{"id":"https://openalex.org/W2091312350","doi":"https://doi.org/10.1371/journal.pcbi.1000606","title":"Transcriptome and Proteome Exploration to Model Translation Efficiency and Protein Stability in Lactococcus lactis","display_name":"Transcriptome and Proteome Exploration to Model Translation Efficiency and Protein Stability in Lactococcus lactis","publication_year":2009,"publication_date":"2009-12-18","ids":{"openalex":"https://openalex.org/W2091312350","doi":"https://doi.org/10.1371/journal.pcbi.1000606","mag":"2091312350"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1000606","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000606","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000606&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000606&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032969305","display_name":"Cl\u00e9mentine Dressaire","orcid":null},"institutions":[{"id":"https://openalex.org/I17866349","display_name":"Universit\u00e9 F\u00e9d\u00e9rale de Toulouse Midi-Pyr\u00e9n\u00e9es","ror":"https://ror.org/004raaa70","country_code":"FR","type":"education","lineage":["https://openalex.org/I17866349"]},{"id":"https://openalex.org/I4210110888","display_name":"Laboratoire d'Ing\u00e9nierie des Syst\u00e8mes Biologiques et des Proc\u00e9d\u00e9s","ror":"https://ror.org/01yypjb30","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I196454796","https://openalex.org/I4210088668","https://openalex.org/I4210095849","https://openalex.org/I4210110888","https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I134560555","display_name":"Universit\u00e9 Toulouse III - Paul Sabatier","ror":"https://ror.org/02v6kpv12","country_code":"FR","type":"education","lineage":["https://openalex.org/I134560555","https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Cl\u00e9mentine Dressaire","raw_affiliation_strings":["CNRS, UMR5504, Toulouse, France","INRA, UMR792 Ing\u00e9nierie des Syst\u00e8mes Biologiques et des Proc\u00e9d\u00e9s, Toulouse, France","Universit\u00e9 de Toulouse; INSA, UPS, INP; LISBP, Toulouse, France","LISBP, Toulouse, France","Universit\u00e9 de Toulouse","INSA, UPS, INP"],"affiliations":[{"raw_affiliation_string":"CNRS, UMR5504, Toulouse, France","institution_ids":["https://openalex.org/I1294671590"]},{"raw_affiliation_string":"INRA, UMR792 Ing\u00e9nierie des Syst\u00e8mes Biologiques et des Proc\u00e9d\u00e9s, Toulouse, France","institution_ids":["https://openalex.org/I4210110888"]},{"raw_affiliation_string":"Universit\u00e9 de Toulouse; INSA, UPS, INP; LISBP, Toulouse, France","institution_ids":["https://openalex.org/I134560555","https://openalex.org/I17866349"]},{"raw_affiliation_string":"LISBP, Toulouse, France","institution_ids":["https://openalex.org/I4210110888"]},{"raw_affiliation_string":"Universit\u00e9 de Toulouse","institution_ids":["https://openalex.org/I17866349"]},{"raw_affiliation_string":"INSA, UPS, INP","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108376958","display_name":"Christophe Gitton","orcid":null},"institutions":[{"id":"https://openalex.org/I4210116501","display_name":"D\u00e9partement G\u00e9n\u00e9tique Animale","ror":"https://ror.org/029xmsm82","country_code":"FR","type":"government","lineage":["https://openalex.org/I4210088668","https://openalex.org/I4210116501"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Christophe Gitton","raw_affiliation_strings":["INRA, Unit\u00e9 de Biochimie Bact\u00e9rienne, UR477, Jouy en Josas, France"],"affiliations":[{"raw_affiliation_string":"INRA, Unit\u00e9 de Biochimie Bact\u00e9rienne, UR477, Jouy en Josas, France","institution_ids":["https://openalex.org/I4210116501"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105778495","display_name":"Pascal Loubi\u00e8re","orcid":null},"institutions":[{"id":"https://openalex.org/I17866349","display_name":"Universit\u00e9 F\u00e9d\u00e9rale de Toulouse Midi-Pyr\u00e9n\u00e9es","ror":"https://ror.org/004raaa70","country_code":"FR","type":"education","lineage":["https://openalex.org/I17866349"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I4210110888","display_name":"Laboratoire d'Ing\u00e9nierie des Syst\u00e8mes Biologiques et des Proc\u00e9d\u00e9s","ror":"https://ror.org/01yypjb30","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I196454796","https://openalex.org/I4210088668","https://openalex.org/I4210095849","https://openalex.org/I4210110888","https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I134560555","display_name":"Universit\u00e9 Toulouse III - Paul Sabatier","ror":"https://ror.org/02v6kpv12","country_code":"FR","type":"education","lineage":["https://openalex.org/I134560555","https://openalex.org/I4405258862"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Pascal Loubi\u00e8re","raw_affiliation_strings":["CNRS, UMR5504, Toulouse, France","INRA, UMR792 Ing\u00e9nierie des Syst\u00e8mes Biologiques et des Proc\u00e9d\u00e9s, Toulouse, France","Universit\u00e9 de Toulouse; INSA, UPS, INP; LISBP, Toulouse, France","Universit\u00e9 de Toulouse","INSA, UPS, INP","LISBP, Toulouse, France"],"affiliations":[{"raw_affiliation_string":"CNRS, UMR5504, Toulouse, France","institution_ids":["https://openalex.org/I1294671590"]},{"raw_affiliation_string":"INRA, UMR792 Ing\u00e9nierie des Syst\u00e8mes Biologiques et des Proc\u00e9d\u00e9s, Toulouse, France","institution_ids":["https://openalex.org/I4210110888"]},{"raw_affiliation_string":"Universit\u00e9 de Toulouse; INSA, UPS, INP; LISBP, Toulouse, France","institution_ids":["https://openalex.org/I134560555","https://openalex.org/I17866349"]},{"raw_affiliation_string":"Universit\u00e9 de Toulouse","institution_ids":["https://openalex.org/I17866349"]},{"raw_affiliation_string":"INSA, UPS, INP","institution_ids":[]},{"raw_affiliation_string":"LISBP, Toulouse, France","institution_ids":["https://openalex.org/I4210110888"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034746479","display_name":"V\u00e9ronique Monnet","orcid":"https://orcid.org/0000-0001-7438-5618"},"institutions":[{"id":"https://openalex.org/I4210116501","display_name":"D\u00e9partement G\u00e9n\u00e9tique Animale","ror":"https://ror.org/029xmsm82","country_code":"FR","type":"government","lineage":["https://openalex.org/I4210088668","https://openalex.org/I4210116501"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"V\u00e9ronique Monnet","raw_affiliation_strings":["INRA, Unit\u00e9 de Biochimie Bact\u00e9rienne, UR477, Jouy en Josas, France"],"affiliations":[{"raw_affiliation_string":"INRA, Unit\u00e9 de Biochimie Bact\u00e9rienne, UR477, Jouy en Josas, France","institution_ids":["https://openalex.org/I4210116501"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048256265","display_name":"Isabelle Queinnec","orcid":"https://orcid.org/0000-0003-0783-1977"},"institutions":[{"id":"https://openalex.org/I190497903","display_name":"Laboratoire d'Analyse et d'Architecture des Syst\u00e8mes","ror":"https://ror.org/03vcm6439","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I1294671590","https://openalex.org/I134560555","https://openalex.org/I190497903","https://openalex.org/I196454796","https://openalex.org/I205747304","https://openalex.org/I205747304","https://openalex.org/I4210095849","https://openalex.org/I4210159245","https://openalex.org/I4387153255","https://openalex.org/I4405258862","https://openalex.org/I4405258862","https://openalex.org/I4405258862","https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I17866349","display_name":"Universit\u00e9 F\u00e9d\u00e9rale de Toulouse Midi-Pyr\u00e9n\u00e9es","ror":"https://ror.org/004raaa70","country_code":"FR","type":"education","lineage":["https://openalex.org/I17866349"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Isabelle Queinnec","raw_affiliation_strings":["Universit\u00e9 de Toulouse; LAAS-CNRS, Toulouse, France","Universit\u00e9 de Toulouse","LAAS-CNRS, Toulouse, France"],"affiliations":[{"raw_affiliation_string":"Universit\u00e9 de Toulouse; LAAS-CNRS, Toulouse, France","institution_ids":["https://openalex.org/I17866349","https://openalex.org/I1294671590","https://openalex.org/I190497903"]},{"raw_affiliation_string":"Universit\u00e9 de Toulouse","institution_ids":["https://openalex.org/I17866349"]},{"raw_affiliation_string":"LAAS-CNRS, Toulouse, France","institution_ids":["https://openalex.org/I190497903","https://openalex.org/I1294671590"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035294360","display_name":"Muriel Cocaign\u2010Bousquet","orcid":"https://orcid.org/0000-0003-2033-9901"},"institutions":[{"id":"https://openalex.org/I4210110888","display_name":"Laboratoire d'Ing\u00e9nierie des Syst\u00e8mes Biologiques et des Proc\u00e9d\u00e9s","ror":"https://ror.org/01yypjb30","country_code":"FR","type":"facility","lineage":["https://openalex.org/I1294671590","https://openalex.org/I196454796","https://openalex.org/I4210088668","https://openalex.org/I4210095849","https://openalex.org/I4210110888","https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I134560555","display_name":"Universit\u00e9 Toulouse III - Paul Sabatier","ror":"https://ror.org/02v6kpv12","country_code":"FR","type":"education","lineage":["https://openalex.org/I134560555","https://openalex.org/I4405258862"]},{"id":"https://openalex.org/I17866349","display_name":"Universit\u00e9 F\u00e9d\u00e9rale de Toulouse Midi-Pyr\u00e9n\u00e9es","ror":"https://ror.org/004raaa70","country_code":"FR","type":"education","lineage":["https://openalex.org/I17866349"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Muriel Cocaign-Bousquet","raw_affiliation_strings":["CNRS, UMR5504, Toulouse, France","INRA, UMR792 Ing\u00e9nierie des Syst\u00e8mes Biologiques et des Proc\u00e9d\u00e9s, Toulouse, France","Universit\u00e9 de Toulouse; INSA, UPS, INP; LISBP, Toulouse, France","INSA, UPS, INP","Universit\u00e9 de Toulouse","LISBP, Toulouse, France"],"affiliations":[{"raw_affiliation_string":"CNRS, UMR5504, Toulouse, France","institution_ids":["https://openalex.org/I1294671590"]},{"raw_affiliation_string":"INRA, UMR792 Ing\u00e9nierie des Syst\u00e8mes Biologiques et des Proc\u00e9d\u00e9s, Toulouse, France","institution_ids":["https://openalex.org/I4210110888"]},{"raw_affiliation_string":"Universit\u00e9 de Toulouse; INSA, UPS, INP; LISBP, Toulouse, France","institution_ids":["https://openalex.org/I134560555","https://openalex.org/I17866349"]},{"raw_affiliation_string":"INSA, UPS, INP","institution_ids":[]},{"raw_affiliation_string":"Universit\u00e9 de Toulouse","institution_ids":["https://openalex.org/I17866349"]},{"raw_affiliation_string":"LISBP, Toulouse, France","institution_ids":["https://openalex.org/I4210110888"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5035294360"],"corresponding_institution_ids":["https://openalex.org/I1294671590","https://openalex.org/I134560555","https://openalex.org/I17866349","https://openalex.org/I4210110888"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":2.2811,"has_fulltext":true,"cited_by_count":44,"citation_normalized_percentile":{"value":0.88091399,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"5","issue":"12","first_page":"e1000606","last_page":"e1000606"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9997000098228455,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lactococcus-lactis","display_name":"Lactococcus lactis","score":0.8215977549552917},{"id":"https://openalex.org/keywords/proteome","display_name":"Proteome","score":0.7066522836685181},{"id":"https://openalex.org/keywords/protein-degradation","display_name":"Protein degradation","score":0.6669195294380188},{"id":"https://openalex.org/keywords/translation","display_name":"Translation (biology)","score":0.5559675693511963},{"id":"https://openalex.org/keywords/protein-biosynthesis","display_name":"Protein biosynthesis","score":0.5509921908378601},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5358484983444214},{"id":"https://openalex.org/keywords/transcriptome","display_name":"Transcriptome","score":0.490488737821579},{"id":"https://openalex.org/keywords/translational-efficiency","display_name":"Translational efficiency","score":0.48641514778137207},{"id":"https://openalex.org/keywords/degradation","display_name":"Degradation (telecommunications)","score":0.4785933196544647},{"id":"https://openalex.org/keywords/growth-rate","display_name":"Growth rate","score":0.45676565170288086},{"id":"https://openalex.org/keywords/codon-usage-bias","display_name":"Codon usage bias","score":0.4402436316013336},{"id":"https://openalex.org/keywords/exponential-growth","display_name":"Exponential growth","score":0.420273095369339},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.3987553119659424},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.3776124119758606},{"id":"https://openalex.org/keywords/messenger-rna","display_name":"Messenger RNA","score":0.33360710740089417},{"id":"https://openalex.org/keywords/cell-biology","display_name":"Cell biology","score":0.32321465015411377},{"id":"https://openalex.org/keywords/bacteria","display_name":"Bacteria","score":0.3082146644592285},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.30486342310905457},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.27204424142837524},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.26216018199920654},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.2119198441505432},{"id":"https://openalex.org/keywords/lactic-acid","display_name":"Lactic acid","score":0.13508522510528564},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.109354168176651},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.08719304203987122}],"concepts":[{"id":"https://openalex.org/C2780011460","wikidata":"https://www.wikidata.org/wiki/Q133598","display_name":"Lactococcus lactis","level":4,"score":0.8215977549552917},{"id":"https://openalex.org/C104397665","wikidata":"https://www.wikidata.org/wiki/Q860947","display_name":"Proteome","level":2,"score":0.7066522836685181},{"id":"https://openalex.org/C2992195973","wikidata":"https://www.wikidata.org/wiki/Q33123","display_name":"Protein degradation","level":2,"score":0.6669195294380188},{"id":"https://openalex.org/C149364088","wikidata":"https://www.wikidata.org/wiki/Q185917","display_name":"Translation (biology)","level":4,"score":0.5559675693511963},{"id":"https://openalex.org/C3675279","wikidata":"https://www.wikidata.org/wiki/Q211935","display_name":"Protein biosynthesis","level":2,"score":0.5509921908378601},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5358484983444214},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.490488737821579},{"id":"https://openalex.org/C2775992057","wikidata":"https://www.wikidata.org/wiki/Q16956568","display_name":"Translational efficiency","level":5,"score":0.48641514778137207},{"id":"https://openalex.org/C2779679103","wikidata":"https://www.wikidata.org/wiki/Q5251805","display_name":"Degradation (telecommunications)","level":2,"score":0.4785933196544647},{"id":"https://openalex.org/C2778312390","wikidata":"https://www.wikidata.org/wiki/Q4139973","display_name":"Growth rate","level":2,"score":0.45676565170288086},{"id":"https://openalex.org/C87253356","wikidata":"https://www.wikidata.org/wiki/Q1106472","display_name":"Codon usage bias","level":4,"score":0.4402436316013336},{"id":"https://openalex.org/C75235859","wikidata":"https://www.wikidata.org/wiki/Q582659","display_name":"Exponential growth","level":2,"score":0.420273095369339},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3987553119659424},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3776124119758606},{"id":"https://openalex.org/C105580179","wikidata":"https://www.wikidata.org/wiki/Q188928","display_name":"Messenger RNA","level":3,"score":0.33360710740089417},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.32321465015411377},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.3082146644592285},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.30486342310905457},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.27204424142837524},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.26216018199920654},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.2119198441505432},{"id":"https://openalex.org/C2775920511","wikidata":"https://www.wikidata.org/wiki/Q161249","display_name":"Lactic acid","level":3,"score":0.13508522510528564},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.109354168176651},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.08719304203987122},{"id":"https://openalex.org/C134306372","wikidata":"https://www.wikidata.org/wiki/Q7754","display_name":"Mathematical analysis","level":1,"score":0.0},{"id":"https://openalex.org/C76155785","wikidata":"https://www.wikidata.org/wiki/Q418","display_name":"Telecommunications","level":1,"score":0.0},{"id":"https://openalex.org/C2524010","wikidata":"https://www.wikidata.org/wiki/Q8087","display_name":"Geometry","level":1,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"doi:10.1371/journal.pcbi.1000606","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000606","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000606&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:5008e1d02c7540bf84a505c1499d8288","is_oa":true,"landing_page_url":"https://doaj.org/article/5008e1d02c7540bf84a505c1499d8288","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 5, Iss 12, p e1000606 (2009)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:1894984","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2787624","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/145292","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Transcriptome_and_Proteome_Exploration_to_Model_Translation_Efficiency_and_Protein_Stability_in_Lactococcus_lactis_/145292","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1000606","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000606","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000606&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320323910","display_name":"Institut National de la Recherche Agronomique","ror":"https://ror.org/01x3gbx83"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2091312350.pdf","grobid_xml":"https://content.openalex.org/works/W2091312350.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W1418984735","https://openalex.org/W1898197987","https://openalex.org/W1978486653","https://openalex.org/W1994782818","https://openalex.org/W2009984078","https://openalex.org/W2010958487","https://openalex.org/W2017057004","https://openalex.org/W2018590530","https://openalex.org/W2021583109","https://openalex.org/W2034354682","https://openalex.org/W2036672372","https://openalex.org/W2051084627","https://openalex.org/W2053621368","https://openalex.org/W2059541577","https://openalex.org/W2067525869","https://openalex.org/W2068103032","https://openalex.org/W2079595036","https://openalex.org/W2080451230","https://openalex.org/W2084351411","https://openalex.org/W2085315560","https://openalex.org/W2093772131","https://openalex.org/W2094069261","https://openalex.org/W2094397891","https://openalex.org/W2096826536","https://openalex.org/W2098066769","https://openalex.org/W2098489069","https://openalex.org/W2098751159","https://openalex.org/W2100762672","https://openalex.org/W2101345690","https://openalex.org/W2102878034","https://openalex.org/W2107363136","https://openalex.org/W2108723074","https://openalex.org/W2109281577","https://openalex.org/W2110065044","https://openalex.org/W2112515372","https://openalex.org/W2115955060","https://openalex.org/W2118451712","https://openalex.org/W2127745643","https://openalex.org/W2129178024","https://openalex.org/W2133163771","https://openalex.org/W2134670784","https://openalex.org/W2143784594","https://openalex.org/W2144342921","https://openalex.org/W2148342439","https://openalex.org/W2152353895","https://openalex.org/W2152907240","https://openalex.org/W2168492610","https://openalex.org/W2168772829","https://openalex.org/W2172246310","https://openalex.org/W2180080905","https://openalex.org/W4230189641","https://openalex.org/W4235405440","https://openalex.org/W4247895932","https://openalex.org/W4293021319"],"related_works":["https://openalex.org/W2151102421","https://openalex.org/W2887582884","https://openalex.org/W2123637623","https://openalex.org/W3014759266","https://openalex.org/W2752267826","https://openalex.org/W1937290499","https://openalex.org/W2096426615","https://openalex.org/W4308231998","https://openalex.org/W4313890423","https://openalex.org/W4294925963"],"abstract_inverted_index":{"This":[0,227],"genome-scale":[1],"study":[2],"analysed":[3,186],"the":[4,16,58,138,169],"various":[5],"parameters":[6,113,216],"influencing":[7],"protein":[8,45,86,156,159,172,183,197,208],"levels":[9],"in":[10,26,87,129,225],"cells.":[11],"To":[12],"achieve":[13],"this":[14],"goal,":[15],"model":[17],"bacterium":[18],"Lactococcus":[19],"lactis":[20],"was":[21,185],"grown":[22],"at":[23,29,146,175],"steady":[24],"state":[25],"continuous":[27],"cultures":[28],"different":[30,59],"growth":[31,60,89,131,139,148,177,199],"rates,":[32],"and":[33,35,78,94,101,123,133,198,207,222,231],"proteomic":[34],"transcriptomic":[36],"data":[37,70],"were":[38,46,102,126,134],"thoroughly":[39],"compared.":[40],"Ratios":[41],"of":[42,64,155,171,181],"mRNA":[43],"to":[44,81,137,165,211,219,236],"highly":[47],"variable":[48],"among":[49],"proteins":[50,100],"but":[51,150],"also,":[52],"for":[53,84,104],"a":[54,69,142,192],"given":[55],"gene,":[56],"between":[57,99],"conditions.":[61,200],"The":[62,179,201],"modeling":[63,72,202],"cellular":[65],"processes":[66],"combined":[67],"with":[68,111],"fitting":[71],"approach":[73,203],"allowed":[74],"both":[75],"translation":[76,145],"efficiencies":[77,93,122,206],"degradation":[79,95,124,173,209],"rates":[80,96,125,210],"be":[82,212,234],"estimated":[83],"each":[85,88],"condition.":[90],"Estimated":[91,158],"translational":[92,205],"strongly":[97],"differed":[98],"tested":[103],"their":[105],"biological":[106,215],"significance":[107],"through":[108,187],"statistical":[109],"correlations":[110],"relevant":[112],"such":[114],"as":[115],"codon":[116],"or":[117],"amino":[118],"acid":[119],"bias.":[120],"These":[121],"not":[127],"constant":[128],"all":[130],"conditions":[132],"inversely":[135],"proportional":[136],"rate,":[140],"indicating":[141],"more":[143],"efficient":[144],"low":[147,176],"rate":[149,154],"an":[151],"antagonistic":[152],"higher":[153],"degradation.":[157],"median":[160],"half-lives":[161],"ranged":[162],"from":[163],"23":[164],"224":[166],"min,":[167],"underlying":[168],"importance":[170],"notably":[174],"rates.":[178],"regulation":[180],"intracellular":[182],"level":[184],"regulatory":[188],"coefficient":[189],"calculations,":[190],"revealing":[191],"complex":[193],"control":[194],"depending":[195],"on":[196],"enabled":[204],"estimated,":[213],"two":[214],"extremely":[217],"difficult":[218],"determine":[220],"experimentally":[221],"generally":[223],"lacking":[224],"bacteria.":[226],"method":[228],"is":[229],"generic":[230],"can":[232],"now":[233],"extended":[235],"other":[237,240],"environments":[238],"and/or":[239],"micro-organisms.":[241]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":6}],"updated_date":"2026-03-10T16:38:18.471706","created_date":"2016-06-24T00:00:00"}
