7, Iss 2, p e1001058 (2011)","raw_type":"article"},{"id":"pmh:oai:osti.gov:1627210","is_oa":true,"landing_page_url":"https://www.osti.gov/biblio/1627210","pdf_url":null,"source":{"id":"https://openalex.org/S4306402487","display_name":"OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I139351228","host_organization_name":"Office of Scientific and Technical Information","host_organization_lineage":["https://openalex.org/I139351228"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:3033366","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3033366","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"public-domain","license_id":"https://openalex.org/licenses/public-domain","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1001058","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1001058","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1001058&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.4399999976158142,"display_name":"Good health and well-being"}],"awards":[{"id":"https://openalex.org/G1300609800","display_name":null,"funder_award_id":"RR06555","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G1872210597","display_name":null,"funder_award_id":"DE-AC52-06NA2539","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G2031045238","display_name":null,"funder_award_id":"DE-AC52-06NA253","funder_id":"https://openalex.org/F4320338304","funder_display_name":"Los Alamos National Laboratory"},{"id":"https://openalex.org/G2148279209","display_name":null,"funder_award_id":"LANL/LDRD","funder_id":"https://openalex.org/F4320337547","funder_display_name":"Laboratory Directed Research and Development"},{"id":"https://openalex.org/G3369036323","display_name":"Collaborative Research: EMT/MISC: Behavior-Based Molecular Robotics","funder_award_id":"0829541","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G359075050","display_name":null,"funder_award_id":"DE-AC52-06NA25396","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G3700687868","display_name":null,"funder_award_id":"AC52-06NA25396","funder_id":"https://openalex.org/F4320338304","funder_display_name":"Los Alamos National Laboratory"},{"id":"https://openalex.org/G4237675041","display_name":null,"funder_award_id":"LANL/LDRD","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G5083158263","display_name":null,"funder_award_id":"DE-AC52-06NA25396","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G5657628048","display_name":null,"funder_award_id":"AC52-06NA25396","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"},{"id":"https://openalex.org/G5713387433","display_name":null,"funder_award_id":"DE-AC52-06NA25396","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6390143893","display_name":null,"funder_award_id":"AI28433","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6932788750","display_name":null,"funder_award_id":"DE-AC52-06NA25396","funder_id":"https://openalex.org/F4320337547","funder_display_name":"Laboratory Directed Research and Development"},{"id":"https://openalex.org/G75892134","display_name":null,"funder_award_id":"DE-AC52-06NA25396","funder_id":"https://openalex.org/F4320338304","funder_display_name":"Los Alamos National Laboratory"},{"id":"https://openalex.org/G8527529014","display_name":null,"funder_award_id":"DE-AC52-06NA2539","funder_id":"https://openalex.org/F4320338304","funder_display_name":"Los Alamos National Laboratory"},{"id":"https://openalex.org/G8611951938","display_name":null,"funder_award_id":"AI67854","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G928841278","display_name":null,"funder_award_id":"contract DE-AC52-06NA25396","funder_id":"https://openalex.org/F4320306084","funder_display_name":"U.S. Department of Energy"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306084","display_name":"U.S. Department of Energy","ror":"https://ror.org/01bj3aw27"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337547","display_name":"Laboratory Directed Research and Development","ror":"https://ror.org/01e41cf67"},{"id":"https://openalex.org/F4320338304","display_name":"Los Alamos National Laboratory","ror":"https://ror.org/01e41cf67"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2124252812.pdf","grobid_xml":"https://content.openalex.org/works/W2124252812.grobid-xml"},"referenced_works_count":71,"referenced_works":["https://openalex.org/W34945428","https://openalex.org/W100501468","https://openalex.org/W1522687244","https://openalex.org/W1546043352","https://openalex.org/W1606697907","https://openalex.org/W2002574877","https://openalex.org/W2009420628","https://openalex.org/W2009471367","https://openalex.org/W2010672055","https://openalex.org/W2013602955","https://openalex.org/W2013914180","https://openalex.org/W2022212158","https://openalex.org/W2024946691","https://openalex.org/W2034895572","https://openalex.org/W2035722382","https://openalex.org/W2040139732","https://openalex.org/W2040622094","https://openalex.org/W2044403736","https://openalex.org/W2050031723","https://openalex.org/W2051269276","https://openalex.org/W2060701294","https://openalex.org/W2061536824","https://openalex.org/W2061657962","https://openalex.org/W2063617625","https://openalex.org/W2064059889","https://openalex.org/W2064975723","https://openalex.org/W2065190721","https://openalex.org/W2069251911","https://openalex.org/W2074248745","https://openalex.org/W2075421877","https://openalex.org/W2076967360","https://openalex.org/W2078358826","https://openalex.org/W2085722235","https://openalex.org/W2085789074","https://openalex.org/W2088012076","https://openalex.org/W2090297178","https://openalex.org/W2096193010","https://openalex.org/W2096641399","https://openalex.org/W2098439468","https://openalex.org/W2099311529","https://openalex.org/W2113826765","https://openalex.org/W2114705914","https://openalex.org/W2120915945","https://openalex.org/W2122816742","https://openalex.org/W2137268328","https://openalex.org/W2138293866","https://openalex.org/W2146797068","https://openalex.org/W2155418451","https://openalex.org/W2158035002","https://openalex.org/W2160226661","https://openalex.org/W2165032352","https://openalex.org/W2166309712","https://openalex.org/W2168736565","https://openalex.org/W2168776079","https://openalex.org/W2170271908","https://openalex.org/W2172297142","https://openalex.org/W2312994949","https://openalex.org/W2320114104","https://openalex.org/W2433896906","https://openalex.org/W2587926013","https://openalex.org/W2751862591","https://openalex.org/W2947171186","https://openalex.org/W2963503659","https://openalex.org/W3023069629","https://openalex.org/W3027202947","https://openalex.org/W4230394883","https://openalex.org/W4285719527","https://openalex.org/W4388299012","https://openalex.org/W4388364567","https://openalex.org/W6632536082","https://openalex.org/W7018901030"],"related_works":["https://openalex.org/W1599920801","https://openalex.org/W2587085640","https://openalex.org/W1973691824","https://openalex.org/W4386071021","https://openalex.org/W2054394682","https://openalex.org/W2000404450","https://openalex.org/W3102854518","https://openalex.org/W2724244987","https://openalex.org/W4293723385","https://openalex.org/W2986905278"],"abstract_inverted_index":{"Viral":[0],"production":[1,23,84],"from":[2,153,161],"infected":[3,57,105,118,164],"cells":[4,58,106,119],"can":[5,38],"occur":[6],"continuously":[7],"or":[8],"in":[9,73],"a":[10,155,162],"burst":[11,131],"that":[12,72,96],"generally":[13],"kills":[14],"the":[15,49,60,79,94,109,113,136,146],"cell.":[16],"For":[17],"HIV":[18],"infection,":[19],"both":[20,112,154,167],"modes":[21,44,81,168],"of":[22,34,45,64,76,82,102,115,138,148,169],"have":[24],"been":[25],"suggested.":[26],"Standard":[27],"viral":[28,46,77,83],"dynamic":[29],"models":[30,75],"formulated":[31],"as":[32,48,54,56,143,145,158,160],"sets":[33],"ordinary":[35],"differential":[36],"equations":[37],"not":[39],"distinguish":[40],"between":[41],"these":[42],"two":[43,80],"production,":[47],"predicted":[50],"dynamics":[51],"is":[52],"identical":[53],"long":[55],"produce":[59],"same":[61],"total":[62],"number":[63,101],"virions":[65,103,116],"over":[66],"their":[67],"lifespan.":[68],"Here":[69],"we":[70,91],"show":[71,122],"stochastic":[74],"infection":[78,142],"yield":[85],"different":[86,126],"early":[87],"term":[88],"dynamics.":[89],"Further,":[90],"analytically":[92],"determine":[93],"probability":[95],"infections":[97],"initiated":[98],"with":[99],"any":[100],"and":[104,117,121,130],"reach":[107],"extinction,":[108],"state":[110],"when":[111],"population":[114],"vanish,":[120],"this":[123],"too":[124],"has":[125],"solutions":[127],"for":[128,166],"continuous":[129],"production.":[132,171],"We":[133],"also":[134],"compute":[135],"distributions":[137],"times":[139,149],"to":[140,150],"establish":[141],"well":[144,159],"distribution":[147],"extinction":[151],"starting":[152],"single":[156,163],"virion":[157,170],"cell":[165]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":12},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":11},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":15},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":8},{"year":2012,"cited_by_count":17}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}