{"id":"https://openalex.org/W7136837176","doi":"https://doi.org/10.1371/journal.pcbi.1013997","title":"Slow spatial migration can help eradicate cooperative antimicrobial resistance in time-varying environments","display_name":"Slow spatial migration can help eradicate cooperative antimicrobial resistance in time-varying environments","publication_year":2026,"publication_date":"2026-03-16","ids":{"openalex":"https://openalex.org/W7136837176","doi":"https://doi.org/10.1371/journal.pcbi.1013997","pmid":"https://pubmed.ncbi.nlm.nih.gov/41838786"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1013997","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1013997","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.pcbi.1013997","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Llu\u00eds Hern\u00e1ndez-Navarro","orcid":"https://orcid.org/0000-0002-7272-7597"},"institutions":[{"id":"https://openalex.org/I130828816","display_name":"University of Leeds","ror":"https://ror.org/024mrxd33","country_code":"GB","type":"education","lineage":["https://openalex.org/I130828816"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Llu\u00eds Hern\u00e1ndez-Navarro","raw_affiliation_strings":["Department of Applied Mathematics, School of Mathematics, University of Leeds, Leeds, United Kingdom"],"affiliations":[{"raw_affiliation_string":"Department of Applied Mathematics, School of Mathematics, University of Leeds, Leeds, United Kingdom","institution_ids":["https://openalex.org/I130828816"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Kenneth Distefano","orcid":null},"institutions":[{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenneth Distefano","raw_affiliation_strings":["Department of Physics & Center for Soft Matter and Biological Physics, Virginia Tech, Blacksburg, Virginia, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Physics & Center for Soft Matter and Biological Physics, Virginia Tech, Blacksburg, Virginia, United States of America","institution_ids":["https://openalex.org/I859038795"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Uwe C. T\u00e4uber","orcid":"https://orcid.org/0000-0001-7854-2254"},"institutions":[{"id":"https://openalex.org/I859038795","display_name":"Virginia Tech","ror":"https://ror.org/02smfhw86","country_code":"US","type":"education","lineage":["https://openalex.org/I859038795"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Uwe C. T\u00e4uber","raw_affiliation_strings":["Department of Physics & Center for Soft Matter and Biological Physics, Virginia Tech, Blacksburg, Virginia, United States of America","Faculty of Health Sciences, Virginia Tech, Blacksburg, Virginia, United States of America"],"affiliations":[{"raw_affiliation_string":"Department of Physics & Center for Soft Matter and Biological Physics, Virginia Tech, Blacksburg, Virginia, United States of America","institution_ids":["https://openalex.org/I859038795"]},{"raw_affiliation_string":"Faculty of Health Sciences, Virginia Tech, Blacksburg, Virginia, United States of America","institution_ids":["https://openalex.org/I859038795"]}]},{"author_position":"last","author":{"id":null,"display_name":"Mauro Mobilia","orcid":null},"institutions":[{"id":"https://openalex.org/I130828816","display_name":"University of Leeds","ror":"https://ror.org/024mrxd33","country_code":"GB","type":"education","lineage":["https://openalex.org/I130828816"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Mauro Mobilia","raw_affiliation_strings":["Department of Applied Mathematics, School of Mathematics, University of Leeds, Leeds, United Kingdom"],"affiliations":[{"raw_affiliation_string":"Department of Applied Mathematics, School of Mathematics, University of Leeds, Leeds, United Kingdom","institution_ids":["https://openalex.org/I130828816"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I130828816"],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.9253947,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":null,"biblio":{"volume":"22","issue":"3","first_page":"e1013997","last_page":"e1013997"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11252","display_name":"Evolutionary Game Theory and Cooperation","score":0.5602999925613403,"subfield":{"id":"https://openalex.org/subfields/3312","display_name":"Sociology and Political Science"},"field":{"id":"https://openalex.org/fields/33","display_name":"Social Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T11252","display_name":"Evolutionary Game Theory and Cooperation","score":0.5602999925613403,"subfield":{"id":"https://openalex.org/subfields/3312","display_name":"Sociology and Political Science"},"field":{"id":"https://openalex.org/fields/33","display_name":"Social Sciences"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.16200000047683716,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10897","display_name":"Antibiotic Use and Resistance","score":0.09440000355243683,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/metapopulation","display_name":"Metapopulation","score":0.8790000081062317},{"id":"https://openalex.org/keywords/biological-dispersal","display_name":"Biological dispersal","score":0.7789999842643738},{"id":"https://openalex.org/keywords/resistance","display_name":"Resistance (ecology)","score":0.6388999819755554},{"id":"https://openalex.org/keywords/population","display_name":"Population","score":0.5342000126838684},{"id":"https://openalex.org/keywords/human-migration","display_name":"Human migration","score":0.4101000130176544},{"id":"https://openalex.org/keywords/strain","display_name":"Strain (injury)","score":0.3953999876976013},{"id":"https://openalex.org/keywords/extinction","display_name":"Extinction (optical mineralogy)","score":0.3903000056743622},{"id":"https://openalex.org/keywords/drug-resistance","display_name":"Drug resistance","score":0.37459999322891235}],"concepts":[{"id":"https://openalex.org/C189569837","wikidata":"https://www.wikidata.org/wiki/Q954495","display_name":"Metapopulation","level":4,"score":0.8790000081062317},{"id":"https://openalex.org/C47559259","wikidata":"https://www.wikidata.org/wiki/Q778143","display_name":"Biological dispersal","level":3,"score":0.7789999842643738},{"id":"https://openalex.org/C57473165","wikidata":"https://www.wikidata.org/wiki/Q7315604","display_name":"Resistance (ecology)","level":2,"score":0.6388999819755554},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5874999761581421},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.5342000126838684},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.45590001344680786},{"id":"https://openalex.org/C170595211","wikidata":"https://www.wikidata.org/wiki/Q177626","display_name":"Human migration","level":3,"score":0.4101000130176544},{"id":"https://openalex.org/C2778022156","wikidata":"https://www.wikidata.org/wiki/Q576145","display_name":"Strain (injury)","level":2,"score":0.3953999876976013},{"id":"https://openalex.org/C101991246","wikidata":"https://www.wikidata.org/wiki/Q5422078","display_name":"Extinction (optical mineralogy)","level":2,"score":0.3903000056743622},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.37459999322891235},{"id":"https://openalex.org/C26271046","wikidata":"https://www.wikidata.org/wiki/Q187097","display_name":"Economic geography","level":1,"score":0.3239000141620636},{"id":"https://openalex.org/C35527583","wikidata":"https://www.wikidata.org/wiki/Q189156","display_name":"Cellular automaton","level":2,"score":0.31790000200271606},{"id":"https://openalex.org/C94665300","wikidata":"https://www.wikidata.org/wiki/Q63391344","display_name":"Antibiotic resistance","level":3,"score":0.31060001254081726},{"id":"https://openalex.org/C16989226","wikidata":"https://www.wikidata.org/wiki/Q16934857","display_name":"Environmental change","level":3,"score":0.3100999891757965},{"id":"https://openalex.org/C103316784","wikidata":"https://www.wikidata.org/wiki/Q3634109","display_name":"Microbial genetics","level":3,"score":0.3086000084877014},{"id":"https://openalex.org/C87590526","wikidata":"https://www.wikidata.org/wiki/Q3592884","display_name":"Experimental evolution","level":3,"score":0.30489999055862427},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.29350000619888306},{"id":"https://openalex.org/C158709400","wikidata":"https://www.wikidata.org/wiki/Q3578586","display_name":"Spatial ecology","level":2,"score":0.2897999882698059},{"id":"https://openalex.org/C94747663","wikidata":"https://www.wikidata.org/wiki/Q7574086","display_name":"Spatial variability","level":2,"score":0.2806999981403351},{"id":"https://openalex.org/C186744025","wikidata":"https://www.wikidata.org/wiki/Q7574064","display_name":"Spatial epidemiology","level":3,"score":0.2754000127315521},{"id":"https://openalex.org/C2909468537","wikidata":"https://www.wikidata.org/wiki/Q58734","display_name":"Environmental pollution","level":2,"score":0.26420000195503235},{"id":"https://openalex.org/C180478619","wikidata":"https://www.wikidata.org/wiki/Q7574066","display_name":"Spatial heterogeneity","level":2,"score":0.26010000705718994},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.2529999911785126},{"id":"https://openalex.org/C52103748","wikidata":"https://www.wikidata.org/wiki/Q2624927","display_name":"Susceptible individual","level":3,"score":0.2526000142097473}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1371/journal.pcbi.1013997","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1013997","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:41838786","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41838786","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1013997","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1013997","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":130,"referenced_works":["https://openalex.org/W91439453","https://openalex.org/W1563736841","https://openalex.org/W1672262423","https://openalex.org/W1881299912","https://openalex.org/W1939346899","https://openalex.org/W1963975966","https://openalex.org/W1966054814","https://openalex.org/W1969672552","https://openalex.org/W1969875128","https://openalex.org/W1974326595","https://openalex.org/W1981371317","https://openalex.org/W1991698856","https://openalex.org/W1992128496","https://openalex.org/W1992206934","https://openalex.org/W1996245404","https://openalex.org/W2001924625","https://openalex.org/W2005545097","https://openalex.org/W2012901500","https://openalex.org/W2018127512","https://openalex.org/W2019638172","https://openalex.org/W2020281792","https://openalex.org/W2023844649","https://openalex.org/W2025216709","https://openalex.org/W2028067959","https://openalex.org/W2029665217","https://openalex.org/W2031232438","https://openalex.org/W2033787149","https://openalex.org/W2035849178","https://openalex.org/W2040889971","https://openalex.org/W2059905849","https://openalex.org/W2060496722","https://openalex.org/W2063558597","https://openalex.org/W2064437009","https://openalex.org/W2065673339","https://openalex.org/W2066636468","https://openalex.org/W2071653135","https://openalex.org/W2082592039","https://openalex.org/W2082929763","https://openalex.org/W2089170761","https://openalex.org/W2090651792","https://openalex.org/W2102868720","https://openalex.org/W2104344909","https://openalex.org/W2105950028","https://openalex.org/W2107990492","https://openalex.org/W2109208152","https://openalex.org/W2118015073","https://openalex.org/W2118408915","https://openalex.org/W2120564921","https://openalex.org/W2122721391","https://openalex.org/W2126218947","https://openalex.org/W2127833097","https://openalex.org/W2129596641","https://openalex.org/W2131090481","https://openalex.org/W2133600525","https://openalex.org/W2135645964","https://openalex.org/W2146433021","https://openalex.org/W2147033669","https://openalex.org/W2147490589","https://openalex.org/W2155652560","https://openalex.org/W2171463101","https://openalex.org/W2174461436","https://openalex.org/W2295190630","https://openalex.org/W2316111522","https://openalex.org/W2326607751","https://openalex.org/W2350656777","https://openalex.org/W2396861954","https://openalex.org/W2401891657","https://openalex.org/W2463871935","https://openalex.org/W2511099695","https://openalex.org/W2581071829","https://openalex.org/W2739458880","https://openalex.org/W2744710357","https://openalex.org/W2750198471","https://openalex.org/W2752840650","https://openalex.org/W2763048132","https://openalex.org/W2765970410","https://openalex.org/W2781011101","https://openalex.org/W2793686504","https://openalex.org/W2793809831","https://openalex.org/W2896913088","https://openalex.org/W2918059589","https://openalex.org/W2943148793","https://openalex.org/W2948945081","https://openalex.org/W2950374406","https://openalex.org/W2958696995","https://openalex.org/W2979786936","https://openalex.org/W2980895619","https://openalex.org/W3000043994","https://openalex.org/W3007321348","https://openalex.org/W3008170249","https://openalex.org/W3011261628","https://openalex.org/W3012685345","https://openalex.org/W3016048262","https://openalex.org/W3024963524","https://openalex.org/W3043863276","https://openalex.org/W3047942346","https://openalex.org/W3086113574","https://openalex.org/W3094325431","https://openalex.org/W3116727653","https://openalex.org/W3124255594","https://openalex.org/W3137925787","https://openalex.org/W3158514322","https://openalex.org/W3169853868","https://openalex.org/W3185768166","https://openalex.org/W3198865802","https://openalex.org/W3210890336","https://openalex.org/W3214355212","https://openalex.org/W4211117603","https://openalex.org/W4220718067","https://openalex.org/W4220766074","https://openalex.org/W4241722143","https://openalex.org/W4290786633","https://openalex.org/W4311495912","https://openalex.org/W4362552237","https://openalex.org/W4385801843","https://openalex.org/W4386601021","https://openalex.org/W4387574295","https://openalex.org/W4388074590","https://openalex.org/W4388324015","https://openalex.org/W4388666939","https://openalex.org/W4388722059","https://openalex.org/W4390702068","https://openalex.org/W4396849575","https://openalex.org/W4400647511","https://openalex.org/W4402557213","https://openalex.org/W4402999612","https://openalex.org/W4406537614","https://openalex.org/W4407358167","https://openalex.org/W4409129510","https://openalex.org/W4414828738"],"related_works":[],"abstract_inverted_index":{"Antimicrobial":[0],"resistance":[1,55,155,168,213],"(AMR)":[2],"is":[3,11,56],"a":[4,19,43,73,87,92],"global":[5],"threat":[6],"and":[7,38,49,82,106,112,137,156,177,211,215,233],"combating":[8],"its":[9],"spread":[10],"of":[12,51,77,135,167,227,239],"paramount":[13],"importance.":[14],"AMR":[15,142],"often":[16],"results":[17],"from":[18],"cooperative":[20],"behaviour":[21],"with":[22],"shared":[23,99],"drug":[24,54],"protection.":[25],"Microbial":[26],"communities":[27],"generally":[28,198],"evolve":[29,85],"in":[30,60,65,79,86,169],"volatile,":[31],"spatially":[32,67],"structured":[33,68],"settings.":[34],"Migration,":[35],"space,":[36],"fluctuations,":[37],"environmental":[39,138,161],"variability":[40,139],"all":[41],"have":[42],"significant":[44],"impact":[45,226],"on":[46,117,140,230],"the":[47,110,113,118,133,141,159,164,170,187,193,217,225],"development":[48],"proliferation":[50],"AMR.":[52],"While":[53,196],"enhanced":[57],"by":[58,129,145,184],"migration":[59,136,149,207],"static":[61],"conditions,":[62],"this":[63,221],"changes":[64],"time-fluctuating":[66],"environments.":[69],"Here,":[70],"we":[71,180,203],"consider":[72],"two-dimensional":[74],"metapopulation":[75],"consisting":[76],"demes":[78,105],"which":[80,95],"drug-resistant":[81],"sensitive":[83],"cells":[84],"time-changing":[88],"environment.":[89],"This":[90],"contains":[91],"toxin":[93],"against":[94],"protection":[96],"can":[97,152,208],"be":[98],"(cooperative":[100],"AMR).":[101],"Cells":[102],"migrate":[103],"between":[104],"connect":[107],"them.":[108],"When":[109],"environment":[111],"deme":[114],"composition":[115],"vary":[116],"same":[119],"timescale,":[120],"strong":[121],"population":[122],"bottlenecks":[123],"cause":[124],"fluctuation-driven":[125],"extinction":[126],"events,":[127],"countered":[128],"migration.":[130],"We":[131,223],"investigate":[132],"influence":[134],"eco-evolutionary":[143],"dynamics":[144],"asking":[146],"at":[147],"what":[148,157],"rate":[150],"fluctuations":[151],"help":[153],"clear":[154],"are":[158],"near-optimal":[160,218],"conditions":[162,219],"ensuring":[163],"quasi-certain":[165],"eradication":[166],"shortest":[171],"possible":[172],"time.":[173],"By":[174],"combining":[175],"analytical":[176],"computational":[178],"tools,":[179],"answer":[181],"these":[182],"questions":[183],"determining":[185],"when":[186],"resistant":[188],"strain":[189,200],"goes":[190],"extinct":[191],"across":[192],"entire":[194],"metapopulation.":[195],"dispersal":[197],"promotes":[199],"coexistence,":[201],"here":[202],"show":[204],"that":[205],"slow-but-nonzero":[206],"speed":[209],"up":[210],"enhance":[212],"clearance,":[214],"determine":[216],"for":[220],"phenomenon.":[222],"discuss":[224],"our":[228],"findings":[229],"laboratory-controlled":[231],"experiments":[232],"outline":[234],"their":[235],"generalisation":[236],"to":[237],"lattices":[238],"any":[240],"spatial":[241],"dimension.":[242]},"counts_by_year":[],"updated_date":"2026-03-18T06:27:02.140700","created_date":"2025-12-10T00:00:00"}
