{"id":"https://openalex.org/W7139941589","doi":"https://doi.org/10.1371/journal.pcbi.1014051","title":"Prior-guided factorization for reliable imputation of scRNA-seq data","display_name":"Prior-guided factorization for reliable imputation of scRNA-seq data","publication_year":2026,"publication_date":"2026-03-20","ids":{"openalex":"https://openalex.org/W7139941589","doi":"https://doi.org/10.1371/journal.pcbi.1014051","pmid":"https://pubmed.ncbi.nlm.nih.gov/41860953"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1014051","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1014051","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.pcbi.1014051","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5130250020","display_name":"You Wu","orcid":null},"institutions":[{"id":"https://openalex.org/I151727225","display_name":"Harbin Engineering University","ror":"https://ror.org/03x80pn82","country_code":"CN","type":"education","lineage":["https://openalex.org/I151727225"]},{"id":"https://openalex.org/I4210110145","display_name":"Beijing Municipal Government","ror":"https://ror.org/01xp57w77","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210110145"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"You Wu","raw_affiliation_strings":["College of Computer Science and Technology, Harbin Engineering University, Harbin, Heilongjiang, China","National Engineering Laboratory for Modeling and Emulation in E-Government, Beijing, China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"College of Computer Science and Technology, Harbin Engineering University, Harbin, Heilongjiang, China","institution_ids":["https://openalex.org/I151727225"]},{"raw_affiliation_string":"National Engineering Laboratory for Modeling and Emulation in E-Government, Beijing, China","institution_ids":["https://openalex.org/I4210110145"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Li Xu","orcid":"https://orcid.org/0000-0003-4950-0789"},"institutions":[{"id":"https://openalex.org/I151727225","display_name":"Harbin Engineering University","ror":"https://ror.org/03x80pn82","country_code":"CN","type":"education","lineage":["https://openalex.org/I151727225"]},{"id":"https://openalex.org/I4210110145","display_name":"Beijing Municipal Government","ror":"https://ror.org/01xp57w77","country_code":"CN","type":"government","lineage":["https://openalex.org/I4210110145"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li Xu","raw_affiliation_strings":["College of Computer Science and Technology, Harbin Engineering University, Harbin, Heilongjiang, China","National Engineering Laboratory for Modeling and Emulation in E-Government, Beijing, China"],"raw_orcid":"https://orcid.org/0000-0003-4950-0789","affiliations":[{"raw_affiliation_string":"College of Computer Science and Technology, Harbin Engineering University, Harbin, Heilongjiang, China","institution_ids":["https://openalex.org/I151727225"]},{"raw_affiliation_string":"National Engineering Laboratory for Modeling and Emulation in E-Government, Beijing, China","institution_ids":["https://openalex.org/I4210110145"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5130232422","display_name":"Ye Win Aung","orcid":null},"institutions":[{"id":"https://openalex.org/I4210114986","display_name":"Livestock Breeding and Veterinary Department","ror":"https://ror.org/029b4kt29","country_code":"MM","type":"healthcare","lineage":["https://openalex.org/I4210114986"]}],"countries":["MM"],"is_corresponding":false,"raw_author_name":"Ye Win Aung","raw_affiliation_strings":["Defense Services Medical Research Centre, Nay Pyi Taw, Myanmar"],"raw_orcid":"https://orcid.org/0000-0002-1557-3720","affiliations":[{"raw_affiliation_string":"Defense Services Medical Research Centre, Nay Pyi Taw, Myanmar","institution_ids":["https://openalex.org/I4210114986"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5130241217","display_name":"Alex Michel Daoud","orcid":null},"institutions":[{"id":"https://openalex.org/I4210087270","display_name":"Irmandade da Santa Casa de Miseric\u00f3rdia de S\u00e3o Paulo","ror":"https://ror.org/003nnep52","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210087270"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Alex Michel Daoud","raw_affiliation_strings":["Division of Neurosurgery, Department of Surgery, Irmandade da Santa Casa de Miseric\u00f3rdia de S\u00e3o Paulo, S\u00e3o Paulo, SP, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Neurosurgery, Department of Surgery, Irmandade da Santa Casa de Miseric\u00f3rdia de S\u00e3o Paulo, S\u00e3o Paulo, SP, Brazil","institution_ids":["https://openalex.org/I4210087270"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":4.2857,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.92647252,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":94,"max":97},"biblio":{"volume":"22","issue":"3","first_page":"e1014051","last_page":"e1014051"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11289","display_name":"Single-cell and spatial transcriptomics","score":0.9983000159263611,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10885","display_name":"Gene expression and cancer classification","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11255","display_name":"Microfluidic and Bio-sensing Technologies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/imputation","display_name":"Imputation (statistics)","score":0.7824000120162964},{"id":"https://openalex.org/keywords/inference","display_name":"Inference","score":0.6823999881744385},{"id":"https://openalex.org/keywords/spurious-relationship","display_name":"Spurious relationship","score":0.557200014591217},{"id":"https://openalex.org/keywords/robustness","display_name":"Robustness (evolution)","score":0.4318999946117401},{"id":"https://openalex.org/keywords/synthetic-data","display_name":"Synthetic data","score":0.34130001068115234},{"id":"https://openalex.org/keywords/pattern-recognition","display_name":"Pattern recognition (psychology)","score":0.32749998569488525}],"concepts":[{"id":"https://openalex.org/C58041806","wikidata":"https://www.wikidata.org/wiki/Q1660484","display_name":"Imputation (statistics)","level":3,"score":0.7824000120162964},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.7135999798774719},{"id":"https://openalex.org/C2776214188","wikidata":"https://www.wikidata.org/wiki/Q408386","display_name":"Inference","level":2,"score":0.6823999881744385},{"id":"https://openalex.org/C97256817","wikidata":"https://www.wikidata.org/wiki/Q1462316","display_name":"Spurious relationship","level":2,"score":0.557200014591217},{"id":"https://openalex.org/C124101348","wikidata":"https://www.wikidata.org/wiki/Q172491","display_name":"Data mining","level":1,"score":0.4731000065803528},{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.4318999946117401},{"id":"https://openalex.org/C154945302","wikidata":"https://www.wikidata.org/wiki/Q11660","display_name":"Artificial intelligence","level":1,"score":0.41029998660087585},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.3643999993801117},{"id":"https://openalex.org/C160920958","wikidata":"https://www.wikidata.org/wiki/Q7662746","display_name":"Synthetic data","level":2,"score":0.34130001068115234},{"id":"https://openalex.org/C153180895","wikidata":"https://www.wikidata.org/wiki/Q7148389","display_name":"Pattern recognition (psychology)","level":2,"score":0.32749998569488525},{"id":"https://openalex.org/C42355184","wikidata":"https://www.wikidata.org/wiki/Q1361088","display_name":"Matrix decomposition","level":3,"score":0.31630000472068787},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.31619998812675476},{"id":"https://openalex.org/C179926584","wikidata":"https://www.wikidata.org/wiki/Q207714","display_name":"Transcription (linguistics)","level":2,"score":0.3154999911785126},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.31380000710487366},{"id":"https://openalex.org/C201797286","wikidata":"https://www.wikidata.org/wiki/Q4914986","display_name":"Biological data","level":2,"score":0.31119999289512634},{"id":"https://openalex.org/C11413529","wikidata":"https://www.wikidata.org/wiki/Q8366","display_name":"Algorithm","level":1,"score":0.2906999886035919},{"id":"https://openalex.org/C132964779","wikidata":"https://www.wikidata.org/wiki/Q2110223","display_name":"Raw data","level":2,"score":0.28949999809265137},{"id":"https://openalex.org/C90559484","wikidata":"https://www.wikidata.org/wiki/Q778379","display_name":"Expression (computer science)","level":2,"score":0.28029999136924744}],"mesh":[{"descriptor_ui":"D000081246","descriptor_name":"RNA-Seq","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D000081246","descriptor_name":"RNA-Seq","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D000081246","descriptor_name":"RNA-Seq","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D000081246","descriptor_name":"RNA-Seq","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D000081246","descriptor_name":"RNA-Seq","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D000081246","descriptor_name":"RNA-Seq","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true},{"descriptor_ui":"D000081246","descriptor_name":"RNA-Seq","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true},{"descriptor_ui":"D000081246","descriptor_name":"RNA-Seq","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true},{"descriptor_ui":"D000092386","descriptor_name":"Single-Cell Gene Expression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D000092386","descriptor_name":"Single-Cell Gene Expression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000092386","descriptor_name":"Single-Cell Gene Expression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000092386","descriptor_name":"Single-Cell Gene Expression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000092386","descriptor_name":"Single-Cell Gene Expression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000092386","descriptor_name":"Single-Cell Gene Expression Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000465","descriptor_name":"Algorithms","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000544","descriptor_name":"Alzheimer Disease","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005796","descriptor_name":"Genes","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012326","descriptor_name":"RNA Splicing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012984","descriptor_name":"Software","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D014158","descriptor_name":"Transcription, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D017423","descriptor_name":"Sequence Analysis, RNA","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D020869","descriptor_name":"Gene Expression Profiling","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053595","descriptor_name":"Embryonic Stem Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053595","descriptor_name":"Embryonic Stem Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true},{"descriptor_ui":"D059010","descriptor_name":"Single-Cell Analysis","qualifier_ui":"Q000706","qualifier_name":"statistics & numerical data","is_major_topic":true},{"descriptor_ui":"D066264","descriptor_name":"Datasets as Topic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1371/journal.pcbi.1014051","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1014051","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:41860953","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41860953","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:doaj.org/article:8ddd41de51a44969bb8c589123db5fcf","is_oa":true,"landing_page_url":"https://doaj.org/article/8ddd41de51a44969bb8c589123db5fcf","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 22, Iss 3, p e1014051 (2026)","raw_type":"article"},{"id":"pmh:oai:doaj.org/article:f259f1b54c7c473d883360340bd6f183","is_oa":true,"landing_page_url":"https://doaj.org/article/f259f1b54c7c473d883360340bd6f183","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Computational Biology, Vol 22, Iss 3 (2026)","raw_type":"article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13004523","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13004523/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1014051","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1014051","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Quality Education","score":0.4954751431941986,"id":"https://metadata.un.org/sdg/4"}],"awards":[{"id":"https://openalex.org/G2914502512","display_name":null,"funder_award_id":"No. 62172122","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"},{"id":"https://openalex.org/G6276705006","display_name":null,"funder_award_id":"No. SQ2025YFE0204912","funder_id":"https://openalex.org/F4320335774","funder_display_name":"Key Technologies Research and Development Program"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320335774","display_name":"Key Technologies Research and Development Program","ror":null},{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W2069089843","https://openalex.org/W2469823050","https://openalex.org/W2751468300","https://openalex.org/W2757764553","https://openalex.org/W2792693509","https://openalex.org/W2800392236","https://openalex.org/W2898718502","https://openalex.org/W2916020270","https://openalex.org/W2944189019","https://openalex.org/W2949067670","https://openalex.org/W2951217100","https://openalex.org/W2951381561","https://openalex.org/W2980495984","https://openalex.org/W3041535345","https://openalex.org/W3044713319","https://openalex.org/W3138479716","https://openalex.org/W3164292723","https://openalex.org/W4210587306","https://openalex.org/W4220837089","https://openalex.org/W4221065117","https://openalex.org/W4229801112","https://openalex.org/W4308484211","https://openalex.org/W4311474543","https://openalex.org/W4317796275","https://openalex.org/W4362737480","https://openalex.org/W4385982259","https://openalex.org/W4388451406","https://openalex.org/W4388626959","https://openalex.org/W4389166577","https://openalex.org/W4393241094","https://openalex.org/W4401845993","https://openalex.org/W4402644678","https://openalex.org/W4403011519","https://openalex.org/W4407042613","https://openalex.org/W4410517693","https://openalex.org/W4415798331"],"related_works":[],"abstract_inverted_index":{"Single-cell":[0],"RNA":[1],"sequencing":[2],"(scRNA-seq)":[3],"provides":[4,184],"an":[5],"important":[6],"means":[7],"to":[8,176],"reveal":[9],"the":[10,50,57,79,102,112,118],"heterogeneity":[11],"and":[12,18,31,70,72,90,97,120,123,160,191,197],"dynamic":[13],"processes":[14],"of":[15,65,128,142],"tissues,":[16],"organisms,":[17],"complex":[19,147],"diseases,":[20],"but":[21],"technical":[22,43],"capture":[23,111],"loss":[24],"(dropout)":[25],"often":[26],"obscures":[27],"true":[28,113],"biological":[29,38],"expression,":[30],"existing":[32],"imputation":[33,51,74,190],"methods":[34],"have":[35],"difficulty":[36],"distinguishing":[37],"zeros":[39],"(silent":[40],"expression)":[41],"from":[42,62,94],"noise.":[44],"To":[45],"address":[46],"this,":[47],"we":[48],"propose":[49],"framework":[52,187],"scZN.":[53],"scZN":[54,109,151,169,183],"assumes":[55],"that":[56,108,130,194],"observed":[58],"scRNA-seq":[59,180],"data":[60],"arise":[61],"a":[63,185],"combination":[64],"RNA's":[66],"two-state":[67],"transcription":[68],"process":[69],"dropout,":[71],"formulates":[73],"as":[75],"nonnegative":[76,86],"factorization:":[77],"decomposing":[78],"raw":[80],"count":[81],"matrix":[82],"into":[83],"two":[84],"interpretable":[85],"factors,":[87],"performing":[88],"learning":[89],"optimization":[91],"under":[92],"constraints":[93],"prior":[95],"knowledge":[96],"multiple":[98,136],"regularizations,":[99],"thereby":[100],"reconstructing":[101],"cellular":[103],"expression":[104,192],"landscape.":[105],"Experiments":[106],"show":[107],"can":[110,170],"distributional":[114],"characteristics":[115],"at":[116],"both":[117],"gene":[119],"cell":[121],"levels":[122],"significantly":[124],"suppress":[125],"spurious":[126],"activation":[127],"genes":[129],"should":[131],"not":[132],"be":[133],"expressed.":[134],"Across":[135],"real":[137],"datasets,":[138],"it":[139],"outperforms":[140],"dozens":[141],"state-of-the-art":[143],"methods.":[144],"Especially":[145],"in":[146],"experimental":[148],"design":[149],"scenarios,":[150],"markedly":[152],"improves":[153],"trajectory":[154],"inference":[155],"for":[156,188],"embryonic":[157],"stem":[158],"cells":[159],"mouse":[161],"dentate":[162],"gyrus":[163],"data.":[164],"In":[165],"Alzheimer's":[166],"disease":[167],"data,":[168],"also":[171],"effectively":[172],"recover":[173],"pathways":[174],"related":[175],"neuroinflammation,":[177],"improving":[178],"downstream":[179],"analysis.":[181],"Overall,":[182],"unified":[186],"missing-value":[189],"reconstruction":[193],"combines":[195],"accuracy":[196],"interpretability.":[198]},"counts_by_year":[{"year":2026,"cited_by_count":1}],"updated_date":"2026-07-18T07:39:51.176621","created_date":"2026-03-21T00:00:00"}
