{"id":"https://openalex.org/W7140232059","doi":"https://doi.org/10.1371/journal.pcbi.1014111","title":"A minimal mathematical model of red blood cell homeostasis in anemia","display_name":"A minimal mathematical model of red blood cell homeostasis in anemia","publication_year":2026,"publication_date":"2026-03-24","ids":{"openalex":"https://openalex.org/W7140232059","doi":"https://doi.org/10.1371/journal.pcbi.1014111","pmid":"https://pubmed.ncbi.nlm.nih.gov/41875175"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1014111","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1014111","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.pcbi.1014111","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Herut Dor","orcid":"https://orcid.org/0000-0001-5535-7013"},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Herut Dor","raw_affiliation_strings":["Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel"],"raw_orcid":"https://orcid.org/0000-0001-5535-7013","affiliations":[{"raw_affiliation_string":"Gray Faculty of Medical and Health Sciences, Tel Aviv University, Tel Aviv, Israel","institution_ids":["https://openalex.org/I16391192"]}]},{"author_position":"last","author":{"id":null,"display_name":"Uri Alon","orcid":null},"institutions":[{"id":"https://openalex.org/I53964585","display_name":"Weizmann Institute of Science","ror":"https://ror.org/0316ej306","country_code":"IL","type":"education","lineage":["https://openalex.org/I53964585"]}],"countries":["IL"],"is_corresponding":false,"raw_author_name":"Uri Alon","raw_affiliation_strings":["Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel","institution_ids":["https://openalex.org/I53964585"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I16391192"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.52053398,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"22","issue":"3","first_page":"e1014111","last_page":"e1014111"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11534","display_name":"Erythropoietin and Anemia Treatment","score":0.8888999819755554,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11534","display_name":"Erythropoietin and Anemia Treatment","score":0.8888999819755554,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.07660000026226044,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10554","display_name":"Hemoglobinopathies and Related Disorders","score":0.010499999858438969,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/erythropoietin","display_name":"Erythropoietin","score":0.8956999778747559},{"id":"https://openalex.org/keywords/erythropoiesis","display_name":"Erythropoiesis","score":0.8355000019073486},{"id":"https://openalex.org/keywords/anemia","display_name":"Anemia","score":0.751800000667572},{"id":"https://openalex.org/keywords/hemoglobin","display_name":"Hemoglobin","score":0.6850000023841858},{"id":"https://openalex.org/keywords/red-blood-cell","display_name":"Red blood cell","score":0.5317999720573425},{"id":"https://openalex.org/keywords/haematopoiesis","display_name":"Haematopoiesis","score":0.4081000089645386},{"id":"https://openalex.org/keywords/homeostasis","display_name":"Homeostasis","score":0.4074999988079071},{"id":"https://openalex.org/keywords/regulator","display_name":"Regulator","score":0.3889000117778778},{"id":"https://openalex.org/keywords/red-cell","display_name":"Red Cell","score":0.3727000057697296}],"concepts":[{"id":"https://openalex.org/C2778534260","wikidata":"https://www.wikidata.org/wiki/Q218706","display_name":"Erythropoietin","level":2,"score":0.8956999778747559},{"id":"https://openalex.org/C2779703530","wikidata":"https://www.wikidata.org/wiki/Q837174","display_name":"Erythropoiesis","level":3,"score":0.8355000019073486},{"id":"https://openalex.org/C2778248108","wikidata":"https://www.wikidata.org/wiki/Q5445","display_name":"Anemia","level":2,"score":0.751800000667572},{"id":"https://openalex.org/C2778917026","wikidata":"https://www.wikidata.org/wiki/Q43041","display_name":"Hemoglobin","level":2,"score":0.6850000023841858},{"id":"https://openalex.org/C2776557347","wikidata":"https://www.wikidata.org/wiki/Q37187","display_name":"Red blood cell","level":2,"score":0.5317999720573425},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.5297999978065491},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.46459999680519104},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.45179998874664307},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.41839998960494995},{"id":"https://openalex.org/C109159458","wikidata":"https://www.wikidata.org/wiki/Q919283","display_name":"Haematopoiesis","level":3,"score":0.4081000089645386},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.4074999988079071},{"id":"https://openalex.org/C6929976","wikidata":"https://www.wikidata.org/wiki/Q3771881","display_name":"Regulator","level":3,"score":0.3889000117778778},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3772999942302704},{"id":"https://openalex.org/C2777208419","wikidata":"https://www.wikidata.org/wiki/Q4347672","display_name":"Red Cell","level":2,"score":0.3727000057697296},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.36629998683929443},{"id":"https://openalex.org/C201750760","wikidata":"https://www.wikidata.org/wiki/Q1896218","display_name":"Progenitor cell","level":3,"score":0.3555999994277954},{"id":"https://openalex.org/C2781440808","wikidata":"https://www.wikidata.org/wiki/Q846316","display_name":"Aplastic anemia","level":3,"score":0.3555000126361847},{"id":"https://openalex.org/C71315377","wikidata":"https://www.wikidata.org/wiki/Q11364","display_name":"Hormone","level":2,"score":0.35199999809265137},{"id":"https://openalex.org/C2779979121","wikidata":"https://www.wikidata.org/wiki/Q211709","display_name":"Blood cell","level":2,"score":0.3492000102996826},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.34380000829696655},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.33730000257492065},{"id":"https://openalex.org/C2780959883","wikidata":"https://www.wikidata.org/wiki/Q111146","display_name":"Hematocrit","level":2,"score":0.31940001249313354},{"id":"https://openalex.org/C2780844101","wikidata":"https://www.wikidata.org/wiki/Q2380264","display_name":"Ineffective erythropoiesis","level":4,"score":0.2996000051498413},{"id":"https://openalex.org/C2777422296","wikidata":"https://www.wikidata.org/wiki/Q751631","display_name":"Pure red cell aplasia","level":3,"score":0.2809999883174896},{"id":"https://openalex.org/C37557685","wikidata":"https://www.wikidata.org/wiki/Q1896673","display_name":"Blood volume","level":2,"score":0.26589998602867126},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.2590999901294708}],"mesh":[{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000328","descriptor_name":"Adult","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000740","descriptor_name":"Anemia","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000740","descriptor_name":"Anemia","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000740","descriptor_name":"Anemia","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D000740","descriptor_name":"Anemia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D000740","descriptor_name":"Anemia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D000740","descriptor_name":"Anemia","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004912","descriptor_name":"Erythrocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D004920","descriptor_name":"Erythropoiesis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004920","descriptor_name":"Erythropoiesis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004920","descriptor_name":"Erythropoiesis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004921","descriptor_name":"Erythropoietin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D004921","descriptor_name":"Erythropoietin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D004921","descriptor_name":"Erythropoietin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D004921","descriptor_name":"Erythropoietin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004921","descriptor_name":"Erythropoietin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004921","descriptor_name":"Erythropoietin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006454","descriptor_name":"Hemoglobins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006454","descriptor_name":"Hemoglobins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006454","descriptor_name":"Hemoglobins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006706","descriptor_name":"Homeostasis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1371/journal.pcbi.1014111","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1014111","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:41875175","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41875175","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:f5c364c77d9c40b59f6c5cea0ed9aecf","is_oa":true,"landing_page_url":"https://doaj.org/article/f5c364c77d9c40b59f6c5cea0ed9aecf","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 22, Iss 3, p e1014111 (2026)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13048500","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13048500/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1014111","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1014111","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.5652548670768738,"display_name":"Good health and well-being"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":108,"referenced_works":["https://openalex.org/W8180710","https://openalex.org/W148611885","https://openalex.org/W258492293","https://openalex.org/W1484334243","https://openalex.org/W1498198717","https://openalex.org/W1501784999","https://openalex.org/W1508664328","https://openalex.org/W1511580831","https://openalex.org/W1528664908","https://openalex.org/W1575336769","https://openalex.org/W1584852339","https://openalex.org/W1789486470","https://openalex.org/W1965783996","https://openalex.org/W1966982554","https://openalex.org/W1967699007","https://openalex.org/W1969576864","https://openalex.org/W1972226511","https://openalex.org/W1980002707","https://openalex.org/W1980042430","https://openalex.org/W1986157870","https://openalex.org/W1992477005","https://openalex.org/W1992958125","https://openalex.org/W1993642530","https://openalex.org/W1996821186","https://openalex.org/W1998024272","https://openalex.org/W2000837348","https://openalex.org/W2001699070","https://openalex.org/W2002062638","https://openalex.org/W2007403640","https://openalex.org/W2010742291","https://openalex.org/W2011619734","https://openalex.org/W2016879423","https://openalex.org/W2019234685","https://openalex.org/W2021201633","https://openalex.org/W2022766125","https://openalex.org/W2026083876","https://openalex.org/W2026452824","https://openalex.org/W2028034405","https://openalex.org/W2028695639","https://openalex.org/W2036292236","https://openalex.org/W2042100599","https://openalex.org/W2050243922","https://openalex.org/W2053120155","https://openalex.org/W2062899869","https://openalex.org/W2063382772","https://openalex.org/W2066036872","https://openalex.org/W2066403664","https://openalex.org/W2066914106","https://openalex.org/W2066929242","https://openalex.org/W2082855303","https://openalex.org/W2092704973","https://openalex.org/W2099867389","https://openalex.org/W2099981091","https://openalex.org/W2105766695","https://openalex.org/W2111901036","https://openalex.org/W2111945506","https://openalex.org/W2113338326","https://openalex.org/W2114497161","https://openalex.org/W2115870410","https://openalex.org/W2118798840","https://openalex.org/W2122586704","https://openalex.org/W2122676446","https://openalex.org/W2124839834","https://openalex.org/W2128626254","https://openalex.org/W2128945118","https://openalex.org/W2129612306","https://openalex.org/W2132679838","https://openalex.org/W2141628422","https://openalex.org/W2144795074","https://openalex.org/W2150897436","https://openalex.org/W2152233370","https://openalex.org/W2154327042","https://openalex.org/W2159812471","https://openalex.org/W2168877654","https://openalex.org/W2272758509","https://openalex.org/W2313772754","https://openalex.org/W2320172709","https://openalex.org/W2331565502","https://openalex.org/W2336116827","https://openalex.org/W2340124568","https://openalex.org/W2346749050","https://openalex.org/W2418476825","https://openalex.org/W2432799817","https://openalex.org/W2461223933","https://openalex.org/W2517135953","https://openalex.org/W2528271650","https://openalex.org/W2541678333","https://openalex.org/W2596955988","https://openalex.org/W2605250829","https://openalex.org/W2891178353","https://openalex.org/W2893775225","https://openalex.org/W2996077149","https://openalex.org/W3022133501","https://openalex.org/W3037604111","https://openalex.org/W3140909591","https://openalex.org/W3210487642","https://openalex.org/W4235415945","https://openalex.org/W4239373478","https://openalex.org/W4240197418","https://openalex.org/W4240369490","https://openalex.org/W4253267709","https://openalex.org/W4253440008","https://openalex.org/W4290618097","https://openalex.org/W4292603729","https://openalex.org/W4296187715","https://openalex.org/W4385412860","https://openalex.org/W4387542000","https://openalex.org/W4413035574"],"related_works":[],"abstract_inverted_index":{"Anemias":[0,40],"are":[1,12],"diverse":[2],"and":[3,7,24,31,47,89,119,129,145,182,204,217,234,270],"cause":[4],"significant":[5],"morbidity":[6],"mortality,":[8],"but":[9],"their":[10],"mechanisms":[11,93],"not":[13,240],"fully":[14],"understood.":[15],"To":[16],"unravel":[17],"this":[18],"complexity":[19],"requires":[20],"understanding":[21],"how":[22],"hemoglobin":[23,45,177],"red":[25,52],"blood":[26,53,180],"cell":[27],"function":[28],"is":[29,64,77,211,250],"regulated,":[30],"what":[32],"goes":[33],"wrong":[34],"in":[35,74,170,196,244],"each":[36],"form":[37],"of":[38,51,71,104,107,176,221,259],"anemia.":[39],"present":[41],"puzzling":[42],"imbalance":[43],"between":[44,86],"(Hb)":[46],"the":[48,56,69,84,155,165,173],"main":[49],"regulator":[50],"cells":[54],"-":[55],"hormone":[57],"erythropoietin":[58,90,253],"(EPO).":[59],"In":[60],"some":[61],"anemias":[62],"EPO":[63,195,215,232,243],"markedly":[65],"elevated":[66],"relative":[67],"to":[68,131,153],"degree":[70],"anemia,":[72],"whereas":[73],"others":[75],"it":[76],"inappropriately":[78],"low.":[79],"This":[80],"variability":[81],"suggests":[82],"that":[83,251],"feedback":[85],"oxygen":[87,96],"delivery":[88],"production":[91],"involves":[92],"beyond":[94],"simple":[95],"sensing.":[97],"We":[98],"developed":[99],"a":[100,256],"minimal":[101],"mechanistic":[102],"model":[103,163],"erythropoiesis":[105],"composed":[106],"four":[108],"coupled":[109],"differential":[110],"equations":[111],"representing":[112],"erythroid":[113,202,268],"progenitors,":[114],"marrow":[115,218,261],"reticulocytes,":[116],"circulating":[117],"RBCs,":[118],"plasma":[120],"EPO.":[121],"Most":[122],"parameters":[123],"were":[124,151],"derived":[125],"from":[126,135,200,225],"experimental":[127],"measurements":[128],"correspond":[130],"physiological":[132],"quantities.":[133],"Data":[134],"~1,830":[136],"adults":[137],"across":[138],"36":[139],"published":[140],"studies,":[141],"encompassing":[142],"healthy":[143],"individuals":[144],"patients":[146],"with":[147,158,213,263],"major":[148],"anemia":[149,198,220],"types,":[150],"used":[152],"validate":[154],"model,":[156],"along":[157],"blood-donor":[159],"recovery":[160,178],"cohorts.":[161],"The":[162],"reproduces":[164],"near-exponential":[166],"Hb-EPO":[167],"relationship":[168],"observed":[169],"reference":[171],"populations,":[172],"characteristic":[174],"trajectory":[175],"after":[179],"loss,":[181],"disease-specific":[183],"deviations":[184],"through":[185],"physiologically":[186],"plausible":[187],"parameter":[188],"changes,":[189],"without":[190,229],"ad":[191],"hoc":[192],"fitting.":[193],"Elevated":[194],"aplastic":[197],"emerges":[199],"reduced":[201,226,267],"mass":[203,269],"diminished":[205,271],"receptor-mediated":[206,272],"clearance;":[207],"chronic":[208,222],"kidney":[209],"disease":[210,223],"consistent":[212],"impaired":[214],"synthesis":[216],"suppression;":[219],"arises":[224],"progenitor":[227],"differentiation":[228],"requiring":[230],"primary":[231],"failure;":[233],"shortened":[235],"RBC":[236],"lifespan":[237],"alone":[238],"does":[239],"lower":[241],"steady-state":[242,252],"hemolysis.":[245],"Of":[246],"potential":[247],"clinical":[248],"significance":[249],"levels":[254,265],"provide":[255],"noninvasive":[257],"indicator":[258],"bone":[260],"activity,":[262],"higher":[264],"reflecting":[266],"uptake.":[273]},"counts_by_year":[],"updated_date":"2026-05-25T08:39:21.599409","created_date":"2026-03-25T00:00:00"}
