{"id":"https://openalex.org/W2041051514","doi":"https://doi.org/10.1371/journal.pcbi.1000480","title":"Detection of Functional Modes in Protein Dynamics","display_name":"Detection of Functional Modes in Protein Dynamics","publication_year":2009,"publication_date":"2009-08-27","ids":{"openalex":"https://openalex.org/W2041051514","doi":"https://doi.org/10.1371/journal.pcbi.1000480","mag":"2041051514","pmid":"https://pubmed.ncbi.nlm.nih.gov/19714202"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1000480","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000480","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000480&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000480&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068002595","display_name":"Jochen S. Hub","orcid":"https://orcid.org/0000-0001-7716-1767"},"institutions":[{"id":"https://openalex.org/I4210131661","display_name":"Max Planck Institute for Biophysical Chemistry","ror":"https://ror.org/03e76ya46","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210131661"]},{"id":"https://openalex.org/I149899117","display_name":"Max Planck Society","ror":"https://ror.org/01hhn8329","country_code":"DE","type":"funder","lineage":["https://openalex.org/I149899117"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Jochen S. Hub","raw_affiliation_strings":["Computational Biomolecular Dynamics Group, Max-Planck-Institute for Biophysical Chemistry, G\u00f6ttingen, Germany","Computational Biomolecular Dynamics Group,  Max-Planck-Institute for Biophysical Chemistry, Gottingen, Germany"],"affiliations":[{"raw_affiliation_string":"Computational Biomolecular Dynamics Group, Max-Planck-Institute for Biophysical Chemistry, G\u00f6ttingen, Germany","institution_ids":["https://openalex.org/I4210131661"]},{"raw_affiliation_string":"Computational Biomolecular Dynamics Group,  Max-Planck-Institute for Biophysical Chemistry, Gottingen, Germany","institution_ids":["https://openalex.org/I149899117"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044839728","display_name":"Bert L. de Groot","orcid":"https://orcid.org/0000-0003-3570-3534"},"institutions":[{"id":"https://openalex.org/I4210131661","display_name":"Max Planck Institute for Biophysical Chemistry","ror":"https://ror.org/03e76ya46","country_code":"DE","type":"facility","lineage":["https://openalex.org/I149899117","https://openalex.org/I4210131661"]},{"id":"https://openalex.org/I149899117","display_name":"Max Planck Society","ror":"https://ror.org/01hhn8329","country_code":"DE","type":"funder","lineage":["https://openalex.org/I149899117"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Bert L. de Groot","raw_affiliation_strings":["Computational Biomolecular Dynamics Group, Max-Planck-Institute for Biophysical Chemistry, G\u00f6ttingen, Germany","Computational Biomolecular Dynamics Group,  Max-Planck-Institute for Biophysical Chemistry, Gottingen, Germany"],"affiliations":[{"raw_affiliation_string":"Computational Biomolecular Dynamics Group, Max-Planck-Institute for Biophysical Chemistry, G\u00f6ttingen, Germany","institution_ids":["https://openalex.org/I4210131661"]},{"raw_affiliation_string":"Computational Biomolecular Dynamics Group,  Max-Planck-Institute for Biophysical Chemistry, Gottingen, Germany","institution_ids":["https://openalex.org/I149899117"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5044839728"],"corresponding_institution_ids":["https://openalex.org/I149899117","https://openalex.org/I4210131661"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":1735,"currency":"EUR","value_usd":1871},"fwci":2.1569,"has_fulltext":true,"cited_by_count":152,"citation_normalized_percentile":{"value":0.87047494,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"5","issue":"8","first_page":"e1000480","last_page":"e1000480"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11177","display_name":"Spectroscopy and Quantum Chemical Studies","score":0.9995999932289124,"subfield":{"id":"https://openalex.org/subfields/3107","display_name":"Atomic and Molecular Physics, and Optics"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T12748","display_name":"Molecular spectroscopy and chirality","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1607","display_name":"Spectroscopy"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/function","display_name":"Function (biology)","score":0.5492090582847595},{"id":"https://openalex.org/keywords/biological-system","display_name":"Biological system","score":0.5347565412521362},{"id":"https://openalex.org/keywords/observable","display_name":"Observable","score":0.496786892414093},{"id":"https://openalex.org/keywords/collective-motion","display_name":"Collective motion","score":0.4880741834640503},{"id":"https://openalex.org/keywords/protein-structure","display_name":"Protein structure","score":0.43663471937179565},{"id":"https://openalex.org/keywords/statistical-physics","display_name":"Statistical physics","score":0.433566153049469},{"id":"https://openalex.org/keywords/protein-dynamics","display_name":"Protein dynamics","score":0.4284762740135193},{"id":"https://openalex.org/keywords/trajectory","display_name":"Trajectory","score":0.4215392768383026},{"id":"https://openalex.org/keywords/protein-function","display_name":"Protein function","score":0.41991347074508667},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.38932523131370544},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.20754331350326538},{"id":"https://openalex.org/keywords/classical-mechanics","display_name":"Classical mechanics","score":0.13204190135002136}],"concepts":[{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.5492090582847595},{"id":"https://openalex.org/C186060115","wikidata":"https://www.wikidata.org/wiki/Q30336093","display_name":"Biological system","level":1,"score":0.5347565412521362},{"id":"https://openalex.org/C32848918","wikidata":"https://www.wikidata.org/wiki/Q845789","display_name":"Observable","level":2,"score":0.496786892414093},{"id":"https://openalex.org/C2780499737","wikidata":"https://www.wikidata.org/wiki/Q24755076","display_name":"Collective motion","level":2,"score":0.4880741834640503},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.43663471937179565},{"id":"https://openalex.org/C121864883","wikidata":"https://www.wikidata.org/wiki/Q677916","display_name":"Statistical physics","level":1,"score":0.433566153049469},{"id":"https://openalex.org/C2775981520","wikidata":"https://www.wikidata.org/wiki/Q17156992","display_name":"Protein dynamics","level":3,"score":0.4284762740135193},{"id":"https://openalex.org/C13662910","wikidata":"https://www.wikidata.org/wiki/Q193139","display_name":"Trajectory","level":2,"score":0.4215392768383026},{"id":"https://openalex.org/C2986374874","wikidata":"https://www.wikidata.org/wiki/Q8054","display_name":"Protein function","level":3,"score":0.41991347074508667},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.38932523131370544},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.20754331350326538},{"id":"https://openalex.org/C74650414","wikidata":"https://www.wikidata.org/wiki/Q11397","display_name":"Classical mechanics","level":1,"score":0.13204190135002136},{"id":"https://openalex.org/C1276947","wikidata":"https://www.wikidata.org/wiki/Q333","display_name":"Astronomy","level":1,"score":0.0},{"id":"https://openalex.org/C46141821","wikidata":"https://www.wikidata.org/wiki/Q209402","display_name":"Nuclear magnetic resonance","level":1,"score":0.0},{"id":"https://openalex.org/C62520636","wikidata":"https://www.wikidata.org/wiki/Q944","display_name":"Quantum mechanics","level":1,"score":0.0},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008968","descriptor_name":"Molecular Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008968","descriptor_name":"Molecular Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008968","descriptor_name":"Molecular Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009113","descriptor_name":"Muramidase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009113","descriptor_name":"Muramidase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D009113","descriptor_name":"Muramidase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012997","descriptor_name":"Solvents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012997","descriptor_name":"Solvents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D012997","descriptor_name":"Solvents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014364","descriptor_name":"Tryptophan","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014364","descriptor_name":"Tryptophan","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014364","descriptor_name":"Tryptophan","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017122","descriptor_name":"Bacteriophage T4","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D017122","descriptor_name":"Bacteriophage T4","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D017122","descriptor_name":"Bacteriophage T4","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D029968","descriptor_name":"Escherichia coli Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D033902","descriptor_name":"Periplasmic Binding Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D033902","descriptor_name":"Periplasmic Binding Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D033902","descriptor_name":"Periplasmic Binding Proteins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D055672","descriptor_name":"Static Electricity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055672","descriptor_name":"Static Electricity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D055672","descriptor_name":"Static Electricity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":9,"locations":[{"id":"doi:10.1371/journal.pcbi.1000480","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000480","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000480&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:19714202","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19714202","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.398.8966","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.398.8966","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://www3.mpibpc.mpg.de/groups/de_groot/pdf/Hub_PCB_2009.pdf","raw_type":"text"},{"id":"pmh:oai:RePEc:plo:pcbi00:1000480","is_oa":false,"landing_page_url":"https://journals.plos.org/ploscompbiol/article?id=10.1371/journal.pcbi.1000480","pdf_url":null,"source":{"id":"https://openalex.org/S4306401271","display_name":"RePEc: Research Papers in Economics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I77793887","host_organization_name":"Federal Reserve Bank of St. Louis","host_organization_lineage":["https://openalex.org/I77793887"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article"},{"id":"pmh:oai:doaj.org/article:5c724f88942a4a7a9701a777877ae0b3","is_oa":true,"landing_page_url":"https://doaj.org/article/5c724f88942a4a7a9701a777877ae0b3","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 5, Iss 8, p e1000480 (2009)","raw_type":"article"},{"id":"pmh:oai:edoc.mpg.de:435689","is_oa":false,"landing_page_url":"http://edoc.mpg.de/435689","pdf_url":null,"source":{"id":"https://openalex.org/S4406922265","display_name":"Max Planck Institute for Plasma Physics","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, v.5 (2009)","raw_type":"Article"},{"id":"pmh:oai:escidoc.org:escidoc:641638","is_oa":true,"landing_page_url":"http://hdl.handle.net/11858/00-001M-0000-0010-9343-F","pdf_url":null,"source":{"id":"https://openalex.org/S7407052962","display_name":"Max Planck Digital Library","issn_l":null,"issn":[],"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:figshare.com:article/146571","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Detection_of_Functional_Modes_in_Protein_Dynamics/146571","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:2721685","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2721685","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1000480","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000480","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000480&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2041051514.pdf","grobid_xml":"https://content.openalex.org/works/W2041051514.grobid-xml"},"referenced_works_count":65,"referenced_works":["https://openalex.org/W255996521","https://openalex.org/W614018474","https://openalex.org/W1557601443","https://openalex.org/W1663973292","https://openalex.org/W1965270719","https://openalex.org/W1976499671","https://openalex.org/W1980739203","https://openalex.org/W1981159786","https://openalex.org/W1984398455","https://openalex.org/W1987048011","https://openalex.org/W1990387274","https://openalex.org/W1990606222","https://openalex.org/W1991794210","https://openalex.org/W1996084127","https://openalex.org/W1997310186","https://openalex.org/W1998412941","https://openalex.org/W2001773296","https://openalex.org/W2008708467","https://openalex.org/W2008954354","https://openalex.org/W2018529040","https://openalex.org/W2028798616","https://openalex.org/W2030852504","https://openalex.org/W2031573489","https://openalex.org/W2035266068","https://openalex.org/W2035687084","https://openalex.org/W2035834851","https://openalex.org/W2037760012","https://openalex.org/W2041638382","https://openalex.org/W2042285588","https://openalex.org/W2047580257","https://openalex.org/W2048822589","https://openalex.org/W2049961618","https://openalex.org/W2054881399","https://openalex.org/W2067174909","https://openalex.org/W2068128475","https://openalex.org/W2069123478","https://openalex.org/W2081693079","https://openalex.org/W2083179556","https://openalex.org/W2086748420","https://openalex.org/W2087596773","https://openalex.org/W2088906583","https://openalex.org/W2099111195","https://openalex.org/W2103945336","https://openalex.org/W2105254477","https://openalex.org/W2122932778","https://openalex.org/W2123768693","https://openalex.org/W2128572087","https://openalex.org/W2132589721","https://openalex.org/W2135085018","https://openalex.org/W2142578757","https://openalex.org/W2145340452","https://openalex.org/W2146332813","https://openalex.org/W2150092099","https://openalex.org/W2153049516","https://openalex.org/W2156350373","https://openalex.org/W2162870748","https://openalex.org/W2171268876","https://openalex.org/W2309236877","https://openalex.org/W2594639291","https://openalex.org/W3151837896","https://openalex.org/W4238149895","https://openalex.org/W6609701964","https://openalex.org/W6629510986","https://openalex.org/W6698414294","https://openalex.org/W7011740287"],"related_works":["https://openalex.org/W2027077329","https://openalex.org/W3131724274","https://openalex.org/W2155648172","https://openalex.org/W2378801510","https://openalex.org/W2290574198","https://openalex.org/W2951012447","https://openalex.org/W2311509164","https://openalex.org/W2010414728","https://openalex.org/W2946078915","https://openalex.org/W1981159786"],"abstract_inverted_index":{"Proteins":[0],"frequently":[1],"accomplish":[2],"their":[3],"biological":[4],"function":[5,21,113],"by":[6],"collective":[7,14,46,81,190],"atomic":[8],"motions.":[9],"Yet":[10],"the":[11,45,71,75,77,80,88,112,115,119,123,132,138,149,160,171,182],"identification":[12],"of":[13,61,74,114,168,187,200],"motions":[15],"related":[16,51],"to":[17,43,52,87,97,111,126,177],"a":[18,24,34,53,98,128,179,188,198,203],"specific":[19],"protein":[20,55,140],"from,":[22],"e.g.,":[23,95],"molecular":[25],"dynamics":[26],"trajectory":[27],"is":[28,49,84,109,135,195],"often":[29],"non-trivial.":[30],"Here,":[31],"we":[32],"propose":[33],"novel":[35],"technique":[36,78],"termed":[37],"\"functional":[38,67],"mode":[39],"analysis\"":[40],"that":[41,48,69,83,108,121,153,163],"aims":[42],"detect":[44],"motion":[47,82,120,174],"directly":[50],"particular":[54],"function.":[56],"Based":[57],"on":[58],"an":[59,65],"ensemble":[60],"structures,":[62],"together":[63],"with":[64],"arbitrary":[66],"quantity\"":[68],"quantifies":[70],"functional":[72,89,92,133,183],"state":[73,184],"protein,":[76],"detects":[79],"maximally":[85,172],"correlated":[86,173],"quantity.":[90],"The":[91,192],"quantity":[93,134],"could,":[94],"correspond":[96],"geometric,":[99],"electrostatic,":[100],"or":[101,104],"chemical":[102],"observable,":[103],"any":[105,166],"other":[106],"variable":[107],"relevant":[110],"protein.":[116,210],"In":[117],"addition,":[118],"displays":[122],"largest":[124],"likelihood":[125],"induce":[127],"substantial":[129],"change":[130],"in":[131,185],"estimated":[136],"from":[137],"given":[139],"ensemble.":[141],"Two":[142],"different":[143],"correlation":[144,151,156],"measures":[145,154],"are":[146],"applied:":[147],"first,":[148],"Pearson":[150],"coefficient":[152],"linear":[155],"only;":[157],"and":[158,208],"second,":[159],"mutual":[161],"information":[162],"can":[164],"assess":[165],"kind":[167],"interdependence.":[169],"Detecting":[170],"allows":[175],"one":[176],"derive":[178],"model":[180],"for":[181],"terms":[186],"single":[189],"coordinate.":[191],"new":[193],"approach":[194],"illustrated":[196],"using":[197],"number":[199],"biomolecules,":[201],"including":[202],"polyalanine-helix,":[204],"T4":[205],"lysozyme,":[206],"Trp-cage,":[207],"leucine-binding":[209]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":5},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":9},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":12},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":11},{"year":2016,"cited_by_count":21},{"year":2015,"cited_by_count":14},{"year":2014,"cited_by_count":9},{"year":2013,"cited_by_count":13},{"year":2012,"cited_by_count":8}],"updated_date":"2026-04-23T09:07:50.710637","created_date":"2025-10-10T00:00:00"}