{"id":"https://openalex.org/W2001221216","doi":"https://doi.org/10.1371/journal.pcbi.1000556","title":"A Hidden Markov Model for Single Particle Tracks Quantifies Dynamic Interactions between LFA-1 and the Actin Cytoskeleton","display_name":"A Hidden Markov Model for Single Particle Tracks Quantifies Dynamic Interactions between LFA-1 and the Actin Cytoskeleton","publication_year":2009,"publication_date":"2009-11-05","ids":{"openalex":"https://openalex.org/W2001221216","doi":"https://doi.org/10.1371/journal.pcbi.1000556","mag":"2001221216","pmid":"https://pubmed.ncbi.nlm.nih.gov/19893741"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1000556","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000556","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000556&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000556&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100893468","display_name":"Raibatak Das","orcid":null},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"Raibatak Das","raw_affiliation_strings":["Department of Mathematics and Institute of Applied Mathematics, University of British Columbia, Vancouver, British Columbia, Canada. dodo@math.ubc.ca","Department of Mathematics and Institute of Applied Mathematics, University of British Columbia, Vancouver, British Columbia, Canada"],"affiliations":[{"raw_affiliation_string":"Department of Mathematics and Institute of Applied Mathematics, University of British Columbia, Vancouver, British Columbia, Canada. dodo@math.ubc.ca","institution_ids":["https://openalex.org/I141945490"]},{"raw_affiliation_string":"Department of Mathematics and Institute of Applied Mathematics, University of British Columbia, Vancouver, British Columbia, Canada","institution_ids":["https://openalex.org/I141945490"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058045281","display_name":"Christopher W. Cairo","orcid":"https://orcid.org/0000-0003-3363-8708"},"institutions":[{"id":"https://openalex.org/I154425047","display_name":"University of Alberta","ror":"https://ror.org/0160cpw27","country_code":"CA","type":"education","lineage":["https://openalex.org/I154425047"]},{"id":"https://openalex.org/I4210159304","display_name":"Alberta Glycomics Centre","ror":"https://ror.org/05etm5g34","country_code":"CA","type":"facility","lineage":["https://openalex.org/I4210159304"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Christopher W. Cairo","raw_affiliation_strings":["Alberta Ingenuity Centre for Carbohydrate Science, Department of Chemistry, University of Alberta, Edmonton, Alberta, Canada"],"affiliations":[{"raw_affiliation_string":"Alberta Ingenuity Centre for Carbohydrate Science, Department of Chemistry, University of Alberta, Edmonton, Alberta, Canada","institution_ids":["https://openalex.org/I4210159304","https://openalex.org/I154425047"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047644129","display_name":"Daniel Coombs","orcid":"https://orcid.org/0000-0002-8038-6278"},"institutions":[{"id":"https://openalex.org/I141945490","display_name":"University of British Columbia","ror":"https://ror.org/03rmrcq20","country_code":"CA","type":"education","lineage":["https://openalex.org/I141945490"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Daniel Coombs","raw_affiliation_strings":["Department of Mathematics and Institute of Applied Mathematics, University of British Columbia, Vancouver, British Columbia, Canada"],"affiliations":[{"raw_affiliation_string":"Department of Mathematics and Institute of Applied Mathematics, University of British Columbia, Vancouver, British Columbia, Canada","institution_ids":["https://openalex.org/I141945490"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5100893468"],"corresponding_institution_ids":["https://openalex.org/I141945490"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.8199,"has_fulltext":true,"cited_by_count":139,"citation_normalized_percentile":{"value":0.84901263,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"5","issue":"11","first_page":"e1000556","last_page":"e1000556"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9958000183105469,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9958000183105469,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10540","display_name":"Advanced Fluorescence Microscopy Techniques","score":0.9955000281333923,"subfield":{"id":"https://openalex.org/subfields/1304","display_name":"Biophysics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10831","display_name":"Cell Adhesion Molecules Research","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2723","display_name":"Immunology and Allergy"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/statistical-physics","display_name":"Statistical physics","score":0.6257889866828918},{"id":"https://openalex.org/keywords/markov-chain","display_name":"Markov chain","score":0.6060435771942139},{"id":"https://openalex.org/keywords/cytoskeleton","display_name":"Cytoskeleton","score":0.5780565142631531},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.5678231120109558},{"id":"https://openalex.org/keywords/diffusion","display_name":"Diffusion","score":0.5481550693511963},{"id":"https://openalex.org/keywords/particle","display_name":"Particle (ecology)","score":0.5328693389892578},{"id":"https://openalex.org/keywords/hidden-markov-model","display_name":"Hidden Markov model","score":0.5244258642196655},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.4805058240890503},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.4793844223022461},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.30121910572052},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.20785292983055115},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.16617581248283386},{"id":"https://openalex.org/keywords/cell","display_name":"Cell","score":0.09392467141151428},{"id":"https://openalex.org/keywords/machine-learning","display_name":"Machine learning","score":0.09348273277282715},{"id":"https://openalex.org/keywords/quantum-mechanics","display_name":"Quantum mechanics","score":0.08946621417999268}],"concepts":[{"id":"https://openalex.org/C121864883","wikidata":"https://www.wikidata.org/wiki/Q677916","display_name":"Statistical physics","level":1,"score":0.6257889866828918},{"id":"https://openalex.org/C98763669","wikidata":"https://www.wikidata.org/wiki/Q176645","display_name":"Markov chain","level":2,"score":0.6060435771942139},{"id":"https://openalex.org/C142669718","wikidata":"https://www.wikidata.org/wiki/Q154626","display_name":"Cytoskeleton","level":3,"score":0.5780565142631531},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.5678231120109558},{"id":"https://openalex.org/C69357855","wikidata":"https://www.wikidata.org/wiki/Q163214","display_name":"Diffusion","level":2,"score":0.5481550693511963},{"id":"https://openalex.org/C2778517922","wikidata":"https://www.wikidata.org/wiki/Q7140482","display_name":"Particle (ecology)","level":2,"score":0.5328693389892578},{"id":"https://openalex.org/C23224414","wikidata":"https://www.wikidata.org/wiki/Q176769","display_name":"Hidden Markov model","level":2,"score":0.5244258642196655},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4805058240890503},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.4793844223022461},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.30121910572052},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20785292983055115},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.16617581248283386},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.09392467141151428},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.09348273277282715},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.08946621417999268},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003599","descriptor_name":"Cytoskeleton","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003599","descriptor_name":"Cytoskeleton","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D003599","descriptor_name":"Cytoskeleton","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D009038","descriptor_name":"Motion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009038","descriptor_name":"Motion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009038","descriptor_name":"Motion","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016169","descriptor_name":"Lymphocyte Function-Associated Antigen-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016169","descriptor_name":"Lymphocyte Function-Associated Antigen-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016169","descriptor_name":"Lymphocyte Function-Associated Antigen-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D025941","descriptor_name":"Protein Interaction Mapping","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1000556","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000556","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000556&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:19893741","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19893741","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:RePEc:plo:pcbi00:1000556","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1000556","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:f801ba571e6d4fa0a1aaee2467962baa","is_oa":true,"landing_page_url":"https://doaj.org/article/f801ba571e6d4fa0a1aaee2467962baa","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 5, Iss 11, p e1000556 (2009)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/145740","is_oa":true,"landing_page_url":"https://figshare.com/articles/A_Hidden_Markov_Model_for_Single_Particle_Tracks_Quantifies_Dynamic_Interactions_between_LFA_1_and_the_Actin_Cytoskeleton/145740","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:2768823","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2768823","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1000556","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000556","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000556&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322675","display_name":"Mitacs","ror":"https://ror.org/00cjrc276"},{"id":"https://openalex.org/F4320334593","display_name":"Natural Sciences and Engineering Research Council of Canada","ror":"https://ror.org/01h531d29"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2001221216.pdf","grobid_xml":"https://content.openalex.org/works/W2001221216.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W361632705","https://openalex.org/W1479880028","https://openalex.org/W1560013842","https://openalex.org/W1597994956","https://openalex.org/W1963985909","https://openalex.org/W1967816643","https://openalex.org/W1968815565","https://openalex.org/W1973713182","https://openalex.org/W1978769331","https://openalex.org/W1986332628","https://openalex.org/W1986490461","https://openalex.org/W1989737071","https://openalex.org/W1993356393","https://openalex.org/W1999788765","https://openalex.org/W2000032473","https://openalex.org/W2001816990","https://openalex.org/W2007321142","https://openalex.org/W2007408185","https://openalex.org/W2007700411","https://openalex.org/W2009435671","https://openalex.org/W2014313849","https://openalex.org/W2018512361","https://openalex.org/W2029298164","https://openalex.org/W2030985239","https://openalex.org/W2033073750","https://openalex.org/W2045331820","https://openalex.org/W2055255447","https://openalex.org/W2060737841","https://openalex.org/W2062552264","https://openalex.org/W2067790068","https://openalex.org/W2073240020","https://openalex.org/W2075670599","https://openalex.org/W2078286807","https://openalex.org/W2080352750","https://openalex.org/W2080967824","https://openalex.org/W2087165533","https://openalex.org/W2096033084","https://openalex.org/W2097720340","https://openalex.org/W2099906733","https://openalex.org/W2107885482","https://openalex.org/W2114336941","https://openalex.org/W2125838338","https://openalex.org/W2132218454","https://openalex.org/W2136864234","https://openalex.org/W2146122766","https://openalex.org/W2147688960","https://openalex.org/W2147845309","https://openalex.org/W2151803635","https://openalex.org/W3099458211"],"related_works":["https://openalex.org/W2053269318","https://openalex.org/W2364370872","https://openalex.org/W2097963413","https://openalex.org/W2025614924","https://openalex.org/W2294335174","https://openalex.org/W3145575561","https://openalex.org/W2995886640","https://openalex.org/W1591475660","https://openalex.org/W2001275470","https://openalex.org/W2700035481"],"abstract_inverted_index":{"The":[0],"extraction":[1],"of":[2,22,45,49,85,116,123,138,149,167],"hidden":[3,88],"information":[4],"from":[5],"complex":[6],"trajectories":[7,18,78,148],"is":[8,43,169,174],"a":[9,39,60,65,86,110,129],"continuing":[10],"problem":[11],"in":[12,31,179],"single-particle":[13,147],"and":[14,25,70,120,173],"single-molecule":[15],"experiments.":[16],"Particle":[17],"are":[19,34],"the":[20,83,104,113,117,121,150,165],"result":[21],"multiple":[23,47],"phenomena,":[24],"new":[26],"methods":[27],"for":[28,59,108],"revealing":[29],"changes":[30,178],"molecular":[32],"processes":[33],"needed.":[35],"We":[36,54,127,141],"have":[37,142],"developed":[38],"practical":[40],"technique":[41],"that":[42,96,164],"capable":[44],"identifying":[46],"states":[48],"diffusion":[50,114,166],"within":[51],"experimental":[52],"trajectories.":[53],"model":[55,98],"single":[56],"particle":[57,77],"tracks":[58],"membrane-associated":[61],"protein":[62],"interacting":[63],"with":[64,73],"homogeneously":[66],"distributed":[67],"binding":[68],"partner":[69],"show":[71],"that,":[72],"certain":[74],"simplifying":[75],"assumptions,":[76],"can":[79,99],"be":[80,100],"regarded":[81],"as":[82],"outcome":[84],"two-state":[87],"Markov":[89],"model.":[90],"Using":[91],"simulated":[92],"trajectories,":[93],"we":[94],"demonstrate":[95],"this":[97,144],"used":[101],"to":[102,133,146],"identify":[103],"key":[105],"biophysical":[106],"parameters":[107],"such":[109],"system,":[111],"namely":[112],"coefficients":[115],"underlying":[118],"states,":[119],"rates":[122],"transition":[124],"between":[125],"them.":[126],"use":[128],"stochastic":[130],"optimization":[131],"scheme":[132],"compute":[134],"maximum":[135],"likelihood":[136],"estimates":[137],"these":[139],"parameters.":[140],"applied":[143],"analysis":[145,162],"integrin":[151],"receptor":[152],"lymphocyte":[153],"function-associated":[154],"antigen-1":[155],"(LFA-1)":[156],"on":[157],"live":[158],"T":[159],"cells.":[160],"Our":[161],"reveals":[163],"LFA-1":[168],"indeed":[170],"approximately":[171],"two-state,":[172],"characterized":[175],"by":[176],"large":[177],"cytoskeletal":[180],"interactions":[181],"upon":[182],"cellular":[183],"activation.":[184]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":12},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":8},{"year":2020,"cited_by_count":10},{"year":2019,"cited_by_count":15},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":14},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":7}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}