{"id":"https://openalex.org/W1988599715","doi":"https://doi.org/10.1371/journal.pcbi.1000562","title":"Discovery of Regulatory Elements is Improved by a Discriminatory Approach","display_name":"Discovery of Regulatory Elements is Improved by a Discriminatory Approach","publication_year":2009,"publication_date":"2009-11-12","ids":{"openalex":"https://openalex.org/W1988599715","doi":"https://doi.org/10.1371/journal.pcbi.1000562","mag":"1988599715","pmid":"https://pubmed.ncbi.nlm.nih.gov/19911049"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1000562","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000562","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000562&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000562&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067360861","display_name":"Eivind Valen","orcid":"https://orcid.org/0000-0003-1840-6108"},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":true,"raw_author_name":"Eivind Valen","raw_affiliation_strings":["The Bioinformatics Centre, Department of Biology and the Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Copenhagen, Denmark. eivind@binf.ku.dk","The Bioinformatics Centre, Department of Biology and the Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Copenhagen, Denmark"],"affiliations":[{"raw_affiliation_string":"The Bioinformatics Centre, Department of Biology and the Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Copenhagen, Denmark. eivind@binf.ku.dk","institution_ids":["https://openalex.org/I124055696"]},{"raw_affiliation_string":"The Bioinformatics Centre, Department of Biology and the Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026910430","display_name":"Albin Sandelin","orcid":"https://orcid.org/0000-0002-7109-7378"},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Albin Sandelin","raw_affiliation_strings":["The Bioinformatics Centre, Department of Biology and the Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Copenhagen, Denmark"],"affiliations":[{"raw_affiliation_string":"The Bioinformatics Centre, Department of Biology and the Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082357240","display_name":"Ole Winther","orcid":"https://orcid.org/0000-0002-1966-3205"},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]},{"id":"https://openalex.org/I96673099","display_name":"Technical University of Denmark","ror":"https://ror.org/04qtj9h94","country_code":"DK","type":"education","lineage":["https://openalex.org/I96673099"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Ole Winther","raw_affiliation_strings":["DTU Informatics, Technical University of Denmark, Lyngby, Denmark","The Bioinformatics Centre, Department of Biology and the Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Copenhagen, Denmark"],"affiliations":[{"raw_affiliation_string":"DTU Informatics, Technical University of Denmark, Lyngby, Denmark","institution_ids":["https://openalex.org/I96673099"]},{"raw_affiliation_string":"The Bioinformatics Centre, Department of Biology and the Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5083542637","display_name":"Anders Krogh","orcid":"https://orcid.org/0000-0002-5147-6282"},"institutions":[{"id":"https://openalex.org/I124055696","display_name":"University of Copenhagen","ror":"https://ror.org/035b05819","country_code":"DK","type":"education","lineage":["https://openalex.org/I124055696"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Anders Krogh","raw_affiliation_strings":["The Bioinformatics Centre, Department of Biology and the Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Copenhagen, Denmark"],"affiliations":[{"raw_affiliation_string":"The Bioinformatics Centre, Department of Biology and the Biotech Research and Innovation Centre (BRIC), University of Copenhagen, Copenhagen, Denmark","institution_ids":["https://openalex.org/I124055696"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5067360861"],"corresponding_institution_ids":["https://openalex.org/I124055696"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.9436,"has_fulltext":true,"cited_by_count":27,"citation_normalized_percentile":{"value":0.73316444,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"5","issue":"11","first_page":"e1000562","last_page":"e1000562"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.9987999796867371,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10521","display_name":"RNA and protein synthesis mechanisms","score":0.9979000091552734,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/promoter","display_name":"Promoter","score":0.8080270290374756},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5647901296615601},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.5545941591262817},{"id":"https://openalex.org/keywords/robustness","display_name":"Robustness (evolution)","score":0.49246296286582947},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.47521334886550903},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.4730626344680786},{"id":"https://openalex.org/keywords/dna-binding-site","display_name":"DNA binding site","score":0.45369791984558105},{"id":"https://openalex.org/keywords/regulatory-sequence","display_name":"Regulatory sequence","score":0.42148810625076294},{"id":"https://openalex.org/keywords/probabilistic-logic","display_name":"Probabilistic logic","score":0.4124259352684021},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.41115057468414307},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.40149760246276855},{"id":"https://openalex.org/keywords/transcription-factor","display_name":"Transcription factor","score":0.3331986665725708},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.2350848913192749},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.12431749701499939}],"concepts":[{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.8080270290374756},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5647901296615601},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.5545941591262817},{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.49246296286582947},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.47521334886550903},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4730626344680786},{"id":"https://openalex.org/C3662595","wikidata":"https://www.wikidata.org/wiki/Q5205743","display_name":"DNA binding site","level":5,"score":0.45369791984558105},{"id":"https://openalex.org/C21592294","wikidata":"https://www.wikidata.org/wiki/Q3238407","display_name":"Regulatory sequence","level":4,"score":0.42148810625076294},{"id":"https://openalex.org/C49937458","wikidata":"https://www.wikidata.org/wiki/Q2599292","display_name":"Probabilistic logic","level":2,"score":0.4124259352684021},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.41115057468414307},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.40149760246276855},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.3331986665725708},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.2350848913192749},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.12431749701499939}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015894","descriptor_name":"Genome, Human","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050436","descriptor_name":"Regulatory Elements, Transcriptional","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050436","descriptor_name":"Regulatory Elements, Transcriptional","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050436","descriptor_name":"Regulatory Elements, Transcriptional","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053263","descriptor_name":"Gene Regulatory Networks","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":9,"locations":[{"id":"doi:10.1371/journal.pcbi.1000562","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000562","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000562&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:19911049","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19911049","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.817.3940","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.817.3940","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/2a/e6/pcbi.1000562.PMC2770120.pdf","raw_type":"text"},{"id":"pmh:oai:RePEc:plo:pcbi00:1000562","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1000562","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:4c87c503637f4369b77fbcc21116d334","is_oa":true,"landing_page_url":"https://doaj.org/article/4c87c503637f4369b77fbcc21116d334","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 5, Iss 11, p e1000562 (2009)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/145708","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Discovery_of_Regulatory_Elements_is_Improved_by_a_Discriminatory_Approach/145708","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:2770120","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2770120","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmh:oai:pure.atira.dk:openaire_cris_publications/a87ec5f0-e656-11de-ba73-000ea68e967b","is_oa":false,"landing_page_url":"https://researchprofiles.ku.dk/da/publications/a87ec5f0-e656-11de-ba73-000ea68e967b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401983","display_name":"Research at the University of Copenhagen (University of Copenhagen)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I124055696","host_organization_name":"University of Copenhagen","host_organization_lineage":["https://openalex.org/I124055696"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Valen , E , Sandelin , A , Winther , O & Krogh , A 2009 , ' Discovery of regulatory elements is improved by a discriminatory approach ' , PLoS Computational Biology , vol. 5 , no. 11 , pp. e1000562 . https://doi.org/10.1371/journal.pcbi.1000562","raw_type":"article"},{"id":"pmh:oai:pure.atira.dk:publications/5da69c94-e83a-45a6-b39d-403fcd9a0f61","is_oa":true,"landing_page_url":"https://orbit.dtu.dk/en/publications/5da69c94-e83a-45a6-b39d-403fcd9a0f61","pdf_url":null,"source":{"id":"https://openalex.org/S4306400705","display_name":"Technical University of Denmark, DTU Orbit (Technical University of Denmark, DTU)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I96673099","host_organization_name":"Technical University of Denmark","host_organization_lineage":["https://openalex.org/I96673099"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Valen , E , Sandelin , A , Winther , O & Krogh , A 2009 , ' Discovery of regulatory elements is improved by a discriminatory approach ' , P L o S Computational Biology (Online) , vol. 5 , pp. e1000562 . https://doi.org/10.1371/journal.pcbi.1000562","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1000562","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000562","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000562&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/10","display_name":"Reduced inequalities","score":0.7699999809265137}],"awards":[{"id":"https://openalex.org/G1816994784","display_name":null,"funder_award_id":"FP7/2007-2013","funder_id":"https://openalex.org/F4320333065","funder_display_name":"Seventh Framework Programme"},{"id":"https://openalex.org/G209546920","display_name":null,"funder_award_id":"FP7/2007","funder_id":"https://openalex.org/F4320333065","funder_display_name":"Seventh Framework Programme"},{"id":"https://openalex.org/G3398586681","display_name":null,"funder_award_id":"(FP7/2007-2013","funder_id":"https://openalex.org/F4320333065","funder_display_name":"Seventh Framework Programme"},{"id":"https://openalex.org/G4001739660","display_name":null,"funder_award_id":"(FP7/2007-2013)","funder_id":"https://openalex.org/F4320333065","funder_display_name":"Seventh Framework Programme"},{"id":"https://openalex.org/G4576709364","display_name":null,"funder_award_id":"FP7/2007-201","funder_id":"https://openalex.org/F4320333065","funder_display_name":"Seventh Framework Programme"},{"id":"https://openalex.org/G5948049603","display_name":null,"funder_award_id":"FP7/2007-2013)","funder_id":"https://openalex.org/F4320333065","funder_display_name":"Seventh Framework Programme"},{"id":"https://openalex.org/G7485613527","display_name":null,"funder_award_id":"2007-2013","funder_id":"https://openalex.org/F4320333065","funder_display_name":"Seventh Framework Programme"},{"id":"https://openalex.org/G7831597309","display_name":null,"funder_award_id":"P7/2007-2013","funder_id":"https://openalex.org/F4320333065","funder_display_name":"Seventh Framework Programme"},{"id":"https://openalex.org/G7876362850","display_name":null,"funder_award_id":"FP7/2007-2013)/ERC","funder_id":"https://openalex.org/F4320333065","funder_display_name":"Seventh Framework Programme"},{"id":"https://openalex.org/G84969007","display_name":null,"funder_award_id":"204135","funder_id":"https://openalex.org/F4320333065","funder_display_name":"Seventh Framework Programme"},{"id":"https://openalex.org/G8983210880","display_name":null,"funder_award_id":"(FP7/2007-2013)/ERC","funder_id":"https://openalex.org/F4320333065","funder_display_name":"Seventh Framework Programme"}],"funders":[{"id":"https://openalex.org/F4320322436","display_name":"Novo Nordisk","ror":"https://ror.org/0435rc536"},{"id":"https://openalex.org/F4320325957","display_name":"Novo Nordisk Fonden","ror":"https://ror.org/04txyc737"},{"id":"https://openalex.org/F4320333065","display_name":"Seventh Framework Programme","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W1988599715.pdf","grobid_xml":"https://content.openalex.org/works/W1988599715.grobid-xml"},"referenced_works_count":42,"referenced_works":["https://openalex.org/W1498410508","https://openalex.org/W1592870802","https://openalex.org/W1663973292","https://openalex.org/W1666571513","https://openalex.org/W1853093403","https://openalex.org/W1966354073","https://openalex.org/W1987079970","https://openalex.org/W1987122345","https://openalex.org/W1998300401","https://openalex.org/W2002638840","https://openalex.org/W2006117179","https://openalex.org/W2013989044","https://openalex.org/W2017309141","https://openalex.org/W2024060531","https://openalex.org/W2031422642","https://openalex.org/W2037940015","https://openalex.org/W2056760934","https://openalex.org/W2057692691","https://openalex.org/W2065782017","https://openalex.org/W2068011423","https://openalex.org/W2072443295","https://openalex.org/W2073977744","https://openalex.org/W2077132193","https://openalex.org/W2089783852","https://openalex.org/W2091230759","https://openalex.org/W2095718954","https://openalex.org/W2099468911","https://openalex.org/W2102304447","https://openalex.org/W2111729969","https://openalex.org/W2124112735","https://openalex.org/W2126561976","https://openalex.org/W2135722286","https://openalex.org/W2138309709","https://openalex.org/W2141408320","https://openalex.org/W2143550361","https://openalex.org/W2148014281","https://openalex.org/W2149769193","https://openalex.org/W2158962723","https://openalex.org/W2168909179","https://openalex.org/W2293652778","https://openalex.org/W4240157490","https://openalex.org/W6654843769"],"related_works":["https://openalex.org/W2146517458","https://openalex.org/W2379997263","https://openalex.org/W2367493320","https://openalex.org/W2131580913","https://openalex.org/W3083097828","https://openalex.org/W2125854412","https://openalex.org/W2972782405","https://openalex.org/W4367173723","https://openalex.org/W1988933877","https://openalex.org/W2030816054"],"abstract_inverted_index":{"A":[0,30],"major":[1],"goal":[2],"in":[3,37,58,71,105,159,169],"post-genome":[4],"biology":[5],"is":[6,22,33,177],"the":[7,11,51,65,76,81,121,124,136,144,147,150,164,170,192,201,204,216,240],"complete":[8],"mapping":[9],"of":[10,19,39,42,55,68,84,120,146,156,167,194,203,224,228],"gene":[12],"regulatory":[13,20,35,56],"networks":[14],"for":[15,25,99,242,249],"every":[16],"organism.":[17],"Identification":[18],"elements":[21],"a":[23,40,72,95,108,112,117,132,208,220,229,245],"prerequisite":[24],"realizing":[26],"this":[27],"ambitious":[28],"goal.":[29],"common":[31,246],"problem":[32],"finding":[34],"patterns":[36],"promoters":[38,106,122,168,226],"group":[41],"co-expressed":[43],"genes,":[44],"but":[45],"contemporary":[46,195],"methods":[47],"are":[48,64,129,140],"challenged":[49],"by":[50,131,142],"size":[52],"and":[53,80,135,153,182,207,215,237],"diversity":[54],"regions":[57,79],"higher":[59,189,234],"metazoans.":[60],"Two":[61],"key":[62],"issues":[63],"small":[66],"amount":[67],"information":[69],"contained":[70],"pattern":[73,251],"compared":[74],"to":[75,90,163,179,233],"large":[77,113,165,221],"promoter":[78],"repetitive":[82],"characteristics":[83],"genomic":[85],"DNA,":[86],"which":[87],"both":[88,160],"lead":[89],"\"pattern":[91],"drowning\".":[92],"We":[93],"present":[94],"new":[96],"computational":[97],"method":[98],"identifying":[100],"transcription":[101],"factor":[102],"binding":[103],"sites":[104],"using":[107],"discriminatory":[109,138,235],"approach":[110],"with":[111],"negative":[114,171],"set":[115,223],"encompassing":[116],"significant":[118],"sample":[119],"from":[123],"relevant":[125],"genome.":[126],"The":[127],"sequences":[128,206],"described":[130],"probabilistic":[133],"model":[134,152,231],"most":[137],"motifs":[139],"identified":[141],"maximizing":[143],"probability":[145],"sets":[148],"given":[149],"motif":[151,157],"prior":[154],"probabilities":[155],"occurrences":[158],"sets.":[161],"Due":[162],"number":[166],"set,":[172],"an":[173],"enhanced":[174],"suffix":[175],"array":[176],"used":[178],"improve":[180],"speed":[181],"performance.":[183],"Using":[184,219],"our":[185,212],"method,":[186],"we":[187],"demonstrate":[188],"accuracy":[190],"than":[191],"best":[193],"methods,":[196],"high":[197],"robustness":[198],"when":[199],"extending":[200],"length":[202],"input":[205],"strong":[209],"correlation":[210],"between":[211],"objective":[213],"function":[214],"correct":[217],"solution.":[218],"background":[222],"real":[225],"instead":[227],"simplified":[230],"leads":[232],"power":[236],"markedly":[238],"reduces":[239],"need":[241],"repeat":[243],"masking;":[244],"pre-processing":[247],"step":[248],"other":[250],"finders.":[252]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":4}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}