{"id":"https://openalex.org/W2004133643","doi":"https://doi.org/10.1371/journal.pcbi.1000560","title":"Interactions between Connected Half-Sarcomeres Produce Emergent Mechanical Behavior in a Mathematical Model of Muscle","display_name":"Interactions between Connected Half-Sarcomeres Produce Emergent Mechanical Behavior in a Mathematical Model of Muscle","publication_year":2009,"publication_date":"2009-11-12","ids":{"openalex":"https://openalex.org/W2004133643","doi":"https://doi.org/10.1371/journal.pcbi.1000560","mag":"2004133643","pmid":"https://pubmed.ncbi.nlm.nih.gov/19911050"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1000560","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000560","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.pcbi.1000560","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5046127236","display_name":"Kenneth S. Campbell","orcid":"https://orcid.org/0000-0001-5615-5958"},"institutions":[{"id":"https://openalex.org/I143302722","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20","country_code":"US","type":"education","lineage":["https://openalex.org/I143302722"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Kenneth S. Campbell","raw_affiliation_strings":["Department of Physiology and Center for Muscle Biology, University of Kentucky, Lexington, Kentucky, USA. k.s.campbell@uky.edu","Department of Physiology and Center for Muscle Biology, University of Kentucky, Lexington, Kentucky, USA"],"affiliations":[{"raw_affiliation_string":"Department of Physiology and Center for Muscle Biology, University of Kentucky, Lexington, Kentucky, USA. k.s.campbell@uky.edu","institution_ids":["https://openalex.org/I143302722"]},{"raw_affiliation_string":"Department of Physiology and Center for Muscle Biology, University of Kentucky, Lexington, Kentucky, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5046127236"],"corresponding_institution_ids":["https://openalex.org/I143302722"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":2.7911,"has_fulltext":true,"cited_by_count":85,"citation_normalized_percentile":{"value":0.90991256,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"5","issue":"11","first_page":"e1000560","last_page":"e1000560"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10882","display_name":"Cardiomyopathy and Myosin Studies","score":0.9998000264167786,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10784","display_name":"Muscle activation and electromyography studies","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sarcomere","display_name":"Sarcomere","score":0.9875479340553284},{"id":"https://openalex.org/keywords/titin","display_name":"Titin","score":0.9085042476654053},{"id":"https://openalex.org/keywords/myofibril","display_name":"Myofibril","score":0.816863477230072},{"id":"https://openalex.org/keywords/isometric-exercise","display_name":"Isometric exercise","score":0.6488870978355408},{"id":"https://openalex.org/keywords/myosin","display_name":"Myosin","score":0.5397461652755737},{"id":"https://openalex.org/keywords/fiber","display_name":"Fiber","score":0.5150530338287354},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.4932331442832947},{"id":"https://openalex.org/keywords/desmin","display_name":"Desmin","score":0.4323121905326843},{"id":"https://openalex.org/keywords/muscle-contraction","display_name":"Muscle contraction","score":0.417321115732193},{"id":"https://openalex.org/keywords/materials-science","display_name":"Materials science","score":0.3832949995994568},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3519418239593506},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.34463900327682495},{"id":"https://openalex.org/keywords/anatomy","display_name":"Anatomy","score":0.3426941931247711},{"id":"https://openalex.org/keywords/mechanics","display_name":"Mechanics","score":0.32839733362197876},{"id":"https://openalex.org/keywords/myocyte","display_name":"Myocyte","score":0.3132014572620392},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.22926786541938782},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.1535607874393463},{"id":"https://openalex.org/keywords/composite-material","display_name":"Composite material","score":0.1344594657421112}],"concepts":[{"id":"https://openalex.org/C68731436","wikidata":"https://www.wikidata.org/wiki/Q1337087","display_name":"Sarcomere","level":3,"score":0.9875479340553284},{"id":"https://openalex.org/C90671521","wikidata":"https://www.wikidata.org/wiki/Q74314","display_name":"Titin","level":4,"score":0.9085042476654053},{"id":"https://openalex.org/C7301908","wikidata":"https://www.wikidata.org/wiki/Q318623","display_name":"Myofibril","level":2,"score":0.816863477230072},{"id":"https://openalex.org/C103486182","wikidata":"https://www.wikidata.org/wiki/Q1216236","display_name":"Isometric exercise","level":2,"score":0.6488870978355408},{"id":"https://openalex.org/C6997183","wikidata":"https://www.wikidata.org/wiki/Q271727","display_name":"Myosin","level":2,"score":0.5397461652755737},{"id":"https://openalex.org/C519885992","wikidata":"https://www.wikidata.org/wiki/Q161","display_name":"Fiber","level":2,"score":0.5150530338287354},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4932331442832947},{"id":"https://openalex.org/C2779072444","wikidata":"https://www.wikidata.org/wiki/Q425146","display_name":"Desmin","level":4,"score":0.4323121905326843},{"id":"https://openalex.org/C2776050358","wikidata":"https://www.wikidata.org/wiki/Q127006","display_name":"Muscle contraction","level":2,"score":0.417321115732193},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3832949995994568},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3519418239593506},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.34463900327682495},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.3426941931247711},{"id":"https://openalex.org/C57879066","wikidata":"https://www.wikidata.org/wiki/Q41217","display_name":"Mechanics","level":1,"score":0.32839733362197876},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.3132014572620392},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.22926786541938782},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.1535607874393463},{"id":"https://openalex.org/C159985019","wikidata":"https://www.wikidata.org/wiki/Q181790","display_name":"Composite material","level":1,"score":0.1344594657421112},{"id":"https://openalex.org/C147447768","wikidata":"https://www.wikidata.org/wiki/Q411624","display_name":"Vimentin","level":3,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.0},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.0},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.0},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001696","descriptor_name":"Biomechanical Phenomena","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001696","descriptor_name":"Biomechanical Phenomena","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D001696","descriptor_name":"Biomechanical Phenomena","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009210","descriptor_name":"Myofibrils","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009210","descriptor_name":"Myofibrils","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009210","descriptor_name":"Myofibrils","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009218","descriptor_name":"Myosins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009218","descriptor_name":"Myosins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009218","descriptor_name":"Myosins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012518","descriptor_name":"Sarcomeres","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012518","descriptor_name":"Sarcomeres","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012518","descriptor_name":"Sarcomeres","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013314","descriptor_name":"Stress, Mechanical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013314","descriptor_name":"Stress, Mechanical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013314","descriptor_name":"Stress, Mechanical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016014","descriptor_name":"Linear Models","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016658","descriptor_name":"Psoas Muscles","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016658","descriptor_name":"Psoas Muscles","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016658","descriptor_name":"Psoas Muscles","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D017711","descriptor_name":"Nonlinear Dynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017711","descriptor_name":"Nonlinear Dynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017711","descriptor_name":"Nonlinear Dynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D049490","descriptor_name":"Systems Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pcbi.1000560","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000560","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:19911050","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19911050","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:uknowledge.uky.edu:physiology_facpub-1012","is_oa":true,"landing_page_url":"https://uknowledge.uky.edu/physiology_facpub/12","pdf_url":null,"source":{"id":"https://openalex.org/S4306402623","display_name":"UKnowledge (University of Kentucky)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I143302722","host_organization_name":"University of Kentucky","host_organization_lineage":["https://openalex.org/I143302722"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Physiology Faculty Publications","raw_type":"text"},{"id":"pmh:oai:RePEc:plo:pcbi00:1000560","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1000560","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:224a73b126cb4bc184626d9ff36d9151","is_oa":true,"landing_page_url":"https://doaj.org/article/224a73b126cb4bc184626d9ff36d9151","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 5, Iss 11, p e1000560 (2009)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/145723","is_oa":true,"landing_page_url":"https://figshare.com/articles/Interactions_between_Connected_Half_Sarcomeres_Produce_Emergent_Mechanical_Behavior_in_a_Mathematical_Model_of_Muscle/145723","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:2770126","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2770126","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1000560","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000560","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Affordable and clean energy","score":0.8199999928474426,"id":"https://metadata.un.org/sdg/7"}],"awards":[{"id":"https://openalex.org/G5278147564","display_name":null,"funder_award_id":"HL090749","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320309434","display_name":"University of Wisconsin-Madison","ror":"https://ror.org/01y2jtd41"},{"id":"https://openalex.org/F4320309825","display_name":"University of Kentucky","ror":"https://ror.org/02k3smh20"},{"id":"https://openalex.org/F4320310638","display_name":"McGill University","ror":"https://ror.org/01pxwe438"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":54,"referenced_works":["https://openalex.org/W96231806","https://openalex.org/W605068603","https://openalex.org/W789458867","https://openalex.org/W1577750487","https://openalex.org/W1963605011","https://openalex.org/W1970406038","https://openalex.org/W1974959278","https://openalex.org/W1983821055","https://openalex.org/W1985893275","https://openalex.org/W1987181390","https://openalex.org/W1993844437","https://openalex.org/W2001056402","https://openalex.org/W2008568258","https://openalex.org/W2009164318","https://openalex.org/W2014383313","https://openalex.org/W2015240491","https://openalex.org/W2016232289","https://openalex.org/W2025627402","https://openalex.org/W2028490275","https://openalex.org/W2036538240","https://openalex.org/W2037858479","https://openalex.org/W2040099865","https://openalex.org/W2046003039","https://openalex.org/W2047917359","https://openalex.org/W2049718632","https://openalex.org/W2053954410","https://openalex.org/W2054188149","https://openalex.org/W2061142561","https://openalex.org/W2063886136","https://openalex.org/W2071156256","https://openalex.org/W2072291360","https://openalex.org/W2075057480","https://openalex.org/W2080758057","https://openalex.org/W2088830521","https://openalex.org/W2095554109","https://openalex.org/W2095595785","https://openalex.org/W2098016509","https://openalex.org/W2100968871","https://openalex.org/W2116827503","https://openalex.org/W2131321439","https://openalex.org/W2133061669","https://openalex.org/W2144575888","https://openalex.org/W2152642061","https://openalex.org/W2159766403","https://openalex.org/W2332167747","https://openalex.org/W2432517183","https://openalex.org/W2953919945","https://openalex.org/W2981264952","https://openalex.org/W4246118847","https://openalex.org/W4285719527","https://openalex.org/W4300325666","https://openalex.org/W4388166335","https://openalex.org/W6703967216","https://openalex.org/W6993211581"],"related_works":["https://openalex.org/W2614062063","https://openalex.org/W1988891920","https://openalex.org/W2788340116","https://openalex.org/W2026298567","https://openalex.org/W2290266665","https://openalex.org/W2048109889","https://openalex.org/W4319937249","https://openalex.org/W2050462507","https://openalex.org/W2141873651","https://openalex.org/W326015596"],"abstract_inverted_index":{"Most":[0],"reductionist":[1],"theories":[2],"of":[3,14,20,26,31,76,110,118,121,131,145,163,226,240,248,263],"muscle":[4,32,60,212],"attribute":[5],"a":[6,15,37,57,111,119,132,142,179,227,241,249,264],"fiber's":[7,242],"mechanical":[8,29,39,243],"properties":[9,30,216,225,244,262],"to":[10,35,49,99,114,157],"the":[11,27,51,72,77,107,115,128,167,197,261],"scaled":[12],"behavior":[13,117,183],"single":[16,228,265],"half-sarcomere.":[17,266],"Mathematical":[18],"models":[19],"this":[21,94],"type":[22],"can":[23],"explain":[24],"many":[25],"known":[28],"but":[33],"have":[34],"incorporate":[36],"passive":[38,78],"component":[40],"that":[41,67,105,127,211,217,236],"becomes":[42],"approximately":[43,83],"300%":[44],"stiffer":[45,85],"in":[46,86,93,149,159,166,188,195,201,230],"activating":[47,160],"conditions":[48],"reproduce":[50],"force":[52,172],"response":[53,109,130],"elicited":[54],"by":[55,257],"stretching":[56],"fast":[58],"mammalian":[59,112],"fiber.":[61],"The":[62,90,123,207],"available":[63],"experimental":[64],"data":[65],"suggests":[66],"titin":[68,155],"filaments,":[69],"which":[70,196],"are":[71,204,223],"mostly":[73],"likely":[74,235],"source":[75],"component,":[79],"become":[80],"at":[81],"most":[82],"30%":[84],"saturating":[87],"Ca2+":[88],"solutions.":[89,161],"work":[91],"described":[92],"manuscript":[95],"used":[96],"computer":[97,168],"modeling":[98],"test":[100],"an":[101],"alternative":[102],"systems":[103],"theory":[104],"attributes":[106],"stretch":[108,129],"fiber":[113,137,251],"composite":[116],"collection":[120],"half-sarcomeres.":[122],"principal":[124],"finding":[125],"was":[126],"chemically":[133],"permeabilized":[134],"rabbit":[135],"psoas":[136],"could":[138],"be":[139,255],"reproduced":[140],"with":[141],"framework":[143],"consisting":[144],"300":[146],"half-sarcomeres":[147,221],"arranged":[148],"6":[150],"parallel":[151],"myofibrils":[152,203],"without":[153],"requiring":[154],"filaments":[156],"stiffen":[158],"Ablation":[162],"inter-myofibrillar":[164],"links":[165],"simulations":[169,209],"lowered":[170,175],"isometric":[171],"values":[173],"and":[174,222,253],"energy":[176],"absorption":[177],"during":[178],"stretch.":[180],"This":[181],"computed":[182],"mimics":[184],"effects":[185],"previously":[186],"observed":[187],"experiments":[189],"using":[190],"muscles":[191],"from":[192],"desmin-deficient":[193],"mice":[194],"connections":[198],"between":[199,220],"Z-disks":[200],"adjacent":[202],"presumably":[205],"compromised.":[206],"current":[208],"suggest":[210],"fibers":[213],"exhibit":[214],"emergent":[215],"reflect":[218],"interactions":[219],"not":[224],"half-sarcomere":[229],"isolation.":[231],"It":[232],"is":[233],"therefore":[234],"full":[237],"quantitative":[238],"understanding":[239],"requires":[245],"detailed":[246],"analysis":[247],"complete":[250],"system":[252],"cannot":[254],"achieved":[256],"focusing":[258],"solely":[259],"on":[260]},"counts_by_year":[{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":7},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":3}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}
