{"id":"https://openalex.org/W2035496934","doi":"https://doi.org/10.1371/journal.pcbi.1000276","title":"Cohesive versus Flexible Evolution of Functional Modules in Eukaryotes","display_name":"Cohesive versus Flexible Evolution of Functional Modules in Eukaryotes","publication_year":2009,"publication_date":"2009-01-29","ids":{"openalex":"https://openalex.org/W2035496934","doi":"https://doi.org/10.1371/journal.pcbi.1000276","mag":"2035496934","pmid":"https://pubmed.ncbi.nlm.nih.gov/19180181"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1000276","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000276","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000276&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000276&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026828191","display_name":"Like Fokkens","orcid":"https://orcid.org/0000-0001-6696-4409"},"institutions":[{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"funder","lineage":["https://openalex.org/I3018483916"]},{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Like Fokkens","raw_affiliation_strings":["Theoretical Biology and Bioinformatics, Utrecht University, Utrecht, The Netherlands. l.fokkens@uu.nl","Theoretical Biology and Bioinformatics, Utrecht University, Utrecht, The Netherlands","Academic Biomedical Centre, Utrecht University, Utrecht, The Netherlands"],"affiliations":[{"raw_affiliation_string":"Theoretical Biology and Bioinformatics, Utrecht University, Utrecht, The Netherlands. l.fokkens@uu.nl","institution_ids":["https://openalex.org/I193662353"]},{"raw_affiliation_string":"Theoretical Biology and Bioinformatics, Utrecht University, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I193662353"]},{"raw_affiliation_string":"Academic Biomedical Centre, Utrecht University, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I3018483916","https://openalex.org/I193662353"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5023718551","display_name":"\u200eBerend Snel","orcid":"https://orcid.org/0000-0002-5804-8547"},"institutions":[{"id":"https://openalex.org/I3018483916","display_name":"University Medical Center Utrecht","ror":"https://ror.org/0575yy874","country_code":"NL","type":"funder","lineage":["https://openalex.org/I3018483916"]},{"id":"https://openalex.org/I193662353","display_name":"Utrecht University","ror":"https://ror.org/04pp8hn57","country_code":"NL","type":"education","lineage":["https://openalex.org/I193662353"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Berend Snel","raw_affiliation_strings":["Academic Biomedical Centre, Utrecht University, Utrecht, The Netherlands","Theoretical Biology and Bioinformatics, Utrecht University, Utrecht, The Netherlands"],"affiliations":[{"raw_affiliation_string":"Academic Biomedical Centre, Utrecht University, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I3018483916","https://openalex.org/I193662353"]},{"raw_affiliation_string":"Theoretical Biology and Bioinformatics, Utrecht University, Utrecht, The Netherlands","institution_ids":["https://openalex.org/I193662353"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5026828191"],"corresponding_institution_ids":["https://openalex.org/I193662353","https://openalex.org/I3018483916"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.2132,"has_fulltext":true,"cited_by_count":19,"citation_normalized_percentile":{"value":0.77803164,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"5","issue":"1","first_page":"e1000276","last_page":"e1000276"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10015","display_name":"Genomics and Phylogenetic Studies","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9940999746322632,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.984000027179718,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/flexibility","display_name":"Flexibility (engineering)","score":0.6273070573806763},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5608528852462769},{"id":"https://openalex.org/keywords/evolutionary-biology","display_name":"Evolutionary biology","score":0.5395703911781311},{"id":"https://openalex.org/keywords/phylogenetic-tree","display_name":"Phylogenetic tree","score":0.5380088686943054},{"id":"https://openalex.org/keywords/biological-evolution","display_name":"Biological evolution","score":0.5240952372550964},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.4773716628551483},{"id":"https://openalex.org/keywords/phylogenetics","display_name":"Phylogenetics","score":0.4767278730869293},{"id":"https://openalex.org/keywords/genome","display_name":"Genome","score":0.4669094681739807},{"id":"https://openalex.org/keywords/group-cohesiveness","display_name":"Group cohesiveness","score":0.44305840134620667},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.2534328103065491},{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.1661524474620819},{"id":"https://openalex.org/keywords/psychology","display_name":"Psychology","score":0.08577927947044373}],"concepts":[{"id":"https://openalex.org/C2780598303","wikidata":"https://www.wikidata.org/wiki/Q65921492","display_name":"Flexibility (engineering)","level":2,"score":0.6273070573806763},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5608528852462769},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.5395703911781311},{"id":"https://openalex.org/C193252679","wikidata":"https://www.wikidata.org/wiki/Q242125","display_name":"Phylogenetic tree","level":3,"score":0.5380088686943054},{"id":"https://openalex.org/C2988562018","wikidata":"https://www.wikidata.org/wiki/Q1063","display_name":"Biological evolution","level":2,"score":0.5240952372550964},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4773716628551483},{"id":"https://openalex.org/C90132467","wikidata":"https://www.wikidata.org/wiki/Q171184","display_name":"Phylogenetics","level":3,"score":0.4767278730869293},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.4669094681739807},{"id":"https://openalex.org/C14641543","wikidata":"https://www.wikidata.org/wiki/Q553270","display_name":"Group cohesiveness","level":2,"score":0.44305840134620667},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.2534328103065491},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1661524474620819},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.08577927947044373},{"id":"https://openalex.org/C33923547","wikidata":"https://www.wikidata.org/wiki/Q395","display_name":"Mathematics","level":0,"score":0.0},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.0},{"id":"https://openalex.org/C77805123","wikidata":"https://www.wikidata.org/wiki/Q161272","display_name":"Social psychology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D005057","descriptor_name":"Eukaryotic Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005057","descriptor_name":"Eukaryotic Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005057","descriptor_name":"Eukaryotic Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008957","descriptor_name":"Models, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019143","descriptor_name":"Evolution, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D029701","descriptor_name":"Saccharomyces cerevisiae Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030562","descriptor_name":"Databases, Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D053858","descriptor_name":"Metabolic Networks and Pathways","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1000276","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000276","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000276&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:19180181","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19180181","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:6bd9b99681844826ac7e55d6827d0e92","is_oa":true,"landing_page_url":"https://doaj.org/article/6bd9b99681844826ac7e55d6827d0e92","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 5, Iss 1, p e1000276 (2009)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/148603","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Cohesive_versus_Flexible_Evolution_of_Functional_Modules_in_Eukaryotes/148603","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:pubmedcentral.nih.gov:2615111","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2615111","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1000276","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000276","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000276&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321010","display_name":"Universiteit Utrecht","ror":"https://ror.org/04pp8hn57"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2035496934.pdf","grobid_xml":"https://content.openalex.org/works/W2035496934.grobid-xml"},"referenced_works_count":32,"referenced_works":["https://openalex.org/W1967837099","https://openalex.org/W1974302044","https://openalex.org/W2008856488","https://openalex.org/W2021769301","https://openalex.org/W2026353653","https://openalex.org/W2041303239","https://openalex.org/W2049311981","https://openalex.org/W2050721857","https://openalex.org/W2053279361","https://openalex.org/W2057885377","https://openalex.org/W2059803549","https://openalex.org/W2067389181","https://openalex.org/W2068750645","https://openalex.org/W2095957046","https://openalex.org/W2100101355","https://openalex.org/W2100371004","https://openalex.org/W2102379149","https://openalex.org/W2103017472","https://openalex.org/W2114605822","https://openalex.org/W2116117181","https://openalex.org/W2116447934","https://openalex.org/W2123836768","https://openalex.org/W2141414843","https://openalex.org/W2152568394","https://openalex.org/W2152859623","https://openalex.org/W2155606054","https://openalex.org/W2159675211","https://openalex.org/W2165533101","https://openalex.org/W2166325055","https://openalex.org/W2167188257","https://openalex.org/W4248865979","https://openalex.org/W4252706339"],"related_works":["https://openalex.org/W2174809885","https://openalex.org/W2883025420","https://openalex.org/W2057191541","https://openalex.org/W2949296710","https://openalex.org/W1992658754","https://openalex.org/W2111939425","https://openalex.org/W2065083790","https://openalex.org/W2604174992","https://openalex.org/W2375383082","https://openalex.org/W1974895455"],"abstract_inverted_index":{"Although":[0],"functionally":[1],"related":[2],"proteins":[3],"can":[4],"be":[5],"reliably":[6],"predicted":[7],"from":[8],"phylogenetic":[9],"profiles,":[10],"many":[11],"functional":[12,40,103,144],"modules":[13,41,104],"do":[14],"not":[15],"seem":[16],"to":[17,21,139],"evolve":[18,105,128],"cohesively":[19,130,152],"according":[20],"case":[22],"studies":[23],"and":[24,44,48,62,75,117,126],"systematic":[25],"analyses":[26],"in":[27,42,64],"prokaryotes.":[28],"In":[29],"this":[30,97],"study":[31],"we":[32],"quantify":[33],"the":[34,46,77,140,143],"extent":[35,78],"of":[36,39,59,79,82,84,87,124,142],"evolutionary":[37],"cohesiveness":[38],"eukaryotes":[43],"probe":[45],"biological":[47],"methodological":[49],"factors":[50],"influencing":[51],"our":[52],"estimates.":[53],"We":[54,67],"have":[55],"collected":[56],"various":[57],"datasets":[58],"protein":[60],"complexes":[61,127],"pathways":[63,125,148],"Saccheromyces":[65],"cerevisiae.":[66],"define":[68],"orthologous":[69,85,120],"groups":[70,86],"on":[71],"34":[72],"eukaryotic":[73],"genomes":[74],"measure":[76],"cohesive":[80],"evolution":[81],"sets":[83],"which":[88],"members":[89],"constitute":[90],"a":[91],"known":[92],"complex":[93],"or":[94],"pathway.":[95],"Within":[96],"framework":[98],"it":[99],"appears":[100],"that":[101],"most":[102],"flexibly":[106],"rather":[107],"than":[108,131,154],"cohesively.":[109],"Even":[110],"after":[111],"correcting":[112],"for":[113],"uncertain":[114],"module":[115,145],"definitions":[116],"potentially":[118],"problematic":[119],"groups,":[121],"only":[122],"46%":[123],"more":[129,151],"random":[132],"modules.":[133],"This":[134],"flexibility":[135],"seems":[136],"partly":[137],"coupled":[138],"nature":[141],"because":[146],"biochemical":[147],"are":[149],"generally":[150],"evolving":[153],"complexes.":[155]},"counts_by_year":[{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2017,"cited_by_count":2},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":4}],"updated_date":"2026-04-21T08:09:41.155169","created_date":"2025-10-10T00:00:00"}