{"id":"https://openalex.org/W2064173421","doi":"https://doi.org/10.1371/journal.pcbi.1000396","title":"The Dynamics of T-Cell Receptor Repertoire Diversity Following Thymus Transplantation for DiGeorge Anomaly","display_name":"The Dynamics of T-Cell Receptor Repertoire Diversity Following Thymus Transplantation for DiGeorge Anomaly","publication_year":2009,"publication_date":"2009-06-11","ids":{"openalex":"https://openalex.org/W2064173421","doi":"https://doi.org/10.1371/journal.pcbi.1000396","mag":"2064173421","pmid":"https://pubmed.ncbi.nlm.nih.gov/19521511"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1000396","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000396","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000396&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000396&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012995340","display_name":"Stanca M. Ciupe","orcid":"https://orcid.org/0000-0002-5386-6946"},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]},{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210153043","display_name":"Duke University Hospital","ror":"https://ror.org/04bct7p84","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876","https://openalex.org/I4210144876","https://openalex.org/I4210153043"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Stanca M. Ciupe","raw_affiliation_strings":["Center for Computational Immunology, Department of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, North Carolina, USA","Center for Computational Immunology, Department of Biostatistics and\n                    Bioinformatics, Duke University Medical Center, Durham, North Carolina, United\n                    States of America"],"affiliations":[{"raw_affiliation_string":"Center for Computational Immunology, Department of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, North Carolina, USA","institution_ids":[]},{"raw_affiliation_string":"Center for Computational Immunology, Department of Biostatistics and\n                    Bioinformatics, Duke University Medical Center, Durham, North Carolina, United\n                    States of America","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210153043","https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057519914","display_name":"Blythe H. Devlin","orcid":null},"institutions":[{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]},{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Blythe H. Devlin","raw_affiliation_strings":["Carolina, United States of America","Department of Pediatrics, Duke University Medical Center, Durham, North","Department of Pediatrics, Duke University Medical Center, Durham, North\n                    Carolina, United States of America"],"affiliations":[{"raw_affiliation_string":"Carolina, United States of America","institution_ids":[]},{"raw_affiliation_string":"Department of Pediatrics, Duke University Medical Center, Durham, North","institution_ids":["https://openalex.org/I4210126298","https://openalex.org/I170897317"]},{"raw_affiliation_string":"Department of Pediatrics, Duke University Medical Center, Durham, North\n                    Carolina, United States of America","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112070704","display_name":"M. Louise Markert","orcid":null},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Louise Markert","raw_affiliation_strings":["Carolina, United States of America","Department of Immunology, Duke University Medical Center, Durham, North","Department of Pediatrics, Duke University Medical Center, Durham, North","Department of Immunology, Duke University Medical Center, Durham, North\n                    Carolina, United States of America","Department of Pediatrics, Duke University Medical Center, Durham, North\n                    Carolina, United States of America"],"affiliations":[{"raw_affiliation_string":"Carolina, United States of America","institution_ids":[]},{"raw_affiliation_string":"Department of Immunology, Duke University Medical Center, Durham, North","institution_ids":["https://openalex.org/I4210126298","https://openalex.org/I170897317"]},{"raw_affiliation_string":"Department of Pediatrics, Duke University Medical Center, Durham, North","institution_ids":["https://openalex.org/I4210126298","https://openalex.org/I170897317"]},{"raw_affiliation_string":"Department of Immunology, Duke University Medical Center, Durham, North\n                    Carolina, United States of America","institution_ids":["https://openalex.org/I4210126298"]},{"raw_affiliation_string":"Department of Pediatrics, Duke University Medical Center, Durham, North\n                    Carolina, United States of America","institution_ids":["https://openalex.org/I4210126298"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047959968","display_name":"Thomas B. Kepler","orcid":"https://orcid.org/0000-0002-1383-6865"},"institutions":[{"id":"https://openalex.org/I170897317","display_name":"Duke University","ror":"https://ror.org/00py81415","country_code":"US","type":"education","lineage":["https://openalex.org/I170897317"]},{"id":"https://openalex.org/I4210153043","display_name":"Duke University Hospital","ror":"https://ror.org/04bct7p84","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876","https://openalex.org/I4210144876","https://openalex.org/I4210153043"]},{"id":"https://openalex.org/I4210101190","display_name":"Cancer Research And Biostatistics","ror":"https://ror.org/01575p865","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210101190"]},{"id":"https://openalex.org/I4210126298","display_name":"Duke Medical Center","ror":"https://ror.org/03njmea73","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210126298","https://openalex.org/I4210144876"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Thomas B. Kepler","raw_affiliation_strings":["Bioinformatics, Duke University Medical Center, Durham, North Carolina, United","Carolina, United States of America","Center for Computational Immunology, Department of Biostatistics and","Department of Immunology, Duke University Medical Center, Durham, North","States of America","Department of Immunology, Duke University Medical Center, Durham, North\n                    Carolina, United States of America","Center for Computational Immunology, Department of Biostatistics and\n                    Bioinformatics, Duke University Medical Center, Durham, North Carolina, United\n                    States of America"],"affiliations":[{"raw_affiliation_string":"Bioinformatics, Duke University Medical Center, Durham, North Carolina, United","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210126298"]},{"raw_affiliation_string":"Carolina, United States of America","institution_ids":[]},{"raw_affiliation_string":"Center for Computational Immunology, Department of Biostatistics and","institution_ids":["https://openalex.org/I4210101190"]},{"raw_affiliation_string":"Department of Immunology, Duke University Medical Center, Durham, North","institution_ids":["https://openalex.org/I4210126298","https://openalex.org/I170897317"]},{"raw_affiliation_string":"States of America","institution_ids":[]},{"raw_affiliation_string":"Department of Immunology, Duke University Medical Center, Durham, North\n                    Carolina, United States of America","institution_ids":["https://openalex.org/I4210126298"]},{"raw_affiliation_string":"Center for Computational Immunology, Department of Biostatistics and\n                    Bioinformatics, Duke University Medical Center, Durham, North Carolina, United\n                    States of America","institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210153043","https://openalex.org/I4210126298"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5047959968"],"corresponding_institution_ids":["https://openalex.org/I170897317","https://openalex.org/I4210101190","https://openalex.org/I4210126298","https://openalex.org/I4210153043"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.9099,"has_fulltext":true,"cited_by_count":27,"citation_normalized_percentile":{"value":0.73920363,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"5","issue":"6","first_page":"e1000396","last_page":"e1000396"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.9998999834060669,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9898999929428101,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/digeorge-syndrome","display_name":"DiGeorge syndrome","score":0.8368273973464966},{"id":"https://openalex.org/keywords/t-cell-receptor","display_name":"T-cell receptor","score":0.7955120205879211},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.7205182313919067},{"id":"https://openalex.org/keywords/t-cell","display_name":"T cell","score":0.6466744542121887},{"id":"https://openalex.org/keywords/transplantation","display_name":"Transplantation","score":0.5751571655273438},{"id":"https://openalex.org/keywords/repertoire","display_name":"Repertoire","score":0.5005838871002197},{"id":"https://openalex.org/keywords/immunology","display_name":"Immunology","score":0.48668819665908813},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.4684572219848633},{"id":"https://openalex.org/keywords/immune-system","display_name":"Immune system","score":0.45415085554122925},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.3417927622795105},{"id":"https://openalex.org/keywords/internal-medicine","display_name":"Internal medicine","score":0.16063538193702698},{"id":"https://openalex.org/keywords/medicine","display_name":"Medicine","score":0.12137499451637268}],"concepts":[{"id":"https://openalex.org/C2779688345","wikidata":"https://www.wikidata.org/wiki/Q525642","display_name":"DiGeorge syndrome","level":2,"score":0.8368273973464966},{"id":"https://openalex.org/C19317047","wikidata":"https://www.wikidata.org/wiki/Q412037","display_name":"T-cell receptor","level":4,"score":0.7955120205879211},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7205182313919067},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.6466744542121887},{"id":"https://openalex.org/C2911091166","wikidata":"https://www.wikidata.org/wiki/Q106419912","display_name":"Transplantation","level":2,"score":0.5751571655273438},{"id":"https://openalex.org/C2778473898","wikidata":"https://www.wikidata.org/wiki/Q2145110","display_name":"Repertoire","level":2,"score":0.5005838871002197},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.48668819665908813},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.4684572219848633},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.45415085554122925},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3417927622795105},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.16063538193702698},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.12137499451637268},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.0},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.0},{"id":"https://openalex.org/C24890656","wikidata":"https://www.wikidata.org/wiki/Q82811","display_name":"Acoustics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004062","descriptor_name":"DiGeorge Syndrome","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D004062","descriptor_name":"DiGeorge Syndrome","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D004062","descriptor_name":"DiGeorge Syndrome","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D004062","descriptor_name":"DiGeorge Syndrome","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D004062","descriptor_name":"DiGeorge Syndrome","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D004062","descriptor_name":"DiGeorge Syndrome","qualifier_ui":"Q000601","qualifier_name":"surgery","is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011948","descriptor_name":"Receptors, Antigen, T-Cell","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011948","descriptor_name":"Receptors, Antigen, T-Cell","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011948","descriptor_name":"Receptors, Antigen, T-Cell","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013950","descriptor_name":"Thymus Gland","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013950","descriptor_name":"Thymus Gland","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013950","descriptor_name":"Thymus Gland","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013950","descriptor_name":"Thymus Gland","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013950","descriptor_name":"Thymus Gland","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013950","descriptor_name":"Thymus Gland","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D013950","descriptor_name":"Thymus Gland","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":false},{"descriptor_ui":"D013950","descriptor_name":"Thymus Gland","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":false},{"descriptor_ui":"D013950","descriptor_name":"Thymus Gland","qualifier_ui":"Q000637","qualifier_name":"transplantation","is_major_topic":false},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015233","descriptor_name":"Models, Statistical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018448","descriptor_name":"Models, Immunological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018448","descriptor_name":"Models, Immunological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018448","descriptor_name":"Models, Immunological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018655","descriptor_name":"Lymphocyte Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018655","descriptor_name":"Lymphocyte Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018655","descriptor_name":"Lymphocyte Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1371/journal.pcbi.1000396","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000396","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000396&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:19521511","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19521511","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:bb0e51bf6af4459cb9307e3de6dac77e","is_oa":true,"landing_page_url":"https://doaj.org/article/bb0e51bf6af4459cb9307e3de6dac77e","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 5, Iss 6, p e1000396 (2009)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/147315","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/The_Dynamics_of_T_Cell_Receptor_Repertoire_Diversity_Following_Thymus___Transplantation_for_DiGeorge_Anomaly/147315","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:2690399","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2690399","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"},{"id":"pmh:oai:vtechworks.lib.vt.edu:10919/74401","is_oa":true,"landing_page_url":"http://hdl.handle.net/10919/74401","pdf_url":null,"source":{"id":"https://openalex.org/S4306400248","display_name":"VTechWorks (Virginia Tech)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I859038795","host_organization_name":"Virginia Tech","host_organization_lineage":["https://openalex.org/I859038795"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article - Refereed"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1000396","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000396","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000396&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320337375","display_name":"National Center for Research Resources","ror":"https://ror.org/04pw6fb54"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2064173421.pdf","grobid_xml":"https://content.openalex.org/works/W2064173421.grobid-xml"},"referenced_works_count":65,"referenced_works":["https://openalex.org/W614559041","https://openalex.org/W1509514214","https://openalex.org/W1510734879","https://openalex.org/W1537543309","https://openalex.org/W1556399965","https://openalex.org/W1575016278","https://openalex.org/W1601504908","https://openalex.org/W1763148533","https://openalex.org/W1931194348","https://openalex.org/W1966432380","https://openalex.org/W1970925500","https://openalex.org/W1972254316","https://openalex.org/W1976823750","https://openalex.org/W1977574094","https://openalex.org/W1980785340","https://openalex.org/W1985093013","https://openalex.org/W1991381808","https://openalex.org/W1992031335","https://openalex.org/W2001651366","https://openalex.org/W2003717645","https://openalex.org/W2005613406","https://openalex.org/W2006516179","https://openalex.org/W2008227462","https://openalex.org/W2009630518","https://openalex.org/W2015937424","https://openalex.org/W2016430734","https://openalex.org/W2017615592","https://openalex.org/W2018243210","https://openalex.org/W2023848817","https://openalex.org/W2025370733","https://openalex.org/W2029479054","https://openalex.org/W2042450205","https://openalex.org/W2044125894","https://openalex.org/W2047528341","https://openalex.org/W2049295412","https://openalex.org/W2050451162","https://openalex.org/W2055792041","https://openalex.org/W2057906795","https://openalex.org/W2067296217","https://openalex.org/W2068888843","https://openalex.org/W2087189381","https://openalex.org/W2098275062","https://openalex.org/W2101182621","https://openalex.org/W2102369355","https://openalex.org/W2103914623","https://openalex.org/W2105381977","https://openalex.org/W2107012083","https://openalex.org/W2109270556","https://openalex.org/W2111686340","https://openalex.org/W2122553231","https://openalex.org/W2122830690","https://openalex.org/W2129860342","https://openalex.org/W2137055925","https://openalex.org/W2146598895","https://openalex.org/W2149259516","https://openalex.org/W2151636013","https://openalex.org/W2152056295","https://openalex.org/W2155950436","https://openalex.org/W2156449737","https://openalex.org/W2159162888","https://openalex.org/W2408716805","https://openalex.org/W4210255498","https://openalex.org/W4246441622","https://openalex.org/W4292691288","https://openalex.org/W6675133444"],"related_works":["https://openalex.org/W2060496539","https://openalex.org/W4280506224","https://openalex.org/W2018330851","https://openalex.org/W2143290387","https://openalex.org/W3201606428","https://openalex.org/W3087255036","https://openalex.org/W2040128205","https://openalex.org/W2060075608","https://openalex.org/W2026444950","https://openalex.org/W2092033815"],"abstract_inverted_index":{"T":[0,69,91,108,278],"cell":[1,70,279],"populations":[2],"are":[3],"regulated":[4],"both":[5],"by":[6,15,241],"signals":[7,16,157],"specific":[8],"to":[9,87,129,137,213,265,283],"the":[10,57,68,82,85,118,131,146,149,159,167,170,193,209,227,230,245,248,274,289,297],"T-cell":[11,47,140,164,176,206,232],"receptor":[12],"(TCR)":[13],"and":[14,17,22,93,182,282],"resources,":[18,224],"such":[19],"as":[20],"cytokines":[21],"space,":[23],"that":[24,35,79,208,221,226],"act":[25],"independently":[26],"of":[27,37,39,56,60,67,84,90,148,152,161,169,192,222,229,247,259,269,277,291],"TCR":[28,249,270,285],"specificity.":[29],"Although":[30],"it":[31],"has":[32,42],"been":[33],"demonstrated":[34],"disruption":[36],"either":[38],"these":[40,61,134,162],"pathways":[41,62],"a":[43,76,202],"profound":[44,94],"effect":[45],"on":[46,201,253],"development,":[48],"we":[49,172],"do":[50],"not":[51],"yet":[52],"have":[53],"an":[54],"understanding":[55],"dynamical":[58],"interactions":[59],"in":[63,81,117,158,273,288],"their":[64,112],"joint":[65],"shaping":[66],"repertoire.":[71],"Complete":[72],"DiGeorge":[73,105,124],"Anomaly":[74],"is":[75,145,216,237,263],"developmental":[77,141],"abnormality":[78],"results":[80],"failure":[83],"thymus":[86,127],"develop,":[88],"absence":[89],"cells,":[92],"immune":[95],"deficiency.":[96],"After":[97],"receiving":[98],"thymic":[99],"tissue":[100],"grafts,":[101],"patients":[102,125],"suffering":[103],"from":[104,111,296],"anomaly":[106],"develop":[107],"cells":[109],"derived":[110],"own":[113],"precursors":[114],"but":[115],"matured":[116],"donor":[119],"tissue.":[120],"We":[121,195],"followed":[122],"three":[123],"after":[126],"transplantation":[128],"utilize":[130],"remarkable":[132],"opportunity":[133],"subjects":[135],"provide":[136],"elucidate":[138],"human":[139],"regulation.":[142,255],"Our":[143],"goal":[144],"determination":[147],"respective":[150],"roles":[151],"TCR-specific":[153,214,254,261],"vs.":[154],"TCR-nonspecific":[155,223,242],"regulatory":[156],"growth":[160],"emerging":[163],"populations.":[165],"During":[166],"course":[168],"study,":[171],"measured":[173],"peripheral":[174,231],"blood":[175],"concentrations,":[177],"TCRbeta":[178],"V":[179],"gene-segment":[180],"usage":[181],"CDR3-length":[183],"spectratypes":[184],"over":[185],"two":[186],"years":[187],"or":[188],"more":[189],"for":[190],"each":[191],"subjects.":[194],"find,":[196],"through":[197],"statistical":[198],"analysis":[199],"based":[200],"novel":[203],"stochastic":[204],"population-dynamic":[205],"model,":[207],"carrying":[210],"capacity":[211],"corresponding":[212],"resources":[215],"approximately":[217],"1000-fold":[218],"larger":[219],"than":[220],"implying":[225],"size":[228],"pool":[233],"at":[234],"steady":[235,298],"state":[236],"determined":[238],"almost":[239],"entirely":[240],"mechanisms.":[243],"Nevertheless,":[244],"diversity":[246,272,287],"repertoire":[250,271,286],"depends":[251],"crucially":[252],"The":[256],"estimated":[257],"strength":[258],"this":[260],"regulation":[262],"sufficient":[264],"ensure":[266],"rapid":[267],"establishment":[268],"early":[275],"phase":[276],"population":[280],"growth,":[281],"maintain":[284],"face":[290],"substantial":[292],"clonal":[293],"expansion-induced":[294],"perturbation":[295],"state.":[299]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":2},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":6}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2016-06-24T00:00:00"}
