{"id":"https://openalex.org/W2058640773","doi":"https://doi.org/10.1371/journal.pcbi.1000343","title":"Probing the Flexibility of Large Conformational Changes in Protein Structures through Local Perturbations","display_name":"Probing the Flexibility of Large Conformational Changes in Protein Structures through Local Perturbations","publication_year":2009,"publication_date":"2009-04-02","ids":{"openalex":"https://openalex.org/W2058640773","doi":"https://doi.org/10.1371/journal.pcbi.1000343","mag":"2058640773","pmid":"https://pubmed.ncbi.nlm.nih.gov/19343225"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1000343","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000343","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000343&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000343&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5111880477","display_name":"Bosco Ho","orcid":null},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Bosco K. Ho","raw_affiliation_strings":["Howard Hughes Medical Institute and the Department of Biochemistry, University of California San Francisco, San Francisco, California, United States of America. boscoh@gmail.com","Howard Hughes Medical Institute and the Department of Biochemistry, University of California San Francisco, San Francisco, California, United States of America"],"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute and the Department of Biochemistry, University of California San Francisco, San Francisco, California, United States of America. boscoh@gmail.com","institution_ids":["https://openalex.org/I1344073410"]},{"raw_affiliation_string":"Howard Hughes Medical Institute and the Department of Biochemistry, University of California San Francisco, San Francisco, California, United States of America","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I180670191"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5081416783","display_name":"David A. Agard","orcid":"https://orcid.org/0000-0003-3512-695X"},"institutions":[{"id":"https://openalex.org/I1344073410","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90","country_code":"US","type":"facility","lineage":["https://openalex.org/I1344073410"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David A. Agard","raw_affiliation_strings":["Howard Hughes Medical Institute and the Department of Biochemistry, University of California San Francisco, San Francisco, California, United States of America"],"affiliations":[{"raw_affiliation_string":"Howard Hughes Medical Institute and the Department of Biochemistry, University of California San Francisco, San Francisco, California, United States of America","institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I180670191"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5111880477"],"corresponding_institution_ids":["https://openalex.org/I1344073410","https://openalex.org/I180670191"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":2.8309,"has_fulltext":true,"cited_by_count":61,"citation_normalized_percentile":{"value":0.90783282,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"5","issue":"4","first_page":"e1000343","last_page":"e1000343"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.9994000196456909,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11162","display_name":"Enzyme Structure and Function","score":0.9988999962806702,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10211","display_name":"Computational Drug Discovery Methods","score":0.9933000206947327,"subfield":{"id":"https://openalex.org/subfields/1703","display_name":"Computational Theory and Mathematics"},"field":{"id":"https://openalex.org/fields/17","display_name":"Computer Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/flexibility","display_name":"Flexibility (engineering)","score":0.5956324338912964},{"id":"https://openalex.org/keywords/protein-structure","display_name":"Protein structure","score":0.5233047008514404},{"id":"https://openalex.org/keywords/biophysics","display_name":"Biophysics","score":0.4302394688129425},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4090661108493805},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.3314134180545807},{"id":"https://openalex.org/keywords/chemistry","display_name":"Chemistry","score":0.3291686773300171},{"id":"https://openalex.org/keywords/statistical-physics","display_name":"Statistical physics","score":0.3205709457397461},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.313614159822464},{"id":"https://openalex.org/keywords/physics","display_name":"Physics","score":0.309226393699646},{"id":"https://openalex.org/keywords/mathematics","display_name":"Mathematics","score":0.1563919186592102},{"id":"https://openalex.org/keywords/biochemistry","display_name":"Biochemistry","score":0.1432555913925171},{"id":"https://openalex.org/keywords/statistics","display_name":"Statistics","score":0.08812180161476135}],"concepts":[{"id":"https://openalex.org/C2780598303","wikidata":"https://www.wikidata.org/wiki/Q65921492","display_name":"Flexibility (engineering)","level":2,"score":0.5956324338912964},{"id":"https://openalex.org/C47701112","wikidata":"https://www.wikidata.org/wiki/Q735188","display_name":"Protein structure","level":2,"score":0.5233047008514404},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.4302394688129425},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4090661108493805},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3314134180545807},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3291686773300171},{"id":"https://openalex.org/C121864883","wikidata":"https://www.wikidata.org/wiki/Q677916","display_name":"Statistical physics","level":1,"score":0.3205709457397461},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.313614159822464},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.309226393699646},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.1563919186592102},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.1432555913925171},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.08812180161476135}],"mesh":[{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008958","descriptor_name":"Models, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011487","descriptor_name":"Protein Conformation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014305","descriptor_name":"Triose-Phosphate Isomerase","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D014305","descriptor_name":"Triose-Phosphate Isomerase","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D014305","descriptor_name":"Triose-Phosphate Isomerase","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D014305","descriptor_name":"Triose-Phosphate Isomerase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014305","descriptor_name":"Triose-Phosphate Isomerase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D014305","descriptor_name":"Triose-Phosphate Isomerase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020539","descriptor_name":"Sequence Analysis, Protein","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1371/journal.pcbi.1000343","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000343","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000343&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:19343225","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19343225","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:55c2663a932d4ab0ba3fc7c9f816d048","is_oa":true,"landing_page_url":"https://doaj.org/article/55c2663a932d4ab0ba3fc7c9f816d048","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 5, Iss 4, p e1000343 (2009)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2660149","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2660149","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1000343","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000343","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000343&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306082","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2058640773.pdf","grobid_xml":"https://content.openalex.org/works/W2058640773.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W1520644305","https://openalex.org/W1966743338","https://openalex.org/W1973433543","https://openalex.org/W1978748870","https://openalex.org/W1982505482","https://openalex.org/W1986956719","https://openalex.org/W1987183940","https://openalex.org/W1994906426","https://openalex.org/W1997349084","https://openalex.org/W2017428798","https://openalex.org/W2037612112","https://openalex.org/W2038441129","https://openalex.org/W2039975390","https://openalex.org/W2048822589","https://openalex.org/W2063896079","https://openalex.org/W2066759906","https://openalex.org/W2066883560","https://openalex.org/W2072972888","https://openalex.org/W2076675152","https://openalex.org/W2080736062","https://openalex.org/W2081211861","https://openalex.org/W2083210953","https://openalex.org/W2087284052","https://openalex.org/W2087782999","https://openalex.org/W2093221728","https://openalex.org/W2093381148","https://openalex.org/W2093547815","https://openalex.org/W2099598754","https://openalex.org/W2100316962","https://openalex.org/W2101244907","https://openalex.org/W2102145519","https://openalex.org/W2107743509","https://openalex.org/W2108700551","https://openalex.org/W2111650618","https://openalex.org/W2113971181","https://openalex.org/W2118385570","https://openalex.org/W2121008575","https://openalex.org/W2125626635","https://openalex.org/W2129153475","https://openalex.org/W2134433601","https://openalex.org/W2139036153","https://openalex.org/W2146249023","https://openalex.org/W2148455468","https://openalex.org/W2153763352","https://openalex.org/W2154297157","https://openalex.org/W2155785386","https://openalex.org/W2159765665","https://openalex.org/W2165969670","https://openalex.org/W2167612644","https://openalex.org/W2594475116","https://openalex.org/W4321317585"],"related_works":["https://openalex.org/W2626808643","https://openalex.org/W2004064826","https://openalex.org/W3103727510","https://openalex.org/W3143779693","https://openalex.org/W97045569","https://openalex.org/W4293054118","https://openalex.org/W2348021072","https://openalex.org/W1871370349","https://openalex.org/W1508207170","https://openalex.org/W2168300075"],"abstract_inverted_index":{"Protein":[0],"conformational":[1,187,267,286,313,323],"changes":[2,314],"and":[3,14,150,160,197,216,315],"dynamic":[4,166],"behavior":[5],"are":[6,153,162],"fundamental":[7],"for":[8,98,283],"such":[9],"processes":[10],"as":[11,259],"catalysis,":[12],"regulation,":[13],"substrate":[15],"recognition.":[16],"Although":[17],"protein":[18,139,159],"dynamics":[19],"have":[20,170,180],"been":[21],"successfully":[22],"explored":[23],"in":[24,76,115,237,320],"computer":[25],"simulation,":[26],"there":[27],"is":[28,126,279,291],"an":[29],"intermediate-scale":[30],"of":[31,42,50,73,122,133,165,220,229,248,265,311],"motions":[32,72],"that":[33,47,152,168,179,205,295],"has":[34,305],"proven":[35],"difficult":[36],"to":[37,83,104,112,147,157,183,191,300,308],"simulate":[38],"-":[39],"the":[40,51,53,62,87,96,130,138,158,181,208,211,218,225,245,250,256,270,275,292,306,316],"motion":[41],"individual":[43,84,177],"segments":[44],"or":[45],"domains":[46],"move":[48],"independently":[49],"body":[52],"protein.":[54],"Here,":[55],"we":[56],"introduce":[57],"a":[58,116,119,232,238,260],"molecular-dynamics":[59],"perturbation":[60],"method,":[61],"Rotamerically":[63],"Induced":[64],"Perturbation":[65],"(RIP),":[66],"which":[67,200,290],"can":[68,109,144],"generate":[69],"large,":[70],"coherent":[71,186],"structural":[74,293],"elements":[75,92],"picoseconds":[77],"by":[78],"applying":[79,99],"large":[80,266,285],"torsional":[81],"perturbations":[82],"sidechains.":[85],"Despite":[86],"large-scale":[88,185],"motions,":[89],"secondary":[90],"structure":[91],"remain":[93],"intact":[94],"without":[95],"need":[97],"backbone":[100],"positional":[101],"restraints.":[102],"Owing":[103],"its":[105],"computational":[106],"efficiency,":[107],"RIP":[108,190,212,226,251,276,303],"be":[110,145],"applied":[111],"every":[113],"residue":[114],"protein,":[117,235],"producing":[118],"global":[120,142],"map":[121,125,143,214,228,239,253,278],"deformability.":[123],"This":[124],"remarkably":[127],"sparse,":[128],"with":[129,240],"dominant":[131],"sites":[132,164,310],"deformation":[134,213,227,252,277],"generally":[135],"found":[136],"on":[137,207],"surface.":[140],"The":[141],"used":[146],"identify":[148,176],"loops":[149,204],"helices":[151],"less":[154],"tightly":[155],"bound":[156],"thus":[161],"likely":[163],"modulation":[167],"may":[169],"important":[171],"functional":[172,312],"consequences.":[173],"Additionally,":[174],"they":[175],"residues":[178,318],"potential":[182,307],"drive":[184],"change.":[188],"Applying":[189],"two":[192],"well-studied":[193],"proteins,":[194],"Dihdydrofolate":[195],"Reductase":[196],"Triosephosphate":[198],"Isomerase,":[199],"possess":[201],"functionally-relevant":[202],"mobile":[203],"fluctuate":[206],"microsecond/millisecond":[209],"timescale,":[210],"identifies":[215,255],"recapitulates":[217],"flexibility":[219],"these":[221,322],"elements.":[222],"In":[223,244,269],"contrast,":[224],"alpha-lytic":[230],"protease,":[231],"kinetically":[233],"stable":[234],"results":[236],"no":[241],"significant":[242],"deformations.":[243],"N-terminal":[246],"domain":[247],"HSP90,":[249],"clearly":[254],"ligand-binding":[257,273],"lid":[258],"highly":[261],"flexible":[262],"region":[263],"capable":[264],"changes.":[268],"Estrogen":[271],"Receptor":[272],"domain,":[274],"quite":[280],"sparse":[281],"except":[282],"one":[284],"change":[287],"involving":[288],"Helix-12,":[289],"element":[294],"allosterically":[296],"links":[297],"ligand":[298],"binding":[299],"receptor":[301],"activation.":[302],"analysis":[304],"discover":[309],"linchpin":[317],"critical":[319],"determining":[321],"states.":[324]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":3},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":6},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":4}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}