{"id":"https://openalex.org/W2075656833","doi":"https://doi.org/10.1371/journal.pcbi.1000141","title":"Embedding mRNA Stability in Correlation Analysis of Time-Series Gene Expression Data","display_name":"Embedding mRNA Stability in Correlation Analysis of Time-Series Gene Expression Data","publication_year":2008,"publication_date":"2008-07-31","ids":{"openalex":"https://openalex.org/W2075656833","doi":"https://doi.org/10.1371/journal.pcbi.1000141","mag":"2075656833","pmid":"https://pubmed.ncbi.nlm.nih.gov/18670596"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1000141","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000141","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000141&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000141&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5074179530","display_name":"Lorenzo Farina","orcid":"https://orcid.org/0000-0001-8314-6029"},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Lorenzo Farina","raw_affiliation_strings":["Dipartimento di Informatica e Sistemistica Antonio Ruberti, Sapienza Universit\u00e0 di Roma, Rome, Italy. lorenzo.farina@uniroma1.it","Dipartimento di Informatica e Sistemistica \u201cAntonio Ruberti\u201d, Sapienza Universit\u00e0 di Roma, Rome, Italy"],"affiliations":[{"raw_affiliation_string":"Dipartimento di Informatica e Sistemistica Antonio Ruberti, Sapienza Universit\u00e0 di Roma, Rome, Italy. lorenzo.farina@uniroma1.it","institution_ids":["https://openalex.org/I861853513"]},{"raw_affiliation_string":"Dipartimento di Informatica e Sistemistica \u201cAntonio Ruberti\u201d, Sapienza Universit\u00e0 di Roma, Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036218807","display_name":"Alberto De Santis","orcid":"https://orcid.org/0000-0001-5175-4951"},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alberto De Santis","raw_affiliation_strings":["Dipartimento di Informatica e Sistemistica \u201cAntonio Ruberti\u201d, Sapienza Universit\u00e0 di Roma, Rome, Italy"],"affiliations":[{"raw_affiliation_string":"Dipartimento di Informatica e Sistemistica \u201cAntonio Ruberti\u201d, Sapienza Universit\u00e0 di Roma, Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016654203","display_name":"Samanta Salvucci","orcid":null},"institutions":[{"id":"https://openalex.org/I4210110528","display_name":"Institute of Molecular Biology and Pathology","ror":"https://ror.org/01nyatq71","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210110528","https://openalex.org/I4210155236"]},{"id":"https://openalex.org/I4210097641","display_name":"Istituto Nazionale di Ricerca per gli Alimenti e la Nutrizione","ror":"https://ror.org/00yd9m083","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210097641"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Samanta Salvucci","raw_affiliation_strings":["Istituto Nazionale di Ricerca per gli Alimenti e la Nutrizione, Rome, Italy","Istituto di Biologia e Patologia Molecolari, Consiglio Nazionale delle Ricerche, Rome, Italy"],"affiliations":[{"raw_affiliation_string":"Istituto Nazionale di Ricerca per gli Alimenti e la Nutrizione, Rome, Italy","institution_ids":["https://openalex.org/I4210097641"]},{"raw_affiliation_string":"Istituto di Biologia e Patologia Molecolari, Consiglio Nazionale delle Ricerche, Rome, Italy","institution_ids":["https://openalex.org/I4210110528"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054693797","display_name":"Giorgio Morelli","orcid":"https://orcid.org/0000-0002-8994-4838"},"institutions":[{"id":"https://openalex.org/I4210097641","display_name":"Istituto Nazionale di Ricerca per gli Alimenti e la Nutrizione","ror":"https://ror.org/00yd9m083","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210097641"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Giorgio Morelli","raw_affiliation_strings":["Istituto Nazionale di Ricerca per gli Alimenti e la Nutrizione, Rome, Italy"],"affiliations":[{"raw_affiliation_string":"Istituto Nazionale di Ricerca per gli Alimenti e la Nutrizione, Rome, Italy","institution_ids":["https://openalex.org/I4210097641"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076534214","display_name":"Ida Ruberti","orcid":"https://orcid.org/0000-0002-4974-5818"},"institutions":[{"id":"https://openalex.org/I4210110528","display_name":"Institute of Molecular Biology and Pathology","ror":"https://ror.org/01nyatq71","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210110528","https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Ida Ruberti","raw_affiliation_strings":["Istituto di Biologia e Patologia Molecolari, Consiglio Nazionale delle Ricerche, Rome, Italy"],"affiliations":[{"raw_affiliation_string":"Istituto di Biologia e Patologia Molecolari, Consiglio Nazionale delle Ricerche, Rome, Italy","institution_ids":["https://openalex.org/I4210110528"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5074179530"],"corresponding_institution_ids":["https://openalex.org/I861853513"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":1.1063,"has_fulltext":true,"cited_by_count":20,"citation_normalized_percentile":{"value":0.767557,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":95},"biblio":{"volume":"4","issue":"8","first_page":"e1000141","last_page":"e1000141"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10887","display_name":"Bioinformatics and Genomic Networks","score":0.9991000294685364,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.9983999729156494,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gene","display_name":"Gene","score":0.6906505823135376},{"id":"https://openalex.org/keywords/biology","display_name":"Biology","score":0.5760825276374817},{"id":"https://openalex.org/keywords/gene-expression","display_name":"Gene expression","score":0.5603116154670715},{"id":"https://openalex.org/keywords/computational-biology","display_name":"Computational biology","score":0.5273725986480713},{"id":"https://openalex.org/keywords/genetics","display_name":"Genetics","score":0.4922131597995758},{"id":"https://openalex.org/keywords/gene-regulatory-network","display_name":"Gene regulatory network","score":0.47432583570480347},{"id":"https://openalex.org/keywords/regulation-of-gene-expression","display_name":"Regulation of gene expression","score":0.47032463550567627},{"id":"https://openalex.org/keywords/metric","display_name":"Metric (unit)","score":0.4586387574672699},{"id":"https://openalex.org/keywords/similarity","display_name":"Similarity (geometry)","score":0.4112025499343872},{"id":"https://openalex.org/keywords/bioinformatics","display_name":"Bioinformatics","score":0.3504534959793091},{"id":"https://openalex.org/keywords/computer-science","display_name":"Computer science","score":0.23947632312774658},{"id":"https://openalex.org/keywords/artificial-intelligence","display_name":"Artificial intelligence","score":0.13035252690315247}],"concepts":[{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6906505823135376},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5760825276374817},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5603116154670715},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5273725986480713},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4922131597995758},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.47432583570480347},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.47032463550567627},{"id":"https://openalex.org/C176217482","wikidata":"https://www.wikidata.org/wiki/Q860554","display_name":"Metric (unit)","level":2,"score":0.4586387574672699},{"id":"https://openalex.org/C103278499","wikidata":"https://www.wikidata.org/wiki/Q254465","display_name":"Similarity (geometry)","level":3,"score":0.4112025499343872},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3504534959793091},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.23947632312774658},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.13035252690315247},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C21547014","wikidata":"https://www.wikidata.org/wiki/Q1423657","display_name":"Operations management","level":1,"score":0.0},{"id":"https://openalex.org/C115961682","wikidata":"https://www.wikidata.org/wiki/Q860623","display_name":"Image (mathematics)","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001185","descriptor_name":"Artificial Intelligence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002453","descriptor_name":"Cell Cycle","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005800","descriptor_name":"Genes, Fungal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005800","descriptor_name":"Genes, Fungal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D005800","descriptor_name":"Genes, Fungal","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010363","descriptor_name":"Pattern Recognition, Automated","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010363","descriptor_name":"Pattern Recognition, Automated","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010363","descriptor_name":"Pattern Recognition, Automated","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012441","descriptor_name":"Saccharomyces cerevisiae","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020411","descriptor_name":"Oligonucleotide Array Sequence Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020871","descriptor_name":"RNA Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020871","descriptor_name":"RNA Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D020871","descriptor_name":"RNA Stability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D030541","descriptor_name":"Databases, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":7,"locations":[{"id":"doi:10.1371/journal.pcbi.1000141","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000141","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000141&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},{"id":"pmid:18670596","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18670596","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.275.4562","is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.275.4562","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/a1/6e/PLoS_Comput_Biol_2008_Aug_1_4(8)_e1000141.tar.gz","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:c0a5040f920e4f10b3795595fb6875ed","is_oa":true,"landing_page_url":"https://doaj.org/article/c0a5040f920e4f10b3795595fb6875ed","pdf_url":null,"source":{"id":"https://openalex.org/S112646816","display_name":"SHILAP Revista de lepidopterolog\u00eda","issn_l":"0300-5267","issn":["0300-5267","2340-4078"],"is_oa":true,"is_in_doaj":true,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 4, Iss 8, p e1000141 (2008)","raw_type":"article"},{"id":"pmh:oai:europepmc.org:1217860","is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2453326","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:figshare.com:article/149874","is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Embedding_mRNA_Stability_in_Correlation_Analysis_of_Time_Series_Gene_Expression_Data/149874","pdf_url":null,"source":{"id":"https://openalex.org/S4306400572","display_name":"OPAL (Open@LaTrobe) (La Trobe University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I196829312","host_organization_name":"La Trobe University","host_organization_lineage":["https://openalex.org/I196829312"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":null},{"id":"pmh:oai:iris.uniroma1.it:11573/228575","is_oa":false,"landing_page_url":"http://hdl.handle.net/11573/228575","pdf_url":null,"source":{"id":"https://openalex.org/S4377196107","display_name":"IRIS Research product catalog (Sapienza University of Rome)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1000141","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1000141","pdf_url":"https://journals.plos.org/ploscompbiol/article/file?id=10.1371/journal.pcbi.1000141&type=printable","source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2075656833.pdf","grobid_xml":"https://content.openalex.org/works/W2075656833.grobid-xml"},"referenced_works_count":57,"referenced_works":["https://openalex.org/W65153156","https://openalex.org/W1501400124","https://openalex.org/W1544439962","https://openalex.org/W1579608990","https://openalex.org/W1588911128","https://openalex.org/W1627372813","https://openalex.org/W1644724366","https://openalex.org/W1849539769","https://openalex.org/W1925571297","https://openalex.org/W1973260612","https://openalex.org/W2000567731","https://openalex.org/W2009559661","https://openalex.org/W2033393656","https://openalex.org/W2037451497","https://openalex.org/W2047138284","https://openalex.org/W2049402769","https://openalex.org/W2057226690","https://openalex.org/W2061439657","https://openalex.org/W2065458745","https://openalex.org/W2073506826","https://openalex.org/W2076372398","https://openalex.org/W2083691092","https://openalex.org/W2088860412","https://openalex.org/W2090592322","https://openalex.org/W2096324459","https://openalex.org/W2098222328","https://openalex.org/W2102406695","https://openalex.org/W2103014023","https://openalex.org/W2103453943","https://openalex.org/W2104820327","https://openalex.org/W2107608478","https://openalex.org/W2108156626","https://openalex.org/W2115662646","https://openalex.org/W2115772919","https://openalex.org/W2121905499","https://openalex.org/W2121995533","https://openalex.org/W2123902215","https://openalex.org/W2124821604","https://openalex.org/W2125508747","https://openalex.org/W2132585078","https://openalex.org/W2135000328","https://openalex.org/W2135187880","https://openalex.org/W2139956963","https://openalex.org/W2142460132","https://openalex.org/W2147390656","https://openalex.org/W2150926065","https://openalex.org/W2153624566","https://openalex.org/W2157441710","https://openalex.org/W2161409973","https://openalex.org/W2161477969","https://openalex.org/W2161646573","https://openalex.org/W2164078761","https://openalex.org/W2166103265","https://openalex.org/W2168846334","https://openalex.org/W2171252114","https://openalex.org/W4214816144","https://openalex.org/W6632811028"],"related_works":["https://openalex.org/W2010571965","https://openalex.org/W3128451840","https://openalex.org/W2002709996","https://openalex.org/W4387092964","https://openalex.org/W2103471012","https://openalex.org/W2966064480","https://openalex.org/W2380236774","https://openalex.org/W2277277196","https://openalex.org/W2107149076","https://openalex.org/W2115810854"],"abstract_inverted_index":{"Current":[0],"methods":[1],"for":[2,66,94,159],"the":[3,18,21,41,67,88,95,111,124,133,140],"identification":[4,96],"of":[5,20,43,69,91,97,105,113,117,142,144],"putatively":[6,120],"co-regulated":[7,98,121],"genes":[8,99,157],"directly":[9],"from":[10],"gene":[11,32,70,82,136],"expression":[12,83,137],"time":[13,22],"profiles":[14],"are":[15],"based":[16],"on":[17],"similarity":[19,58,107],"profile.":[23],"Such":[24],"association":[25],"metrics,":[26],"despite":[27],"their":[28],"central":[29],"role":[30],"in":[31,47],"network":[33],"inference":[34],"and":[35,76,139],"machine":[36],"learning,":[37],"have":[38],"largely":[39],"ignored":[40],"impact":[42],"dynamics":[44,141],"or":[45],"variation":[46],"mRNA":[48,74],"stability.":[49],"Here":[50],"we":[51,85,149],"introduce":[52],"a":[53,114,151,160],"simple,":[54],"but":[55],"powerful,":[56],"new":[57,119],"metric":[59,126],"called":[60],"lead-lag":[61,92,125,153],"R(2)":[62,93,154],"that":[63,87,104],"successfully":[64],"accounts":[65],"properties":[68],"dynamics,":[71],"including":[72],"varying":[73],"degradation":[75],"delays.":[77],"Using":[78],"yeast":[79],"cell-cycle":[80],"time-series":[81,138],"data,":[84],"demonstrate":[86],"predictive":[89],"power":[90],"is":[100],"significantly":[101],"higher":[102],"than":[103],"standard":[106],"measures,":[108],"thus":[109],"allowing":[110],"selection":[112],"large":[115],"number":[116],"entirely":[118],"genes.":[122],"Furthermore,":[123],"can":[127],"also":[128],"be":[129],"used":[130],"to":[131],"uncover":[132],"relationship":[134],"between":[135],"formation":[143],"multiple":[145],"protein":[146],"complexes.":[147],"Remarkably,":[148],"found":[150],"high":[152],"value":[155],"among":[156],"coding":[158],"transient":[161],"complex.":[162]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-04-04T16:13:02.066488","created_date":"2025-10-10T00:00:00"}