{"id":"https://openalex.org/W2067803486","doi":"https://doi.org/10.1371/journal.pcbi.1000612","title":"Nano-motion Dynamics are Determined by Surface-Tethered Selectin Mechanokinetics and Bond Formation","display_name":"Nano-motion Dynamics are Determined by Surface-Tethered Selectin Mechanokinetics and Bond Formation","publication_year":2009,"publication_date":"2009-12-18","ids":{"openalex":"https://openalex.org/W2067803486","doi":"https://doi.org/10.1371/journal.pcbi.1000612","mag":"2067803486","pmid":"https://pubmed.ncbi.nlm.nih.gov/20019797"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1000612","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000612","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000612&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000612&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087220120","display_name":"Brian J. Schmidt","orcid":"https://orcid.org/0000-0001-6015-9636"},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian J. Schmidt","raw_affiliation_strings":["Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia, USA","Department of Biomedical Engineering, University of Virginia Charlottesville Virginia USA"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia, USA","institution_ids":["https://openalex.org/I51556381"]},{"raw_affiliation_string":"Department of Biomedical Engineering, University of Virginia Charlottesville Virginia USA","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000119406","display_name":"Jason A. Papin","orcid":"https://orcid.org/0000-0002-2769-5805"},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jason A. Papin","raw_affiliation_strings":["Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia, United States of America","Dept of Biomedical Engineering, University of Virginia, Charlottesville, Virginia, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia, United States of America","institution_ids":["https://openalex.org/I51556381"]},{"raw_affiliation_string":"Dept of Biomedical Engineering, University of Virginia, Charlottesville, Virginia, United States of America","institution_ids":["https://openalex.org/I51556381"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102977836","display_name":"Michael B. Lawrence","orcid":"https://orcid.org/0000-0001-9028-0162"},"institutions":[{"id":"https://openalex.org/I51556381","display_name":"University of Virginia","ror":"https://ror.org/0153tk833","country_code":"US","type":"education","lineage":["https://openalex.org/I51556381"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Michael B. Lawrence","raw_affiliation_strings":["Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia, United States of America","Dept of Biomedical Engineering, University of Virginia, Charlottesville, Virginia, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, University of Virginia, Charlottesville, Virginia, United States of America","institution_ids":["https://openalex.org/I51556381"]},{"raw_affiliation_string":"Dept of Biomedical Engineering, University of Virginia, Charlottesville, Virginia, United States of America","institution_ids":["https://openalex.org/I51556381"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5102977836"],"corresponding_institution_ids":["https://openalex.org/I51556381"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.9226,"has_fulltext":true,"cited_by_count":10,"citation_normalized_percentile":{"value":0.74890833,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"5","issue":"12","first_page":"e1000612","last_page":"e1000612"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10923","display_name":"Force Microscopy Techniques and Applications","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/3107","display_name":"Atomic and Molecular Physics, and Optics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10923","display_name":"Force Microscopy Techniques and Applications","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/3107","display_name":"Atomic and Molecular Physics, and Optics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10379","display_name":"Cellular Mechanics and Interactions","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.6510635018348694},{"id":"https://openalex.org/keywords/microbead","display_name":"Microbead (research)","score":0.6241084933280945},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.49528756737709045},{"id":"https://openalex.org/keywords/nanotechnology","display_name":"Nanotechnology","score":0.45375561714172363},{"id":"https://openalex.org/keywords/adhesion","display_name":"Adhesion","score":0.45297637581825256},{"id":"https://openalex.org/keywords/molecular-dynamics","display_name":"Molecular dynamics","score":0.43647730350494385},{"id":"https://openalex.org/keywords/cell-adhesion","display_name":"Cell adhesion","score":0.41503268480300903},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.4083719253540039},{"id":"https://openalex.org/keywords/chemical-physics","display_name":"Chemical physics","score":0.3319585919380188},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.30178970098495483},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.21932315826416016},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.13104036450386047},{"id":"https://openalex.org/keywords/computational-chemistry","display_name":"Computational chemistry","score":0.10501343011856079}],"concepts":[{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.6510635018348694},{"id":"https://openalex.org/C2776363448","wikidata":"https://www.wikidata.org/wiki/Q12008238","display_name":"Microbead (research)","level":2,"score":0.6241084933280945},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.49528756737709045},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.45375561714172363},{"id":"https://openalex.org/C84416704","wikidata":"https://www.wikidata.org/wiki/Q188666","display_name":"Adhesion","level":2,"score":0.45297637581825256},{"id":"https://openalex.org/C59593255","wikidata":"https://www.wikidata.org/wiki/Q901663","display_name":"Molecular dynamics","level":2,"score":0.43647730350494385},{"id":"https://openalex.org/C85789140","wikidata":"https://www.wikidata.org/wiki/Q187640","display_name":"Cell adhesion","level":3,"score":0.41503268480300903},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.4083719253540039},{"id":"https://openalex.org/C159467904","wikidata":"https://www.wikidata.org/wiki/Q2001702","display_name":"Chemical physics","level":1,"score":0.3319585919380188},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.30178970098495483},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.21932315826416016},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.13104036450386047},{"id":"https://openalex.org/C147597530","wikidata":"https://www.wikidata.org/wiki/Q369472","display_name":"Computational chemistry","level":1,"score":0.10501343011856079},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D001696","descriptor_name":"Biomechanical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001696","descriptor_name":"Biomechanical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001696","descriptor_name":"Biomechanical Phenomena","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008863","descriptor_name":"Microspheres","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008863","descriptor_name":"Microspheres","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008863","descriptor_name":"Microspheres","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009038","descriptor_name":"Motion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009038","descriptor_name":"Motion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009038","descriptor_name":"Motion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013499","descriptor_name":"Surface Properties","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013499","descriptor_name":"Surface Properties","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013499","descriptor_name":"Surface Properties","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015203","descriptor_name":"Reproducibility of Results","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019087","descriptor_name":"Selectins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019087","descriptor_name":"Selectins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019087","descriptor_name":"Selectins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019087","descriptor_name":"Selectins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019087","descriptor_name":"Selectins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019087","descriptor_name":"Selectins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D036103","descriptor_name":"Nanotechnology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D036103","descriptor_name":"Nanotechnology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D036103","descriptor_name":"Nanotechnology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1000612","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000612","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000612&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:20019797","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20019797","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:RePEc:plo:pcbi00:1000612","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1000612","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:83ac1a5cff814eb1bedb123a84c86c1e","is_oa":true,"landing_page_url":"https://doaj.org/article/83ac1a5cff814eb1bedb123a84c86c1e","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 5, Iss 12, p e1000612 (2009)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:1894802","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2787012","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/145299","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Nano_motion_Dynamics_are_Determined_by_Surface_Tethered_Selectin_Mechanokinetics_and_Bond_Formation/145299","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1000612","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000612","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000612&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[{"id":"https://openalex.org/G1157040454","display_name":null,"funder_award_id":"02185","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2067803486.pdf","grobid_xml":"https://content.openalex.org/works/W2067803486.grobid-xml"},"referenced_works_count":76,"referenced_works":["https://openalex.org/W1502078581","https://openalex.org/W1884700299","https://openalex.org/W1965731960","https://openalex.org/W1965998502","https://openalex.org/W1969731472","https://openalex.org/W1969834815","https://openalex.org/W1971783741","https://openalex.org/W1974872356","https://openalex.org/W1981572498","https://openalex.org/W1983756804","https://openalex.org/W1987654715","https://openalex.org/W1993622985","https://openalex.org/W1996583965","https://openalex.org/W1997405293","https://openalex.org/W2000108132","https://openalex.org/W2003426856","https://openalex.org/W2010080800","https://openalex.org/W2014253601","https://openalex.org/W2015211029","https://openalex.org/W2015776459","https://openalex.org/W2017425886","https://openalex.org/W2019877102","https://openalex.org/W2030181238","https://openalex.org/W2032231424","https://openalex.org/W2037370475","https://openalex.org/W2041387847","https://openalex.org/W2046737206","https://openalex.org/W2051369945","https://openalex.org/W2052192720","https://openalex.org/W2053363846","https://openalex.org/W2053907724","https://openalex.org/W2055596401","https://openalex.org/W2056673837","https://openalex.org/W2057383363","https://openalex.org/W2062212084","https://openalex.org/W2063952895","https://openalex.org/W2064262499","https://openalex.org/W2067353129","https://openalex.org/W2070954903","https://openalex.org/W2071045195","https://openalex.org/W2071166532","https://openalex.org/W2077534353","https://openalex.org/W2077820055","https://openalex.org/W2084445306","https://openalex.org/W2084677920","https://openalex.org/W2087966520","https://openalex.org/W2090400738","https://openalex.org/W2090892643","https://openalex.org/W2095228825","https://openalex.org/W2099675490","https://openalex.org/W2106524559","https://openalex.org/W2108928354","https://openalex.org/W2113040115","https://openalex.org/W2115710476","https://openalex.org/W2124268744","https://openalex.org/W2126278579","https://openalex.org/W2128493116","https://openalex.org/W2131435922","https://openalex.org/W2131710476","https://openalex.org/W2134811744","https://openalex.org/W2136169984","https://openalex.org/W2136864234","https://openalex.org/W2138623142","https://openalex.org/W2138819257","https://openalex.org/W2151124861","https://openalex.org/W2155708268","https://openalex.org/W2160648230","https://openalex.org/W2160710430","https://openalex.org/W2161838518","https://openalex.org/W2168142569","https://openalex.org/W2169678562","https://openalex.org/W2507370390","https://openalex.org/W2541988902","https://openalex.org/W3162464574","https://openalex.org/W4285719527","https://openalex.org/W6725125144"],"related_works":["https://openalex.org/W2392388241","https://openalex.org/W1965866142","https://openalex.org/W1988655739","https://openalex.org/W2278657244","https://openalex.org/W1989257177","https://openalex.org/W2061084809","https://openalex.org/W1600127933","https://openalex.org/W2789349812","https://openalex.org/W2352776361","https://openalex.org/W2143950663"],"abstract_inverted_index":{"The":[0,91,210],"interaction":[1],"of":[2,24,39,73,76,97,100,230,237,243,296,299,313],"proteins":[3,44],"at":[4],"cellular":[5,265],"interfaces":[6],"is":[7,306],"critical":[8,29],"for":[9,158],"many":[10],"biological":[11],"processes,":[12],"from":[13,252],"intercellular":[14],"signaling":[15],"to":[16,56,123,149,175,218,260],"cell":[17,254],"adhesion.":[18],"For":[19],"example,":[20],"the":[21,74,98,128,190,202,207,222,235,297,309],"selectin":[22],"family":[23],"adhesion":[25,83,107],"receptors":[26,84,108],"plays":[27],"a":[28,70,77],"role":[30],"in":[31,65,85,94,134,171,180,221,231,275,287,308],"trafficking":[32],"during":[33],"inflammation":[34],"and":[35,52,114,311],"immunosurveillance.":[36],"Quantitative":[37],"measurements":[38,64],"binding":[40],"rates":[41],"between":[42],"surface-constrained":[43,111,300],"elicit":[45],"insight":[46],"into":[47,109,247],"how":[48],"molecular":[49,104,192,304],"structural":[50],"details":[51],"post-translational":[53],"modifications":[54],"contribute":[55,217],"function.":[57,245,302],"However,":[58,195],"nano-scale":[59,115],"transport":[60,117,215],"effects":[61,99,286,298],"can":[62,216],"obfuscate":[63],"experimental":[66],"assays.":[67,182],"We":[68],"constructed":[69],"biophysical":[71],"simulation":[72,92],"motion":[75,147,292],"rigid":[78],"microsphere":[79],"coated":[80],"with":[81,138,280],"biomolecular":[82,156,301],"shearing":[86],"flow":[87,253],"undergoing":[88],"thermal":[89,291],"motion.":[90,314],"enabled":[93,293],"silico":[95,232,276],"investigation":[96],"kinetic":[101],"force":[102],"dependence,":[103],"deformation,":[105],"grouping":[106],"clusters,":[110],"bond":[112,177,185,224,249],"formation,":[113],"vertical":[116,214],"on":[118],"outputs":[119],"that":[120,213],"directly":[121],"map":[122],"observable":[124],"motions.":[125],"Simulations":[126],"recreated":[127],"jerky,":[129],"discrete":[130],"stop-and-go":[131],"motions":[132,233],"observed":[133,179],"P-selectin/PSGL-1":[135,159,167],"microbead":[136,181],"assays":[137,255],"physiologic":[139],"ligand":[140],"densities.":[141],"Motion":[142],"statistics":[143,312],"tied":[144],"detailed":[145,228],"simulated":[146],"data":[148],"experimentally":[150],"reported":[151],"quantities.":[152],"New":[153],"deductions":[154,295],"about":[155],"function":[157],"interactions":[160],"were":[161,199],"made.":[162],"Distributing":[163],"adhesive":[164],"forces":[165],"among":[166],"molecules":[168],"closely":[169],"grouped":[170],"clusters":[172],"was":[173,278],"necessary":[174],"achieve":[176],"lifetimes":[178],"Initial,":[183],"capturing":[184],"formation":[186,225,250],"effectively":[187],"occurred":[188],"across":[189],"entire":[191],"contour":[193],"length.":[194],"subsequent":[196],"rebinding":[197],"events":[198],"enhanced":[200],"by":[201],"reduced":[203],"separation":[204,289],"distance":[205],"following":[206],"initial":[208],"capture.":[209],"result":[211],"demonstrates":[212],"an":[219,241],"enhancement":[220],"apparent":[223],"rate.":[226],"A":[227,272],"analysis":[229],"prompted":[234],"proposition":[236],"wobble":[238],"autocorrelation":[239],"as":[240,268],"indicator":[242],"two-dimensional":[244,248],"Insight":[246],"gained":[251],"might":[256],"therefore":[257],"be":[258],"important":[259],"understand":[261],"processes":[262],"involving":[263],"extended":[264],"interactions,":[266],"such":[267],"immunological":[269],"synapse":[270],"formation.":[271],"biologically":[273],"informative":[274],"system":[277],"created":[279],"minimal,":[281],"high-confidence":[282],"inputs.":[283],"Incorporating":[284],"random":[285],"surface":[288],"through":[290],"new":[294],"Important":[303],"information":[305],"embedded":[307],"patterns":[310]},"counts_by_year":[{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-04-10T15:06:20.359241","created_date":"2025-10-10T00:00:00"}
