{"id":"https://openalex.org/W7117484577","doi":"https://doi.org/10.1371/journal.pcbi.1013838","title":"Ion dynamics underlying the seizure delay effect of low-frequency electrical stimulation","display_name":"Ion dynamics underlying the seizure delay effect of low-frequency electrical stimulation","publication_year":2025,"publication_date":"2025-12-29","ids":{"openalex":"https://openalex.org/W7117484577","doi":"https://doi.org/10.1371/journal.pcbi.1013838","pmid":"https://pubmed.ncbi.nlm.nih.gov/41460946"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pcbi.1013838","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1013838","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1371/journal.pcbi.1013838","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026080004","display_name":"Guillaume Girier","orcid":"https://orcid.org/0000-0002-3987-1554"},"institutions":[{"id":"https://openalex.org/I202391551","display_name":"Czech Academy of Sciences","ror":"https://ror.org/053avzc18","country_code":"CZ","type":"government","lineage":["https://openalex.org/I202391551"]},{"id":"https://openalex.org/I4210155092","display_name":"Czech Academy of Sciences, Institute of Computer Science","ror":"https://ror.org/0496n6574","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210155092"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Guillaume Girier","raw_affiliation_strings":["Department of Complex Systems, Institute of Computer Science of the Czech Academy of Sciences, Prague, Czech Republic"],"raw_orcid":"https://orcid.org/0000-0002-3987-1554","affiliations":[{"raw_affiliation_string":"Department of Complex Systems, Institute of Computer Science of the Czech Academy of Sciences, Prague, Czech Republic","institution_ids":["https://openalex.org/I202391551","https://openalex.org/I4210155092"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048836220","display_name":"Isa Dallmer\u2010Zerbe","orcid":"https://orcid.org/0000-0001-9581-0281"},"institutions":[{"id":"https://openalex.org/I202391551","display_name":"Czech Academy of Sciences","ror":"https://ror.org/053avzc18","country_code":"CZ","type":"government","lineage":["https://openalex.org/I202391551"]},{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]},{"id":"https://openalex.org/I4210155092","display_name":"Czech Academy of Sciences, Institute of Computer Science","ror":"https://ror.org/0496n6574","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210155092"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Isa Dallmer-Zerbe","raw_affiliation_strings":["Department of Complex Systems, Institute of Computer Science of the Czech Academy of Sciences, Prague, Czech Republic","Department of Physiology, Second Faculty of Medicine, Charles University, Prague, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Complex Systems, Institute of Computer Science of the Czech Academy of Sciences, Prague, Czech Republic","institution_ids":["https://openalex.org/I202391551","https://openalex.org/I4210155092"]},{"raw_affiliation_string":"Department of Physiology, Second Faculty of Medicine, Charles University, Prague, Czech Republic","institution_ids":["https://openalex.org/I21250087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032033543","display_name":"Jan Chvojka","orcid":"https://orcid.org/0000-0002-7957-858X"},"institutions":[{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Jan Chvojka","raw_affiliation_strings":["Department of Physiology, Second Faculty of Medicine, Charles University, Prague, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Second Faculty of Medicine, Charles University, Prague, Czech Republic","institution_ids":["https://openalex.org/I21250087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080290771","display_name":"Jan Kudl\u00e1\u010dek","orcid":"https://orcid.org/0000-0001-5597-8709"},"institutions":[{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Jan Kudlacek","raw_affiliation_strings":["Department of Physiology, Second Faculty of Medicine, Charles University, Prague, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Second Faculty of Medicine, Charles University, Prague, Czech Republic","institution_ids":["https://openalex.org/I21250087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053757899","display_name":"P\u0159emysl Jiru\u0161ka","orcid":"https://orcid.org/0000-0003-4955-8577"},"institutions":[{"id":"https://openalex.org/I21250087","display_name":"Charles University","ror":"https://ror.org/024d6js02","country_code":"CZ","type":"education","lineage":["https://openalex.org/I21250087"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Premysl Jiruska","raw_affiliation_strings":["Department of Physiology, Second Faculty of Medicine, Charles University, Prague, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Second Faculty of Medicine, Charles University, Prague, Czech Republic","institution_ids":["https://openalex.org/I21250087"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040682292","display_name":"Jaroslav Hlinka","orcid":"https://orcid.org/0000-0003-1402-1470"},"institutions":[{"id":"https://openalex.org/I202391551","display_name":"Czech Academy of Sciences","ror":"https://ror.org/053avzc18","country_code":"CZ","type":"government","lineage":["https://openalex.org/I202391551"]},{"id":"https://openalex.org/I4210155092","display_name":"Czech Academy of Sciences, Institute of Computer Science","ror":"https://ror.org/0496n6574","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210155092"]},{"id":"https://openalex.org/I4210167247","display_name":"National Institute of Mental Health","ror":"https://ror.org/05xj56w78","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I4210167247"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Jaroslav Hlinka","raw_affiliation_strings":["Department of Complex Systems, Institute of Computer Science of the Czech Academy of Sciences, Prague, Czech Republic","National Institute of Mental Health, Klecany, Czech Republic"],"raw_orcid":"https://orcid.org/0000-0003-1402-1470","affiliations":[{"raw_affiliation_string":"Department of Complex Systems, Institute of Computer Science of the Czech Academy of Sciences, Prague, Czech Republic","institution_ids":["https://openalex.org/I202391551","https://openalex.org/I4210155092"]},{"raw_affiliation_string":"National Institute of Mental Health, Klecany, Czech Republic","institution_ids":["https://openalex.org/I4210167247"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5121475840","display_name":"Helmut Schmidt","orcid":null},"institutions":[{"id":"https://openalex.org/I202391551","display_name":"Czech Academy of Sciences","ror":"https://ror.org/053avzc18","country_code":"CZ","type":"government","lineage":["https://openalex.org/I202391551"]},{"id":"https://openalex.org/I4210155092","display_name":"Czech Academy of Sciences, Institute of Computer Science","ror":"https://ror.org/0496n6574","country_code":"CZ","type":"facility","lineage":["https://openalex.org/I202391551","https://openalex.org/I4210155092"]}],"countries":["CZ"],"is_corresponding":false,"raw_author_name":"Helmut Schmidt","raw_affiliation_strings":["Department of Complex Systems, Institute of Computer Science of the Czech Academy of Sciences, Prague, Czech Republic"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Complex Systems, Institute of Computer Science of the Czech Academy of Sciences, Prague, Czech Republic","institution_ids":["https://openalex.org/I202391551","https://openalex.org/I4210155092"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2655,"currency":"USD","value_usd":2655},"apc_paid":{"value":2655,"currency":"USD","value_usd":2655},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.63070786,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"21","issue":"12","first_page":"e1013838","last_page":"e1013838"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10919","display_name":"Neurological disorders and treatments","score":0.3244999945163727,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10919","display_name":"Neurological disorders and treatments","score":0.3244999945163727,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10429","display_name":"EEG and Brain-Computer Interfaces","score":0.2856000065803528,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.16089999675750732,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/stimulation","display_name":"Stimulation","score":0.8641999959945679},{"id":"https://openalex.org/keywords/epilepsy","display_name":"Epilepsy","score":0.715399980545044},{"id":"https://openalex.org/keywords/hippocampal-formation","display_name":"Hippocampal formation","score":0.6636000275611877},{"id":"https://openalex.org/keywords/brain-stimulation","display_name":"Brain stimulation","score":0.5418000221252441},{"id":"https://openalex.org/keywords/electroencephalography","display_name":"Electroencephalography","score":0.423799991607666},{"id":"https://openalex.org/keywords/electrical-brain-stimulation","display_name":"Electrical brain stimulation","score":0.4142000079154968},{"id":"https://openalex.org/keywords/dynamics","display_name":"Dynamics (music)","score":0.3840000033378601}],"concepts":[{"id":"https://openalex.org/C24998067","wikidata":"https://www.wikidata.org/wiki/Q4114622","display_name":"Stimulation","level":2,"score":0.8641999959945679},{"id":"https://openalex.org/C2778186239","wikidata":"https://www.wikidata.org/wiki/Q41571","display_name":"Epilepsy","level":2,"score":0.715399980545044},{"id":"https://openalex.org/C148762608","wikidata":"https://www.wikidata.org/wiki/Q3748185","display_name":"Hippocampal formation","level":2,"score":0.6636000275611877},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6424999833106995},{"id":"https://openalex.org/C2985799443","wikidata":"https://www.wikidata.org/wiki/Q4955838","display_name":"Brain stimulation","level":3,"score":0.5418000221252441},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4648999869823456},{"id":"https://openalex.org/C522805319","wikidata":"https://www.wikidata.org/wiki/Q179965","display_name":"Electroencephalography","level":2,"score":0.423799991607666},{"id":"https://openalex.org/C177825189","wikidata":"https://www.wikidata.org/wiki/Q5357702","display_name":"Electrical brain stimulation","level":3,"score":0.4142000079154968},{"id":"https://openalex.org/C145912823","wikidata":"https://www.wikidata.org/wiki/Q113558","display_name":"Dynamics (music)","level":2,"score":0.3840000033378601},{"id":"https://openalex.org/C2781161787","wikidata":"https://www.wikidata.org/wiki/Q48360","display_name":"Hippocampus","level":2,"score":0.3474999964237213},{"id":"https://openalex.org/C185263204","wikidata":"https://www.wikidata.org/wiki/Q1154774","display_name":"Electrophysiology","level":2,"score":0.32199999690055847},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.2732999920845032},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.2689000070095062},{"id":"https://openalex.org/C3020056645","wikidata":"https://www.wikidata.org/wiki/Q1327643","display_name":"Electric stimulation","level":3,"score":0.26489999890327454},{"id":"https://openalex.org/C2777803345","wikidata":"https://www.wikidata.org/wiki/Q7140388","display_name":"partial seizures","level":3,"score":0.26269999146461487},{"id":"https://openalex.org/C2778542668","wikidata":"https://www.wikidata.org/wiki/Q618076","display_name":"Deep brain stimulation","level":4,"score":0.25760000944137573}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003198","descriptor_name":"Computer Simulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004558","descriptor_name":"Electric Stimulation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D004558","descriptor_name":"Electric Stimulation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D004558","descriptor_name":"Electric Stimulation","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D004827","descriptor_name":"Epilepsy","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006624","descriptor_name":"Hippocampus","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D012640","descriptor_name":"Seizures","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012640","descriptor_name":"Seizures","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012640","descriptor_name":"Seizures","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012640","descriptor_name":"Seizures","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D012640","descriptor_name":"Seizures","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D012640","descriptor_name":"Seizures","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D012640","descriptor_name":"Seizures","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D012640","descriptor_name":"Seizures","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D012640","descriptor_name":"Seizures","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1371/journal.pcbi.1013838","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1013838","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},{"id":"pmid:41460946","is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/41460946","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS computational biology","raw_type":null},{"id":"pmh:oai:pubmedcentral.nih.gov:12758816","is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC12758816/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS Comput Biol","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1371/journal.pcbi.1013838","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pcbi.1013838","pdf_url":null,"source":{"id":"https://openalex.org/S86033158","display_name":"PLoS Computational Biology","issn_l":"1553-734X","issn":["1553-734X","1553-7358"],"is_oa":true,"is_in_doaj":true,"is_core":true,"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLOS Computational Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.6904541850090027}],"awards":[{"id":"https://openalex.org/G2920341115","display_name":null,"funder_award_id":"247132","funder_id":"https://openalex.org/F4320309755","funder_display_name":"Univerzita Karlova v Praze"},{"id":"https://openalex.org/G3666736682","display_name":null,"funder_award_id":"UNCE24/MED/021","funder_id":"https://openalex.org/F4320309755","funder_display_name":"Univerzita Karlova v Praze"},{"id":"https://openalex.org/G5404499270","display_name":null,"funder_award_id":"LQ100302301","funder_id":"https://openalex.org/F4320322482","funder_display_name":"Akademie V\u011bd \u010cesk\u00e9 Republiky"},{"id":"https://openalex.org/G7076191078","display_name":null,"funder_award_id":"RVO:67985807","funder_id":"https://openalex.org/F4320322482","funder_display_name":"Akademie V\u011bd \u010cesk\u00e9 Republiky"}],"funders":[{"id":"https://openalex.org/F4320309755","display_name":"Univerzita Karlova v Praze","ror":"https://ror.org/024d6js02"},{"id":"https://openalex.org/F4320322482","display_name":"Akademie V\u011bd \u010cesk\u00e9 Republiky","ror":"https://ror.org/053avzc18"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":62,"referenced_works":["https://openalex.org/W1547704806","https://openalex.org/W1596837735","https://openalex.org/W1667372541","https://openalex.org/W1779015127","https://openalex.org/W1968259409","https://openalex.org/W1969564013","https://openalex.org/W1973275441","https://openalex.org/W1979047980","https://openalex.org/W1993113754","https://openalex.org/W1994421931","https://openalex.org/W1997953085","https://openalex.org/W2001043195","https://openalex.org/W2007495909","https://openalex.org/W2008452090","https://openalex.org/W2014030060","https://openalex.org/W2032941343","https://openalex.org/W2080438790","https://openalex.org/W2093301371","https://openalex.org/W2093627269","https://openalex.org/W2095796165","https://openalex.org/W2103596611","https://openalex.org/W2107974789","https://openalex.org/W2116068443","https://openalex.org/W2119130526","https://openalex.org/W2121613199","https://openalex.org/W2121840032","https://openalex.org/W2135629133","https://openalex.org/W2144739538","https://openalex.org/W2155965080","https://openalex.org/W2156847888","https://openalex.org/W2156969532","https://openalex.org/W2157629216","https://openalex.org/W2192749205","https://openalex.org/W2219448291","https://openalex.org/W2343448033","https://openalex.org/W2346609767","https://openalex.org/W2399625234","https://openalex.org/W2483809583","https://openalex.org/W2559437358","https://openalex.org/W2563036039","https://openalex.org/W2622488119","https://openalex.org/W2736047232","https://openalex.org/W2771435422","https://openalex.org/W2807174788","https://openalex.org/W2810196604","https://openalex.org/W2898840518","https://openalex.org/W2900585348","https://openalex.org/W2987418729","https://openalex.org/W2995459561","https://openalex.org/W3005543067","https://openalex.org/W3006997665","https://openalex.org/W3011409319","https://openalex.org/W3026608688","https://openalex.org/W3043850893","https://openalex.org/W3145775671","https://openalex.org/W3197553115","https://openalex.org/W4283464463","https://openalex.org/W4376871570","https://openalex.org/W4381469717","https://openalex.org/W4389977312","https://openalex.org/W4392747970","https://openalex.org/W4402949153"],"related_works":[],"abstract_inverted_index":{"The":[0,59],"biological":[1],"mechanisms":[2,141],"underlying":[3],"the":[4,12,56,70,83,91,110,140,148,152,155,161,168,181,195,199,206,226,238],"spontaneous":[5,121,145],"and":[6,36,74,89,142,154,176,180,204,211,236],"recurrent":[7],"transition":[8],"to":[9,39,81,159,216],"seizures":[10,22,122,218,235],"in":[11,25,54,113,124,126,132,190,198,233],"epileptic":[13],"brain":[14,42],"are":[15],"still":[16],"poorly":[17],"understood.":[18],"As":[19],"a":[20,26,103,106,127],"result,":[21],"remain":[23],"uncontrolled":[24],"substantial":[27],"proportion":[28],"of":[29,76,86,109,130,144,151,184,229],"patients.":[30],"Brain":[31],"stimulation":[32,48,60,66,88,118,157,187,208],"is":[33],"an":[34],"emerging":[35],"promising":[37],"method":[38],"treat":[40],"various":[41],"disorders,":[43],"including":[44],"drug-refractory":[45],"epilepsy.":[46],"Selected":[47],"protocols":[49],"previously":[50],"demonstrated":[51],"therapeutic":[52],"efficacy":[53,61],"reducing":[55],"seizure":[57,146,178,202],"rate.":[58],"critically":[62],"depends":[63],"on":[64,120],"chosen":[65],"parameters,":[67],"such":[68,117],"as":[69],"time":[71],"point,":[72],"amplitude,":[73,210],"frequency":[75],"stimulation.":[77],"This":[78],"study":[79,99,224],"aims":[80],"explore":[82],"neurobiological":[84],"impact":[85],"1Hz":[87],"provide":[90],"mechanistic":[92],"explanation":[93],"behind":[94],"its":[95],"seizure-delaying":[96,149],"effects.":[97],"We":[98,165,193],"this":[100],"effect":[101,150],"using":[102],"computational":[104],"model,":[105,112],"modified":[107,169],"version":[108],"Epileptor-2":[111,170],"close":[114],"comparison":[115],"with":[116],"effects":[119,183],"recorded":[123],"vitro":[125],"high-potassium":[128],"model":[129,171,200],"ictogenesis":[131],"rat":[133],"hippocampal":[134,191],"slices.":[135,192],"In":[136],"particular,":[137],"we":[138],"investigate":[139],"dynamics":[143,179,232],"emergence,":[147],"stimulation,":[153],"optimal":[156,207],"parameters":[158],"achieve":[160],"maximal":[162],"anti-seizure":[163,182],"effect.":[164,240],"show":[166],"that":[167],"replicates":[172],"key":[173],"experimental":[174],"observations,":[175],"captures":[177],"low-frequency":[185],"electrical":[186],"(LFES)":[188],"observed":[189],"identify":[194],"critical":[196],"thresholds":[197,215],"for":[201],"onset":[203],"determine":[205],"parameters-timing,":[209],"duration-that":[212],"exceed":[213],"specific":[214],"delay":[217],"without":[219],"triggering":[220],"premature":[221],"seizures.":[222],"Our":[223],"highlights":[225],"central":[227],"role":[228],"sodium-potassium":[230],"pump":[231],"terminating":[234],"mediating":[237],"LFES":[239]},"counts_by_year":[],"updated_date":"2026-06-24T13:16:06.693445","created_date":"2025-12-29T00:00:00"}